Functional neurology最新文献_第9页

European core curriculum in neurorehabilitation. 欧洲神经康复核心课程。

Functional neurology Pub Date : 2017-04-01 DOI: 10.11138/fneur/2017.32.2.063

Giorgio Sandrini, H Binder, Volker Hömberg, Leopold Saltuari, I Tarkka, Nicola Smania, C Corradini, A Giustini, Christian Kätterer, L Picari, Karin Diserens, E Koenig, A Geurts, Aurelian Anghelescu, Józef Opara, P Tonin, Gert Kwakkel, Volodymyr Golyk, G Onose, Dominique Pérennou, A Picelli

{"title":"European core curriculum in neurorehabilitation.","authors":"Giorgio Sandrini, H Binder, Volker Hömberg, Leopold Saltuari, I Tarkka, Nicola Smania, C Corradini, A Giustini, Christian Kätterer, L Picari, Karin Diserens, E Koenig, A Geurts, Aurelian Anghelescu, Józef Opara, P Tonin, Gert Kwakkel, Volodymyr Golyk, G Onose, Dominique Pérennou, A Picelli","doi":"10.11138/fneur/2017.32.2.063","DOIUrl":"https://doi.org/10.11138/fneur/2017.32.2.063","url":null,"abstract":"To date, medical education lacks Europe-wide standards on neurorehabilitation. To address this, the European Federation of NeuroRehabilitation Societies (EFNR) here proposes a postgraduate neurorehabilitation training scheme. In particular, the European medical core curriculum in neurorehabilitation should include a two-year residency in a neurorehabilitation setting where trainees can gain practical experience. Furthermore, it should comprise six modules of classroom training organized as weekend seminars or summer/winter schools. In conclusion, after defining the European medical core curriculum in neurorehabilitation, the next activities of the EFNR will be to try and reach the largest possible consensus on its content among all national societies across Europe in order to further validate it and try to extend it to the other, non-medical, professionals on the neurorehabilitation team in line with their core curricula defined by each professional association.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"32 2","pages":"63-68"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507154/pdf/63-68.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35142921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

HLA-DRB1*15 association with multiple sclerosis is confirmed in a multigenerational Italian family. HLA-DRB1*15与多发性硬化症的关联在一个多代意大利家庭中得到证实。

Functional neurology Pub Date : 2017-04-01 DOI: 10.11138/fneur/2017.32.2.083

L Mosca, V Mantero, S Penco, L La Mantia, S De Benedetti, M R Marazzi, C Spreafico, C Erminio, L Grassi, G Lando, M Zagaria, E Agostoni, A Protti

{"title":"HLA-DRB1*15 association with multiple sclerosis is confirmed in a multigenerational Italian family.","authors":"L Mosca, V Mantero, S Penco, L La Mantia, S De Benedetti, M R Marazzi, C Spreafico, C Erminio, L Grassi, G Lando, M Zagaria, E Agostoni, A Protti","doi":"10.11138/fneur/2017.32.2.083","DOIUrl":"https://doi.org/10.11138/fneur/2017.32.2.083","url":null,"abstract":"Environmental and genetic factors seem to play a pathogenetic role in multiple sclerosis (MS). The genetic component is partly suggested by familial aggregation of cases; however, MS families with affected subjects over different generations have rarely been described. The aim of this study was to report clinical and genetic features of a multigenerational MS family and to perform a review of the literature on this topic. We describe a multigenerational Italian family with six individuals affected by MS, showing different clinical and neuroradiological findings. HLA-DRB1* typing revealed the presence of the DRB1*15:01 allele in all the MS cases and in 4/5 non-affected subjects. Reports on six multigenerational MS families have previously been published, giving similar results. The HLA-DRB1*15:01 allele was confirmed to be linked to MS disease in this family; moreover, its presence in non-affected subjects suggests the involvement of other susceptibility factors in the development and expression of the disease, in accordance with the complex disease model now attributed to MS.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"32 2","pages":"83-88"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/fneur/2017.32.2.083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35141373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Ixcellence Network®: an international educational network to improve current practice in the management of cervical dystonia or spastic paresis by botulinum toxin injection. Ixcellence网络®:一个国际教育网络，旨在改善目前通过注射肉毒杆菌毒素治疗颈椎肌张力障碍或痉挛性麻痹的实践。

Functional neurology Pub Date : 2017-04-01 DOI: 10.11138/fneur/2017.32.2.103

Klemens Fheodoroff, Roongroj Bhidayasiri, Luis Jorge Jacinto, Tae Mo Chung, Kailash Bhatia, Therese Landreau, Carlo Colosimo

{"title":"Ixcellence Network®: an international educational network to improve current practice in the management of cervical dystonia or spastic paresis by botulinum toxin injection.","authors":"Klemens Fheodoroff, Roongroj Bhidayasiri, Luis Jorge Jacinto, Tae Mo Chung, Kailash Bhatia, Therese Landreau, Carlo Colosimo","doi":"10.11138/fneur/2017.32.2.103","DOIUrl":"https://doi.org/10.11138/fneur/2017.32.2.103","url":null,"abstract":"Botulinum toxin is a well-established treatment for a number of conditions involving muscle hyperactivity, such as focal dystonia and spastic paresis. However, current injection practice is not standardized and there is a clear need for structured training. An international group of experts in the management of patients with cervical dystonia (CD) and spastic paresis created a steering committee (SC). For each therapeutic area, the SC developed a core slide set on best practice, based on the literature. International sites of expertise were identified for training and courses were designed to include lectures and casebased learning. Where possible, courses received accreditation from the European Union of Medical Specialists (UEMS). Each course was peer reviewed by the SC, the UEMS accreditation board and the attendees themselves (through evaluation questionnaires). Attendees' feedback was shared with the SC and the trainers to tailor future training sessions. From the program launch in 2012 to December 2014, 328 physicians from 34 countries were trained in a total of 58 courses; 67% of the courses focused on spastic paresis and 33% on CD. Of the 225 (69%) physicians who completed feedback forms, 95% rated their course as 'above average/excellent' in meeting the preset learning objectives. Most (90%) physicians declared that attending a course would lead them to change their practice. The development of the 'Ixcellence Network' for continuous medical education in the fields of spastic paresis and CD has provided a novel and interactive way of training physicians with previous experience in botulinum toxin injection.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"32 2","pages":"103-110"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507152/pdf/103-110.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35141380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Object decision and multiple sclerosis: a preliminary study. 目标决策与多发性硬化症:初步研究。

Functional neurology Pub Date : 2017-04-01 DOI: 10.11138/fneur/2017.32.2.069

N Caputi, A Matrella, Rocco Totaro, C Raparelli, S Pontecorvo, D Di Giacomo, D Passafiume

{"title":"Object decision and multiple sclerosis: a preliminary study.","authors":"N Caputi, A Matrella, Rocco Totaro, C Raparelli, S Pontecorvo, D Di Giacomo, D Passafiume","doi":"10.11138/fneur/2017.32.2.069","DOIUrl":"https://doi.org/10.11138/fneur/2017.32.2.069","url":null,"abstract":"The aim of this research was to study cognitive dysfunctions in multiple sclerosis (MS) by exploring subtle cognitive tasks, usually not included in the standard neuropsychological assessment. We wished to investigate whether it is possible to identify object decision deficits in MS patients without evident cognitive impairment; secondary objectives were to understand whether these deficits can be detected in the early stages of the disease and whether there are differences related to different phenotypes. Participants were divided into four groups: (a) 12 patients with early relapsing-remitting MS [ERR]; (b) 14 with late relapsing-remitting MS [LRR]; (c) 10 with secondary progressive MS [SP]; (d) 36 healthy controls [HCs]. All participants performed a series of experimental tasks: an object decision task (recognition of chimeric and real figures) and naming and visual discrimination tasks. Our results suggest that object decision disorders are detectable in patients without overt cognitive impairments and that performances on these tasks are related to phenotypes. On the other hand, the Chimeric Figures task is not appropriate for identifying cognitive dysfunctions in early MS.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"32 2","pages":"69-75"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507155/pdf/69-75.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35142922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Italian real-life post-stroke spasticity survey: unmet needs in the management of spasticity with botulinum toxin type A. 意大利现实生活卒中后痉挛调查:A型肉毒杆菌毒素痉挛管理的未满足需求。

Functional neurology Pub Date : 2017-04-01 DOI: 10.11138/fneur/2017.32.2.089

A Picelli, A Baricich, C Cisari, Stefano Paolucci, Nicola Smania, Giorgio Sandrini

{"title":"The Italian real-life post-stroke spasticity survey: unmet needs in the management of spasticity with botulinum toxin type A.","authors":"A Picelli, A Baricich, C Cisari, Stefano Paolucci, Nicola Smania, Giorgio Sandrini","doi":"10.11138/fneur/2017.32.2.089","DOIUrl":"https://doi.org/10.11138/fneur/2017.32.2.089","url":null,"abstract":"The present national survey seeking to identify unmet needs in the management of spasticity with botulinum toxin type A focused on the use of OnabotulinumoxinA, since this is the brand with the widest range of licensed indications in Italy. Physicians from twenty-four Italian neurorehabilitation units compiled a questionnaire about \"real-life\" post-stroke spasticity management. OnabotulinumtoxinA was reported to be used in the following average doses: upper limb 316.7 ± 79.1 units; lower limb 327.8 ± 152.3; upper and lower limb 543.7 ± 123.7 units. Of the physicians surveyed, 37.5% felt that increasing the frequency of OnabotulinumtoxinA injection would improve its efficacy; 70.8% use electrical stimulation/electromyography guidance (one fourth of injections with no instrumental guidance). Instrumental evaluation was used by 41.7% of the physicians. The participants expressed the view that early identification of post-stroke spasticity would be facilitated by the availability of a post-stroke checklist, and that this should be used by physiotherapists (91.7%), physiatrists (58.3%), family doctors (50%), stroke unit physicians (25%), patients and caregivers (79.2%). According to our findings, the management of poststroke spasticity has several unmet needs that, were they addressed, might improve these patients' clinical outcomes and quality of life. These needs concern patient follow-up, where a clearly defined pathway is lacking; furthermore, there is a need to use maximum doses per treatment and to ensure early intervention on post-stroke spasticity.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"32 2","pages":"89-96"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507158/pdf/89-96.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35141374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

The past and future of Functional Neurology. 功能神经病学的过去与未来。

Functional neurology Pub Date : 2017-04-01 DOI: 10.11138/fneur/2017.32.2.061

E D'Angelo, F Boller, Claudia Gandini Wheeler-Kingshott, N Vanacore, Giorgio Sandrini, C Cisari, S Tamburin, Alessio Baricich

引用次数: 0

The coefficient of friction in Parkinson's disease gait. 帕金森病步态的摩擦系数。

Functional neurology Pub Date : 2017-01-01 DOI: 10.11138/fneur/2017.32.1.017

Ana Kleiner, M Galli, M Franceschini, M F De Pandis, F Stocchi, G Albertini, Ricardo Machado Leite de Barros

{"title":"The coefficient of friction in Parkinson's disease gait.","authors":"Ana Kleiner, M Galli, M Franceschini, M F De Pandis, F Stocchi, G Albertini, Ricardo Machado Leite de Barros","doi":"10.11138/fneur/2017.32.1.017","DOIUrl":"10.11138/fneur/2017.32.1.017","url":null,"abstract":"This study aimed to characterize the coefficient of friction (COF) curves of patients with Parkinson's disease (PD) during barefoot gait and to evaluate the relationships between this variable and functional scales. Twenty-two subjects with PD (ON phase of levodopa) and 22 healthy subjects participated in this study. The participants walked barefoot along a pathway that went over two force plates embedded in the floor of the data collection room. The instantaneous COF was calculated as the ratio between the horizontal and vertical components of the ground reaction forces. Two-sample t-tests applied to every 1% of the support phase of the COF curve were used to compare the groups and to identify the phases in which the two groups were different. Specifically, three COF areas were computed: Area 1 (for the loading response phase), Area 2 (for the midstance phase) and Area 3 (for the terminal stance phase). Pearson's tests were applied to assess the associations between the COF curve areas and the clinical scales. The subjects with PD exhibited lower COF values during the loading response and terminal stance phases and higher COF values during the mid-stance phase compared with the control group. A strong positive correlation was observed between Area 1 and the Timed Up and Go Test (90.3%). In conclusion, the patients' COFs exhibited patterns that were different from those of the control group. Moreover, during the loading response phase, these differences were well-correlated with the Timed Up and Go Test scale data; Timed Up and Go Test data can be used to identify the risk of falls among PD patients.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"32 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505525/pdf/17-22.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34887775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the molecular genetics of frontotemporal lobar degeneration. 额颞叶变性分子遗传学的最新进展。

Functional neurology Pub Date : 2017-01-01 DOI: 10.11138/fneur/2017.32.1.007

Innocenzo Rainero, E Rubino, A Michelerio, F D'Agata, Salvatore Gentile, Lorenzo Pinessi

引用次数: 0

A 15-year epileptogenic period after perinatal brain injury. 围产期脑损伤后15年的癫痫发病期。

Functional neurology Pub Date : 2017-01-01 DOI: 10.11138/fneur/2017.32.1.049

F Pisani, E Pavlidis, C Facini, C La Morgia, C Fusco, G Cantalupo

引用次数: 7

Gait analysis and clinical correlations in early Parkinson's disease. 早期帕金森病的步态分析及临床相关性。

Functional neurology Pub Date : 2017-01-01 DOI: 10.11138/fneur/2017.32.1.028

M Pistacchi, M Gioulis, F Sanson, E De Giovannini, G Filippi, F Rossetto, S Zambito Marsala

{"title":"Gait analysis and clinical correlations in early Parkinson's disease.","authors":"M Pistacchi, M Gioulis, F Sanson, E De Giovannini, G Filippi, F Rossetto, S Zambito Marsala","doi":"10.11138/fneur/2017.32.1.028","DOIUrl":"https://doi.org/10.11138/fneur/2017.32.1.028","url":null,"abstract":"The aim of our study was to identify and quantify spatiotemporal and kinematic gait parameters obtained by 3D gait analysis (GA) in a group of Parkinson's disease (PD) patients compared with healthy subjects in order to investigate whether early PD patients could present an abnormal gait pattern. Forty-four patients affected by early-stage PD compared with a control group were analyzed. All participants were evaluated with 3D GA in the gait laboratory. The greatest significance in temporal parameters was found in cadence (102.46 ± 13.17 steps/min in parkinsonian patients vs 113.84 ± 4.30 steps/min in control subjects), followed by stride duration (1.19 ± 0.18 seconds right limb and 1.19 ± 0.19 seconds left limb in PD patients vs 0.426 ± 0.16 seconds right limb and 0.429 ± 0.23 seconds left limb in normal subjects) and stance duration. Marked differences were also found in the swing phase and in swing duration (p<0.05), while the stance phase was not significantly different in patients compared with healthy subjects. A statistically different velocity in PD patients (0.082 ± 0.29 m/s) vs healthy subjects (1.33 ± 0.06 m/s) was shown by spatial parameter analysis. Step width, stride length and swing velocity were highly significant parameters, as was average velocity. Our study highlighted some distinguishing characteristics of gait in early PD. Ambulation disorders may be present in the early stage of PD and their detection allows for early medical treatment and possible rehabilitation.","PeriodicalId":12560,"journal":{"name":"Functional neurology","volume":"32 1","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/fneur/2017.32.1.028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34887777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 148