Frontiers of Medicine最新文献_第2页

Anti-angiogenic therapy as a beacon of hope in the battle against pulmonary NUT midline carcinoma. 抗血管生成治疗作为对抗肺NUT中线癌的希望灯塔。

IF 3.9 3区医学

Frontiers of Medicine Pub Date : 2025-06-14 DOI: 10.1007/s11684-025-1145-3

Linyan Tian, Siyu Lei, Yaning Yang, Haiyan Xu, Chengming Liu, Yan Wang

{"title":"Anti-angiogenic therapy as a beacon of hope in the battle against pulmonary NUT midline carcinoma.","authors":"Linyan Tian, Siyu Lei, Yaning Yang, Haiyan Xu, Chengming Liu, Yan Wang","doi":"10.1007/s11684-025-1145-3","DOIUrl":"https://doi.org/10.1007/s11684-025-1145-3","url":null,"abstract":"Primary pulmonary nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare and highly aggressive thoracic malignancy that poses significant diagnostic and therapeutic challenges in clinical practice. This tumor is characterized by its heterogeneous clinical presentations and poor prognosis, often evading accurate initial diagnosis. In this study, we present two cases of primary pulmonary NMC treated with an integrated therapeutic approach combining anti-angiogenic agents, platinum-based chemotherapy, and radiotherapy. This multimodal strategy achieved survival durations of 32 and 13 months, respectively, surpassing the currently reported median survival of advanced NMC. Through a systematic literature review of reported cases, we have summarized the currently used diagnostic methods and treatment modalities for NMC. Our findings suggest that multimodal therapy incorporating anti-angiogenic treatment may offer superior clinical outcomes compared to conventional monotherapy regimens, particularly for patients who are not eligible for surgery. This comprehensive investigation enhances our understanding of NMC management by elucidating diagnostic pitfalls through histopathological correlation and proposing an effective therapeutic combination that demonstrates improved survival outcomes. By providing valuable insights into the diagnosis and treatment of primary pulmonary NMC, we hope to contribute to the development of more effective strategies for managing this rare and aggressive malignancy.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review. 绝经后骨质疏松症肠道菌群及其代谢物短链脂肪酸的研究进展

IF 3.9 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-05-10 DOI: 10.1007/s11684-025-1129-3

Yao Chen, Ying Xie, Xijie Yu

{"title":"Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review.","authors":"Yao Chen, Ying Xie, Xijie Yu","doi":"10.1007/s11684-025-1129-3","DOIUrl":"10.1007/s11684-025-1129-3","url":null,"abstract":"Postmenopausal osteoporosis (PMOP) is a systemic metabolic bone disease caused by the decrease in estrogen levels after menopause. It leads to bone loss, microstructural damage, and an increased risk of fractures. Studies have found that the gut microbiota and its metabolites can regulate bone metabolism through the gut-bone axis and the gut-brain axis. As research progresses, PMOP has been found to be associated with gut microbiota dysbiosis and Th17/Treg imbalance. The gut microbiota is closely related to the development and differentiation of Treg and Th17 cells. Among them, the metabolites of the gut microbiota such as short-chain fatty acids (SCFAs) can regulate the differentiation of effector T cells by acting on molecular receptors on immune cells, thereby regulating the bone immune process. The multifaceted relationship among the gut microbiota, SCFAs, Th17/Treg cell-mediated bone immunity, and bone metabolism is eliciting attention from researchers. Through a review of existing literature, we have comprehensively summarized the effects of the gut microbiota and SCFAs on PMOP, especially from the perspective of Th17/Treg balance. Regulating this balance may provide new opportunities for PMOP treatment.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"474-492"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular senescence in age-related musculoskeletal diseases. 与年龄相关的肌肉骨骼疾病中的细胞衰老。

IF 3.9 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-05-02 DOI: 10.1007/s11684-025-1125-7

Jinming Xiong, Qiaoyue Guo, Xianghang Luo

引用次数: 0

A promising new TERT activator: unraveling the molecular mechanisms behind its natural aging mitigation. 一种有前途的新TERT激活剂：揭示其自然衰老减缓背后的分子机制。

IF 3.9 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-04-12 DOI: 10.1007/s11684-025-1139-1

Qin Li, Fengting Guo, Lanfang Li, Lifang Li

引用次数: 0

HOXB13 in cancer development: molecular mechanisms and clinical implications. HOXB13在癌症发展中的分子机制和临床意义

IF 3.9 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-11 DOI: 10.1007/s11684-024-1119-x

Jian Zhang, Ying Ju Li, Bo Peng, Xuna Yang, Miao Chen, Yongxing Li, Hengbin Gao, Haitao Li, Ji Zheng

引用次数: 0

Aging and metabolic dysfunction-associated steatotic liver disease: a bidirectional relationship. 衰老与代谢功能障碍相关的脂肪变性肝病：双向关系

IF 3.9 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-05-03 DOI: 10.1007/s11684-025-1133-7

Chen Chen, Lin Wang

{"title":"Aging and metabolic dysfunction-associated steatotic liver disease: a bidirectional relationship.","authors":"Chen Chen, Lin Wang","doi":"10.1007/s11684-025-1133-7","DOIUrl":"10.1007/s11684-025-1133-7","url":null,"abstract":"In recent years, aging and cellular senescence have triggered an increased interest in corresponding research fields. Evidence shows that the complex aging process is involved in the development of many chronic liver diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). In fact, aging has a tremendous effect on the liver, leading to a gradual decline in the metabolism, detoxification and immune functions of the liver, which in turn increases the risk of liver disease. These changes can be based on the aging of liver cells (hepatocytes, liver sinusoidal endothelial cells, hepatic stellate cells, and Kupffer cells). Similarly, patients with liver diseases exhibit increases in the aging phenotype and aging cells, often manifesting as faster physical functional decline, which is closely related to the promoting effect of liver disease on aging. This review summarizes the interplay between MASLD/MASH development and aging, aiming to reveal the complex relationships that exacerbate one another. Moreover, the corresponding schemes for delaying aging or treating diseases are discussed to provide a basis for the development of effective prevention and treatment strategies in the future.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"427-438"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-acting lenacapavir is a breakthrough for preventing HIV infection, but HIV vaccine research must continue. 长效lenacapavir是预防HIV感染的一个突破，但是HIV疫苗的研究必须继续。

IF 3.9 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-06-11 DOI: 10.1007/s11684-025-1137-3

Caijun Sun, Linghua Li, Pingchao Li, Weiping Cai, Xiaoping Tang, Yiming Shao, Ling Chen

引用次数: 0

Determining the biomarkers and pathogenesis of myocardial infarction combined with ankylosing spondylitis via a systems biology approach. 通过系统生物学方法确定心肌梗死合并强直性脊柱炎的生物标志物和发病机制。

IF 3.9 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-05-03 DOI: 10.1007/s11684-025-1132-8

Chunying Liu, Chengfei Peng, Xiaodong Jia, Chenghui Yan, Dan Liu, Xiaolin Zhang, Haixu Song, Yaling Han

{"title":"Determining the biomarkers and pathogenesis of myocardial infarction combined with ankylosing spondylitis via a systems biology approach.","authors":"Chunying Liu, Chengfei Peng, Xiaodong Jia, Chenghui Yan, Dan Liu, Xiaolin Zhang, Haixu Song, Yaling Han","doi":"10.1007/s11684-025-1132-8","DOIUrl":"10.1007/s11684-025-1132-8","url":null,"abstract":"Ankylosing spondylitis (AS) is linked to an increased prevalence of myocardial infarction (MI). However, research dedicated to elucidating the pathogenesis of AS-MI is lacking. In this study, we explored the biomarkers for enhancing the diagnostic and therapeutic efficiency of AS-MI. Datasets were obtained from the Gene Expression Omnibus database. We employed weighted gene co-expression network analysis and machine learning models to screen hub genes. A receiver operating characteristic curve and a nomogram were designed to assess diagnostic accuracy. Gene set enrichment analysis was conducted to reveal the potential function of hub genes. Immune infiltration analysis indicated the correlation between hub genes and the immune landscape. Subsequently, we performed single-cell analysis to identify the expression and subcellular localization of hub genes. We further constructed a transcription factor (TF)-microRNA (miRNA) regulatory network. Finally, drug prediction and molecular docking were performed. S100A12 and MCEMP1 were identified as hub genes, which were correlated with immune-related biological processes. They exhibited high diagnostic value and were predominantly expressed in myeloid cells. Furthermore, 24 TFs and 9 miRNA were associated with these hub genes. Enzastaurin, meglitinide, and nifedipine were predicted as potential therapeutic agents. Our study indicates that S100A12 and MCEMP1 exhibit significant potential as biomarkers and therapeutic targets for AS-MI, offering novel insights into the underlying etiology of this condition.","PeriodicalId":12558,"journal":{"name":"Frontiers of Medicine","volume":" ","pages":"507-522"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burning lactic acid: a road to revitalizing antitumor immunity. 燃烧乳酸：振兴抗肿瘤免疫之路。

IF 3.9 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-22 DOI: 10.1007/s11684-025-1126-6

Jingwei Ma, Liang Tang, Jingxuan Xiao, Ke Tang, Huafeng Zhang, Bo Huang

引用次数: 0

An expanded view of disease continuum centered on rheumatoid arthritis: from single to systemic perspectives. 以类风湿关节炎为中心的疾病连续体的扩展观点：从单一到系统的观点。

IF 3.9 3区医学

Frontiers of Medicine Pub Date : 2025-06-01 Epub Date: 2025-04-21 DOI: 10.1007/s11684-025-1135-5

Ming Zheng

引用次数: 0