Genes & genetic systems最新文献_第5页

Retrotransposon-derived transcripts and their functions in immunity and disease. 逆转录病毒载体产生的转录本及其在免疫和疾病中的功能

IF 1.1 4区生物学

Genes & genetic systems Pub Date : 2024-02-10 Epub Date: 2024-01-10 DOI: 10.1266/ggs.23-00187

Mahoko Takahashi Ueda

{"title":"Retrotransposon-derived transcripts and their functions in immunity and disease.","authors":"Mahoko Takahashi Ueda","doi":"10.1266/ggs.23-00187","DOIUrl":"10.1266/ggs.23-00187","url":null,"abstract":"Retrotransposons, which account for approximately 42% of the human genome, have been increasingly recognized as \"non-self\" pathogen-associated molecular patterns (PAMPs) due to their virus-like sequences. In abnormal conditions such as cancer and viral infections, retrotransposons that are aberrantly expressed due to impaired epigenetic suppression display PAMPs, leading to their recognition by pattern recognition receptors (PRRs) of the innate immune system and triggering inflammation. This viral mimicry mechanism has been observed in various human diseases, including aging and autoimmune disorders. However, recent evidence suggests that retrotransposons possess highly regulated immune reactivity and play important roles in the development and function of the immune system. In this review, I discuss a wide range of retrotransposon-derived transcripts, their role as targets in immune recognition, and the diseases associated with retrotransposon activity. Furthermore, I explore the implications of chimeric transcripts formed between retrotransposons and known gene mRNAs, which have been previously underestimated, for the increase of immune-related gene isoforms and their influence on immune function. Retrotransposon-derived transcripts have profound and multifaceted effects on immune system function. The aim of this comprehensive review is to provide a better understanding of the complex relationship between retrotransposon transcripts and immune defense.","PeriodicalId":12690,"journal":{"name":"Genes & genetic systems","volume":" ","pages":"305-319"},"PeriodicalIF":1.1,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139416827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of transposable elements in human evolution and methods for their functional analysis: current status and future perspectives. 转座元件在人类进化中的作用及其功能分析方法：现状和未来展望。

IF 1.1 4区生物学

Genes & genetic systems Pub Date : 2024-02-10 Epub Date: 2023-10-20 DOI: 10.1266/ggs.23-00140

Kei Fukuda

引用次数: 0

Author Index (vol. 99, 2024). 作者索引（第99卷，2024）。

IF 1 4区生物学

Genes & genetic systems Pub Date : 2024-01-01 DOI: 10.1266/ggs.authorindex_99_2024

引用次数: 0

Corrigendum: A new variant of the ectodysplasin A receptor death domain gene associated with anhidrotic ectodermal dysplasia in a Turkish family and its simple diagnosis by restriction fragment length polymorphism [Genes Genet. Syst. (2023) 98, p. 171-178]. 更正：一个土耳其家族中与湿疹性外胚层发育不良相关的外胚层发育蛋白 A 受体死亡域基因的新变异及其通过限制性片段长度多态性的简单诊断[基因遗传学系统（2023）98，第 171-178 页]。

IF 1 4区生物学

Genes & genetic systems Pub Date : 2024-01-01 DOI: 10.1266/ggs.corrigendum_22-00138

Eyyup Rencuzogullari, Banu Guven Ezer

引用次数: 0

GGS Prize 2024. 2024年GGS奖。

IF 1 4区生物学

Genes & genetic systems Pub Date : 2024-01-01 DOI: 10.1266/ggs.prize_2024

引用次数: 0

Subject Index (vol. 99, 2024). 主题索引（vol. 99, 2024）。

IF 1 4区生物学

Genes & genetic systems Pub Date : 2024-01-01 DOI: 10.1266/ggs.subjectindex_99_2024

引用次数: 0

A four-gene-based methylation signature associated with lymph node metastasis predicts overall survival in lung squamous cell carcinoma. 与淋巴结转移相关的基于四个基因的甲基化特征预测肺鳞状细胞癌的总生存率。

IF 1.1 4区生物学

Genes & genetic systems Pub Date : 2023-11-21 Epub Date: 2023-10-13 DOI: 10.1266/ggs.22-00111

Yufei Deng, Lifeng Liu, Xia Xiao, Yin Zhao

{"title":"A four-gene-based methylation signature associated with lymph node metastasis predicts overall survival in lung squamous cell carcinoma.","authors":"Yufei Deng, Lifeng Liu, Xia Xiao, Yin Zhao","doi":"10.1266/ggs.22-00111","DOIUrl":"10.1266/ggs.22-00111","url":null,"abstract":"We aimed to identify prognostic methylation genes associated with lymph node metastasis (LNM) in lung squamous cell carcinoma (LUSC). Bioinformatics methods were used to obtain optimal prognostic genes for risk model construction using data from the Cancer Genome Atlas database. ROC curves were adopted to predict the prognostic value of the risk model. Multivariate regression was carried out to identify independent prognostic factors and construct a prognostic nomogram. The differences in overall survival, gene mutation and pathways between high- and low-risk groups were analyzed. Finally, the expression and methylation level of the optimal prognostic genes among different LNM stages were analyzed. FGA, GPR39, RRAD and TINAGL1 were identified as the optimal prognostic genes and were applied to establish a prognostic risk model. Significant differences were found among the different LNM stages. The risk model could predict overall survival, showing a moderate performance with AUC of 0.64-0.68. The model possessed independent prognostic value, and could accurately predict 1-, 3- and 5-year survival. Patients with a high risk score showed poorer survival. Lower gene mutation frequencies and enrichment of leukocyte transendothelial migration and the VEGF signaling pathway in the high-risk group may lead to the poor prognosis. This study identified several specific methylation markers associated with LNM in LUSC and generated a prognostic model to predict overall survival for LUSC patients.","PeriodicalId":12690,"journal":{"name":"Genes & genetic systems","volume":" ","pages":"209-219"},"PeriodicalIF":1.1,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41234588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-speed system to generate congenic strains in medaka. 高速系统，以在梅达卡产生适宜的菌株。

IF 1.1 4区生物学

Genes & genetic systems Pub Date : 2023-11-21 Epub Date: 2023-10-13 DOI: 10.1266/ggs.23-00075

Minori Shinya, Tetsuaki Kimura, Kiyoshi Naruse

{"title":"High-speed system to generate congenic strains in medaka.","authors":"Minori Shinya, Tetsuaki Kimura, Kiyoshi Naruse","doi":"10.1266/ggs.23-00075","DOIUrl":"10.1266/ggs.23-00075","url":null,"abstract":"The congenic strain, an inbred strain containing a small genomic region from another strain, is a powerful tool to assess the phenotypic effect of polymorphisms and/or mutations in the substituted genomic region. Recent substantial progress in the genetic studies of complex traits increases the necessity of congenic strains and, therefore, a quick breeding system for congenic strains has become increasingly important in model organisms such as mouse and medaka. Traditionally, more than ten generations are necessary to produce a congenic strain. In contrast, a quick method has been reported previously for the mouse, in which the use of genetic markers reduces the required number of backcross generations to about a half that of the traditional method, so that it would take around six generations to obtain a congenic strain. Here, we present an even quicker congenic production system, which takes only about four generations. The system can produce medaka congenic strains having part of the HNI-II (an inbred medaka strain derived from the northern Japanese population, Oryzias sakaizumii) genome in the HdrR-II1 (another inbred strain from the southern Japanese population, O. latipes) background. In this system, the availability of frozen sperm and genotype data of the BC1 male population makes it possible to start marker-assisted congenic production after obtaining the BC2 population. Our evaluation revealed that the system could work well to increase the percentage of recipient genome as expected, so that a congenic strain may be obtained in about one year.","PeriodicalId":12690,"journal":{"name":"Genes & genetic systems","volume":" ","pages":"267-275"},"PeriodicalIF":1.1,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41234589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fine mapping of Green a, Ga, on chromosome 27 in Bombyx mori. 家蚕绿色a，Ga在27号染色体上的精细定位。

IF 1.1 4区生物学

Genes & genetic systems Pub Date : 2023-11-21 Epub Date: 2023-10-06 DOI: 10.1266/ggs.23-00060

Keisuke Mase, Chikara Hirayama, Junko Narukawa, Seigo Kuwazaki, Kimiko Yamamoto

引用次数: 0

Unveiling the expansion of keratin genes in lungfishes: a possible link to terrestrial adaptation. 揭示肺鱼角蛋白基因的扩展：与陆地适应的可能联系。

IF 1.1 4区生物学

Genes & genetic systems Pub Date : 2023-11-21 Epub Date: 2023-10-17 DOI: 10.1266/ggs.23-00188

Yuki Kimura, Masato Nikaido

引用次数: 0