Global Cardiology Science & Practice最新文献_第10页

Impact of human immunodeficiency virus on pulmonary vascular disease. 人类免疫缺陷病毒对肺血管疾病的影响。

Global Cardiology Science & Practice Pub Date : 2021-06-30 DOI: 10.21542/gcsp.2021.12

Ashok Kumar, Aatish Mahajan, Ethan A Salazar, Kevin Pruitt, Christian Arce Guzman, Matthias A Clauss, Sharilyn Almodovar, Navneet K Dhillon

{"title":"Impact of human immunodeficiency virus on pulmonary vascular disease.","authors":"Ashok Kumar, Aatish Mahajan, Ethan A Salazar, Kevin Pruitt, Christian Arce Guzman, Matthias A Clauss, Sharilyn Almodovar, Navneet K Dhillon","doi":"10.21542/gcsp.2021.12","DOIUrl":"https://doi.org/10.21542/gcsp.2021.12","url":null,"abstract":"With the advent of anti-retroviral therapy, non-AIDS-related comorbidities have increased in people living with HIV. Among these comorbidities, pulmonary hypertension (PH) is one of the most common causes of morbidity and mortality. Although chronic HIV-1 infection is independently associated with the development of pulmonary arterial hypertension, PH in people living with HIV may also be the outcome of various co-morbidities commonly observed in these individuals including chronic obstructive pulmonary disease, left heart disease and co-infections. In addition, the association of these co-morbidities and other risk factors, such as illicit drug use, can exacerbate the development of pulmonary vascular disease. This review will focus on these complex interactions contributing to PH development and exacerbation in HIV patients. We also examine the interactions of HIV proteins, including Nef, Tat, and gp120 in the pulmonary vasculature and how these proteins alter the endothelial and smooth muscle function by transforming them into susceptible PH phenotype. The review also discusses the available infectious and non-infectious animal models to study HIV-associated PAH, highlighting the advantages and disadvantages of each model, along with their ability to mimic the clinical manifestations of HIV-PAH.","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2021 2","pages":"e202112"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39206753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Three-dimensional images of a pulmonary dominant truncus arteriosus before and after a novel repair. 三维图像的肺优势动脉干前后的新修复。

Global Cardiology Science & Practice Pub Date : 2021-04-30 DOI: 10.21542/gcsp.2021.9

Mohamed Nagy, Hatem Hosny, Ahmed Afifi, Abdelrahman Elafifi, Magdi H Yacoub

引用次数: 1

A case of intoxication with tea made from Digitalis purpurea. 一例洋地黄茶中毒病例。

Global Cardiology Science & Practice Pub Date : 2021-04-30 DOI: 10.21542/gcsp.2021.2

Anouk Lehmann, Selina Späni, Annette Harings-Kaim, Cecilia Probst, Andreas Christ, Anne B Leuppi-Taegtmeyer

{"title":"A case of intoxication with tea made from Digitalis purpurea.","authors":"Anouk Lehmann, Selina Späni, Annette Harings-Kaim, Cecilia Probst, Andreas Christ, Anne B Leuppi-Taegtmeyer","doi":"10.21542/gcsp.2021.2","DOIUrl":"10.21542/gcsp.2021.2","url":null,"abstract":"We present the case of a 34-year-old woman with recurrent depressive disorder who ingested purple foxglove with suicidal intent. She bought a foxglove plant (Digitalis purpurea) over the internet and used all of its leaves to make a tea that she then drank over a period of a few hours. Seventeen hours later, she developed abdominal pain, emesis and bradycardia and was admitted via the emergency department to the intensive care unit for further treatment and monitoring. The plasma digoxin concentration measured 3.53 nmol/l (therapeutic reference range 0.77-1.50 nmol/l) 21 hours after ingestion of the tea. She remained heamodynamically and neurologically stable, was treated with antiemetics and simple analgesia and did not require digoxin-specific antibodies. Despite normal renal function, her plasma digoxin half-life was prolonged (estimated 76 h), reflecting the long half-life of the parent compound digitoxin which is the main cardiac glycoside in Digitalis purpurea. She was transferred to psychiatric care 48 h after admission. In this report, we compare this case to other similar cases, which to date have only been rarely reported in the literature.","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2021 1","pages":"e202102"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39018887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could heart rate recovery and exercise capacity predict abnormal 99mTc-MIBI myocardial perfusion scan findings? 心率恢复和运动能力能否预测99mTc-MIBI异常心肌灌注扫描结果?

Global Cardiology Science & Practice Pub Date : 2021-04-30 DOI: 10.21542/gcsp.2021.7

Aryan Naghedi, Nasim Namiranian, Mohsen Goudarzi, Reza Nafisi Moghadam, Seid Kazem Razavi-Ratki

{"title":"Could heart rate recovery and exercise capacity predict abnormal 99mTc-MIBI myocardial perfusion scan findings?","authors":"Aryan Naghedi, Nasim Namiranian, Mohsen Goudarzi, Reza Nafisi Moghadam, Seid Kazem Razavi-Ratki","doi":"10.21542/gcsp.2021.7","DOIUrl":"https://doi.org/10.21542/gcsp.2021.7","url":null,"abstract":"Background and aim: Ischemic heart diseases lead to numerous deaths worldwide. Prevention, rapid diagnosis and treatment are principal strategies in controlling mortality due to coronary artery diseases (CAD). Considering variety of options, finding suitable diagnostic modality for each patient has been controversial for long times. Exercise treadmill test (ETT) is a well-known and old modality compared to radionuclide scintigraphy. In this study we aimed to assess if heart rate recovery (HRR) and exercise capacity (EC) in ETT can predict perfusion defects in 99mTc-MIBI SPECT myocardial perfusion imaging (MPI). Materials and methods: In this cross-sectional, descriptive-analytic study, we enrolled 254 patients referred for MPI to nuclear medicine department of Afshar or Shahid Sadoughi Hospital, Yazd, Iran. All patients underwent ETT and MPI. HRR and EC in ETT plus abnormal perfusion findings in MPI along with patient's history and demographic information were recorded in a questionnaire. Finally, all data were analyzed using SPSS ver.22 software. Results: Based on our results, 161 (63.4%) of patients were men. Half of patients were diagnosed with hypertension. 45% were diagnosed with diabetes, 41% had hyperlipidemia and 8.3% were smokers. Based on our findings, 18.1% of patients had abnormal MPI results. Our analytic results indicated that there is no statistically significant association between transient RV visualization, transient ischemic dilation or lung to heart ratio with 1st and 2nd minute HRR and EC. Conclusion: Considering lack of association between ETT indices and MPI findings, it seems that ETT is not adequately sensitive in predicting perfusion defects in MPI. Thus, it seems logical in some cases to ignore expenses of MPI and suggest it to patients before ETT based on clinical judgement.","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2021 1","pages":"e202107"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39018876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Epicardial mapping and ablation for ventricular arrhythmias in experienced center without onsite cardiac surgery. 在没有现场心脏外科的经验丰富的中心进行心外膜映射和消融术治疗室性心律失常。

Global Cardiology Science & Practice Pub Date : 2021-04-30 DOI: 10.21542/gcsp.2021.3

Shaojie Chen, K R Julian Chun, Stefano Bordignon, Shota Tohoku, Boris Schmidt

{"title":"Epicardial mapping and ablation for ventricular arrhythmias in experienced center without onsite cardiac surgery.","authors":"Shaojie Chen, K R Julian Chun, Stefano Bordignon, Shota Tohoku, Boris Schmidt","doi":"10.21542/gcsp.2021.3","DOIUrl":"10.21542/gcsp.2021.3","url":null,"abstract":"Objective: Epicardial access is sometimes required to effectively treat ventricular arrhythmias, but it can be associated with increased risk of procedural complications needing surgical intervention. The present study aimed to evaluate the feasibility and safety of epicardial mapping/ablation in experienced center without onsite cardiac surgery. Methods: Patients who had drug-refractory, recurrent ventricular arrhythmias were scheduled for catheter ablation. All operators (SC, JC, SB, BS) had at least fifty pericardial puncture experiences. Epicardial puncture and perioperative anticoagulation were carried out based on institutional protocol. Phrenic nerve was mapped by 3-D mapping system. Coronary anatomy was delineated by coronary angiography. Results: A total of 44 patients (63.3 years, male 86.4%) received epicardial access. Of them 7 (15.9%) were scheduled for PVC ablation, 37 (84.1%) for VT ablation (ICM: 25%, NICM: 59.1%). Mean LVEF was 41.3%. Acute ablation success rate was 35 (79.5%). Procedural adverse events included: pericardial effusion occurred in 3 (6.8%) patients who all well treated with pericardial drainage; and pericardial tamponade in 1 (2.3%) patient requiring transfer to surgical intervention. No death, stroke, phrenic nerves palsy, or coronary artery injury were observed. Median hospitalization was 4 (3-6) days. Univariable analysis and ROC curve showed that patients' age was a significant predictor of epicardial procedural complication (area under curve (AUC): 0.813, P = 0.041). Conclusions: Guided by a tailored procedural protocol, the majority of the epicardial access related complications can be treated conservatively without needing onsite surgery. Older age is a risk factor associated with epicardial access related complications.","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2021 1","pages":"e202103"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39018889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ablation of a life-threatening arrhythmia in a patient with Brugada syndrome. Brugada综合征患者危及生命的心律失常的消融治疗。

Global Cardiology Science & Practice Pub Date : 2021-04-30 DOI: 10.21542/gcsp.2021.4

Omnia Kamel, Wessam Gamal, Aliaa Tarek, Walaa Ibrahim, Mohamed Sayed, Josep Brugada, Javier Moreno

引用次数: 1

Cardiovascular adverse events in pregnancy: A global perspective. 妊娠期心血管不良事件：全球视角。

Global Cardiology Science & Practice Pub Date : 2021-04-30 DOI: 10.21542/gcsp.2021.5

Susy Kotit, Magdi Yacoub

{"title":"Cardiovascular adverse events in pregnancy: A global perspective.","authors":"Susy Kotit, Magdi Yacoub","doi":"10.21542/gcsp.2021.5","DOIUrl":"10.21542/gcsp.2021.5","url":null,"abstract":"Pregnant women with heart disease are vulnerable to many adverse cardiovascular events (AE). AEs during and after pregnancy continue to be important causes of maternal mortality and morbidity worldwide, with huge variations in burden in different countries and regions. These AEs are classified as having direct or indirect causes, depending on whether they are directly caused by pregnancy or due to some pre-existing disease and/or non-obstetric cause, respectively. The risks continue throughout pregnancy and even after childbirth. Apart from immediate complications during pregnancy, there is increasing evidence of a significant link between several events and the risk of cardiovascular disease (CVD) later in life. A significant number of pregnancy-related deaths caused by cardiovascular disease are preventable. This prevention can be realized through increasing awareness of cardiovascular AE in pregnancy, coupled with the application of strategies for prevention and treatment. Knowledge of the risks associated with CVD and pregnancy is of extreme importance in that regard. We discuss the global distribution of cardiovascular maternal mortality, adverse events during and after pregnancy, their predictors and risk stratification. In addition, we enumerate possible solutions, particularly the role of cardio-obstetric clinics.","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2021 1","pages":"e202105"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39018874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time for cardiac care in pregnancy: beyond 42 days post-partum. 妊娠期心脏护理时间:产后42天以上。

Global Cardiology Science & Practice Pub Date : 2021-04-30 DOI: 10.21542/gcsp.2021.6

Karen Sliwa, Ana Mocumbi

引用次数: 0

A case of left atrial free ball thrombus in a patient with prosthetic mitral valve. 二尖瓣置换术后左心房游离球型血栓1例。

Global Cardiology Science & Practice Pub Date : 2021-04-30 DOI: 10.21542/gcsp.2021.8

Ahmed Mohamed Fawzy Ellaien

引用次数: 1

Journey to the center of the heart: Bilateral absent superior vena cava with heart block. 前往心脏中心:双侧上腔静脉缺失伴心脏传导阻滞。

Global Cardiology Science & Practice Pub Date : 2020-12-31 DOI: 10.21542/gcsp.2020.33

Ahmed Elborae, Ramy Doss, Mahmoud Shaaban, Ahmed A Elkhouly, Mohamed Abdullah, Khalid Sorour

引用次数: 0