Frontiers of Medicine最新文献_第5页

Albumin-bound paclitaxel plus anlotinib in patients with recurrent, platinum-resistant primary epithelial ovarian cancer (A-Plus): a phase II, single-arm, prospective study. 白蛋白结合紫杉醇加anlotinib治疗复发性铂耐药原发性上皮性卵巢癌（a - plus）：一项II期单组前瞻性研究

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 DOI: 10.1007/s11684-025-1155-1

Yun Zhou, Jian Zhou, Yin Wang, Ji-Bin Li, Rongzhen Luo, Chanjuan Zeng, Yingxin He, Yanfang Li

{"title":"Albumin-bound paclitaxel plus anlotinib in patients with recurrent, platinum-resistant primary epithelial ovarian cancer (A-Plus): a phase II, single-arm, prospective study.","authors":"Yun Zhou, Jian Zhou, Yin Wang, Ji-Bin Li, Rongzhen Luo, Chanjuan Zeng, Yingxin He, Yanfang Li","doi":"10.1007/s11684-025-1155-1","DOIUrl":"10.1007/s11684-025-1155-1","url":null,"abstract":"This study aimed to evaluate the efficacy and safety of combining albumin-bound paclitaxel (abpaclitaxel) and anlotinib for ovarian cancer. In this study, 44 patients diagnosed with platinum-resistant ovarian cancer were enrolled. Patients received ab-paclitaxel along with anlotinib until disease progression or intolerable toxicity. Efficacy was assessed according to RECIST 1.1 criteria or Rustin's criteria. The primary endpoint was the investigator-evaluated objective response rate (ORR). 44 patients were enrolled between January 2021 and March 2023 with a median age of 49 years. Twenty-nine had measurable lesions and 15 had non-measurable lesions. Overall, the investigator-evaluated ORR was 56.8% (25/44; 95% CI 0.411-0.713) in intention-to-treat population and 58.1% (25/43; 95% CI 0.422-0.726) in per-protocol population. The median progression-free survival was 9.8 months, and the median duration of response was 7.4 months. For safety, grade 3/4 adverse events (AEs) included leukopenia, gum pain, hypertension, and hand-foot syndrome. The response rates were 55.0% (11/20) in patients with previous use of antiangiogenic reagents and who had previous use of PARP inhibitors. The combination of ab-paclitaxel and anlotinib showed promising anti-tumor activity and a manageable safety profile in platinum-resistant ovarian cancer. Patients with previous use of antiangiogenic drugs or PARP inhibitors still benefited from this protocol.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"820-830"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspective on strengthening dementia prevention and control system: a comprehensive framework for national health. 加强痴呆症预防和控制体系的展望：国家卫生的综合框架。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-09-30 DOI: 10.1007/s11684-025-1154-2

Bin Cong, Hengge Xie, Yongan Sun, Jingnian Ni, Jing Shi, Mingqing Wei, Fuyao Li, Huali Wang, Luning Wang, Bin Qin, Jing Cheng, Demin Han, Wei Xiao, Boli Zhang, Jinzhou Tian

引用次数: 0

Predictive biomarkers for immunotherapy in nasopharyngeal carcinoma: from tumor microenvironment to macroenvironment. 鼻咽癌免疫治疗的预测性生物标志物：从肿瘤微环境到宏观环境。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-09-29 DOI: 10.1007/s11684-025-1151-5

Saiwei Huang, Yelin Liang, Na Liu, Jun Ma

引用次数: 0

Global, regional and national burden and trends of congenital musculoskeletal and limb deformities among under-5 children from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021. 1990年至2021年5岁以下儿童先天性肌肉骨骼和肢体畸形的全球、区域和国家负担和趋势：对2021年全球疾病负担研究的系统分析

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-09-29 DOI: 10.1007/s11684-025-1156-0

Qinglin Yang, Zhuanmei Jin, Yongping Wang

{"title":"Global, regional and national burden and trends of congenital musculoskeletal and limb deformities among under-5 children from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021.","authors":"Qinglin Yang, Zhuanmei Jin, Yongping Wang","doi":"10.1007/s11684-025-1156-0","DOIUrl":"10.1007/s11684-025-1156-0","url":null,"abstract":"Congenital musculoskeletal and limb deformities (CMLD) seriously affect the physical and mental health of patients, and pose great challenges to healthcare systems worldwide. We explored the specific situation and changes of incidence, prevalence, disability-adjusted life years rates, and mortality of CMLD in under-5 children from 1990 to 2021 in different groups, including different regions, periods, genders and socio-demographic indices (SDI), through corresponding analytical models. Overall, the global disease burden of CMLD in under-5 children has decreased from 1990 to 2021. The disease burden of CMLD in under-5 children varied significantly among different regions and countries, and there was a strong correlation between the corresponding burden of disease and the level of SDI. In addition, cross-country inequality analysis showed that while absolute inequalities in the disease burden of CMLD in under-5 children have improved, relative inequalities have worsened. It is essential to reduce the global health impact of CMLD by implementing targeted interventions to improve health care in underdeveloped areas.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"807-819"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RRS1 regulates proliferation, migration, and invasion of HTR-8/SVneo human trophoblasts. RRS1调控HTR-8/SVneo人滋养细胞的增殖、迁移和侵袭。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-10-30 DOI: 10.1007/s11684-025-1150-6

Yixuan Wu, Yao Li, Jing Wang, Qianying Guo, Wei Chen, Jie Qiao, Liying Yan, Peng Yuan

{"title":"RRS1 regulates proliferation, migration, and invasion of HTR-8/SVneo human trophoblasts.","authors":"Yixuan Wu, Yao Li, Jing Wang, Qianying Guo, Wei Chen, Jie Qiao, Liying Yan, Peng Yuan","doi":"10.1007/s11684-025-1150-6","DOIUrl":"10.1007/s11684-025-1150-6","url":null,"abstract":"Trophoblast cells serve as the foundation for placental development. We analyzed published multiomics sequencing data and found that trophoblast cells highly expressed RRS1 compared to primitive endoderm and epiblast. We used HTR-8/SVneo cells for further investigation, and Western blot and immunofluorescence staining confirmed that HTR-8/SVneo cells highly expressed RRS1. RRS1 was successfully knocked down in HTR-8/SVneo cells using siRNA. Using IncuCyte S3 live-cell analysis system based on continuous live-cell imaging and real-time data, we observed that proliferation, migration, and invasion abilities were all significantly decreased in RRS1-knockdown cells. RNA-seq revealed that knockdown of RRS1 affected the gene transcription, and upregulated pathways in extracellular matrix organization, DNA damage response, and intrinsic apoptotic signaling, downregulated pathways in embryo implantation, trophoblast cell migration, and wound healing. Differentially expressed genes were enriched in diseases related to placental development. Consistent with these findings, human chorionic villus samples collected from spontaneous abortion cases exhibited significantly reduced RRS1 expression compared to normal controls. Our results highlight the functional importance of RRS1 in human trophoblasts and suggest that its deficiency contributes to early pregnancy loss.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":"19 5","pages":"831-841"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on molecular mechanism and future perspectives of leonurine. leonurine的分子机制研究进展及展望。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-06-20 DOI: 10.1007/s11684-025-1138-2

Ran Wang, Aiying Li, Zongran Pang

{"title":"Research progress on molecular mechanism and future perspectives of leonurine.","authors":"Ran Wang, Aiying Li, Zongran Pang","doi":"10.1007/s11684-025-1138-2","DOIUrl":"10.1007/s11684-025-1138-2","url":null,"abstract":"Leonurus japonicas Houtt., has been recorded as \"light body and long life\" properties in the oldest classical medicinal book Shennong Bencao Jing thousands of years ago. Herba leonuri, also named Chinese Motherwort or Siberian Motherwort, has the effects of activating blood circulation, regulating menstruation, diuresis and detumescence, clearing heat and detoxifying, and is known as the \"sacred medicine of gynecology.\" It has been well known by doctors and usually used in the treatment of common gynecological diseases in clinic. Leonurine is a very important alkaloid in Herba leonuri, which has many biological activities such as anti-oxidation, anti-inflammation, and anti-apoptosis. Diseases of the cardiovascular system and central nervous system are \"major health threats\" that threaten human life and health worldwide, however, many drugs have certain side effects right now. This paper reviews the potential molecular therapeutic effects of leonurine on cardiovascular system and central nervous system diseases, highlights the current findings of research progress, and focuses on the therapeutic effects of leonurine in various diseases. At present, leonurine is in the stage of clinical experiment, and we hope that our summary can provide guidance for its future molecular mechanism study and clinical application.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"612-625"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crigler-Najjar syndrome type 2 complicating cholecystitis in a patient with UGT1A1 gene double homozygous mutations. 1例UGT1A1基因双纯合突变患者的Crigler-Najjar综合征2型合并胆囊炎

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-05 DOI: 10.1007/s11684-025-1142-6

Jianhui Zhang, Rongrong Chen, Xiang Chen, Ying Chen, Qilin Chen, Shiyun Lu, Jiewei Luo, Xiaoling Zheng, Mengshi Chen

{"title":"Crigler-Najjar syndrome type 2 complicating cholecystitis in a patient with UGT1A1 gene double homozygous mutations.","authors":"Jianhui Zhang, Rongrong Chen, Xiang Chen, Ying Chen, Qilin Chen, Shiyun Lu, Jiewei Luo, Xiaoling Zheng, Mengshi Chen","doi":"10.1007/s11684-025-1142-6","DOIUrl":"10.1007/s11684-025-1142-6","url":null,"abstract":"Crigler-Najjar syndrome (CNS) and Gilbert syndrome (GS; OMIM: 143500) are rare autosomal recessive diseases that cause unconjugated hyperbilirubinemia due to decreased UGT1A1 enzyme activity. Crigler-Najjar syndrome type 2 (CNS2; OMIM: 606785) increases the risk of gallbladder stone formation and cholecystitis, while GS seldom causes health issues. We found a 28-year-old male patient with recurring right upper abdomen pain who experienced persistent jaundice from birth. CNS2 with gallbladder stones and cholecystitis was diagnosed after genetic testing revealed rare double homozygous mutations A(TA)7TAA (rs3064744) and P229Q (rs35350960) in the UGT1A1 gene. After pedigree investigation, we found that the patient's parents with modestly increased bilirubin had compound heterozygous mutations A(TA)7TAA and P229Q, which were GS. Bioinformatics analysis showed that A(TA)7TAA is in the TATA-box region of the gene UGT1A1 promoter, affecting gene transcriptional initiation, whereas P229Q modifies protein three-dimensional structure and may be harmful. In this pedigree, double homozygous mutations have a more severe phenotype than compound heterozygous mutations. Inherited causes of hyperbilirubinemia should be suspected after ruling out biliary obstruction, and early bilirubin reduction (< 103 µmol/L (6 mg/dL)) may reduce the risk of complications like cholecystitis in CNS2 patients, though further studies with longer follow-up are needed to confirm this observation.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"675-680"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suppressing DBNDD2 promotes neuron growth and axon regeneration in adult mammals. 抑制DBNDD2可促进成年哺乳动物神经元生长和轴突再生。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-14 DOI: 10.1007/s11684-025-1146-2

Lan Zhang, Yucong Wu, Zhuheng Zhong, Tianyun Chen, Yuyue Qian, Sheng Yi, Leilei Gong

{"title":"Suppressing DBNDD2 promotes neuron growth and axon regeneration in adult mammals.","authors":"Lan Zhang, Yucong Wu, Zhuheng Zhong, Tianyun Chen, Yuyue Qian, Sheng Yi, Leilei Gong","doi":"10.1007/s11684-025-1146-2","DOIUrl":"10.1007/s11684-025-1146-2","url":null,"abstract":"Effective axon regeneration is essential for the successful restoration of nerve functions in patients suffering from axon injury-associated neurological diseases. Certain self-regeneration occurs in injured peripheral axonal branches of dorsal root ganglion (DRG) neurons but does not occur in their central axonal branches. By performing rat sciatic nerve or dorsal root axotomy, we determined the expression of the dysbindin domain containing 2 (DBNDD2) in the DRGs after the regenerative peripheral axon injury or the non-regenerative central axon injury, respectively, and found that DBNDD2 is down-regulated in the DRGs after peripheral axon injury but up-regulated after central axon injury. Furthermore, we found that DBNDD2 expression differs in neonatal and adult rat DRGs and is gradually increased during development. Functional analysis through DBNDD2 knockdown revealed that silencing DBNDD2 promotes the outgrowth of neurites in both neonatal and adult rat DRG neurons and stimulates robust axon regeneration in adult rats after sciatic nerve crush injury. Bioinformatic analysis data showed that transcription factor estrogen receptor 1 (ESR1) interacts with DBNDD2, exhibits a similar expression trend as DBNDD2 after axon injury, and may targets DBDNN2. These studies indicate that reduced level of DBNDD2 after peripheral axon injury and low abundance of DBNDD2 in neonates contribute to axon regeneration and thus suggest the manipulation of DBNDD2 expression as a promising therapeutic approach for improving recovery after axon damage.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"636-652"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Premature mortality projection for diabetes to 2030: a subnational evaluation towards the Healthy China 2030 Goals. 2030年糖尿病过早死亡率预测：对健康中国2030目标的地方评估。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI: 10.1007/s11684-025-1141-7

Hongrui Zhao, Zhenping Zhao, Xuan Yang, Yuchang Zhou, Ainan Jia, Jiangmei Liu, Peng Yin, Yamin Bai, Zhenxing Yang, Maigeng Zhou, Xiujuan Zhang

{"title":"Premature mortality projection for diabetes to 2030: a subnational evaluation towards the Healthy China 2030 Goals.","authors":"Hongrui Zhao, Zhenping Zhao, Xuan Yang, Yuchang Zhou, Ainan Jia, Jiangmei Liu, Peng Yin, Yamin Bai, Zhenxing Yang, Maigeng Zhou, Xiujuan Zhang","doi":"10.1007/s11684-025-1141-7","DOIUrl":"10.1007/s11684-025-1141-7","url":null,"abstract":"The Healthy China 2030 Plan set the goal of reducing premature deaths from diabetes by 30% by 2030. However, there has been a lack of assessment of premature mortality for diabetes since the action plan was issued. This study used data from the Global Burden of Disease Study 2021, calculated the premature deaths for diabetes by sex, provinces, and subtypes from 1990 to 2021. We explored the temporal trend of premature mortality using the average annual percent change (AAPC) for different sexes, provinces, and subtypes from 1990 to 2021. Furthermore, we predicted premature mortality for diabetes through 2030 for China and its provinces according to the average annual change rate from 2010 to 2021. There was a first slow upward trend in premature mortality for diabetes from 0.5% in 1990 to 0.6% in 2004, and then a decline until 2021 with premature mortality of 0.4%. By 2030, only Fujian (30.3%) will achieve the desired level of reduction, with only seven provinces meeting the target for females and none for males. There is a large range in the degree of decline between inland and coastal regions, showing obvious geographic differences, and there should be a focus on balancing medical resources.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"626-635"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ALKBH5 exacerbates psoriatic dermatitis in mice by promoting angiogenesis. ALKBH5通过促进血管生成加重小鼠银屑病皮炎。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-06-16 DOI: 10.1007/s11684-025-1147-1

Chengfang Zhang, Fei Li, Bao Chai, Jian Jiang, Yinlian Zhang, Xuemei Li, Jingyu Zhang, Yuqiong Huang, Zilin Jin, Yixuan Wang Wan, Suwen Liu, Nan Yu, Hongxiang Chen

{"title":"ALKBH5 exacerbates psoriatic dermatitis in mice by promoting angiogenesis.","authors":"Chengfang Zhang, Fei Li, Bao Chai, Jian Jiang, Yinlian Zhang, Xuemei Li, Jingyu Zhang, Yuqiong Huang, Zilin Jin, Yixuan Wang Wan, Suwen Liu, Nan Yu, Hongxiang Chen","doi":"10.1007/s11684-025-1147-1","DOIUrl":"10.1007/s11684-025-1147-1","url":null,"abstract":"Psoriasis is a chronic inflammatory skin disease, and its pathogenesis is largely modulated by abnormal angiogenesis. Previous research has indicated that AlkB homolog 5 (ALKBH5), an important demethylase affecting N6-methyladenosine (m6A) modification, plays a role in regulating angiogenesis in cardiovascular and eye diseases. Our present study found that ALKBH5 was upregulated and co-localized with cluster of differentiation 31 (CD31) in the skin of IMQ group compared with control group. ALKBH5-deficient mice decreased IMQ-induced psoriatic dermatitis and exhibited histological improvements, including decreased epidermal thickness, hyperkeratosis, numbers of dermal capillary vessels and inflammatory cell infiltration. ALKBH5-KO mice alleviated angiogenesis in psoriatic lesions by downregulating the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway. Additionally, the expression of ALKBH5 was significantly upregulated in IL-17A-induced human umbilical vein endothelial cells (HUVECs), which further promoted the expression of angiogenesis-related cytokines and endothelial cell proliferation. Cell proliferation and angiogenesis were suppressed in ALKBH5 knockdown group, whereas ALKBH5 overexpression promoted these processes. The regulation of angiogenesis in HUVECs by ALKBH5 was facilitated through the AKT-mTOR pathway. Collectively, ALKBH5 plays a pivotal role in psoriatic dermatitis and angiogenesis, which may offer a new potential targets for treating psoriasis.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"653-664"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0