Antoine Fakhry AbdelMassih, Abdullah Faris Nasser, Gawahir AbdelRahman, Lama Ebrahim Mkarem, Mariam Mousa AbuShashieh, Rahaf AbuGhosh, Emad Gamaleldin Nasr
{"title":"Shaping the future of cardiac interventions and cardiac surgeries: The impact of virtual reality and artificial intelligence.","authors":"Antoine Fakhry AbdelMassih, Abdullah Faris Nasser, Gawahir AbdelRahman, Lama Ebrahim Mkarem, Mariam Mousa AbuShashieh, Rahaf AbuGhosh, Emad Gamaleldin Nasr","doi":"10.21542/gcsp.2025.37","DOIUrl":"10.21542/gcsp.2025.37","url":null,"abstract":"<p><p><b>Background:</b> Virtual reality (VR) and artificial intelligence (AI) have had a profound impact on transforming cardiac interventions by enhancing procedure planning, execution, and medical education. Virtual reality enables healthcare professionals to refine their skills by practicing procedures in a simulated environment while also improving patient understanding of their conditions. Artificial intelligence enhances diagnosis and treatment planning by analyzing patient data, detecting patterns, and improving both accuracy and personalized care. The aim of this review was to analyze the anatomical scopes of both technologies in the context of cardiac interventions as well as the radiologic modalities involved in image reconstruction in virtual reality. <b>Methodology:</b> A literature search using the keywords \"reviews\", \"artificial intelligence\", \"virtual reality\", and \"cardiac interventions\" was conducted across PubMed, Scopus, and Google Scholar. The search was limited to English-language systematic reviews; narrative reviews, individual research articles, editorials, and opinion papers were excluded. <b>Results:</b> An analysis of three reviews encompassing 71 studies revealed the applications of virtual reality (VR) and artificial intelligence (AI) in cardiac surgery. VR training was most frequently applied to mitral valve repair, while VR planning was most common for conotruncal anomalies. AI-driven decision support was most prevalent in heart transplantation. <b>Conclusion:</b> This article highlights the established roles of virtual reality and artificial intelligence in cardiac care, encompassing surgical training, procedural planning, risk assessment, and outcome prediction. However, current VR training methods often rely on time-consuming and expensive imaging techniques like CMR and CT angiography. Within cardiology, AI-driven decision-making is most prominent in heart transplantation.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 4","pages":"e202537"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial intelligence in coronary artery calcification scoring: Current progress and future directions.","authors":"Mobin Ghaderi, Reza Golchin Vafa, Najmeh Vosoughiyan, Sultan Mujib Dabiry, Omneya Abdelkarem","doi":"10.21542/gcsp.2025.42","DOIUrl":"10.21542/gcsp.2025.42","url":null,"abstract":"<p><strong>Objective: </strong> The primary purpose of this paper is to evaluate the role of artificial intelligence (AI) in enhancing coronary artery calcification (CAC) scoring for improved cardiovascular risk assessment.</p><p><strong>Methods: </strong>A narrative review was performed using data from PubMed, Scopus, and Semantic Scholar, focusing on publications from 2020 to 2025. The study includes research utilizing AI methodologies, including deep learning and machine learning, in CAC scoring. Key measurements included CAC scores from computed tomography (CT) images, inter-observer variability, and patient outcomes. Data analysis involved qualitative synthesis of findings and examination of performance metrics.</p><p><strong>Results: </strong>AI algorithms significantly improved CAC score accuracy, with sensitivity and specificity rates of 90%. The use of AI reduced inter-observer variability by up to 30%, enabling more consistent risk assessments. Additionally, AI-enhanced CAC scoring effectively identified high-risk patients, leading to better-targeted preventive strategies compared to traditional methods.</p><p><strong>Conclusion: </strong>The incorporation of AI into CAC scoring holds promise for transforming cardiovascular risk assessment by enhancing accuracy and reliability. Future research should focus on validating AI tools across diverse populations, developing user-friendly clinical applications, and exploring AI's role in longitudinal cardiovascular health studies. Addressing these challenges will enhance the utility of CAC scoring and ultimately improve patient outcomes.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 4","pages":"e202542"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick Ashinze, Wuraola Salawu, Eniola Akande, Suvam Banerjee, Abdullaah Idris-Agbabiaka, Bethrand Chukwu, Nelson Mafua, Francis Ngirigwa, Tesleem Okeoyo, Stephen Olowookere, Victor Mayowa Adeleye, Joseph Tolulope Olajuwon, Caleb Aboderin, Ayodeji Olasemo, Lukman Abiodun Musa
{"title":"Neurocognitive outcomes and memory transfer in heart transplantation.","authors":"Patrick Ashinze, Wuraola Salawu, Eniola Akande, Suvam Banerjee, Abdullaah Idris-Agbabiaka, Bethrand Chukwu, Nelson Mafua, Francis Ngirigwa, Tesleem Okeoyo, Stephen Olowookere, Victor Mayowa Adeleye, Joseph Tolulope Olajuwon, Caleb Aboderin, Ayodeji Olasemo, Lukman Abiodun Musa","doi":"10.21542/gcsp.2025.43","DOIUrl":"10.21542/gcsp.2025.43","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiac transplantation remains a life-saving intervention for end-stage cardiac disease, substantially improving survival and quality of life. While physiological and immunological challenges, such as graft rejection and immunosuppression, are well-characterized, emerging evidence underscores complex neurocognitive and psychological transformations in recipients. These include debated phenomena such as shifts in memory, behavior, and personality, which challenge conventional paradigms of transplantation outcomes.</p><p><strong>Methodology: </strong>This scoping review was conducted by performing comprehensive literature searches of databases including PubMed, Scopus, Google Scholar, Cochrane Library, and PsycINFO using MeSH keywords: \"heart transplant\", \"neurocognitive outcomes\", \"cellular memory\", AND \"personality transfer\". The timeline spanned 1990 through June 2025.</p><p><strong>Inclusion criteria: </strong>(1) peer-reviewed clinical studies; (2) case reports providing detailed narrative descriptions relevant to memory/personality changes; (3) manuscripts written in English; (4) reports including ≥5 participants/patients.</p><p><strong>Exclusion criteria: </strong>(1) non-transplant cardiac studies; (2) animal research; (3) editorials/opinions/gray literature; (4) non-English manuscripts. Study quality was assessed through manual review of documented accounts alongside corresponding peer-reviewed manuscripts.</p><p><strong>Results: </strong>This review synthesizes theories, case studies, and mechanistic hypotheses from published reports, exploring neurocognitive trajectories and purported memory-behavioral transfer between donors and recipients. Epigenetic modifications-such as DNA methylation and histone remodeling-are hypothesized to alter gene expression in donor-derived cells, potentially influencing recipient cognition and behavior. Concurrently, immune-brain crosstalk, mediated by cytokines and neuroinflammatory pathways, may exacerbate psychological distress, including identity dissonance and anxiety. Cognitive-behavioral interventions and psychosocial support emerge as critical tools for post-transplant adaptation.</p><p><strong>Conclusion: </strong>Current evidence on memory transfer remains inconclusive, yet its implications for biological-psychological interconnectedness warrant rigorous interdisciplinary inquiry. By integrating neuroscientific, immunological, and psychological frameworks, future research can elucidate the mechanisms underlying post-transplant neurocognitive phenomena, optimizing therapeutic strategies and patient counseling.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 4","pages":"e202543"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jace C Bradshaw, AlleaBelle Bradshaw, Rishab Agarwal, P Logan Weygandt
{"title":"Blunt trauma causing thrombotic occlusive myocardial infarction.","authors":"Jace C Bradshaw, AlleaBelle Bradshaw, Rishab Agarwal, P Logan Weygandt","doi":"10.21542/gcsp.2025.44","DOIUrl":"10.21542/gcsp.2025.44","url":null,"abstract":"<p><p><b>Introduction:</b> Traumatic myocardial infarction (TMI) is a rare but serious complication of blunt chest trauma, typically arising from coronary artery dissection, intramural hematoma, or myocardial contusion. Early recognition and intervention are critical, but diagnosis can be challenging given the broad differential for chest pain in trauma patients. <b>Case presentation:</b> A 66-year-old female presented to a quaternary academic emergency department after a motor vehicle collision with progressive chest pain. Initial electrocardiogram (ECG) showed hyperacute T-waves in lead III, ST depression with T-wave inversion in aVL, and ST depression in V2, with posterior leads revealing ST elevation in V7-V9. Trauma imaging ruled out aortic injury but revealed right coronary artery (RCA) occlusion. Left heart catheterization demonstrated complete occlusion of the mid-RCA, managed successfully with drug-eluting stent placement. The patient was discharged chest-pain free on hospital day four with plans for cardiac rehabilitation. <b>Discussion:</b> This case highlights a rare presentation of TMI in an older patient, with RCA involvement rather than the more common left anterior descending artery involvement. While TMI often occurs in patients under 45 and typically results from coronary dissection, the occlusion observed in this case is most consistent with intraluminal thrombosis, though this cannot be definitively determined. Diagnosing TMI requires maintaining a high index of suspicion, as symptoms may mimic myocardial contusion. Timely PCI is preferred over thrombolytics, given the potential for underlying coronary artery dissection. <b>Conclusion:</b> TMI, though rare, must be considered in trauma patients with chest pain and ischemic ECG changes. Early ECG acquisition and imaging are essential. PCI and CABG are the most common primary interventions, while thrombolytics should generally be avoided. Continued research is needed to refine diagnostic and management strategies for this complex condition.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 4","pages":"e202544"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ceria Halim, Billy Putra Teruna, Indah Ramadhani Harahap, Eric Teo Fernando, L Brianto Christian Nugroho
{"title":"Coagulation biomarkers as prognostic indicators in heart failure: A systematic review and meta-analysis of 14,773 patients.","authors":"Ceria Halim, Billy Putra Teruna, Indah Ramadhani Harahap, Eric Teo Fernando, L Brianto Christian Nugroho","doi":"10.21542/gcsp.2025.41","DOIUrl":"10.21542/gcsp.2025.41","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Heart failure (HF) patients are at risk of developing thrombosis due to low cardiac output, systemic inflammatory response, and endothelial dysfunction. Thromboembolic complications in HF patients most commonly lead to fatal consequences.</p><p><strong>Methods: </strong>The protocol for this study was registered in PROSPERO with identification number CRD42024532861. We performed random-effects meta-analyses on extracted data of hazard ratios (HR) and odds ratios (OR) using Review Manager 5.4.</p><p><strong>Results: </strong>Twenty-two studies with a total population of 14,773 patients were included. INR was associated with risk of mortality (per 0.1 increase, univariate HR = 1.17, 95% CI: 1.08-1.28, <i>p</i> = 0.0004; multivariate HR = 1.35, 95% CI: 0.80-2.29, <i>p</i> = 0.26). Increased D-dimer significantly increased risk of mortality (per 1 ng/mL increase; univariate HR = 1.87, 95% CI: 1.22-2.89, <i>p</i> = 0.004; multivariate HR = 1.90, 95% CI: 1.09-3.32, <i>p</i> = 0.02), and fibrinogen did not increase risk of mortality (per 1 mg/dL increase; HR = 0.93, 95% CI: 0.77-1.13, <i>p</i> = 0.45). Substantial heterogeneity was observed in D-dimer analyses. Cautious interpretation, noting 95% prediction intervals: 0.75-4.67 (univariate) and 0.58-6.19 (multivariate), should be implemented. Several analyses had insufficient data.</p><p><strong>Conclusion: </strong>Low-certainty evidence weakly supports the potential of D-dimer as an independent prognostic marker in predicting HF mortality.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 4","pages":"e202541"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zinya H Talukder, Enad Haddad, Asha Marwaha, Ross G Biggs
{"title":"Burned out Takayasu arteritis in a young caucasian female: A rare case of aortic regurgitation and aneurysm requiring surgical repair.","authors":"Zinya H Talukder, Enad Haddad, Asha Marwaha, Ross G Biggs","doi":"10.21542/gcsp.2025.38","DOIUrl":"10.21542/gcsp.2025.38","url":null,"abstract":"<p><p>Takayasu arteritis (TAK), also known as pulseless disease, is a granulomatous vasculitis that affects the aorta and its primary branches. It predominantly affects Asian women aged 10 to 40 years and leads to occlusion, stenosis, and aneurysmal changes in large vessels. Aneurysmal changes are observed in the burned-out stage of TAK and are typically found in older patients. Here, we present a rare case of burned-out Takayasu arteritis in a 27-year-old Caucasian female presenting with isolated moderate-to-severe aortic regurgitation and aortic aneurysm requiring surgical repair. TAK initially presents with nonspecific symptoms; thus, diagnosis can be missed or delayed until late in the disease course. We highlight the need for high clinical suspicion, as delay in diagnosis and appropriate treatment can lead to significant morbidity and mortality.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 4","pages":"e202538"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kellyn Trycia Zenjaya, I Gede Putu Bayu Tirta Permana, Ragil Nur Rosyadi
{"title":"BRASH syndrome in a patient with coexisting anxiety disorder and long-term benzodiazepine use: A case report.","authors":"Kellyn Trycia Zenjaya, I Gede Putu Bayu Tirta Permana, Ragil Nur Rosyadi","doi":"10.21542/gcsp.2025.40","DOIUrl":"10.21542/gcsp.2025.40","url":null,"abstract":"<p><strong>Background: </strong> BRASH syndrome represents a constellation of symptoms characterized by bradycardia, renal impairment, AV block, shock, and hyperkalemia. This vicious cycle leads to rapid clinical worsening and requires optimal management. This case illustrates the importance of rapid decision-making and management to navigate the critical phase of BRASH syndrome.</p><p><strong>Case summary: </strong>A 73-year-old woman with a pre-existing anxiety disorder presented with sudden generalized fatigue and several episodes of dyspnea. The initial electrocardiogram (ECG) revealed bradycardia (30 beats/min) with episodes of sinus arrest, RBBB, and PVC bigeminy. Laboratory tests indicated hyperkalemia, hyponatremia, elevated blood urea nitrogen, and elevated creatinine levels. Long-term alprazolam and recent bisoprolol use were documented in this patient. Dopamine was administered for inotropic and vasopressor support. Calcium gluconate was given, and a temporary pacemaker was considered. After three days of hospitalization, the patient's condition improved, with an ECG showing a heart rate of 66 beats per minute and improved renal function following the correction of hyperkalemia.</p><p><strong>Discussion: </strong>We recommend considering BRASH syndrome in patients presenting with bradycardia and hyperkalemia with recent AV nodal blocking agent use. In our case, bisoprolol was the most likely precipitating factor. The patient's long-term alprazolam use was also noted; while any potential modulatory role remains speculative, it may warrant further investigation. It is important to recognize this so that appropriate synergistic treatment for all contributing factors can be implemented, rather than focusing on a single component.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 4","pages":"e202540"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Echocardiographic predictors of right ventricular failure following left ventricular assist device implantation: Systematic review and meta-analysis.","authors":"Shruti Rajendra, Yousuf Salmasi, Espeed Khoshbin","doi":"10.21542/gcsp.2025.35","DOIUrl":"10.21542/gcsp.2025.35","url":null,"abstract":"<p><strong>Introduction: </strong> Right ventricular failure (RVF) is a significant complication following left ventricular assist device (LVAD) implantation, with no universally accepted predictors. This meta-analysis identifies the most reliable echocardiographic predictors.</p><p><strong>Methods: </strong>OVID Medline was systematically searched for observational studies reporting ten preoperative echocardiographic parameters in patients who did and did not develop RVF post-LVAD. Random-effects meta-analyses were performed. Subgroup analyses and meta-regression assessed the influence of RVF definitions and clinical characteristics on predictive capacity. Logistic regression modeling identified key cutoffs.</p><p><strong>Results: </strong>Thirty-nine studies involving 2,975 patients were included, with pooled RVF prevalence of 0.30 (0.26-0.34). Higher right ventricular end-diastolic diameter (RVEDD) (SMD: 0.368, <i>p</i> < 0.0001, I<sup>2</sup>: 1.73%) and less negative right ventricular free wall strain (RVFWS) (SMD: 0.931, <i>p</i> < 0.0001, I<sup>2</sup>: 82.9%) were significant predictors. Higher right ventricular end-diastolic area (RVEDA) was also reliable but weaker (SMD: 0.224, <i>p</i> = 0.0282, I<sup>2</sup>: 0.00%). Lower tricuspid annular plane systolic excursion (TAPSE) was a strong predictor (SMD: -0.512, <i>p</i> < 0.0001,) but less reliable due to high heterogeneity (I<sup>2</sup>: 86.1%). Subgroup analyses of TAPSE by RVF definition showed modestly reduced heterogeneity (43.7%). Predictive capacity was significantly better in more stable patients (i.e., no inotropes/IABP, higher INTERMACS status). Logistic regression identified increased RVF risk at RVEDD ≥41.5 mm (sensitivity: 50.0%, specificity: 83.3%) and RVFWS ≥ -11.3% (sensitivity: 88.9%, specificity: 88.9%). Conclusion: RVEDD ≥ 41.5 mm and RVFWS ≥ -11.3% are the strongest, most reliable predictors of RVF post-LVAD. Variations in RVF endpoint definitions only partially explain the observed heterogeneity, while patient characteristics significantly influence predictive accuracy. Future studies should explore subgroup-specific cutoffs.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 4","pages":"e202535"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Razan Moghnieh, Mohammad Kheir Chahine, Riyad Mroweh, Nadim Chaarani, Issa Zalzali, Saleh-Yezan Abdulaal, Amer Yazbak, Hadi Farhat, Joy Raheb Khelo, Razan Abdulaal
{"title":"Resveratrol and atherosclerosis: A comprehensive review of its cardioprotective mechanisms and therapeutic potential.","authors":"Razan Moghnieh, Mohammad Kheir Chahine, Riyad Mroweh, Nadim Chaarani, Issa Zalzali, Saleh-Yezan Abdulaal, Amer Yazbak, Hadi Farhat, Joy Raheb Khelo, Razan Abdulaal","doi":"10.21542/gcsp.2025.39","DOIUrl":"10.21542/gcsp.2025.39","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) remain a major global health issue, with atherosclerosis being a primary driver of their development. Atherosclerosis is driven by oxidative stress, chronic inflammation, and lipid dysregulation, which ultimately lead to endothelial dysfunction and plaque formation. Resveratrol, a polyphenolic compound found in grapes and red wine, has emerged as a promising therapeutic agent due to its multivalent protective effects against atherosclerosis. This review outlines the role of resveratrol in the inhibition of key pathologic processes, including suppression of pro-inflammatory signaling pathways, enhancement of antioxidant defense mechanisms, and regulation of cholesterol homeostasis. Resveratrol inhibits NF-κB activation, resulting in decreased vascular inflammation and reduced expression of adhesion molecules such as Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intercellular Cell Adhesion Molecule-1 (ICAM-1), thereby preventing infiltration of immune cells into arterial vessels. Additionally, it increases cholesterol efflux by promoting ATP-binding cassette transporters (ABCA1), enhancing high-density lipoprotein (HDL) function, and lowering lipid levels. Evidence from preclinical and clinical studies suggests that resveratrol holds potential as a natural treatment for the prevention of atherosclerosis.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 4","pages":"e202539"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rising sudden cardiac deaths among young Indian actors and models: The role of steroids, extreme fitness, and societal pressure.","authors":"Shrishti P Khetan, Shruti Suresh Suvarna","doi":"10.21542/gcsp.2025.27","DOIUrl":"10.21542/gcsp.2025.27","url":null,"abstract":"","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 3","pages":"e202527"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12673861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}