Frontiers of Medicine最新文献_第6页

Developing a polygenic risk score for pelvic organ prolapse: a combined risk assessment approach in Chinese women. 开发盆腔器官脱垂的多基因风险评分：中国妇女的综合风险评估方法。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-03 DOI: 10.1007/s11684-024-1114-2

Xi Cheng, Lei Li, Xijuan Lin, Na Chen, Xudong Liu, Yaqian Li, Zhaoai Li, Jian Gong, Qing Liu, Yuling Wang, Juntao Wang, Zhijun Xia, Yongxian Lu, Hangmei Jin, Xiaowei Zhang, Luwen Wang, Juan Chen, Guorong Fan, Shan Deng, Sen Zhao, Lan Zhu

{"title":"Developing a polygenic risk score for pelvic organ prolapse: a combined risk assessment approach in Chinese women.","authors":"Xi Cheng, Lei Li, Xijuan Lin, Na Chen, Xudong Liu, Yaqian Li, Zhaoai Li, Jian Gong, Qing Liu, Yuling Wang, Juntao Wang, Zhijun Xia, Yongxian Lu, Hangmei Jin, Xiaowei Zhang, Luwen Wang, Juan Chen, Guorong Fan, Shan Deng, Sen Zhao, Lan Zhu","doi":"10.1007/s11684-024-1114-2","DOIUrl":"10.1007/s11684-024-1114-2","url":null,"abstract":"Pelvic organ prolapse (POP), whose etiology is influenced by genetic and clinical risk factors, considerably impacts women's quality of life. However, the genetic underpinnings in non-European populations and comprehensive risk models integrating genetic and clinical factors remain underexplored. This study constructed the first polygenic risk score (PRS) for POP in the Chinese population by utilizing 20 disease-associated variants from the largest existing genome-wide association study. We analyzed a discovery cohort of 576 cases and 623 controls and a validation cohort of 264 cases and 200 controls. Results showed that the case group exhibited a significantly higher PRS than the control group. Moreover, the odds ratio of the top 10% risk group was 2.6 times higher than that of the bottom 10%. A high PRS was significantly correlated with POP occurrence in women older than 50 years old and in those with one or no childbirths. As far as we know, the integrated prediction model, which combined PRS and clinical risk factors, demonstrated better predictive accuracy than other existing PRS models. This combined risk assessment model serves as a robust tool for POP risk prediction and stratification, thereby offering insights into individualized preventive measures and treatment strategies in future clinical practice.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"665-674"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to "A critical perspective on patient activation through integrative healthcare counselling in oncology", based on the "CCC-Integrativ" study. 对基于“cc - integrativ”研究的“通过肿瘤学综合保健咨询对患者激活的关键观点”的回应。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-05 DOI: 10.1007/s11684-025-1153-3

Jan Valentini, Daniela Froehlich, Cornelia Mahler, Stefanie Joos

引用次数: 0

Development of therapeutic cancer vaccines based on cancer immunity cycle. 基于肿瘤免疫周期的治疗性癌症疫苗的研制。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-14 DOI: 10.1007/s11684-025-1134-6

Jing Zhang, Yiyuan Zheng, Lili Xu, Jing Gao, Ziqi Ou, Mingzhao Zhu, Wenjun Wang

引用次数: 0

Neurokinin-1 receptor antagonists in the current management of chemotherapy-induced nausea and vomiting. 神经激肽-1受体拮抗剂在化疗引起的恶心和呕吐的当前管理。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-05 DOI: 10.1007/s11684-025-1140-8

Haohua Zhu, Song Huang, Xingsheng Hu

引用次数: 0

Betaine: an exercise mimetics for healthy aging? 甜菜碱：健康衰老的运动模拟剂？

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-21 DOI: 10.1007/s11684-025-1157-z

Yiliang Zhang, Xiaomin Liu, Yan Wang

引用次数: 0

Anti-angiogenic therapy as a beacon of hope in the battle against pulmonary NUT midline carcinoma. 抗血管生成治疗作为对抗肺NUT中线癌的希望灯塔。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-06-14 DOI: 10.1007/s11684-025-1145-3

Linyan Tian, Siyu Lei, Yaning Yang, Haiyan Xu, Chengming Liu, Yan Wang

{"title":"Anti-angiogenic therapy as a beacon of hope in the battle against pulmonary NUT midline carcinoma.","authors":"Linyan Tian, Siyu Lei, Yaning Yang, Haiyan Xu, Chengming Liu, Yan Wang","doi":"10.1007/s11684-025-1145-3","DOIUrl":"10.1007/s11684-025-1145-3","url":null,"abstract":"Primary pulmonary nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare and highly aggressive thoracic malignancy that poses significant diagnostic and therapeutic challenges in clinical practice. This tumor is characterized by its heterogeneous clinical presentations and poor prognosis, often evading accurate initial diagnosis. In this study, we present two cases of primary pulmonary NMC treated with an integrated therapeutic approach combining anti-angiogenic agents, platinum-based chemotherapy, and radiotherapy. This multimodal strategy achieved survival durations of 32 and 13 months, respectively, surpassing the currently reported median survival of advanced NMC. Through a systematic literature review of reported cases, we have summarized the currently used diagnostic methods and treatment modalities for NMC. Our findings suggest that multimodal therapy incorporating anti-angiogenic treatment may offer superior clinical outcomes compared to conventional monotherapy regimens, particularly for patients who are not eligible for surgery. This comprehensive investigation enhances our understanding of NMC management by elucidating diagnostic pitfalls through histopathological correlation and proposing an effective therapeutic combination that demonstrates improved survival outcomes. By providing valuable insights into the diagnosis and treatment of primary pulmonary NMC, we hope to contribute to the development of more effective strategies for managing this rare and aggressive malignancy.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"681-688"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical perspective on patient activation through integrative healthcare counseling in oncology. 通过肿瘤学综合保健咨询对患者激活的关键观点。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-07 DOI: 10.1007/s11684-025-1152-4

Carlos M Ardila, Pradeep K Yadalam

引用次数: 0

Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review. 绝经后骨质疏松症肠道菌群及其代谢物短链脂肪酸的研究进展

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-05-10 DOI: 10.1007/s11684-025-1129-3

Yao Chen, Ying Xie, Xijie Yu

{"title":"Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review.","authors":"Yao Chen, Ying Xie, Xijie Yu","doi":"10.1007/s11684-025-1129-3","DOIUrl":"10.1007/s11684-025-1129-3","url":null,"abstract":"Postmenopausal osteoporosis (PMOP) is a systemic metabolic bone disease caused by the decrease in estrogen levels after menopause. It leads to bone loss, microstructural damage, and an increased risk of fractures. Studies have found that the gut microbiota and its metabolites can regulate bone metabolism through the gut-bone axis and the gut-brain axis. As research progresses, PMOP has been found to be associated with gut microbiota dysbiosis and Th17/Treg imbalance. The gut microbiota is closely related to the development and differentiation of Treg and Th17 cells. Among them, the metabolites of the gut microbiota such as short-chain fatty acids (SCFAs) can regulate the differentiation of effector T cells by acting on molecular receptors on immune cells, thereby regulating the bone immune process. The multifaceted relationship among the gut microbiota, SCFAs, Th17/Treg cell-mediated bone immunity, and bone metabolism is eliciting attention from researchers. Through a review of existing literature, we have comprehensively summarized the effects of the gut microbiota and SCFAs on PMOP, especially from the perspective of Th17/Treg balance. Regulating this balance may provide new opportunities for PMOP treatment.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"474-492"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular senescence in age-related musculoskeletal diseases. 与年龄相关的肌肉骨骼疾病中的细胞衰老。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-05-02 DOI: 10.1007/s11684-025-1125-7

Jinming Xiong, Qiaoyue Guo, Xianghang Luo

引用次数: 0

A promising new TERT activator: unraveling the molecular mechanisms behind its natural aging mitigation. 一种有前途的新TERT激活剂：揭示其自然衰老减缓背后的分子机制。

IF 3.5 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-04-12 DOI: 10.1007/s11684-025-1139-1

Qin Li, Fengting Guo, Lanfang Li, Lifang Li

引用次数: 0