Global Cardiology Science & Practice最新文献

{"title":"Takotsubo cardiomyopathy in endurance athletes: Clinical insights from marathon-related cases.","authors":"Husam Katib, Ngoc Thai Kieu, Sabeeh Islam","doi":"10.21542/gcsp.2026.6","DOIUrl":"10.21542/gcsp.2026.6","url":null,"abstract":"<p><p><b>Background:</b> Takotsubo cardiomyopathy (TTC), or stress-induced cardiomyopathy, is characterized by transient left ventricular dysfunction often triggered by emotional or physical stress. Although classically associated with postmenopausal women under psychological stress, cases among endurance athletes, particularly marathon runners, have emerged, suggesting a unique pathophysiological link between extreme exercise, catecholamine surge, and microvascular dysfunction. <b>Objective:</b> This review synthesizes published cases and mechanistic studies of TTC occurring in endurance athletes, emphasizing marathon-related presentations, diagnostic challenges, and clinical implications. <b>Methods:</b> A structured literature review of PubMed, Scopus, and Web of Science identified case reports and series meeting predefined diagnostic and methodological criteria. Dual extraction, quality appraisal, and PRISMA-guided selection were performed. <b>Results:</b> A total of 42 documented cases were analyzed. The majority occurred in middle-aged athletes, predominantly female, with acute chest pain or dyspnea immediately after race completion. Troponin elevations were modest, and coronary angiography was negative for obstructive lesions. Echocardiography and cardiac MRI typically demonstrated apical or mid-ventricular ballooning with rapid recovery. Mechanistic data support transient catecholamine-mediated myocardial stunning and microvascular dysfunction as central features. <b>Conclusion:</b> TTC in endurance athletes represents a distinct clinical entity within the spectrum of stress cardiomyopathies. Recognition of this condition is crucial in differentiating it from acute coronary syndromes and preventing recurrence through risk modification and psychological or autonomic management.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2026 1","pages":"e202606"},"PeriodicalIF":0.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac amyloidosis presenting as refractory heart failure: Role of GLS in diagnosis and on follow up.","authors":"Chigullapalli Sridevi, Susheel Kumar Malani, Prakyath Shetty","doi":"10.21542/gcsp.2026.7","DOIUrl":"10.21542/gcsp.2026.7","url":null,"abstract":"<p><p><b>Background:</b> Cardiac amyloidosis represents a challenging diagnosis in patients with multiple myeloma, often presenting as refractory heart failure with subtle early manifestations that can delay appropriate treatment. <b>Case:</b> We report a 55-year-old male with a three-year history of multiple myeloma who presented with progressive dyspnea and bilateral lower limb edema. Despite being normotensive and non-diabetic, he exhibited clinical signs of volume overload with elevated jugular venous pressure and bilateral crepitations. Electrocardiography revealed left ventricular hypertrophy with strain pattern, left axis deviation, and left bundle branch block, raising suspicion for infiltrative cardiomyopathy. Transthoracic echocardiography demonstrated moderate concentric left ventricular hypertrophy with reduced ejection fraction (40%) and severe grade III diastolic dysfunction. Global longitudinal strain analysis revealed markedly reduced GLS at -9.7% with characteristic apical sparing pattern, creating the pathognomonic \"cherry-on-top\" appearance. Despite optimal heart failure management and continued multiple myeloma treatment, six-month follow-up demonstrated dramatic GLS deterioration to -1.9% , indicating progressive cardiac amyloidosis and poor prognosis. <b>Conclusion:</b> Global longitudinal strain serves as both a sensitive diagnostic tool and powerful prognostic marker in cardiac amyloidosis secondary to multiple myeloma, supporting its integration into routine cardiac surveillance protocols for patients with plasma cell disorders to enable earlier diagnosis and better risk stratification.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2026 1","pages":"e202607"},"PeriodicalIF":0.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reimagining cardiac care with AI, LLMs, blockchain, and metaverse.","authors":"Ahmad Musamih, Khaled Salah, Mohammed Omar, Samer Ellaham","doi":"10.21542/gcsp.2026.9","DOIUrl":"10.21542/gcsp.2026.9","url":null,"abstract":"<p><p><b>Objective:</b> Artificial intelligence (AI) is reshaping cardiology by analyzing complex data and enabling precision care. Among its recent advances, large language models (LLMs) have gained prominence for their potential to enhance clinical reasoning, documentation, and education. Alongside AI, blockchain, and metaverse-based extended reality (XR) are transforming data security, interoperability, and immersive visualization. This review consolidates the current literature on these technologies, evaluates their roles in cardiology, and introduces a conceptual framework for integrating them to support a secure, intelligent, and interactive digital ecosystem. <b>Methods:</b> A structured narrative review was conducted using PubMed and Scopus to identify peer-reviewed studies published between 2018 and 2025. Systematic identification and screening of the literature were performed and reported using PRISMA 2020. Eligible publications included original research, reviews, and conceptual papers addressing the use of AI, LLMs, blockchain, or XR in cardiology. The literature was analyzed thematically, and findings were synthesized qualitatively to describe applications, limitations, and opportunities for integration. <b>Results:</b> Across 50 studies, LLMs showed promise in documentation, education, and decision support but faced challenges in accuracy, validation, and bias. Blockchain applications improved data exchange, consent management, and provenance tracking, though scalability and interoperability remain unresolved. XR technologies enhanced procedural precision, training, and patient engagement but were limited by cost and validation. A conceptual integration model illustrates how these technologies function within a unified cardiovascular ecosystem where blockchain provides the trust layer, LLMs deliver analytical intelligence, and XR enables immersive interaction. <b>Conclusion:</b> Integrating AI, LLMs, blockchain, and XR offers a pathway toward intelligent, secure, and interactive cardiovascular care. Future research should validate integrated frameworks, develop ethical and regulatory standards, and promote responsible adoption of AI in cardiology.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2026 1","pages":"e202609"},"PeriodicalIF":0.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term changes in interleukin 10 following drug-eluting stent placement in stable angina patients: Influence of hypertension.","authors":"Zeyad Albadri, Monte Badri, Reem Almousali","doi":"10.21542/gcsp.2026.2","DOIUrl":"10.21542/gcsp.2026.2","url":null,"abstract":"<p><p><b>Background:</b> Drug-eluting stents (DES) are widely used in percutaneous coronary interventions (PCI) to reduce restenosis. However, their effect on acute inflammatory and anti-inflammatory responses is not completely understood. Interleukin-10 (IL-10) is a key anti-inflammatory cytokine implicated in vascular healing and modulation of immune responses following endothelial injury. <b>Objective:</b> To evaluate the acute-phase response of IL-10 following DES implantation in patients with stable angina, with a particular focus on differences between hypertensive and normotensive individuals. <b>Methods:</b> Thirteen patients with stable angina undergoing elective DES implantation were included. Arterial blood samples were collected at baseline and immediately post-procedure, and venous samples were collected at 24 h post-PCI. Serum IL-10 levels were measured using ELISA. Patients were stratified based on hypertensive status. <b>Results:</b> IL-10 levels significantly increased immediately after stenting (16.65 ± 1.49 pg/ml) compared to baseline (11.88 ± 0.42 pg/ml; <i>P</i> < 0.05). However, levels declined significantly at 24 h post-procedure (10.15 ± 1.04 pg/ml). Hypertensive patients showed a greater post-procedure increase in IL-10 (18.16 ± 2.4 pg/ml) than normotensive patients (15.16 ± 1.08 pg/ml), though this difference was not statistically significant. At 24 h, IL-10 levels fell below baseline in both groups. The IL-6/IL-10 ratio, used as an index of net inflammatory activity, significantly increased at 24 h (1.05 ± 0.13), suggesting a delayed shift toward a pro-inflammatory state. <b>Conclusion</b>: DES implantation in patients with stable angina induces a transient increase in IL-10 levels, particularly among hypertensive individuals. The subsequent decline in IL-10 and rise in the IL-6/IL-10 ratio at 24 h may indicate a pro-inflammatory rebound phase. These findings underscore the dynamic nature of cytokine regulation following PCI and support further investigation into IL-10's role in modulating vascular inflammation and restenosis risk.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2026 1","pages":"e202602"},"PeriodicalIF":0.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From STEMI to saddle pulmonary embolism: Management challenges and the role of VA-ECMO.","authors":"Enad Haddad, Irfan Ahsan, Sudeep Nugooru, Gregary D Marhefka","doi":"10.21542/gcsp.2026.4","DOIUrl":"10.21542/gcsp.2026.4","url":null,"abstract":"<p><p>Acute pulmonary embolism and acute myocardial infarction are critical conditions with overlapping presentations, and their coexistence can be catastrophic. We report a 45-year-old man with prior mid LAD stent who presented with chest pain and ventricular fibrillation arrest, diagnosed with inferior/posterior STEMI. Emergent PCI to the mid RCA restored stability. The patient developed persistent hypoxia over the next two days requiring intubation and mechanical ventilation. Worsening hypoxia and shock prompted urgent transesophageal echocardiography to evaluate for mechanical complications, instead revealing a mobile echo density spanning the right and left main pulmonary arteries, consistent with acute saddle pulmonary embolism, and right ventricular dilation and hypokinesis. Due to rapidly progressive hypoxia and shock, he was placed on VA-ECMO and started on anticoagulation, improving without the need for urgent interventional or surgical embolectomy. This case underscores the importance of considering acute pulmonary embolism in post-myocardial infarction patients with unexplained hypoxia or shock, where overlapping features may delay diagnosis. Early VA-ECMO initiation can provide a bridge to recovery in such critically ill patients.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2026 1","pages":"e202604"},"PeriodicalIF":0.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends and demographic patterns in hypertension-related mortality with intracerebral hemorrhage in the United States: 1999-2020.","authors":"Paraag Vashist, Khansa Younus, Sindiri Rohit, Sowkarthick K S, Abhishek Hanumanpratap Singh Kshatri, Surya Vamsi Gadde","doi":"10.21542/gcsp.2026.3","DOIUrl":"10.21542/gcsp.2026.3","url":null,"abstract":"<p><p><b>Introduction:</b> Hypertension contributes to cardiovascular mortality, yet its role as an underlying cause with intracerebral hemorrhage (ICH) as a contributing cause is underexplored. Understanding demographic and geographic patterns can guide prevention. <b>Aim:</b> To analyze mortality trends and demographic disparities in deaths with hypertension as the underlying cause and ICH as a contributing cause, using the CDC Multiple Cause of Death (MCD) database from 1999-2020. <b>Methods:</b> Retrospective observational analysis of the CDC MCD database for adults aged ≥25 years in the United States from 1999-2020. Deaths were included if hypertension (I10-I15) was the underlying cause and intracerebral hemorrhage (ICH I61) a contributing cause. Data were stratified by gender, race, geographic region, and place of death. Crude and age-adjusted mortality rates per 1,000,000 and annual percentage change (APC) were calculated. Temporal trends were assessed using Joinpoint software. <b>Results</b>: Among 14,613 deaths (crude rate 3.3 per million), most decedents were male (56.5%) and White (62.8%); Black/African American individuals accounted for 31.2%, Asian/Pacific Islander 5.3%, and American Indian/Alaska Native 0.7%. Most deaths occurred in metropolitan areas (89.4%) and in medical facilities (61.0%), while 25.2% occurred at home. Age-adjusted rates were stable from 1999-2007, declined 2007-2013, then rose 2013-2020. Females showed larger early declines followed by a modest rise, whereas males experienced a later sharper increase. Black/African American decedents had early declines with a subsequent plateau, while White decedents showed smaller early change, followed by decline and later increase. <b>Conclusion:</b> Deaths with hypertension as the underlying cause and ICH as a contributing cause were concentrated among males, White and Black populations, and metropolitan residents, with most deaths in medical facilities. Notably, after a period of decline, mortality rates increased again after 2013, particularly among males and White individuals, underscoring the urgency of renewed prevention efforts.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2026 1","pages":"e202603"},"PeriodicalIF":0.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of dobutamine versus milrinone in cardiogenic shock: Systematic review and meta-analysis.","authors":"Arga Setyo Adji, Rizka Kusuma Wardahni, Isnia Maulidah, Diski Saisa, Angela Puspita, Antonius Dwi Saputra, Aufa Baraja, Anne Mantofa, Intan Komalasari","doi":"10.21542/gcsp.2026.5","DOIUrl":"10.21542/gcsp.2026.5","url":null,"abstract":"<p><p><b>Background:</b> Cardiogenic shock (CS) is a life-threatening condition requiring timely pharmacological support. Dobutamine and milrinone are commonly used inotropes, yet their comparative efficacy and safety in CS management remain uncertain. This systematic review and meta-analysis aims to evaluate the outcomes associated with dobutamine versus milrinone in CS patients. <b>Methods:</b> A thorough literature search was conducted across databases including MEDLINE (via PubMed), CENTRAL (Cochrane Central Register of Controlled Trials), and Scopus, spanning publications up to February 2025. Randomized controlled trials and observational studies comparing dobutamine and milrinone in adult patients diagnosed with CS were incorporated. Statistical analyses were performed employing a random-effects model. Effect measures comprised odds ratios (OR) for binary outcomes and standardized mean differences (SMD) for continuous outcomes, accompanied by 95% confidence intervals (CI), with heterogeneity evaluated using <i>I</i> ² statistics. <b>Results:</b> Dobutamine was associated with higher in-hospital mortality (OR 1.56, 95% CI 1.01-2.39; <i>I</i> ² = 93%; <i>p</i> = 0.04), which was non-significant in RCTs (OR 1.24, 95% CI 0.70-2.19; <i>I</i> ² = 0%; <i>p</i> = 0.46; moderate certainty) but significant in observational studies (OR 1.63, 95% CI 1.02-2.59; <i>I</i> ² = 94%; <i>p</i> = 0.04; very low certainty). Mortality was markedly increased in ICU settings (OR 2.85, 95% CI 1.42-5.69; <i>I</i> ² = 93%; <i>p</i> < 0.001; moderate certainty), whereas non-ICU settings showed no significant difference (OR 0.68, 95% CI 0.32-1.45; <i>I</i> ² = 84%; low certainty). Overall all-cause mortality was also higher with dobutamine (OR 1.54, 95% CI 1.07-2.21; <i>I</i> ² = 87%; <i>p</i> = 0.02), remaining non-significant in RCT data (OR 1.30, 95% CI 0.73-2.32; moderate certainty) but significant in observational data (OR 1.58, 95% CI 1.06-2.35; <i>I</i> ² = 89%; low certainty). No significant differences were observed in ICU length of stay (SMD -0.13, 95% CI -0.99 to 0.73; <i>I</i> ² = 93%) or hospital length of stay (SMD -0.69, 95% CI -4.49 to 3.11; <i>I</i> ² = 98%), and significant arrhythmias were comparable (OR 0.88, 95% CI 0.40-1.93; <i>I</i> ² = 76%). However, acute renal failure was significantly more frequent with dobutamine (OR 1.22, 95% CI 1.01-1.47; <i>I</i> ² = 0%; <i>p</i> = 0.03). <b>Conclusion:</b> Dobutamine is associated with increased mortality particularly in ICU patients and a higher risk of acute renal failure compared with milrinone, with evidence certainty ranging from moderate to very low and substantial heterogeneity across mortality outcomes.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2026 1","pages":"e202605"},"PeriodicalIF":0.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"D-dimer in heart failure: Promising prognostic value but limited evidence for guiding clinical decisions.","authors":"Humberto Morais, Fidel Manuel Caceres-Loriga","doi":"10.21542/gcsp.2025.64","DOIUrl":"10.21542/gcsp.2025.64","url":null,"abstract":"","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 6","pages":"e202564"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatic mitral valve disease: Comparative outcomes of repair versus replacement.","authors":"Sofia Araujo, Hugo Silva, Renato Filho, Natalia Alves, Arthur de Lima, João Aires, Fernanda Chaves","doi":"10.21542/gcsp.2025.60","DOIUrl":"10.21542/gcsp.2025.60","url":null,"abstract":"<p><p>Rheumatic mitral valve disease remains a major cause of cardiovascular morbidity and mortality in developing countries where rheumatic fever is still prevalent. In advanced stages, surgical treatment becomes necessary, with mitral valve repair/valvuloplasty (MVP) and mitral valve replacement (MVR) representing the main strategies. However, evidence comparing their long-term outcomes is heterogeneous and often conflicting. The objective of this study was to map and synthesize the scientific evidence comparing the long-term results of repair versus replacement in rheumatic mitral disease. A systematic review was conducted in accordance with established methodological guidelines. Searches were performed in PubMed, Virtual Health Library, and Cochrane databases. Eligible studies, published between 2016 and April 2025, included adult patients undergoing surgical treatment with follow-up of at least five years. Nine studies met the inclusion criteria, comprising 36,136 patients, with 12,042 undergoing repair and 24,094 undergoing replacements. Repair was associated with lower early mortality (0.96% versus 2.2%), fewer thromboembolic events (114 versus 323), fewer hemorrhagic events (39 versus 252), and better preservation of left ventricular function. However, reoperation rates were higher after repair (7-19%) compared to replacement (<2%). Quality-of-life measures also favored repair, while replacement remained the preferred strategy in cases of extensive calcification, fibrosis, or severe stenosis. In conclusion, repair, when anatomically feasible, provides superior early outcomes and fewer long-term complications. Surgical decisions should be individualized, considering valve anatomy, patient profile, and surgical expertise.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 6","pages":"e202560"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal Aspergillus endocarditis: Comprehensive imaging of extensive cardiac involvement in a transplant recipient.","authors":"Nikola Dobrilovic, Athena Poppas, Arun Singh","doi":"10.21542/gcsp.2025.65","DOIUrl":"10.21542/gcsp.2025.65","url":null,"abstract":"<p><p>Aspergillus endocarditis is an exceedingly rare entity associated with mortality rates of 60-80% even with combined surgical and medical therapy. It most commonly occurs in immunocompromised patients or those with prosthetic cardiac devices. We present a case with unusually extensive cardiac aspergillosis affecting multiple anatomical sites rarely seen simultaneously in a single patient. Surgical management required radical debridement of infected tissue with subsequent reconstruction. This case uniquely illustrates the spectrum of pathologic involvement across multiple cardiac structures in a single patient, emphasizing both the diagnostic challenges and aggressive surgical approach necessary for survival.</p>","PeriodicalId":12669,"journal":{"name":"Global Cardiology Science & Practice","volume":"2025 6","pages":"e202565"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}