Global Cardiology Science & Practice最新文献

{"title":"Cytomegalovirus as a potential trigger for acute coronary syndrome: A case of NSTEMI in a previously healthy patient.","authors":"Hussam Al Hennawi, Muhammad Salman Sabri, David Teng, Maxwell Berman, Botros Shenoda","doi":"10.21542/gcsp.2025.59","DOIUrl":"10.21542/gcsp.2025.59","url":null,"abstract":"<p><p>Cytomegalovirus (CMV) infection has been implicated in endothelial dysfunction and atherogenesis, yet its role as a potential trigger for acute coronary syndrome (ACS) remains underrecognized. We present a case of a 32-year-old male with no prior medical history who developed non-ST elevation myocardial infarction (NSTEMI) and was subsequently found to have active CMV infection. The patient had no known history cardiovascular disease, though subsequent testing did reveal additional underlying risk factors. This case highlights the need to consider infectious etiologies, including CMV, as contributors to ACS in young, otherwise apparently healthy individuals. Understanding the interplay between viral infections and atherosclerotic disease may lead to improved risk stratification and management of patients presenting with ACS.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 6","pages":"e202559"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid steal syndrome with recurrent syncope: A novel manifestation of Takayasu arteritis.","authors":"Jasmin Kaur Bhullar, Hiten Patel","doi":"10.21542/gcsp.2025.62","DOIUrl":"10.21542/gcsp.2025.62","url":null,"abstract":"<p><p>Syncope as a manifestation of Takayasu arteritis is rare. We present a case of recurrent syncope in a 33-year-old woman. Clinical, laboratory, and imaging findings confirmed a new diagnosis of Takayasu arteritis. There was severe cerebrovascular involvement. Invasive angiography revealed vertebro-carotid artery collaterals causing a steal phenomenon. This resulted in vertebrobasilar insufficiency. To our knowledge, this is the first reported case of syncope due to carotid steal syndrome in Takayasu arteritis.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 6","pages":"e202562"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An uncommon case of a rapidly growing intracardiac mass.","authors":"Afendoulis Dimitrios, Matthaios Didaggelos, Perreas Konstantinos, Kartalis Athanasios","doi":"10.21542/gcsp.2025.66","DOIUrl":"10.21542/gcsp.2025.66","url":null,"abstract":"<p><p>Cardiac myxomas typically demonstrate slow growth rates, with rapid enlargement raising suspicion for malignancy. We present a 77-year-old male with a history of non-Hodgkin lymphoma who developed symptomatic atrial fibrillation. Transthoracic echocardiography revealed a left atrial mass measuring 2.5 cm that was absent six months earlier, suggesting a growth rate of approximately 5 mm/month. Multimodality imaging including transesophageal echocardiography, cardiac CT, and MRI showed features suggestive of myxoma but could not definitively exclude lymphoma recurrence given the patient's oncological history and atypical growth pattern. Thoracoscopic resection was successfully performed. Histopathology confirmed a cardiac myxoma with central necrosis-a rare finding occurring in less than 3% of cases-which likely contributed to the unusually rapid growth. This case highlights the diagnostic value of multimodality imaging and the importance of multidisciplinary decision-making in managing complex cardiac masses.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 6","pages":"e202566"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of in-bed exercise testing using a clamp-on pedaling device: A single-center pragmatic study.","authors":"Neil K Jairath, Joshua Mijares, Kishore M Vora","doi":"10.21542/gcsp.2025.63","DOIUrl":"10.21542/gcsp.2025.63","url":null,"abstract":"<p><strong>Background: </strong>Exercise stress testing is the gold standard for evaluating peripheral arterial disease (PAD) and exercise-induced pulmonary hypertension, but traditional treadmill testing has operational limitations including need for patient transport, specialized facilities, and inability to perform invasive hemodynamic monitoring during exercise.</p><p><strong>Methods: </strong>This prospective single-center feasibility study enrolled 54 consecutive patients undergoing ABI (<i>n</i> = 35) or RHC (<i>n</i> = 19) procedures at Owensboro Medical Practice. The Bedside Bike (Bedside Bike, LLC; 510(k)-exempt Class I device, product code ION) was integrated into routine vascular laboratory and catheterization laboratory workflows. Primary endpoints included exercise completion rates, data interpretability, and safety. Prespecified success criteria were: completion rate ⩾90% and interpretability ⩾80% for ABI; completion rate ⩾90% and interpretability ⩾70% for RHC; system usability ⩾80% for both.</p><p><strong>Results: </strong>Exercise was attempted in 94.4% (51/54; 95% CI: 87.0-100%) of patients with a 94.1% (48/51; 95% CI: 86.3-100%) completion rate among those who attempted. Data interpretability was excellent: 97.1% (34/35; 95% CI: 91.4-100%) for ABI and 84.2% (16/19; 95% CI: 68.4-100%) for RHC. All prespecified feasibility criteria were met. System usability ratings were 85.7% (95% CI: 74.3-97.1%) for ABI and 89.5% (95% CI: 73.7-100%) for RHC. Adverse events were minor and occurred in 14.3% of ABI and 5.3% of RHC procedures. Among RHC patients with paired measurements, median cardiac output increased from 4.0 [IQR: 3.8-4.7] L/min at rest to 5.0 [4.8-6.5] L/min with exercise, with a median mPAP/CO slope of 8.26 [6.88-14.12] mmHg/L/min.</p><p><strong>Conclusion: </strong>This feasibility study demonstrates that bedside exercise testing using a portable pedaling device is technically feasible, safe, and well-tolerated for both ABI and RHC procedures. These preliminary results support larger studies to evaluate diagnostic validity and clinical utility.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 6","pages":"e202563"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redo totally endoscopic 3D surgery for recurrent left atrial myxoma causing cerebrovascular accidents with a novel technique: A case report.","authors":"Phan Quang Thuan, Lam Dac Huy, Pham Tran Viet Chuong, Cao Dang Khang, Nguyen Hoang Dinh","doi":"10.21542/gcsp.2025.67","DOIUrl":"10.21542/gcsp.2025.67","url":null,"abstract":"<p><strong>Background: </strong>Recurrent left atrial myxoma is rare but clinically significant due to its potential for embolic complications, including cerebrovascular accidents (CVA). Minimally invasive redo procedures remain technically challenging, particularly in the presence of postoperative adhesions.</p><p><strong>Case presentation: </strong>We report the case of a 39-year-old Asian female with a history of totally endoscopic myxoma resection via axillary thoracotomy in June 2023, who presented with new-onset right upper limb weakness. Imaging revealed a recurrent left atrial myxoma (20 × 30 mm) attached to the interatrial septum, along with acute ischemic infarcts in the left cerebral hemisphere. The patient underwent successful redo totally endoscopic 3D surgery using a right atrial approach and a double-port (Double-port approach, Camera and main port in the same intercostal space, Totally endoscopic with a skin incision <3 cm, DCT) technique. Partial resection of the interatrial septum was performed to minimize recurrence risk. Cardiopulmonary bypass and aortic cross-clamp times were 110 and 90 min, respectively. Recovery was uneventful, with complete neurological and cardiac function restored.</p><p><strong>Conclusion: </strong>This case demonstrates that redo totally endoscopic 3D resection of recurrent left atrial myxoma is feasible and safe, even in the setting of pleural adhesions. The right atrial approach, combined with the DCT technique, offers a precise and minimally invasive strategy for managing recurrent cardiac tumors with embolic potential.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 6","pages":"e202567"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When delivery matters: Diffuse coronary vasospasm with continuous, but not bolus, 5-FU infusion.","authors":"Muhammad Salman Sabri, Zinya Talukder, Angad Bedi, Sung-Hae Cho","doi":"10.21542/gcsp.2025.61","DOIUrl":"10.21542/gcsp.2025.61","url":null,"abstract":"<p><p>5-Fluorouracil (5-FU) is a fluorinated pyrimidine chemotherapy analogue used to treat various gastrointestinal solid malignancy. It is known to be associated with cardiotoxicity. Here, we present a case of 58-year-old male with mucinous adenocarcinoma of the sigmoid colon who experienced global coronary vasospasm in setting of continuous 5-FU infusion refractory to prophylactic antianginal treatment. However, he was asymptotic when given bolus of 5-FU. Our case highlights the difference in toxicity between continuous and bolus 5-FU therapy and emphasizes the need for further research in the pathophysiology and treatment of cardiotoxicity related to 5-FU therapy.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 6","pages":"e202561"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of arterial hypertension in Morocco: Screening results from 'May Measurement Month' 2024.","authors":"Nora Taiek, Abderrahmane Belkacem, Faiza Aziouaz, Abdelkader Jalil El Hangouche","doi":"10.21542/gcsp.2025.51","DOIUrl":"10.21542/gcsp.2025.51","url":null,"abstract":"<p><strong>Background: </strong>Arterial hypertension is the leading cause of mortality worldwide. The International Society of Hypertension initiated an annual global initiative called the May Measurement Month screening campaign to raise awareness regarding arterial hypertension and its adverse outcomes.</p><p><strong>Aim: </strong>To evaluate the prevalence of arterial hypertension in Morocco, as well as the prevalence of uncontrolled and untreated hypertension.</p><p><strong>Methods: </strong>Adult participants (≥18 years) were screened through opportunistic sampling across Morocco during May 2024. Trained volunteers recorded standardized blood pressure measurements, with the last two readings being averaged from community volunteer participants, along with socio-demographic parameters, weight, height, lifestyle factors, and comorbidities. Hypertension was defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg and/or taking antihypertensive medication.</p><p><strong>Results: </strong>A total of 1421 participants were screened in May 2024, comprising 727 (51,2%) females and 694 (48,8%) males with a median age of 48 years (SD 20.1). Of all 1421 participants, 524 (36.9%) were hypertensive, while 52.9% were unaware of their hypertension status. Among participants who were previously diagnosed with hypertension, 79.4% were on antihypertensive medication, and only 45,9% had controlled hypertension.</p><p><strong>Conclusion: </strong>Our study registered a high prevalence of arterial hypertension in Morocco. It also pointed to a high burden of undiagnosed and uncontrolled hypertension.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 5","pages":"e202551"},"PeriodicalIF":0.0,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends in mortality related to heart failure and depression in the United States: 1999-2020.","authors":"Pravallika Puvvadi, Akash Ranganatha, Nikita Talpallikar, Emi Kosa Zerzan, Nikhil Vamsi Chitte, Shaheer Ahmad Dar","doi":"10.21542/gcsp.2025.45","DOIUrl":"10.21542/gcsp.2025.45","url":null,"abstract":"<p><strong>Introduction: </strong>Heart failure (HF) remains a leading cause of death in the United States. While depression is known to affect 17-37% of HF patients, its contribution to recorded mortality is poorly characterized in national datasets. Death certificate documentation of comorbid depression in HF deaths provides insight into clinical recognition and reporting patterns rather than the comprehensive burden of disease.</p><p><strong>Aims: </strong>To analyze temporal trends and demographic disparities in death certificate documentation of depression among decedents with HF as the underlying cause, using the CDC Multiple Causes of Death (MCD) database from 1999-2020.</p><p><strong>Methodology: </strong>A retrospective observational study was conducted using the CDC MCD database for adults aged ≥25 years in the U.S. from 1999-2020. Deaths with HF (ICD-10: I50) as the underlying cause and depression (ICD-10: F32) as a contributing cause were identified. Age-adjusted mortality rates (AAMRs) per 1,000,000 population were calculated using the 2000 U.S. standard population, and trends were assessed with Joinpoint regression, expressed as annual percentage change (APC) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A total of 3,593 deaths were recorded where HF was listed as the underlying cause and depression as a contributing cause. The overall AAMR for HF with depression showed a declining trend from 1999-2009 (APC = -6.24; 95% CI = -8.31 to -4.12), followed by a plateau from 2009-2020 (APC = 0.05; 95% CI = -0.31 to 0.42). Females accounted for 69.6% of deaths, with higher AAMRs than males. The highest mortality documentation occurred in metropolitan areas and among White individuals (95.1%).</p><p><strong>Conclusions: </strong>This study reveals declining documentation of depression on HF-related death certificates through 2009, followed by stabilization thereafter. The low absolute count of 3,593 deaths across two decades indicates substantial under-ascertainment compared to the known clinical prevalence of depression in HF patients. These findings primarily reflect documentation and reporting patterns rather than the total mortality burden, emphasizing the need for improved recognition and recording of mental health comorbidities in cardiovascular disease surveillance.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 5","pages":"e202545"},"PeriodicalIF":0.0,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel insights into no-reflow post-PCI: The predictive value of coronary sinus hemodynamics.","authors":"Shimaa Gamal Zein-Elabdeen, Mahmoud Abdelaziz Abdelrashid, Montaser Elsekely, Ahmed Atef Hasan, Mohamed Salah Abdelbasit","doi":"10.21542/gcsp.2025.56","DOIUrl":"10.21542/gcsp.2025.56","url":null,"abstract":"<p><strong>Background: </strong>Coronary no-reflow (NR) represents a significant complication associated with increased mortality in patients with acute myocardial infarction undergoing percutaneous coronary intervention (PCI). The identification of novel predictors for early recognition and timely management warrants investigation in order to improve patient outcomes.</p><p><strong>Aim: </strong>The coronary sinus has emerged as a versatile tool in various diagnostic and therapeutic interventions. Accordingly, we aimed to measure coronary sinus filling time (CSFT) in patients who developed NR during primary PCI and evaluate its potential role in NR prediction.</p><p><strong>Methods: </strong>A total of 180 patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI were enrolled in this study. Patients were stratified into two groups based on the occurrence of no-reflow phenomenon: the NR group (<i>n</i> = 69) and the normal reflow group (<i>n</i> = 111). CSFT was measured following culprit vessel revascularization.</p><p><strong>Results: </strong>NR developed in 38.3% of patients. CSFT was significantly prolonged in the NR group compared with the normal reflow group (69.13 ± 12.20 vs. 60.19 ± 23.22 frame counts, <i>p</i> = 0.001). Regression analysis identified five independent predictors of NR: diabetes mellitus, hypertension, smoking, use of non-compliant balloon, and CSFT. The optimal CSFT cut-off value for predicting NR was >66 frame counts, with a sensitivity of 60.9% and specificity of 78.4%. The area under the receiver operating characteristic curve was 0.722 (<i>p</i> = 0.004).</p><p><strong>Conclusion: </strong>Coronary sinus filling time represents an underutilized yet potentially valuable tool for the prediction and early identification of the no-reflow phenomenon during PCI. Our findings suggest that prolonged CSFT correlates with impaired microvascular perfusion and may serve as an early physiological indicator of impending no-reflow.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 5","pages":"e202556"},"PeriodicalIF":0.0,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological complications in Takotsubo syndrome: A case of concurrent acute stroke.","authors":"Badr Abdalani, Meriam Amri, Abdellah Boucetta, Omar Moufid, R Habbal","doi":"10.21542/gcsp.2025.55","DOIUrl":"10.21542/gcsp.2025.55","url":null,"abstract":"<p><p>Takotsubo Syndrome (TTS), or stress cardiomyopathy, manifests as acute myocardial dysfunction mimicking acute coronary syndrome, with particular clinical relevance in post-menopausal women. Its diagnosis remains challenging due to overlapping features with other cardiovascular events, despite growing recognition. We report the case of a 76-year-old post-menopausal woman without major cardiovascular risk factors who developed TTS associated with ischemic stroke following the emotional stress of her son's death. She initially presented with chest pain, later complicated by neurological deficits including weakness and speech impairment. Laboratory testing revealed elevated troponin levels, while echocardiography demonstrated typical TTS findings, further supported by the InterTAK diagnostic score and the absence of coronary obstruction on angiography. This case emphasizes the importance of considering TTS in elderly women under acute stress, highlighting the complex interplay between TTS and ischemic stroke. A multidisciplinary evaluation is required, while further studies are needed to clarify mechanisms and optimize management.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 5","pages":"e202555"},"PeriodicalIF":0.0,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}