Frontiers in Immunology最新文献

{"title":"Efficacy of MLN9708 (ixazomib) in experimental autoimmune myasthenia gravis and in anti-AChR producing primary thymic cell cultures from myasthenia gravis patients.","authors":"Marina Mané-Damas, Abhishek Saxena, Gisela Nogales-Gadea, Jo Stevens, Shannen Vincken, Maarten van Beek, Nynke J van den Hoogen, Elbert A J Joosten, Nick Willcox, Hans Duimel, Jos G Maessen, Peter C Molenaar, Marc H De Baets, Mario Losen, Pilar Martinez-Martinez","doi":"10.3389/fimmu.2025.1521432","DOIUrl":"https://doi.org/10.3389/fimmu.2025.1521432","url":null,"abstract":"<p><p>Proteasome inhibitors can eliminate malignant, alloreactive, or autoreactive plasma cells. These cells are key players in antibody-mediated autoimmune disorders and thus suitable therapeutic targets for these drugs. However, certain proteasome inhibitors cause toxic peripheral neuropathy in patients. Ixazomib (MLN9708, Ninlaro), an oral proteasome inhibitor, has a more favorable safety profile in multiple myeloma patients. Here we tested its efficacy in preventing and treating experimental autoimmune myasthenia gravis (EAMG). Female Lewis rats were treated with two subcutaneous doses of 0.35 mg/kg of ixazomib per week, starting either 4 weeks before or at disease onset; both substantially lowered final total IgG and rat acetylcholine receptor (AChR) autoantibody levels. Interestingly, two weekly doses of 0.20 mg/kg of ixazomib for the last 4 weeks did not reduce autoantibody levels. A single dose of 0.50 mg/kg was acutely toxic in rats. In cultures of thymic cells from early-onset myasthenia gravis (EOMG) patients, 30 nM ixazomib or higher almost completely eliminated plasma cells and halted their IgG and AChR antibody production. We conclude that proteasome inhibition with ixazomib effectively depletes plasma cells from MG patients <i>in vitro</i> and in a rat model <i>in vivo</i>. These results encourage further investigations into therapeutic plasma cell targeting for MG patients.</p>","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":"16 ","pages":"1521432"},"PeriodicalIF":5.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent reduction of <i>Bifidobacterium longum</i> in the infant gut microbiome in the first year of age following <i>intrapartum</i> penicillin prophylaxis for maternal GBS colonization.","authors":"Jana Lucia Teuscher, Mariia Lupatsii, Simon Graspeuntner, Sinje Jonassen, Arne Bringewatt, Egbert Herting, Guido Stichtenoth, Verena Bossung, Jan Rupp, Christoph Härtel, Martin Demmert","doi":"10.3389/fimmu.2025.1540979","DOIUrl":"https://doi.org/10.3389/fimmu.2025.1540979","url":null,"abstract":"<p><strong>Introduction: </strong>Group B Streptococcus is a significant cause of early-onset disease in term newborns, with a global incidence of 0.41/1000 live births. Intrapartum antibiotic prophylaxis (IAP) has reduced EOD incidence by over 80%, but concerns exist about its impact on the neonatal gut microbiome and potential long-term health effects.</p><p><strong>Methods: </strong>This single center study examines the effects of IAP on the fecal infant microbiome in the first year of age and on the T cell phenotype in the first days after birth among 22 infants receiving IAP with penicillin due to maternal GBS colonization and 26 infants not exposed to IAP. The fecal microbiome was analyzed at birth, one month and one year of age through 16S rRNA gene sequencing. Additionally, a T cell phenotyping of peripheral blood was performed between the second and fifth day of age.</p><p><strong>Results: </strong>At one month, IAP exposed infants had a significantly lower relative abundance of Bifidobacterium longum in fecal samples, an effect which was sustained at one year. In IAP exposed infants we found a proinflammatory T-helper cell profile, characterized by higher IL-17A, RORgt, and TGF-b expression.</p><p><strong>Discussion: </strong>This study proposes a sustained impact of IAP on the neonatal microbiome and T cell repertoire.</p>","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":"16 ","pages":"1540979"},"PeriodicalIF":5.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the immunosuppressive microenvironment of glioblastoma and advancements in treatment.","authors":"Dongxin Jiang, Yunqian Li","doi":"10.3389/fimmu.2025.1590781","DOIUrl":"https://doi.org/10.3389/fimmu.2025.1590781","url":null,"abstract":"<p><p>Glioblastoma, the most common and aggressive primary brain tumor, remains a significant challenge in oncology due to its immunosuppressive tumor microenvironment (TME). This review summarizes the complex interplay of immune cells and cytokines within the TME, which contribute to immune evasion and tumor progression. We further emphasize the synergistic crosstalk among these components and how it shapes therapeutic vulnerability. Besides, we highlight recent advancements in immunotherapy, including immune checkpoint inhibitors, CAR-T cell therapy, NK cell therapy, oncolytic viruses, and vaccine-based strategies. Despite promising preclinical and clinical results, overcoming the immunosuppressive TME remains a critical hurdle. This review underscores the potential of targeting the TME to enhance therapeutic outcomes in glioblastoma.</p>","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":"16 ","pages":"1590781"},"PeriodicalIF":5.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specialized pro-resolving mediators in neutrophil apoptosis regulation: unlocking novel therapeutic potential in kidney diseases.","authors":"Yi Kang, Qian Jin, Mengqi Zhou, Huijuan Zheng, Danwen Li, Xuezhe Wang, Jingwei Zhou, Yaoxian Wang, Jie Lv","doi":"10.3389/fimmu.2025.1589923","DOIUrl":"https://doi.org/10.3389/fimmu.2025.1589923","url":null,"abstract":"<p><p>Kidney diseases represent a diverse group of disorders with pathogenic mechanisms involving multiple pathological processes, including inflammation, immunity, and cell death. Neutrophils, as primary effector cells in inflammatory immune responses, participate in defending against renal infection and injury by releasing reactive oxygen species, proteases, and cytokines. However, persistent neutrophil activation is considered a crucial driver of kidney disease progression. Neutrophil apoptosis represents a critical turning point between inflammatory progression and resolution. Specialized pro-resolving mediators (SPMs) are endogenous anti-inflammatory mediators that play a critical role in resolving inflammation. They not only induce neutrophil programmed cell death and promote macrophage-mediated efferocytosis of apoptotic cells but also inhibit neutrophil infiltration and degranulation, ultimately facilitating the restoration of inflammatory microenvironment and tissue homeostasis. This review concentrates on elucidating the mechanisms by which SPMs regulate neutrophil apoptosis and systematically demonstrates their potential as novel therapeutic targets in kidney diseases.</p>","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":"16 ","pages":"1589923"},"PeriodicalIF":5.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics meets machine learning: identifying circulating biomarkers for vitiligo across blood and tissues.","authors":"Qiyu Wang, Jingwei Yuan, Mengdi Zhang, Haiyan Jia, Hongjie Lu, Yan Wu","doi":"10.3389/fimmu.2025.1543355","DOIUrl":"https://doi.org/10.3389/fimmu.2025.1543355","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is a skin disorder characterized by the progressive loss of pigmentation in the skin and mucous membranes. The exact aetiology and pathogenesis of vitiligo remain incompletely understood.</p><p><strong>Methods: </strong>First, a microarray dataset of blood samples from multiple patients with vitiligo was collected from GEO database.The limma package was used to analyze the microarray data and identify significant differentially expressed genes (DEGs). The merged microarray data were then used for WGCNA to identify modules of features genes. DEGs selected with the limma package and module genes derived from the WGCNA were intersected using the Venn package in R. Enrichment analyses were performed on the overlapping genes, including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes methodology. Advanced screening was performed using the least absolute shrinkage and selection operator and support vector machine techniques from the machine learning toolkit. CIBERSORT was used to analyse the immune cell composition in the microarray data to assess the relationships among these genes and immune cells. Biological samples were obtained from the patients, and gene expression analysis was performed to evaluate the levels of core genes throughout the progression of vitiligo. Finally, we obtained the microarray datasets GSE53146 and GSE75819 from the affected skin of vitiligo patients and GSE205155 from healthy skin to perform expression analysis and gene set enrichment analysis of the hub genes.</p><p><strong>Results: </strong>Two hub genes, <i>HMGA1</i> and <i>PSMD13</i>, were identified via machine learning and WGCNA. The analysis of immune cell infiltration suggested that different immune cell types could play a role in the progression of vitiligo. Moreover, these hub genes exhibited varying degrees of association with immune cell profiles. qRT-PCR analysis of blood samples from vitiligo patients revealed notable downregulation of the hub genes. Analysis of the microarray datasets derived from skin lesions revealed that <i>HMGA1</i> expression levels remained relatively stable, whereas <i>PSMD13</i> expression levels markedly decreased.</p><p><strong>Conclusion: </strong><i>PSMD13</i> may influence vitiligo development via the Nod-like receptor signaling pathway and could serve as a potential diagnostic marker for evaluating skin lesions in vitiligo.</p>","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":"16 ","pages":"1543355"},"PeriodicalIF":5.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single cell atlas of canine natural killer cells identifies distinct circulating and tissue resident gene profiles.","authors":"Aryana M Razmara, Marshall Lammers, Sean J Judge, William J Murphy, Cameron E Gaskill, William T N Culp, Alicia A Gingrich, Zachary S Morris, Robert B Rebhun, C Titus Brown, David M Vail, Michael S Kent, Robert J Canter","doi":"10.3389/fimmu.2025.1571085","DOIUrl":"https://doi.org/10.3389/fimmu.2025.1571085","url":null,"abstract":"<p><strong>Introduction: </strong>Natural killer (NK) cells in mice and humans are key effectors of the innate immune system with complex immunoregulatory functions, and diverse subsets have been identified with distinct characteristics and roles. Companion dogs with spontaneous cancer have been validated as models of human disease, including cancer immunology and immunotherapy, and greater understanding of NK cell heterogeneity in dogs can inform NK biology across species and optimize NK immunotherapy for both dogs and people.</p><p><strong>Methods: </strong>Here, we assessed canine NK cell populations by single-cell RNA sequencing (scRNAseq) across blood, lung, liver, spleen, and placenta with comparison to human NK cells from blood and the same tissues to better characterize the differential gene expression of canine and human NK cells regarding ontogeny, heterogeneity, patterns of activation, inhibition, and tissue residence.</p><p><strong>Results: </strong>Overall, we observed tissue-specific NK cell signatures consistent with immature NK cells in the placenta, mature and activated NK cells in the lung, and NK cells with a mixed activated and inhibited signature in the liver with significant cross-species homology.</p><p><strong>Discussion: </strong>Together, our results point to heterogeneous canine NK populations highly comparable to human NK cells, and we provide a comprehensive atlas of canine NK cells across organs which will inform future cross-species NK studies and further substantiate the spontaneous canine model to optimize NK immunotherapy across species.</p>","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":"16 ","pages":"1571085"},"PeriodicalIF":5.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary phosphorus restriction induced phospholipid deficiency, endoplasmic reticulum stress, inflammatory response and gut microbiota disorders in <i>Lateolabrax maculatus</i>.","authors":"Zixiang Wu, Jiarong Guo, Kangle Lu, Kai Song, Ling Wang, Ruijuan Ma, Chunxiao Zhang, Xueshan Li","doi":"10.3389/fimmu.2025.1592806","DOIUrl":"https://doi.org/10.3389/fimmu.2025.1592806","url":null,"abstract":"<p><p>This study evaluated the effects of low phosphorus on spotted seabass (<i>Lateolabrax maculatus</i>) from the perspective of phospholipid content and function, endoplasmic reticulum (ER) stress, inflammatory response and gut microbiota. Two diets were prepared to contain available phosphorus levels of 0.37% (low-phosphorus, LP) and 0.75% (normal-phosphorus, NP) and feed fish (3.53 ± 0.34 g) to satiety twice daily for 10 weeks. Compared with fish fed the NP diet, fish fed the LP diet showed lower body weight gain and higher abdominal fat percentage. Further studies showed that the LP diet decreased the content of phospholipid in the serum, liver, and abdominal fat tissue and induced ER stress and disruption of lipid metabolism in both of the liver and abdominal fat tissue and inflammatory responses in abdominal fat tissue. Furthermore, compared with fish fed the NP diet, the LP diet reduced microbial diversity in the gut. In contrast to fish fed the NP diet, fish fed the LP diet exhibited a decrease in the abundance of potential metabolically promoted probiotics (e.g., <i>Lactococcus lactis</i>) and an increase in the abundance of potential pathogenic bacteria (e.g., <i>Plesiomonas</i>) in the gut. The results of PICRUSt2 functional prediction also validated the metabolic disorders occurring in fish fed the LP diet as well as the reduced metabolic capacity. These results suggested that the LP diet decreased phospholipid content, induced ER stress and inflammatory responses then disturbed lipid metabolism and gut microbiota in spotted seabass. These negative effects contributed to poorer growth and higher percentage of abdominal fat in spotted seabass fed the LP diet than those of spotted seabass fed the NP diet.</p>","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":"16 ","pages":"1592806"},"PeriodicalIF":5.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymic stromal lymphopoietin-activated basophil promotes lung inflammation in mouse atopic march model.","authors":"Xu Li, Zizhuo Li, Mindan Tang, Kaoyuan Zhang, Ting Yang, Weilong Zhong, Bo Yu, Fang Wang, Xia Dou","doi":"10.3389/fimmu.2025.1573130","DOIUrl":"https://doi.org/10.3389/fimmu.2025.1573130","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD), a prevalent inflammatory skin disease affecting 10%-20% of the population, is linked to the development of asthma through atopic march (AM). This study aims to explore the role of basophils in OVA-induced lung inflammation in the presence of AD-like skin lesions and investigate the potential contribution of thymic stromal lymphopoietin (TSLP) in activating basophils.</p><p><strong>Methods: </strong>Mouse AM models were established in C57BL/6 mice using MC903 and OVA epicutaneous sensitization, followed by intranasal OVA challenges. An intraperitoneal OVA-sensitized asthma model was employed as the control group. RNA-Seq analysis was conducted on lung CD45⁺ immune cells from these models. Histologic examinations, flow cytometry, and ELISA were used to examine the lung and systemic inflammatory response. Basophil depletion was achieved through intraperitoneal administration of anti-FcϵRIα mAb. The role of TSLP was investigated using TSLPR knockout mice.</p><p><strong>Results: </strong>As in the intraperitoneal sensitization model, AM model also induced eosinophilic lung inflammation in mice, resembling the AM process. The RNA-Seq analysis revealed differential gene expression, with genes related to basophils being prominent in AM model. Increased basophil activation and IL-4 production were observed in OVA epicutaneously sensitized mice. Basophil depletion attenuated the eosinophilic lung inflammation. TSLP levels increased with topical MC903, and TSLPR knockout reduced lung inflammation, suggesting TSLP is involved in basophil activation.</p><p><strong>Conclusion: </strong>Basophils play a crucial role in OVA-induced lung inflammation in the context of AD-like skin lesions, and TSLP appears to drive basophil activation. Understanding these interactions provides insights for potential therapeutic interventions in AM-associated conditions.</p>","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":"16 ","pages":"1573130"},"PeriodicalIF":5.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical spectrum and long-term outcomes of antibody-negative severe autoimmune encephalitis: a retrospective study.","authors":"Fangfang Li, Yu He, Xiaoqian Chen, Ali Yang, Jiewen Zhang, Weizhou Zang","doi":"10.3389/fimmu.2025.1591771","DOIUrl":"https://doi.org/10.3389/fimmu.2025.1591771","url":null,"abstract":"<p><strong>Objective: </strong>The aims of the study were to characterize the clinical manifestations and outcomes of patients with antibody-negative severe autoimmune encephalitis (AE).</p><p><strong>Methods: </strong>This retrospective, monocentric study recruited patients from the Neurology Department of Henan Provincial People's Hospital between April 2017 and December 2023. All patients underwent neural antibody testing in both blood and cerebrospinal fluid (CSF) and met the diagnostic criteria for autoantibody-negative but probable severe AE, with available 1-year follow-up data.</p><p><strong>Results: </strong>In total, 124 patients with autoantibody-negative severe AE were analyzed. Among them, 27.4% achieved good functional outcomes at discharge. Older age (OR 1.034, 95% confidence interval [CI] 1.010-1.058, <i>p</i> = 0.004) and the presence of dyskinesia/dystonia (OR 8.463, 95% CI 3.282-21.820, <i>p</i> < 0.001) were predictive of poor short-term outcomes. At the 1-year follow-up, 54.8% experienced favorable long-term outcomes. Independent predictors of unfavorable long-term outcomes included older age (OR 1.076, 95% CI 1.018-1.136, <i>p</i> = 0.009), longer hospital stays (OR 1.264, 95% CI 1.105-1.446, <i>p</i> = 0.001), the presence of refractory status epilepticus (OR 14.765, 95% CI 1.759-123.935, <i>p</i> = 0.013) and higher CASE scores at discharge (OR 2.079, 95% CI 1.450-2.980, <i>p</i> < 0.001). Additionally, 30.6% of patients had relapsed, with refractory status epilepticus being an independent risk factor for relapse.</p><p><strong>Conclusion: </strong>Although patients with antibody-negative severe AE experience significant disability in the early stages of their disease, the majority eventually regain independent functioning. Older age at disease onset, longer hospital stays, the presence of refractory status epilepticus and higher CASE scores at discharge may predict a poor long-term prognosis.</p>","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":"16 ","pages":"1591771"},"PeriodicalIF":5.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights.","authors":"Xin-Yi Hou, Hai-Lu Xiao, Jing-Yu Wang, Jin Zhang, Bo Ren, Chu-Chu Niu, Fei-Fei Liu, Bin Lu","doi":"10.3389/fimmu.2025.1563553","DOIUrl":"https://doi.org/10.3389/fimmu.2025.1563553","url":null,"abstract":"<p><p>A 62-year-old Chinese woman presented to the hospital for help with generalized pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH). While conventional treatments failed to achieve significant improvement, the patient received two doses of spesolimab, and the effect was remarkable. No adverse reactions were observed in the follow-up period.</p>","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":"16 ","pages":"1563553"},"PeriodicalIF":5.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}