Frontiers in Surgery最新文献

{"title":"Case Report: Bone cement leakage in the right heart: a rare case of misinterpreted echocardiographic findings.","authors":"Dongji Kong, Xiaohong Xie, Yong Jin, Yizhen Zhang","doi":"10.3389/fsurg.2025.1608784","DOIUrl":"10.3389/fsurg.2025.1608784","url":null,"abstract":"<p><p>Bone cement leakage is a relatively common complication following percutaneous vertebroplasty (PVP); however, cement migration to the heart via the venous system is rare, causing severe chest pain and dyspnea. This case reports an 80-year-old male who presented to the Department of Infectious Diseases with mild fever, 2 months after undergoing PVP for a compression fracture of the third lumbar vertebra. A chest computed tomography initially misidentified the lesion as a pacemaker lead within the right ventricle. However, echocardiography revealed that the distal bone cement was embedded in the myocardium of the right ventricular apex, leading to the diagnosis of bone cement leakage. Thereafter, the patient underwent an open-chest procedure with direct cardiac visualization for cement removal in the cardiac surgery department.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":"12 ","pages":"1608784"},"PeriodicalIF":1.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early outcomes of drug-coated balloon angioplasty and stent placement for the treatment of iliac artery lesions.","authors":"Jia-Hao Wen, Chun-Min Li, Zhen-Yi Jin, Sheng-Xing Wang","doi":"10.3389/fsurg.2025.1598354","DOIUrl":"10.3389/fsurg.2025.1598354","url":null,"abstract":"<p><strong>Objective: </strong>The efficacy and safety of drug-coated balloons (DCBs) in the treatment of aortoiliac artery stenosis or occlusion remains poorly explored.</p><p><strong>Methods: </strong>A single-center retrospective cohort study of patients diagnosed with iliac artery stenosis or occlusion who received either iliac artery DCB angioplasty or stent implantation was conducted at our institution. The patients were followed up 6 and 12 months postoperatively. Lower limb computed tomography angiography was performed during the follow-up period. The primary endpoint of the study was the primary patency at 6 and 12 months. Both the clinical and follow-up data were analyzed.</p><p><strong>Results: </strong>50 patients underwent DCB angioplasty, while 71 received stent implantation. Demographic and lesion characteristics were comparable between the two groups (<i>P</i> > 0.05). However, the balloon diameter used in the DCB group was significantly smaller (6.42 ± 0.80 mm vs. 7.39 ± 0.97 mm, <i>P</i> < 0.001). The primary patency values 6 and 12 months postoperatively were 84.2% and 80.7% for the DCB group and 96.1% and 89.6% for the stent group, respectively with no significant difference between the two groups (<i>P</i> = 0.124). However, the 12-month patency in the common iliac artery segment for the DCB group was significantly lower than that for the stent group (75.0% vs. 97.3%, <i>P</i> = 0.006). Univariate and multivariate logistic analyses did not identify any factors associated with long-term patency.</p><p><strong>Conclusion: </strong>Same as stents, DCBs maintained a favorable but lower patency rate across various calcification levels and different TASC Ⅱ classification in patients with aortoiliac artery stenosis or occlusion.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":"12 ","pages":"1598354"},"PeriodicalIF":1.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of tibial nonunion treatment through the combination of PRP, autogenous iliac bone grafting, and augmentation plating.","authors":"Guoliang Lu, Zhiqian Huo, Enliang Chen","doi":"10.3389/fsurg.2025.1573679","DOIUrl":"10.3389/fsurg.2025.1573679","url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinical efficacy of PRP (Platelet-Rich Plasma), autogenous bone combined with augmentation plating in the treatment of tibial nonunion.</p><p><strong>Methods: </strong>A total of 45 patients with tibial nonunion who fulfilled the inclusion criteria were meticulously selected and subsequently randomized into three distinct groups: Group A, which received PRP, autogenous bone grafting, and augmentation plating; Group B, which underwent autogenous bone grafting and augmentation plating; and Group C, which only received autogenous bone grafting. Each group comprised 15 patients. Detailed records were maintained for gender, age, BMI (Body Mass Index) as general information, surgery duration, blood loss, length of hospital stay, fracture healing time, and the Fernadez-Esteve score at three specific time points.</p><p><strong>Results: </strong>No statistically significant differences were observed in the general demographic data, including gender, age, and BMI, among the three groups (<i>P</i> > 0.05). In terms of bone healing time, Group A exhibited the shortest duration, followed closely by Group B and then Group C. Additionally, Group A demonstrated significantly higher Fernadez-Esteve scores compared to Group B, with Group C trailing behind, at 3, 6, and 9 months postoperatively.</p><p><strong>Conclusion: </strong>PRP, autogenous bone combined with augmentation plating in the treatment of tibial nonunion can promote fracture healing and repair, improve fracture healing rate, and the clinical effect is significant.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":"12 ","pages":"1573679"},"PeriodicalIF":1.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting early and late period outcomes in patients undergoing surgical repair due to biliary tract injury.","authors":"İbrahim Çoğal, Burak Yavuz, Yunus Kaycı, Uğur Topal, İshak Aydın, Ahmet Gokhan Saritas, Kubilay Dalci, İsmail Cem Eray, Atilgan Tolga Akcam, Abdullah Ülkü","doi":"10.3389/fsurg.2025.1576454","DOIUrl":"10.3389/fsurg.2025.1576454","url":null,"abstract":"<p><strong>Aim: </strong>Cholecystectomy is the most common elective abdominal surgery globally. With the advent of laparoscopy, laparoscopic cholecystectomy has become the gold standard. However, this has also led to an increase in biliary tract injuries, a complication with high morbidity and mortality that requires a multidisciplinary treatment approach. This study aims to identify factors influencing postoperative outcomes in patients undergoing surgical repair for biliary tract injuries.</p><p><strong>Materials and method: </strong>This study included 66 patients referred to the General Surgery Department of Çukurova University Medical Faculty for biliary tract injuries between January 2005 and June 2022, all of whom underwent hepaticojejunostomy. Demographic data, pre- and post-operative lab values, imaging, and anastomosis types were recorded and analyzed. Early and long-term postoperative outcomes were examined, using the McDonald classification for long-term follow-up.</p><p><strong>Results: </strong>Of the 66 patients, 18 (27.3%) were male, and 48 (72.7%) were female, with a mean follow-up of 105 ± 58 months. Early postoperative complications developed in 28 patients (42.4%). Diabetes and culture positivity were significantly associated with wound infections. Elevated pre- and post-repair ALP and GGT levels were significantly associated with poorer long-term outcomes according to the McDonald classification. Vascular injury was significantly associated with isolated ALP-GGT elevation. Anastomotic stricture developed in 8 patients (12.1%). Of these, 2 (3%) were successfully managed with balloon dilation.</p><p><strong>Conclusion: </strong>Biliary tract injury is a serious complication post-cholecystectomy, requiring a multidisciplinary approach and follow-up in a hepatobiliary center. Surgeon experience and local risk factors are crucial in managing these injuries.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":"12 ","pages":"1576454"},"PeriodicalIF":1.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excellent patient-reported long-term quality of life after an Ivor Lewis esophagectomy for cancer.","authors":"Alisa N Blumenthaler, Cyrus A Feizpour, Shadia I Jalal, Kevin J Lopez, Neal K Ramchandani, Joshua McAlister, Susan M Perkins, Yan Han, Karen M Rieger, JoAnn Brooks, Kenneth A Kesler","doi":"10.3389/fsurg.2025.1491498","DOIUrl":"10.3389/fsurg.2025.1491498","url":null,"abstract":"<p><strong>Background: </strong>Long-term health-related quality of life (HRQOL) may be impacted by upper gastrointestinal tract dysfunction following esophagectomy in up to two-thirds of patients. After esophagectomy, the stomach conduit is passively relying on gravity for drainage. Any resistance to flow through the stomach conduit, therefore, has the potential to significantly impact long-term HRQOL. We have previously reported a side-to-side esophagogastric anastomotic technique, which optimizes anastomotic diameter and vascularity, resulting in a low incidence of leaks and strictures. A wide pyloroplasty is another component of this technique that minimizes resistance to flow. In this study, we aimed to evaluate the long-term HRQOL and esophageal-specific QOL in cancer patients who underwent this surgical approach.</p><p><strong>Methods: </strong>From 2009-2015, 245 consecutive patients underwent Ivor Lewis esophagectomy for cancer utilizing a consistently performed technique including esophagogastric anastomosis, conduit construction, and surgical pyloric drainage. Functional Assessment of Cancer Therapy-Esophageal (FACT-E) questionnaires were distributed to surviving patients. Routine postoperative fluoroscopic contrast studies were used to characterize conduit function as normal or delayed emptying. Summary statistics for FACT-E and subscales were analyzed.</p><p><strong>Results: </strong>Eighty-five (34.7%) patients were alive at a median of 58 months and 66 (77.6%) of these patients participated in the study. Survey participants had higher Charlson-Comorbidity Indices (<i>p</i> = 0.01) and pathologic tumor stages (<i>p</i> = 0.04) compared to non-participants. Participants reported overall very favorable symptom profiles on the Esophageal Cancer Subscale (median, IQR: 55, 48.9-62.0; total possible: 68.0). Early satiety was the only item with >33% negative responses (<i>n</i> = 30, 45%). FACT-E total scores were also favorable (median, IQR: 146.0, 126.0-161.0; total possible: 176.0). Delayed emptying, identified in 17 (27.4%) participants, was not associated with HRQOL scores.</p><p><strong>Conclusion: </strong>Patient-reported long-term HRQOL following a consistently performed esophagectomy technique was very favorable in all subscales, but symptoms of early satiety persisted. Delayed postoperative conduit emptying did not impact HRQOL. These results should be compared to other consistently performed esophagectomy techniques.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":"12 ","pages":"1491498"},"PeriodicalIF":1.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application research on the quantitative measurement of supraspinatus muscle fatty degeneration based on PACS system to improve preoperative assessment.","authors":"Sitong Zhang, Yan Huang, Jian Hu, Shiao Li, Beijie Qi, Wu Wang, Menghong Cao, Qian Wang","doi":"10.3389/fsurg.2025.1627901","DOIUrl":"10.3389/fsurg.2025.1627901","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of a novel quantitative method using the Picture Archiving and Communication System (PACS) for multiplane assessment of supraspinatus muscle fatty infiltration (FI) and compare its reliability and accuracy with traditional single-plane visual evaluations (Under Direct Vision-FF) in preoperative planning for rotator cuff tear (RCT) patients.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients undergoing arthroscopic rotator cuff repair (ARCR) between January and June 2023. Preoperative 3.0 T MRI scans were analyzed using PACS to measure FI in three sagittal planes (medial, Y-plane, lateral). Four orthopedic surgeons performed Goutallier classification and manual FI assessments under direct vision and via PACS. Intra- and interobserver reliability were evaluated using intraclass correlation coefficients (ICCs), while Bland-Altman analysis and paired <i>t</i>-tests compared measurement consistency and differences.</p><p><strong>Results: </strong>PACS-based measurements (PACS-FF) demonstrated superior reliability (intraobserver ICC: 0.973-0.996; interobserver ICC: 0.940-0.978) compared to direct vision assessments (intraobserver ICC: 0.538-0.967; interobserver ICC: 0.864-0.940). Significant discrepancies were observed between methods, with direct vision underestimating FI (<i>p</i> < 0.05-0.0001). Multiplane analysis revealed heterogeneous FI distribution, with lateral-plane FI significantly higher than medial and Y-plane values (<i>p</i> < 0.001). Bland-Altman analysis showed 60%-85% of direct vision measurements exceeded clinically acceptable limits of agreement (±10%).</p><p><strong>Conclusions: </strong>Quantitative multiplane PACS-based FI assessment improves accuracy and reliability over traditional single-plane visual evaluation, better reflecting heterogeneous fat distribution in the supraspinatus muscle. This method enhances preoperative risk stratification and surgical outcome prediction for RCT patients. Future integration of automated tools may further optimize clinical efficiency.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":"12 ","pages":"1627901"},"PeriodicalIF":1.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and treatment for anal fistula: a systematic review of clinical practice guidelines and consensus statements.","authors":"Min-Yuan Lu, Jing Wang, Zhao-Chu Wang, Zhao-Lian Cai, Ning Liang, Rong Shi","doi":"10.3389/fsurg.2025.1566130","DOIUrl":"10.3389/fsurg.2025.1566130","url":null,"abstract":"<p><strong>Background: </strong>Anal fistula constitutes a pathological channel originating either from the anal canal or rectum to the skin surrounding the anus, primarily characterized by recurrent pain, purulent discharge, and pruritus. This study aims to compare and standardize the recommendations for the diagnosis and treatment of anal fistula, drawing on contemporary clinical practice guidelines.</p><p><strong>Methods: </strong>A comprehensive search was conducted across multiple databases including PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang Database, Chinese Science and Technology Periodical Database, and Chinese Biological Medicine Database, from their inception through April 1, 2024. The objective was to collate all published guidelines on anal fistula. The quality of the eligible guidelines was appraised by two reviewers using the Appraisal of Guidelines for Research and Evaluation II instrument.</p><p><strong>Results: </strong>The search yielded fifteen guidance documents -comprising nine guidelines and six consensus statements -each offering specific recommendations. Twelve of these documents address screening and diagnosis of anal fistula, while all fifteen discuss various treatment and management strategies. Document analysis highlighted MRI as the predominant diagnostic recommendation. Treatment and management strategies were categorized into four categories: preoperative management, surgical method selection, pharmacological interventions, and postoperative management. Regarding surgical interventions, all guidelines address incision and drainage of fistulas. Most guidelines offer a low recommendation for cutting setons, mainly attributed to the presence of incontinence. For high-positioned anal fistula, a push-pull flap procedure is recommended, whereas the LIFT procedure is advocated for newly identified, high, and sphincter-penetrating fistulas. Among the 15 guidelines and consensus statements evaluated in this study, more than half demonstrated methodological limitations, with particularly deficient performance in the applicability domain. As a critical determinant of implementation effectiveness, these deficiencies may undermine guidelines' capacity to optimize health outcomes.</p><p><strong>Conclusion: </strong>There is a pressing need for an updated search of potential evidence on the diagnosis and treatment of anal fistula. Effective diagnoses and therapeutic approaches, whether conventional or complementary and alternative medicine, should be thoroughly evaluated and incorporated based on robust evidence.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":"12 ","pages":"1566130"},"PeriodicalIF":1.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical advantages of suctioning flexible ureteroscopy with intelligent pressure control on treating large upper urinary tract calculi.","authors":"Weiping Cai, Bin Zheng, Xinwei Li, Xingjian Gao, Zedong Zhang, Yijin Lu, Hualong Zhao, Junhong You, Gangfeng Zheng, Weilong Bao, Yutong Lai, Yisong Lv","doi":"10.3389/fsurg.2025.1554964","DOIUrl":"10.3389/fsurg.2025.1554964","url":null,"abstract":"<p><p>Suctioning Flexible Ureteroscopy with Intelligent Pressure Control (SFUI) has the advantage of automatically capturing and breaking urinary tract calculi while maintaining renal pelvic pressure stability. This retrospective study aimed to evaluate the efficacy of SFUI in treating upper urinary tract calculi of large sizes. A total of 200 patients with upper urinary tract calculi who underwent SFUI treatment in a single location from 2020 to 2021 were included. Outcomes were a one-session stone-free rate (SFR), one-month SFR, and complications within 4 weeks after SFUI classified by Clavien-Dindo grades. Patients' median age was 50.0 years and a majority (65%) was males. Among them, 119 patients had small calculi (<2 cm) and 81 patients had large calculi (≥ 2 cm); 1 (0.8%) patient in the small calculi group, and 4 (4.9%) patients in the large calculi group had complications ≥ Grade II. Multivariable analysis showed that the large calculi group had significantly lower odds ratio for total one-session SFR [adjusted odds ratio (aOR): 0.22, 95% confidence interval (CI): 0.07-0.67, <i>p</i> = 0.008, S-value = 6.97] and one-month SFR (aOR: 0.27, 95% CI: 0.09-0.83, <i>p</i> = 0.022, S-value = 5.64) compared to the small calculi group, whereas calculi size was not associated with complication rate (aOR: 2.62, 95% CI: 0.23-29.32, <i>p</i> = 0.43, S-value = 1.20). In conclusions, SFUI is safe and effective for immediate stone removal after surgery. The very low complication rate benefits fast recovery, especially for patients with large calculi.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":"12 ","pages":"1554964"},"PeriodicalIF":1.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White blood cells, monocytes and thrombin time in predicting symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage.","authors":"Hui Deng, Hongjuan Yang, Ruoyu Chen, Wei Xing, Jia Shi","doi":"10.3389/fsurg.2025.1598385","DOIUrl":"10.3389/fsurg.2025.1598385","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the value of admission blood routine and coagulation function parameters in predicting acute symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage (aSAH).</p><p><strong>Methods: </strong>This retrospective study included 423 patients with aSAH admitted to the Department of Neurosurgery of the Third Affiliated Hospital of Soochow University from November 2013 to September 2020. Demographic, clinical and laboratory data were collected. The patients were divided into hydrocephalus group (<i>n</i> = 96) and non-hydrocephalus group (<i>n</i> = 327) according to the presence of hydrocephalus on the first head CT. Univariate and multivariate logistic regression analyses were used to determine the independent risk factors for acute symptomatic hydrocephalus after aSAH.</p><p><strong>Results: </strong>Among the 423 aSAH patients, 96 (22.70%) developed acute symptomatic hydrocephalus. Multivariate logistic regression analysis showed that, after adjusting for confounding factors, white blood cells (WBC) (OR = 1.121, 95% CI = 1.067-1.181), monocytes (M) (OR = 2.812, 95% CI = 1.183-6.699), and thrombin time (TT) (OR = 0.843, 95% CI = 0.729-0.948) were independently associated with the development of hydrocephalus. Further analysis of the area under the receiver operating characteristic (ROC) curve indicated that, compared to basic clinical data, the combined prediction model of \"basic clinical data + WBC + M + TT\" performed better (AUC = 0.728, 95% CI = 0.682-0.769, <i>P</i> = 0.004).</p><p><strong>Conclusions: </strong>The WBC, M and TT within 24 h of admission in aSAH patients can be used to predict the occurrence of acute symptomatic hydrocephalus.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":"12 ","pages":"1598385"},"PeriodicalIF":1.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver transplantation for the treatment of neuroendocrine liver metastases.","authors":"Gabriel Orozco, Dharani Ramaiah, Alejandro Cracco, Siddharth Desai, Roberto Gedaly","doi":"10.3389/fsurg.2025.1603704","DOIUrl":"10.3389/fsurg.2025.1603704","url":null,"abstract":"<p><p>Neuroendocrine liver metastases (NELM) are commonly observed in patients with advanced neuroendocrine tumors (NETs) and are associated with poor prognosis, primarily due to liver failure and hormone-related complications. While hepatic resection remains the standard surgical approach, orthotopic liver transplantation (OLT) has emerged as a potentially curative treatment in selected patients with unresectable disease. This review summarizes current evidence on the role of OLT in managing NELM, with a focus on patient selection criteria and existing clinical guidelines. Appropriate selection is essential, as improved long-term survival has been consistently demonstrated in patients who meet established eligibility parameters. In conclusion, OLT offers meaningful survival benefits for carefully selected patients with NELM. A multidisciplinary approach and ongoing research into prognostic markers and adjunctive therapies are critical to optimizing outcomes in this challenging clinical setting.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":"12 ","pages":"1603704"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}