转座元件在人类进化中的作用及其功能分析方法：现状和未来展望。

IF 1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & genetic systems Pub Date : 2024-02-10 Epub Date: 2023-10-20 DOI:10.1266/ggs.23-00140

Kei Fukuda

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引用次数: 0

摘要

可转座元件（TE）是一种可移动的DNA序列，可以将其自身插入基因组内的不同位置，从而引起突变，从而为个体和物种提供优势或劣势。TE的插入可能导致遗传变异，这可能影响包括遗传疾病在内的广泛的人类特征。了解TE在人类生物学中的作用对于进化和医学研究都至关重要。这篇综述讨论了TEs与人类特征和疾病易感性的关系，以及TEs的功能分析方法。

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The role of transposable elements in human evolution and methods for their functional analysis: current status and future perspectives.

Transposable elements (TEs) are mobile DNA sequences that can insert themselves into various locations within the genome, causing mutations that may provide advantages or disadvantages to individuals and species. The insertion of TEs can result in genetic variation that may affect a wide range of human traits including genetic disorders. Understanding the role of TEs in human biology is crucial for both evolutionary and medical research. This review discusses the involvement of TEs in human traits and disease susceptibility, as well as methods for functional analysis of TEs.

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来源期刊

Genes & genetic systems 生物-生化与分子生物学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Genes & Genetic Systems , formerly the Japanese Journal of Genetics , is published bimonthly by the Genetics Society of Japan.