Fukuoka igaku zasshi = Hukuoka acta medica最新文献_第2页

Role of Natural Killer T Cells in Cardiac Remodeling and Failure and the Development of Novel Therapeutic Strategy. 自然杀伤T细胞在心脏重塑和衰竭中的作用及新治疗策略的发展。

Fukuoka igaku zasshi = Hukuoka acta medica Pub Date : 2016-10-01

Hiroyuki Tsutsui

{"title":"Role of Natural Killer T Cells in Cardiac Remodeling and Failure and the Development of Novel Therapeutic Strategy.","authors":"Hiroyuki Tsutsui","doi":"","DOIUrl":"","url":null,"abstract":"Chronic inflammation in the myocardium is involved in the development of left ventricular (LV)\u0000remodeling and failure after myocardial infarction (MI). Invariant natural killer T (iNKT) cells have\u0000been shown to produce inflammatory cytokines and orchestrate tissue inflammation. However, no\u0000previous studies have determined the pathophysiological role of iNKT cells in post-MI LV remodeling.\u0000We thus examined whether the activation of iNKT cells might affect the development of LV\u0000remodeling and failure. After creation of MI, mice received the injection of either a-galactosylceramide\u0000(aGC), the activator of iNKT cells, or phosphate-buffered saline 1 and 4 days after surgery, and\u0000were followed during 28 days. Survival rate was significantly higher in MI +aGC than MI + PBS. LV\u0000cavity dilatation and dysfunction were significantly attenuated inMI +aGC, despite comparable infarct\u0000size, accompanied by a decrease in myocyte hypertrophy, interstitial fibrosis, and apoptosis. The\u0000infiltration of iNKT cells were increased during early phase in noninfarcted LV from MI and aGC\u0000further enhanced them. It also enhanced LV interleukin (IL)-10 gene expression at 7 days, which\u0000persisted until 28 days. AntiIL-10 receptor antibody abrogated these protective effects of aGC on MI\u0000remodeling. The administration of aGC into iNKT cell-deficient Ja18(-/-) mice had no such effects,\u0000suggesting that aGC was a specific activator of iNKT cells. iNKT cells play a protective role against\u0000post-MI LV remodeling and failure through the enhanced expression of cardioprotective cytokines\u0000such as IL-10.","PeriodicalId":12665,"journal":{"name":"Fukuoka igaku zasshi = Hukuoka acta medica","volume":"107 10","pages":"177-84"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35240049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomical Comparison between Rodent and Avian Circuits for Vocal Communication. 啮齿动物和鸟类声音交流回路的解剖学比较。

Fukuoka igaku zasshi = Hukuoka acta medica Pub Date : 2016-09-01

Hisataka Fujimoto

引用次数: 0

Theoretical Models of Vascular Pattern Formation. 维管模式形成的理论模型。

Fukuoka igaku zasshi = Hukuoka acta medica Pub Date : 2016-09-01

Takashi Miura

引用次数: 0

Interaction between Viral Proteins and Mitochondria. 病毒蛋白与线粒体的相互作用。

Fukuoka igaku zasshi = Hukuoka acta medica Pub Date : 2016-08-01

Takuma Yoshizumi, Kai Yasukawa, Takumi Koshiba

引用次数: 0

A case of Basaloid Follicular Hamartoma. 基底细胞卵泡错构瘤1例。

Fukuoka igaku zasshi = Hukuoka acta medica Pub Date : 2016-08-01

Yuko Usagawa, Chikage Mitoma, Takamichiet Ito, Saori Ito, Hiromaro Kiryu, Hiroshi Uchi, Masutaka Furue

{"title":"A case of Basaloid Follicular Hamartoma.","authors":"Yuko Usagawa, Chikage Mitoma, Takamichiet Ito, Saori Ito, Hiromaro Kiryu, Hiroshi Uchi, Masutaka Furue","doi":"","DOIUrl":"","url":null,"abstract":"We here describe a case of solitary basaloid follicular hamartoma (BFH) : the case developing in\u0000company with senile lentigo on the nose. BFH is a relatively rare benign follicular neoplasm of\u0000undetermined etiology. Histologically, the specimen consisted of small-sized squamoid or basaloid cells\u0000and follicular germ-like cells in the periphery of the tumor nests. There were no infundibular cysts.\u0000BFH should be differentiated from infundibulocystic basal cell carcinoma (BCC), which consists of\u0000squamoid or basaloid cells in company with infundibular cysts, tumor of follicular infundibulum or\u0000trichoepithelioma. We analyzed the immunohistochemical findings of the case in comparison with\u0000those of BCC and trichoepithelioma. An immunohistochemical examination revealed 1) that Bcl-2 and\u0000CD10 was preferentially expressed in the outermost cells in the tumor nests consisting of follicular\u0000germ-like cells, 2) that most of the tumor cells, especially germ-like cells, were strongly positive for\u0000Ber-EP4, and 3) that peritumoral stroma was positive for CD34. The immunohistochemical findings of\u0000our cases supported that BFH should be differentiated from BCC, a common malignant neoplasm.","PeriodicalId":12665,"journal":{"name":"Fukuoka igaku zasshi = Hukuoka acta medica","volume":"107 8","pages":"155-60"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35328594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and Clinical Research for Chronic Kidney Disease. 慢性肾脏疾病的流行病学与临床研究

Fukuoka igaku zasshi = Hukuoka acta medica Pub Date : 2016-08-01

Toshiharu Ninomiya

引用次数: 0

Inquiries About Biomarkers of Acute Liver Failure in Patients Who Underwent Living Donor Liver Transplantation Using a Protein Chip Array. 使用蛋白质芯片阵列研究活体肝移植患者急性肝衰竭的生物标志物。

Fukuoka igaku zasshi = Hukuoka acta medica Pub Date : 2016-07-25 DOI: 10.15017/1784634

Y. Yamashita, T. Yoshizumi, T. Ikegami, H. Uchiyama, E. Tsujita, S. Itoh, N. Harimoto, Y. Soejima, A. Taketomi, H. Baba, Y. Maehara

{"title":"Inquiries About Biomarkers of Acute Liver Failure in Patients Who Underwent Living Donor Liver Transplantation Using a Protein Chip Array.","authors":"Y. Yamashita, T. Yoshizumi, T. Ikegami, H. Uchiyama, E. Tsujita, S. Itoh, N. Harimoto, Y. Soejima, A. Taketomi, H. Baba, Y. Maehara","doi":"10.15017/1784634","DOIUrl":"https://doi.org/10.15017/1784634","url":null,"abstract":"The causative agent of hepatic encephalopathy (HE) has not been identified with certainty. The\u0000recovery of consciousness in patients with acute liver failure (ALF) who underwent liver\u0000transplantation (LT) is sometimes drastic ; therefore, we thought that the causative agents of HE\u0000would change markedly peri-operatively in these patients. We examined the biomarkers including\u0000new agents in the serum of patients using the ProteinChip® System 4000 (Ciphergen Biosystems,\u0000Yokohama, JAPAN). Sixteen samples were obtained from four patients with ALF who underwent living donor LT\u0000(LDLT) at four time points ; pre-operative, one post-operative day (1POD), 3POD, and 7POD. We used\u0000three chips made by the Biomek2000 robot. All duplicated samples were assayed and analyzed using\u0000the CiphergenExpressTM data manager. We divided the peri-operative changes in the intensity of\u0000identified peaks into seven patterns. The number of peaks whose intensity shows significant changes\u0000peri-operatively reached 755. Of course, it is difficult to determine each structure in all 755 peaks ; therefore, we should narrow\u0000down the candidates for causative agents of HE in further studies. Our own results suggest that many\u0000difficulties lie ahead in determining the causative agent of HE.","PeriodicalId":12665,"journal":{"name":"Fukuoka igaku zasshi = Hukuoka acta medica","volume":"19 1","pages":"131-5"},"PeriodicalIF":0.0,"publicationDate":"2016-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82515362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inquiries About Biomarkers of Acute Liver Failure in Patients Who Underwent Living Donor Liver Transplantation Using a Protein Chip Array. 使用蛋白质芯片阵列研究活体肝移植患者急性肝衰竭的生物标志物。

Fukuoka igaku zasshi = Hukuoka acta medica Pub Date : 2016-07-01

Yo-ichi Yamashita, Tomoharu Yoshizumi, Toru Ikegami, Hideaki Uchiyama, Eiji Tsujita, Shinji Itoh, Norifumi Harimoto, Yuji Soejima, Akinobu Taketomi, Hideo Baba, Yoshihiko Maehara

{"title":"Inquiries About Biomarkers of Acute Liver Failure in Patients Who Underwent Living Donor Liver Transplantation Using a Protein Chip Array.","authors":"Yo-ichi Yamashita, Tomoharu Yoshizumi, Toru Ikegami, Hideaki Uchiyama, Eiji Tsujita, Shinji Itoh, Norifumi Harimoto, Yuji Soejima, Akinobu Taketomi, Hideo Baba, Yoshihiko Maehara","doi":"","DOIUrl":"","url":null,"abstract":"The causative agent of hepatic encephalopathy (HE) has not been identified with certainty. The\u0000recovery of consciousness in patients with acute liver failure (ALF) who underwent liver\u0000transplantation (LT) is sometimes drastic ; therefore, we thought that the causative agents of HE\u0000would change markedly peri-operatively in these patients. We examined the biomarkers including\u0000new agents in the serum of patients using the ProteinChip® System 4000 (Ciphergen Biosystems,\u0000Yokohama, JAPAN). Sixteen samples were obtained from four patients with ALF who underwent living donor LT\u0000(LDLT) at four time points ; pre-operative, one post-operative day (1POD), 3POD, and 7POD. We used\u0000three chips made by the Biomek2000 robot. All duplicated samples were assayed and analyzed using\u0000the CiphergenExpressTM data manager. We divided the peri-operative changes in the intensity of\u0000identified peaks into seven patterns. The number of peaks whose intensity shows significant changes\u0000peri-operatively reached 755. Of course, it is difficult to determine each structure in all 755 peaks ; therefore, we should narrow\u0000down the candidates for causative agents of HE in further studies. Our own results suggest that many\u0000difficulties lie ahead in determining the causative agent of HE.","PeriodicalId":12665,"journal":{"name":"Fukuoka igaku zasshi = Hukuoka acta medica","volume":"107 7","pages":"131-5"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35329766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case of a Cardiopulmonary Arrest Due to Postoperative Subglottic Stenosis Developed on the Second Day after Lung Surgery. 肺手术后第2天发生声门下狭窄致心肺骤停1例。

Fukuoka igaku zasshi = Hukuoka acta medica Pub Date : 2016-07-01

Tomonari Shimagaki, Tatsuro Okamoto, Yosuke Morodomi, Fumihiro Shoji, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Kazuki Takada, Yuzo Suzuki, Takatoshi Fujishita, Kengo Hayamizu, Kentaro Tokuda, Mitsuhiro Yasuda, Yoshihiko Maehara

引用次数: 0

New Approach to Diagnosis and Treatment of Esophageal Motility Disorders by High-Resolution manometry. 高分辨率测压法诊断和治疗食管运动障碍的新方法。

Fukuoka igaku zasshi = Hukuoka acta medica Pub Date : 2016-07-01

Eikichi Ihara, Kazumasa Muta, Keita Fukaura, Yoshimasa Tanaka, Xiaopeng Bai, Akira Aso, Tsutomu Iwasa, Kazuhiko Nakamura

引用次数: 0