Frontiers of Medicine最新文献_第4页

Risk factors for mortality in neonatal ARDS: a multicenter retrospective cohort study in China. 中国新生儿ARDS死亡率的危险因素：一项多中心回顾性队列研究

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-11-10 DOI: 10.1007/s11684-025-1163-1

Yang Yang, Chuchu Guo, Yunsu Zou, Jinxin Shen, Yan Guo, Rui Cheng, Ying Xu, Xiao Han

{"title":"Risk factors for mortality in neonatal ARDS: a multicenter retrospective cohort study in China.","authors":"Yang Yang, Chuchu Guo, Yunsu Zou, Jinxin Shen, Yan Guo, Rui Cheng, Ying Xu, Xiao Han","doi":"10.1007/s11684-025-1163-1","DOIUrl":"10.1007/s11684-025-1163-1","url":null,"abstract":"As a life-threatening respiratory syndrome, epidemiological data from China has shown that the mortality rate of neonatal acute respiratory distress syndrome (ARDS) is as high as 12.5%. Nevertheless, studies on the influencing factors of this mortality remain limited. This research enrolled newborns with ARDS who initiated invasive mechanical ventilation (IMV) within 72 hours after birth. A Cox regression model with hazard ratio (HR) was constructed using the least absolute shrinkage and selection operator analysis with the lambda.1se screening criterion. Four characteristic variables were identified: inhaled nitric oxide (iNO), high frequency ventilation (HFV), gestational age (GA), and IMV duration. The Kaplan-Meier curve indicated that infants with a higher GA, receiving iNO, or undergoing HFV had a higher risk of death. Restricted cubic spline analysis further revealed that GA ⩾ 38.785 weeks and IMV duration < 117 hours were associated with a significant mortality risk. A linear trend test confirmed a significant linear relationship between GA and mortality risk. Significant interaction effects were observed between \"iNO\" and \"IMV\" as well as between \"HFV\" and \"GA\". This study underscores that neonates with advanced GA who require concomitant HFV and iNO therapy are associated with a significantly heightened mortality risk.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutually reinforcing relationship between Sjögren's syndrome and lung adenocarcinoma: insights from Mendelian randomisation, single-cell, and transcriptomic analyses. Sjögren综合征和肺腺癌之间相互加强的关系：来自孟德尔随机化、单细胞和转录组分析的见解

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-11-10 DOI: 10.1007/s11684-025-1165-z

Kai Xu, Manhua Wang, Zixuan Yang, Yu Tang, Zhen Li, Tao Liu, Yu Wang, Yuqing Wang, Xiaoqian Zhai

{"title":"Mutually reinforcing relationship between Sjögren's syndrome and lung adenocarcinoma: insights from Mendelian randomisation, single-cell, and transcriptomic analyses.","authors":"Kai Xu, Manhua Wang, Zixuan Yang, Yu Tang, Zhen Li, Tao Liu, Yu Wang, Yuqing Wang, Xiaoqian Zhai","doi":"10.1007/s11684-025-1165-z","DOIUrl":"10.1007/s11684-025-1165-z","url":null,"abstract":"Increasing evidence suggests an association between Sjögren's syndrome (SS) and multiple cancers; however, the causal relationships and regulatory mechanisms remain unclear. Using European genome-wide association study data, we employed Mendelian randomisation (MR) and meta-analysis to explore the SS-cancer causality. Bidirectional two-sample MR revealed that SS increased the risk of colorectal (odds ratio (OR) = 1.08) and lung cancers (OR = 1.15), whereas lung (OR = 3.03) and female genital cancers (OR = 6.59) were found to elevate the risk of SS. Co-localisation analysis confirmed bidirectional causality between SS and lung cancer. Summary data-based MR identified HLA-DPB2 as a hub gene, with single-cell RNA and mRNA analyses suggesting its role in memory B cells regulation via MHC-II ligands and lung carcinogenesis. This study demonstrates a mutually positive association between SS and lung cancer, implicating HLA-DPB2 as a potential regulatory gene and offering novel insights into the relationship between SS and cancer, especially lung cancer.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Particulate matter exposure and end-stage renal disease risk in IgA nephropathy. IgA肾病患者的颗粒物暴露与终末期肾病风险

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-09-29 DOI: 10.1007/s11684-025-1162-2

Yilin Chen, Huan Zhou, Siqing Wang, Lingqiu Dong, Yi Tang, Wei Qin

{"title":"Particulate matter exposure and end-stage renal disease risk in IgA nephropathy.","authors":"Yilin Chen, Huan Zhou, Siqing Wang, Lingqiu Dong, Yi Tang, Wei Qin","doi":"10.1007/s11684-025-1162-2","DOIUrl":"10.1007/s11684-025-1162-2","url":null,"abstract":"Long-term exposure to particulate matter has been increasingly implicated in the progression of chronic kidney disease (CKD). However, its impact on IgA nephropathy (IgAN), a leading cause of end-stage renal disease (ESRD), remains unclear. A total of 1768 IgAN patients, confirmed by renal biopsy were included in this cohort study. Long-term exposure to PM2.5 and PM10 was assessed using high-resolution satellite-based data from the China High Air Pollutants (CHAP) dataset. Cox proportional hazards models were used to estimate the associations between PM2.5 or PM10 and ESRD risk, adjusting for demographic, clinical, and biochemical covariates. Over a median follow-up of 3.63 years, 209 participants progressed to ESRD. Higher exposure to both PM2.5 and PM10 was significantly associated with an increased risk, with hazard ratios of 1.62 and 1.36 per 10 µg/m3 increase, respectively. A nonlinear dose-response relationship was observed, with risk increasing markedly beyond threshold levels. Trajectory modeling of prebaseline exposure identified a subgroup with persistently high and fluctuating particulate matter exposure that showed the highest risk. This study provides strong evidence that prolonged exposure to ambient particulate matter contributes to renal disease progression in individuals with IgAN.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"855-864"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

China's biosafety/biosecurity governance: evolution, challenges, and architecture design. 中国生物安全/生物安全治理：演变、挑战和架构设计。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-09-29 DOI: 10.1007/s11684-025-1158-y

Kaiyuan Min, Yi Zhang, Jiangfeng Liu, Juntao Yang, Feng Cao, Zongchao Peng, Depei Liu

引用次数: 0

Exogenous spexin aggravates renal ischemia reperfusion injury and triggers toxicity in healthy kidneys. 外源性spexin加重肾缺血再灌注损伤并触发健康肾脏的毒性。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-09-29 DOI: 10.1007/s11684-025-1159-x

Kadri Kulualp, Meltem Kumaş Kulualp, Zeynep Semen, Gökçen Güvenç Bayram, Aslı Çelik, Melek Yeşim Ak, Osman Yilmaz

{"title":"Exogenous spexin aggravates renal ischemia reperfusion injury and triggers toxicity in healthy kidneys.","authors":"Kadri Kulualp, Meltem Kumaş Kulualp, Zeynep Semen, Gökçen Güvenç Bayram, Aslı Çelik, Melek Yeşim Ak, Osman Yilmaz","doi":"10.1007/s11684-025-1159-x","DOIUrl":"10.1007/s11684-025-1159-x","url":null,"abstract":"Renal ischemia-reperfusion injury (IRI) is a major contributor to acute kidney injury (AKI), leading to substantial morbidity and mortality. Spexin (SPX), a 14-amino acid endogenous peptide involved in metabolic regulation and immune modulation, has not yet been studied in the context of chronic treatment and renal IRI. This study evaluated the effects of exogenous SPX on renal function, histopathological changes, and molecular pathways in both IRI-induced injured and healthy kidneys. Twenty-eight male BALB/c mice were divided into four groups: control, SPX, IRI, and SPX+IRI. IRI was induced by 30 minutes of bilateral renal ischemia followed by 6 hours of reperfusion. Renal injury markers, histopathological changes, inflammatory mediators, apoptotic markers, and fibrosis-related proteins were analyzed. SPX significantly exacerbated IRI-induced kidney injury by activating the Wnt/β-catenin signaling pathway and promoting the upregulation of pro-inflammatory, pro-apoptotic, and pro-fibrotic mediators. It is noteworthy that SPX exerted more severe deleterious nephrotoxic effects in the healthy kidney compared to those observed in the IRI-induced injured kidney. These findings indicate that chronic treatment with SPX administration may have intrinsic pro-inflammatory, pro-apoptotic and fibrotic properties, raising concerns about its therapeutic potential. Further research is needed to clarify its physiological role and therapeutic implications in kidney diseases.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"842-854"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovation and development of stent retrievers in acute ischemic stroke. 急性缺血性脑卒中支架回收器的创新与发展。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-10-30 DOI: 10.1007/s11684-025-1160-4

Nan Zhang, Hongye Xu, Hongjian Zhang, Hongyu Ma, Weilong Hua, Minghao Song, Yongxin Zhang, Jianmin Liu, Lei Zhang, Xiaoxi Zhang, Pengfei Yang

引用次数: 0

Insights into potential therapeutic approaches for long COVID. 对长期COVID的潜在治疗方法的见解。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-09-25 DOI: 10.1007/s11684-025-1149-z

Jingya Zhao, Yingqi Lyu, Jieming Qu

引用次数: 0

Precision medicine for advanced biliary tract cancer in China: current status and future perspectives. 中国晚期胆道癌的精准医疗：现状与未来展望

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-10-15 DOI: 10.1007/s11684-025-1144-4

Zhen Huang, Wen Zhang, Yongkun Sun, Dong Yan, Xijie Zhang, Lu Liang, Hong Zhao

{"title":"Precision medicine for advanced biliary tract cancer in China: current status and future perspectives.","authors":"Zhen Huang, Wen Zhang, Yongkun Sun, Dong Yan, Xijie Zhang, Lu Liang, Hong Zhao","doi":"10.1007/s11684-025-1144-4","DOIUrl":"10.1007/s11684-025-1144-4","url":null,"abstract":"Biliary tract cancer (BTC) is a rare group of malignancies that develop from the epithelial lining of the biliary tree and have a poor prognosis. Although chemotherapy is the standard of care for patients with advanced BTC in China, its clinical benefits are moderate. In recent years, the approval of targeted therapies and immunotherapies has provided new avenues for the management of advanced BTC. Nonetheless, the increasing number of personalized medicine approaches has created a challenge for clinicians choosing individualized treatment strategies based on tumor characteristics. In this article, we discuss recent progress in implementing precision medicine approaches for advanced BTC in China and examine genomic profiling studies in Chinese patients with advanced BTC. We also discuss the challenges and opportunities of using precision medicine approaches, as well as the importance of considering population-specific factors and tailoring treatment approaches to improve outcomes for patients with BTC. In addition to providing a comprehensive overview of current and emerging precision medicine approaches for the management of advanced BTC in China, this review article will support clinicians outside of China by serving as a reference regarding the role of patient- and population-specific factors in clinical decision-making for patients with this rare malignancy.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"743-768"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactate and lactylation in tumor immunity. 乳酸和乳酸化在肿瘤免疫中的作用。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-09-20 DOI: 10.1007/s11684-025-1148-0

Liu Song, Lingjuan Sun, Song Chen, Peixiang Lan

{"title":"Lactate and lactylation in tumor immunity.","authors":"Liu Song, Lingjuan Sun, Song Chen, Peixiang Lan","doi":"10.1007/s11684-025-1148-0","DOIUrl":"10.1007/s11684-025-1148-0","url":null,"abstract":"The Warburg effect, originally discovered by Otto Warburg, refers to the metabolic reprogramming of tumor cells from aerobic oxidation to glycolysis, enabling rapid energy production to support their growth and metastasis. This process is accompanied by the massive production and accumulation of lactate both intracellularly and extracellularly. The resulting acidic microenvironment impairs the normal physiological functions of immune cells and promotes tumor progression. An increasing number of studies indicate that lactate, a key metabolite in the tumor microenvironment (TME), acts as a pivotal immunosuppressive signaling molecule that modulates immune cell function. This review aims to comprehensively examine lactate's role as an immunosuppressive molecule in TME. It focuses on mechanisms such as membrane receptor binding, functional reshaping of immune cells via lactate shuttle transport, epigenetic regulation of gene expression through histone lactylation, and modulation of protein structure and function through nonhistone lactylation, emphasizing lactate's importance in immune regulation within the TME. Ultimately, this review offers novel insights into immunosuppressive therapies aimed at targeting lactate function.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"697-720"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding pain heterogeneity in osteoarthritis patients: a narrative review. 理解骨关节炎患者疼痛的异质性：一个叙述性的回顾。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-10-01 Epub Date: 2025-07-26 DOI: 10.1007/s11684-025-1143-5

Lin Li, Xiwei Fan, Ross Crawford, Xinzhan Mao, Louis Jun Ye Ong, Feng Gao, Antonia Rujia Sun, Indira Prasadam

{"title":"Understanding pain heterogeneity in osteoarthritis patients: a narrative review.","authors":"Lin Li, Xiwei Fan, Ross Crawford, Xinzhan Mao, Louis Jun Ye Ong, Feng Gao, Antonia Rujia Sun, Indira Prasadam","doi":"10.1007/s11684-025-1143-5","DOIUrl":"10.1007/s11684-025-1143-5","url":null,"abstract":"The primary clinical manifestation of osteoarthritis (OA) is pain, yet considerable variability exists in the pain experience among OA patients. This narrative review aims to explore the mechanisms driving OA pain heterogeneity to inform the development of targeted interventions that improve treatment efficacy and patient outcomes. A comprehensive literature search was conducted across multiple databases (PubMed, Scopus, and Google Scholar) for papers published between January 1, 2020, and December 31, 2024. Inclusion criteria focused on studies addressing pain mechanisms and therapeutic interventions in OA. This review identifies key mechanisms of OA pain, including joint alterations, angiogenesis, nervous system involvement, peripheral and central sensitization, and psychosocial factors. It highlights the underlying distinct mechanisms in OA pain, which contribute to the variability in individuals' responses to treatment. It was suggested that interactions between neuroimmune and neurovascular systems are key contributors to chronic pain in OA. This narrative review emphasizes the complexity of OA pain, highlighting the importance of thoroughly understanding the underlying mechanisms for developing personalized and effective pain management strategies. Additional research is required to refine treatment approaches and explore long-term effects.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"769-788"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0