General Thoracic and Cardiovascular Surgery最新文献

{"title":"Intraoperative rapid immunohistochemistry of microsatellite instability using non-contact alternating current electric field mixing.","authors":"Kazuhiro Imai, Naoki Yanagawa, Hajime Saito, Hiroshi Nanjo, Yuki Wakamatsu, Shinogu Takashima, Tsubasa Matsuo, Shoji Kuriyama, Tamotsu Sugai, Yoshihiro Minamiya","doi":"10.1007/s11748-024-02099-7","DOIUrl":"10.1007/s11748-024-02099-7","url":null,"abstract":"<p><strong>Objectives: </strong>Tumors caused by failure of the DNA-mismatch repair system generally show microsatellite instability (MSI). High-frequency MSI cancers have been shown to be susceptible to immuno-oncology therapies. The aim of this study was to evaluate the clinical reliability of a rapid immunohistochemistry (IHC) technique for intraoperatively assessing molecular status through detection of tumoral deficiencies in the expression of mismatch repair proteins (dMMR; MLH1, MSH2, MSH6, and PMS2).</p><p><strong>Methods: </strong>The rapid IHC method uses non-contact alternating current (AC) mixing to achieve more rapid/stable staining within a minimum of 13 min during surgery. Sixteen formalin-fixed paraffin-embedded (FFPE) tumor samples from 3 dMMR patients with Lynch syndrome and 6 FFPE samples from 6 dMMR-cancer patients were collected to establish an IHC protocol for MMR proteins. Next, 26 surgical patients treated and whose MSI status was determined using PCR-based tests were retrospectively analyzed. The concordance of dMMR diagnoses for thoracic tumors between the conventional (frozen section (FS)- and FFPE-IHCs) and rapid AC-mixing IHC with FSs were compared.</p><p><strong>Results: </strong>A rapid IHC protocol using primary antibodies against four MMR proteins (mixed 5-10 min) was established (entire process within 40 min). The concordance rate for MMR-IHC between the conventional and rapid IHC was 100%. dMMR diagnoses including an MSI-high pulmonary sarcoma patient entirely matched between FS- and FFPE-IHC.</p><p><strong>Conclusion: </strong>Rapid MMR-IHC could potentially serve as a clinical tool for intraoperative determination of tumor MSI/dMMR status. AC-mixing technology will contribute to improving pathological diagnostic capability through the development of an original and innovative rapid IHC.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"506-513"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmanubrial approach for en bloc resection of oligometastatic extranodal extension positive lymph nodes with partial common carotid artery and trachea resection after esophagectomy.","authors":"Naoya Okada, Hiroaki Kato, Syuichi Naraoka, Takeshi Yokoyama, Yasushi Furuta, Yoshihiro Kinoshita","doi":"10.1007/s11748-025-02135-0","DOIUrl":"10.1007/s11748-025-02135-0","url":null,"abstract":"<p><strong>Background and aims: </strong>The transmanubrial approach (TMA) provides excellent exposure of the cervical-thoracic border area, allowing for the resection of thoracic outlet structures while preserving the clavicle, avoiding muscle sacrifice, and maintaining full shoulder mobility.</p><p><strong>Methods: </strong>This report presents the first instance of TMA being utilized for oligometastatic, extranodal extension-positive lymph node dissection en bloc with partial resection of the common carotid artery and trachea following esophagectomy.</p><p><strong>Surgical technique: </strong>We describe the surgical technique with illustrated explanations.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"522-525"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic and cardiovascular surgeries in Japan during 2023 : Annual report by the Japanese Association for Thoracic Surgery.","authors":"Naoki Yoshimura, Yukio Sato, Hiroya Takeuchi, Tomonobu Abe, Toshio Doi, Toyofumi Fengshi Yoshikawa, Yasutaka Hirata, Michiko Ishida, Hisashi Iwata, Takashi Kamei, Nobuyoshi Kawaharada, Shunsuke Kawamoto, Kohji Kohno, Kazuo Koyanagi, Hiraku Kumamaru, Goro Matsumiya, Kenji Minatoya, Noboru Motomura, Rie Nakahara, Morihito Okada, Hisashi Saji, Aya Saito, Kenji Suzuki, Hirofumi Takemura, Yasue Kimura, Wataru Tatsuishi, Hiroyuki Yamamoto, Takushi Yasuda, Hideyuki Shimizu, Masayuki Chida","doi":"10.1007/s11748-025-02128-z","DOIUrl":"10.1007/s11748-025-02128-z","url":null,"abstract":"","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"526-565"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial respiratory pathways in immature rat heart tissue using different cardioplegic solutions.","authors":"Arslan Mamedov, Eglė Rumbinaitė, Sebastian Romann, Dovydas Verikas, Povilas Jakuška, Serik Aitaliyev, Rimantas Benetis, Edgaras Stankevičius","doi":"10.1007/s11748-024-02097-9","DOIUrl":"10.1007/s11748-024-02097-9","url":null,"abstract":"<p><strong>Introduction: </strong>Minor defects in the mitochondrial ATP-generating system and post-cardioplegia oxidative phosphorylation can negatively impact cardiac function in immature hearts. This study aimed to examine the mitochondrial respiratory pathway using three different cardioplegic solutions (Custodiol HTK, St. Thomas, and Del Nido) during moderate (1 h) and long (3 h) ischemic periods.</p><p><strong>Methods: </strong>A total of 41 male Wistar albino rats were utilized in this study. Five experiments were conducted without the use of any cardioplegic solution (CP0 group). To assess both moderate and prolonged ischemic periods, six experiments were carried out in each of the following groups: CP1 group (St. Thomas solution), CP2 group (Custodiol HTK solution), and CP3 group (Del Nido solution).</p><p><strong>Results: </strong>After 1 h, the highest mitochondrial respiration rate was observed in the CP3 group and the lowest in the CP1 group (p = 0.006). After adding ADP substrate, the highest mitochondrial ATP-production-coupled respiration was recorded in the CP3 group, which was similar to the control group CP0. After 3 h, while evaluating the ratio between mitochondrial respiration ATP-production coupled and basal respiration, significant differences were found between CP1 group and CP3 group (p = 0.035), as well as between the CP1 and CP0 groups (p = 0.045). Additionally, by assessing the condition of the outer mitochondrial membrane using the Cyt C effect (Cyt/Phos [ADP]), significant differences were observed between the CP1 and CP3 group (p = 0.004), as well as between CP1 and CP0 groups (p = 0.003).</p><p><strong>Conclusion: </strong>Del Nido cardioplegic solution provided optimal mitochondrial protection under moderate and long myocardial ischemia conditions.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"479-486"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risks factors of adverse clinical outcomes in asymptomatic mitral regurgitation patients with preserved ejection fraction: a systematic review and meta-analysis.","authors":"Wilbert Huang, Alvin Frederich, Cynthia Arista, Capella Kezia, Muhammad Irfan Fathoni, Alya Roosrahima Khairunnisa, Lisa Milena Anabela, Siti Shofiah Syahruddin, Samuel Flindy, Alizha Rochana Putri","doi":"10.1007/s11748-024-02094-y","DOIUrl":"10.1007/s11748-024-02094-y","url":null,"abstract":"<p><strong>Introduction and objective: </strong>Indication for mitral valve (MV) surgery in asymptomatic mitral regurgitation (MR) patients with preserved ejection fraction (EF) remains unclear. This study aims to identify risk factors of adverse clinical outcomes in asymptomatic MR patients with preserved EF for early indication of MV surgery.</p><p><strong>Methods: </strong>3 databases were systematically searched to include studies with asymptomatic MR patients with preserved EF. Risk factors of adverse clinical outcomes (composite outcome of MACE and MV surgery indication), mortality, and left ventricular dysfunction (LVD) are pooled with a meta-analysis of random effect model.</p><p><strong>Results: </strong>A total of 39 observational studies with 9135 asymptomatic moderate to severe MR patients are included. We identified 21 statistically significant risk factors for adverse outcomes. Increased natriuretic peptide, presence of atrial fibrillation, LV GLS > 20%, LVEDD > 35 mm, LVESD > 22 mm, and LAVI > 55 ml/mm², ERO > 55mm², and regurgitation volume > 60 ml (HR 2.21, 2.07, 4.23, 2.98, 4.05, 1.84, 4.02, 3.30, respectively; p-value < 0.05; I² 0-87%) are associated with greater risk of adverse clinical outcome. Risk factors associated with postoperative LVD are the increase of LVEDD, LVESD, and RVSP. Risk factors associated with mortality are increasing STS score and LV GLS.</p><p><strong>Conclusion: </strong>Several clinical parameters and risk factors can be used to stratify asymptomatic MR patients with preserved ejection fraction who could benefit from early indication for MV surgery.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"461-471"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142462755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term pulmonary repair in rat lungs after sublobar resection: electrocautery versus stapler methods.","authors":"Shunichiro Matsuoka, Daisuke Hara, Daisuke Nakamura, Hirotaka Kumeda, Kentaro Miura, Mai Iwaya, Takashi Eguchi, Kazutoshi Hamanaka, Takeshi Uehara, Kimihiro Shimizu","doi":"10.1007/s11748-024-02098-8","DOIUrl":"10.1007/s11748-024-02098-8","url":null,"abstract":"<p><strong>Objective: </strong>We investigated and compared the long-term (6-month) histologic changes in a rat model of sublobar resection created using electrocautery or stapler techniques.</p><p><strong>Methods: </strong>Nine-week-old male rats were anesthetized and intubated; thoracotomy with sublobar resection was performed in the right middle lobe using electrocautery or stapler techniques. Histological examination was performed at 2, 4, 8, 12, and 24 weeks post-surgery to assess long-term effects on lung tissue repair and morphologic changes. Lung expansion and alveolar epithelial cell proliferation were evaluated by measuring the mean linear intercept and counting the number of alveolar type I and II cells.</p><p><strong>Results: </strong>The electrocautery group showed signs of lung self-repair at the resected area over time, with inflammatory cell infiltration followed by growth of vessels and bronchioles. Mesothelial cells covered the resected area by 2 weeks; elastic fibers gradually connected from both sides by 24 weeks. Lung expansion, measured by mean linear intercept, was initially small below the electrocautery resection area at 2 weeks but recovered from 4 to 24 weeks. The stapler group showed persistently small mean linear intercept over time. In the electrocautery group, the number of alveolar type II cells was higher just below the resection than in other areas from 2 to 24 weeks, followed by alveolar type I cells (4 to 24 weeks). The stapler group showed a transient alveolar type II cell increase at 2 weeks.</p><p><strong>Conclusions: </strong>Compared to the stapler technique, electrocautery may provide advantages for postoperative lung repair by promoting lung expansion and alveolar epithelial cell proliferation.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"497-505"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of transapical-transcatheter aortic valve replacement.","authors":"Koichi Maeda, Kazuo Shimamura, Isamu Mizote, Daisuke Nakamura, Kizuku Yamashita, Ai Kawamura, Daisuke Yoshioka, Yasushi Sakata, Shigeru Miyagawa","doi":"10.1007/s11748-024-02095-x","DOIUrl":"10.1007/s11748-024-02095-x","url":null,"abstract":"<p><strong>Objective: </strong>Transapical-transcatheter aortic valve replacement is one of the main interventions indicated for patients where access via peripheral vessels is challenging. However, there have been no reports on the long-term outcomes of this intervention. Here, we report the long-term outcomes of this intervention.</p><p><strong>Methods: </strong>Among 178 patients who underwent transapical-transcatheter aortic valve replacement between October 2009 and July 2023, 173 patients who underwent this intervention for native aortic stenosis were included in this study, and early and long-term results were evaluated.</p><p><strong>Results: </strong>The mean age was 82.4 ± 6.4 years, 52.6% were women, mean body area was 1.46 ± 0.17 m², and the Society of Thoracic Surgeons Predicted Risk of Mortality was 11.2 ± 9.9%. In-hospital mortality was observed in three patients (1.7%). Mean follow-up duration was 4.3 ± 2.8 years, and the survival rates at 1-, 3-, 5-, and 8-years were 84.9%, 67.1%, 47.0%, and 22.1%, respectively. Freedom from cardiovascular mortality at 1, 3, 5, and 8-years was 92.9%, 86.1%, 75.8%, and 53.5%, respectively. The freedom from disabling stroke rates at 1, 3, 5, and 8-years were 95.0%, 92.4%, 92.4%, and 90.8%, respectively. Multivariate analysis revealed that male (Hazard Ratio 1.85, 95%Confidence Interval 1.27-2.70, p = 0.0012) and hemodialysis (Hazard Ratio 1.64, 95%Confidence Interval 1.00-2.67, p = 0.049) were significant poor prognosis factors.</p><p><strong>Conclusions: </strong>Long-term outcomes of transapical-transcatheter aortic valve replacement were satisfactory. Despite the variety of available approaches, the role of transapical-transcatheter aortic valve replacement, which has low vascular impact, has not been completely lost.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"472-478"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative outcomes video-assisted thoracic surgery versus open thoracic surgery in pulmonary echinococcosis: a systematic review and meta-analysis.","authors":"Isabella Cabianca Moriguchi Caetano Salvador, Rachid Eduardo Noleto da Nobrega Oliveira, Ingryd de Almeida Silva, Lucas Antônio Fernandes Torres, Maria Tereza Camarotti, Felipe Santos Passos, Alessandro Wasum Mariani","doi":"10.1007/s11748-025-02138-x","DOIUrl":"10.1007/s11748-025-02138-x","url":null,"abstract":"<p><strong>Aim: </strong>This meta-analysis aimed to evaluate and compare the outcomes of video-assisted thoracic surgery (VATS) and open thoracic surgery (OT) in the management of pulmonary echinococcosis.</p><p><strong>Methods: </strong>We conducted a comprehensive search of PubMed, Embase, and Cochrane databases for studies comparing VATS and OT. Odds ratios (ORs) for binary outcomes and mean differences (MDs) for continuous variables were calculated with 95% confidence intervals (CIs) using the DerSimonian and Laird random-effects model. Heterogeneity was assessed using I² statistics.</p><p><strong>Results: </strong>Seven studies involving 2292 patients were included. VATS demonstrated significant advantages over OT, with reductions in intraoperative blood loss (MD - 81.65 mL, 95% CI - 129.90 to - 33.40), duration of thoracic drainage (MD - 2.29 days, 95% CI - 3.61 to - 0.98), operative time (MD - 45.73 min, 95% CI - 68.41 to - 23.05), narcotic use (MD -3.98 days, 95% CI - 6.21 to - 1.75), length of hospital stay (MD - 3.66 days, 95% CI - 5.66 to - 1.67), postoperative drainage volume (MD - 124.77 mL, 95% CI - 206.27 to - 43.27), and visual analogic score pain at 24 h after surgery (MD - 2.05 points, 95% CI - 2.40 to - 1.70). However, VATS was associated with a higher incidence of atelectasis (OR 3.27, 95% CI 1.03-10.35). No significant differences were observed in other complications, such as bronchopulmonary fistula, surgical wound infection, prolonged air leak, or failure of lung expansion.</p><p><strong>Conclusions: </strong>VATS was associated with perioperative benefits, including reduced recovery times and resource utilization. Nonetheless, the higher risk of atelectasis suggests OT may remain favorable in complex cases requiring broader surgical access. Tailoring the surgical approach to the patient's needs remains crucial.</p><p><strong>Trial registry: </strong>International Prospective Register of Systematic Reviews; Nº: CRD42025630187; URL: https://www.crd.york.ac.uk/prospero/ .</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":"453-460"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stent part anastomosis reduces distal stent graft-induced new entry after frozen elephant trunk.","authors":"Yoshinori Nakahara, Akira Marui, Tomohiro Iwakura, Takeyuki Kanemura","doi":"10.1007/s11748-025-02175-6","DOIUrl":"https://doi.org/10.1007/s11748-025-02175-6","url":null,"abstract":"<p><strong>Objectives: </strong>Distal stent graft-induced new entry is a major complication after frozen elephant trunk procedure for type A acute aortic dissection. We investigated the impact of anastomosis location on this complication.</p><p><strong>Methods: </strong>We reviewed 58 patients who underwent total arch replacement using frozen elephant trunk technique (2015-2023). Patients were divided by anastomosis location: Stent group (n = 24; anastomosis at stent part) and Fabric group (n = 34; anastomosis at graft part). We assessed early complications and mid-term distal aortic events during the follow-up.</p><p><strong>Results: </strong>Patient characteristics were similar between groups. Early distal stent graft-induced new entry occurred in none of the Stent group versus 6 patients (18%) in the Fabric group (p = 0.04). Both groups showed similar false lumen thrombosis at arch and descending aorta. Freedom from distal aortic events at 1, 3, and 5 years was 100%, 81%, 81% (Stent group) versus 79%, 67%, 33% (Fabric group) (p = 0.049).</p><p><strong>Conclusions: </strong>Anastomosis at the stent part during frozen elephant trunk procedure reduced distal stent graft-induced new entry and improved mid-term outcomes. In distal anastomosis, the fabric should be as short as possible.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ascending aortic length to detect surgical intervention for ascending aortic aneurysms.","authors":"Toshikuni Yamamoto, Akihiko Usui, Tomonari Uemura, Ryota Yamamoto, Hideki Ito, Tomo Yoshizumi, Sachie Terazawa, Yoshiyuki Tokuda, Yuji Narita, Masato Mutsuga","doi":"10.1007/s11748-025-02176-5","DOIUrl":"https://doi.org/10.1007/s11748-025-02176-5","url":null,"abstract":"<p><strong>Objective: </strong>Ascending aortic length (AAL) has recently garnered attention as an additional parameter of surgical indication. This study aimed to verify that AAL is extended in ascending aortic aneurysm patients when compared with the normal aorta.</p><p><strong>Methods: </strong>The study included 132 patients who were diagnosed with true ascending aortic aneurysms from January 2002 to December 2021. The AAL was measured as the distance from the aortic annulus to the origin of the innominate artery. The data of 295 patients who underwent transcatheter aortic valve replacement during same period were compiled as the control group. In order to index AAL, it was divided by the patient's height (Length height index, LHI).</p><p><strong>Results: </strong>The mean ascending aortic diameter (AAD) and AAL in the 132 patients were 5.3 ± 0.6 cm and 11.7 ± 1.6 cm, respectively. Propensity score matching revealed a significantly longer AAL in the aortic aneurysm group than in the control group (11.7 vs. 8.8 cm, P < 0.05). The LHI in the aortic aneurysm group was significantly greater than in the control group (7.4 vs. 5.7 cm/m, P < 0.05). The relationship between AAD and LHI was analyzed using linear regression analysis. The regression coefficient was 0.59, and the intercept was 4.22. As a tool to predict LHI, the formula: LHI = 0.59 × AAD + 4.22 was obtained.</p><p><strong>Conclusions: </strong>AAL and LHI were significantly increased in patients with ascending aortic aneurysms. Consequently, LHI may serve as an accurate indicator of surgical intervention.</p>","PeriodicalId":12585,"journal":{"name":"General Thoracic and Cardiovascular Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}