Global health & medicine最新文献_第6页

Prevalence and associated factors of low vigor in patients living with HIV and hemophilia in Japan: A cross-sectional observational study. 日本艾滋病病毒感染者和血友病患者活力低下的患病率和相关因素：一项横断面观察研究。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2023.01108

Kensuke Komatsu, Sota Kimura, Yoko Kiryu, Aki Watanabe, Ei Kinai, Shinichi Oka, Satoshi Kimura, Junko Fujitani, Mikiko Ogata, Ryogo Minamimoto, Masatoshi Hotta, Kota Yokoyama, Tomoyuki Noguchi, Koubun Imai

{"title":"Prevalence and associated factors of low vigor in patients living with HIV and hemophilia in Japan: A cross-sectional observational study.","authors":"Kensuke Komatsu, Sota Kimura, Yoko Kiryu, Aki Watanabe, Ei Kinai, Shinichi Oka, Satoshi Kimura, Junko Fujitani, Mikiko Ogata, Ryogo Minamimoto, Masatoshi Hotta, Kota Yokoyama, Tomoyuki Noguchi, Koubun Imai","doi":"10.35772/ghm.2023.01108","DOIUrl":"10.35772/ghm.2023.01108","url":null,"abstract":"People living with human immunodeficiency virus (HIV) are at high risk of mental health problems. However, little is known about this risk in HIV-infected patients with hemophilia (HPH) who contracted the virus through blood products. This cross-sectional, observational study assessed patients' mood states and the factors associated with them among Japanese HPH to evaluate the need for psychosocial support. HPH completed self-administered questionnaires (Profile of Mood States [POMS] and General Health Questionnaire-28), neuropsychological tests, and brain magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography/computerized tomography scans. HIV-infected patients with no hemophilia (HPnH) completed POMS and neuropsychological tests. Socio-demographic characteristics and HIV- and hemophilia-related data were obtained from participants' medical records and interviews. A Mann-Whitney U test and chi-squared analyses were conducted. Fifty-six HPH and 388 HPnH completed the questionnaires and neuropsychological tests. HPH had a significantly lower prevalence of tension-anxiety (HPH, 7%; HPnH, 18%; p = 0.049) and a significantly higher prevalence of low vigor (HPH, 63%; HPnH, 32%; p < 0.001). Low vigor in HPH was significantly associated with impaired executive function (low vigor, 66%; high vigor, 33%; p = 0.019) and a social dysfunction score ≥ 3 (moderate; low vigor, 26%; high vigor, 5%; p = 0.047). Our results highlight the high prevalence of low vigor among HPH, leading to impairments in executive and social functions. Therefore, healthcare workers need to pay attention to the vigor, executive function, and social function of HPH.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"174-182"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary artery stenosis in Japanese people living with HIV-1 with or without haemophilia. 伴有或不伴有血友病的日本 HIV-1 感染者的冠状动脉狭窄。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01101

Ran Nagai, Mikiko Ogata, Shuji Kubota, Masaya Yamamoto, Haruka Uemura, Junko Tanuma, Hiroyuki Gatanaga, Hisao Hara, Shinichi Oka, Yukio Hiroi

{"title":"Coronary artery stenosis in Japanese people living with HIV-1 with or without haemophilia.","authors":"Ran Nagai, Mikiko Ogata, Shuji Kubota, Masaya Yamamoto, Haruka Uemura, Junko Tanuma, Hiroyuki Gatanaga, Hisao Hara, Shinichi Oka, Yukio Hiroi","doi":"10.35772/ghm.2023.01101","DOIUrl":"https://doi.org/10.35772/ghm.2023.01101","url":null,"abstract":"An extremely high prevalence (12.2%) of moderate-to-severe coronary artery stenosis (CAS) was documented in asymptomatic Japanese haemophiliacs living with HIV-1 (JHLH) in our previous study. The cause of this phenomenon remains unknown. We conducted the CAS screening in people living with HIV-1 without haemophilia (PLWH without haemophilia) to compare the prevalence of CAS in JHLH and PLWH without haemophilia and to identify the risk factors including inflammation markers. Ninety-seven age-matched male PLWH without haemophilia who consulted our outpatient clinic between June and July 2021 were randomly selected, and 69 patients who provided informed consent were screened for CAS using coronary computed tomography angiography (CCTA). The number of JHLH cases was 62 in this study. The prevalence of moderate (> 50%) to severe (> 75%) CAS was significantly higher in JHLH [14/57 (24.6%) vs. 6/69 (8.7%), p = 0.015], and the ratio of CAS requiring urgent interventions was significantly higher [7 (12.3%) vs. 1 (1.4%), p = 0.013] in JHLH than in PLWH without haemophilia. Among the inflammatory markers, serum titres of intercellular adhesion molecule-1 (p < 0.05) and interleukin-6 (p < 0.05) in JHLH were significantly higher than those in PLWH without haemophilia. Although some patient demographics were different in the age-matched study, it might be possible to speculate that intravascular inflammation might promote CAS in JHLH.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"124-131"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proposal to apply a "Positive Emotion, Engagement, Relationships, Meaning, and Accomplishment (PERMA)" based approach to manage the COVID-19-related mental health problems in the era of long COVID. 建议采用基于 "积极情绪、参与、关系、意义和成就（PERMA）"的方法，在长 COVID 时代管理与 COVID-19 相关的心理健康问题。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01102

Kai Sun, Rongfeng Zhou, Fang Xu, Hongzhou Lu, Tetsuya Asakawa

{"title":"Proposal to apply a \"Positive Emotion, Engagement, Relationships, Meaning, and Accomplishment (PERMA)\" based approach to manage the COVID-19-related mental health problems in the era of long COVID.","authors":"Kai Sun, Rongfeng Zhou, Fang Xu, Hongzhou Lu, Tetsuya Asakawa","doi":"10.35772/ghm.2023.01102","DOIUrl":"https://doi.org/10.35772/ghm.2023.01102","url":null,"abstract":"Long COVID (LC)-related health problems are highly concerned. Many patients seem to have \"recovered\" from an acute SARS-CoV-2 infection, however, they might experience various symptoms, almost involving all organs and systems. Of those, neuropsychiatric symptoms like depression, anxiety, and post-traumatic stress disorder (PTSD) are not rare. These problems significantly impact the quality of life (QOL) of patients, family, and caregivers, even lead a tragic suicide outcome. Other than the conventional psychological and medical approaches, here, we proposal a positive emotion, engagement, relationships, meaning, and accomplishment (PERMA)-based approach to fight against these COVID-19-related mental health problems (CRMHPs). This approach is characterized by positive psychological interventions and self-achievements, which has been proved to be a powerful tool against mood disorders in common people. Nowadays, abolishment of certain prophylactic measures (such as isolation, lockdown, compulsorily wearing a mask and maintaining social distance, measures to avoid crowding) enables us to have more opportunities to contact patients and implement the PERMA-based approach to the patients with CRMHPs. We believe that application of PERMA-based approach is conducive to alleviate the influence of the CRMHPs and improve their QOL.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"160-163"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient satisfaction with nursing care in infertility patients: A questionnaire survey. 不孕症患者对护理服务的满意度：问卷调查

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01044

Jing Wang, Lisha Li, Jing Zhou, Xinyao Pan, Qing Qi, Hongmei Sun, Ling Wang

{"title":"Patient satisfaction with nursing care in infertility patients: A questionnaire survey.","authors":"Jing Wang, Lisha Li, Jing Zhou, Xinyao Pan, Qing Qi, Hongmei Sun, Ling Wang","doi":"10.35772/ghm.2023.01044","DOIUrl":"https://doi.org/10.35772/ghm.2023.01044","url":null,"abstract":"Infertility remains a persistent global reproductive health challenge, with causative factors encompassing abnormalities in both the male and female reproductive systems. Typically, female partners seek initial consultations for infertility concerns, often within the context of routine annual well-woman check-ups. Nurses providing preventive care play a crucial role, conducting initial diagnostic assessments, and addressing certain causes of infertility. Patient satisfaction serves as a vital indicator of care quality. Identifying factors contributing to patient satisfaction with nursing services is crucial, yet research in this area has been limited. This study aimed to compare infertility patients' assessments of nurse quality and satisfaction with hospital services. The findings could offer valuable insights for healthcare providers, hospitals, and policymakers, guiding improvements in nursing care delivery and enhancing patient satisfaction in China's infertility treatment sector. By understanding patients' perspectives and experiences, healthcare providers can make necessary adjustments to improve care quality and patient outcomes. The sample included 1200 patients, and data collection utilized a self-assessment questionnaire, with percentages employed for analysis. Nurses are integral to caring for infertility patients during visits and conducting research to advance fertility care practices.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"141-148"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developments and current challenges in the process of cell culture-based seasonal influenza vaccine manufacture in Japan. 日本基于细胞培养的季节性流感疫苗生产过程中的发展和当前挑战。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01070

Itsuki Hamamoto

{"title":"Developments and current challenges in the process of cell culture-based seasonal influenza vaccine manufacture in Japan.","authors":"Itsuki Hamamoto","doi":"10.35772/ghm.2023.01070","DOIUrl":"https://doi.org/10.35772/ghm.2023.01070","url":null,"abstract":"Seasonal influenza is an acute respiratory infection primarily caused by influenza A and B viruses, which circulate annually and cause substantial morbidity and mortality worldwide. Annual influenza vaccination is currently the most effective measure for preventing influenza and greatly reduces the risk of disease severity and the incidence of complications and death. Annual seasonal influenza vaccines are traditionally produced in Japan and many other countries using viruses propagated in embryonated chicken eggs. However, at present, the effectiveness of the seasonal influenza vaccines has some significant limitations, partly because of egg-adaptive mutations in the antigenic sites of the influenza virus haemagglutinin, which are caused by the continued evolution of seasonal influenza viruses. To overcome the limitations of egg-based influenza vaccine production, a mammalian cell culture-based influenza vaccine production system has been developed in Japan in the past decade as an alternative to the current production method. In this review, I have summarised the progress in the development of cell-based seasonal influenza vaccines and discussed the technological challenges encountered in the development of influenza vaccines.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"93-100"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of aids to relieve vulvodynia during the postpartum period. 开发缓解产后外阴炎的辅助工具。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01045

Kaori Watanabe, Yumiko Totsu

{"title":"Development of aids to relieve vulvodynia during the postpartum period.","authors":"Kaori Watanabe, Yumiko Totsu","doi":"10.35772/ghm.2023.01045","DOIUrl":"https://doi.org/10.35772/ghm.2023.01045","url":null,"abstract":"Postpartum women live with a low quality of life due to pain caused by episiotomy and perineal laceration. In particular, they endure pain when sitting for long periods of time to breastfeed. The purpose of this study is to develop a sitting aid to alleviate postpartum vulvodynia. This study was conducted in the following four phases from July 2017 to May 2019. They are: material selection and molding, cleaning and disinfection testing, pressure distribution measurement testing, and trial testing by postpartum women. The main material was a 100% polypropylene object with a three-dimensional reticular fiber spring structure and fiber density of 3.8 kg/m2. As a result, a sitting aid that withstands washing and disinfection well in the medical field and is breathable. It had moderate resilience and elasticity and reduced pressure on the seating surface for women weighing approximately 45 kg and 55 kg, but we were skeptical about its use for women weighing more than that. The completed sitting aid is noninvasively effective in improving the quality of life of many postpartum women, but the density and thickness of the main material should be reexamined to meet the needs of women in a wider weight range. In addition, a self-administered questionnaire survey of trial users revealed that some women did not experience relief from vulvodynia even after using the sitting aid. Such women also had physical problems such as discomfort in the lower back, difficulty breastfeeding, and difficulty standing up. For women with multiple physical problems, individual causes should be addressed.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"149-155"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of transmitted drug resistance and phylogenetic analysis of HIV-1 among antiretroviral therapy-naïve patients in Northern Vietnam from 2019 to 2022. 2019年至2022年越南北部抗逆转录病毒疗法无效患者的HIV-1传播耐药性流行率和系统发育分析。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01112

Giang Van Tran, Tsunefusa Hayashida, An Luong-Dieu Dang, Moeko Nagai, Shoko Matsumoto, Linh Khanh Tran, Hoa Nguyen-Minh Le, Trang Dinh Van, Junko Tanuma, Thach Ngoc Pham, Shinichi Oka

{"title":"Prevalence of transmitted drug resistance and phylogenetic analysis of HIV-1 among antiretroviral therapy-naïve patients in Northern Vietnam from 2019 to 2022.","authors":"Giang Van Tran, Tsunefusa Hayashida, An Luong-Dieu Dang, Moeko Nagai, Shoko Matsumoto, Linh Khanh Tran, Hoa Nguyen-Minh Le, Trang Dinh Van, Junko Tanuma, Thach Ngoc Pham, Shinichi Oka","doi":"10.35772/ghm.2023.01112","DOIUrl":"https://doi.org/10.35772/ghm.2023.01112","url":null,"abstract":"Since the rapid expansion of antiretroviral therapy (ART) for HIV, transmitted drug resistance (TDR) has become a major concern in Vietnam. HIV services there are transitioning to be covered by social insurance. Access to pre-exposure prophylaxis (PrEP) is being expanded to tackle the growing HIV epidemic among men who have sex with men. Therefore, a cross-sectional study was conducted at 10 ART facilities in Northern Vietnam from 9th December 2019 to 9th June 2022 to investigate the prevalence and pattern of TDR among ART-naïve people living with HIV (PLWH). TDR mutations were defined according to the World Health Organization 2009 List of Mutations for Surveillance of Transmitted Drug Resistant HIV Strains. Mutation transmission dynamics and TDR clusters were investigated via phylogenetic analysis. We enrolled 391 ART-naïve PLWH. The overall TDR prevalence was 4.6%, with an annual prevalence of 6.0% in 2019/2020, 4.8% in 2021, and 1.3% in 2022. TDR mutations to non-nucleoside reverse transcriptase inhibitors (2.8%), including K103N were the most common. Less commonly, the protease inhibitor-associated mutation M46I and mutations to nucleoside reverse transcriptase inhibitors, including M184V/ I, were observed. CRF01_AE was the most common subtype (77.0%). CRF07_BC (14.3%), which had been rare in Vietnam, was also observed. No genetic association was observed between HIV-1 sequences with TDR mutations. In conclusion, the overall prevalence of TDR was stably low in this region. The phylogenetic tree suggests that TDR clusters have not formed. Continuous monitoring of HIV TDR and strains is crucial to maintaining ART and PrEP efficacy.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"117-123"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, attitudes, practices and prevalence of hepatitis B and C and hepatitis B vaccination coverage among public sector healthcare workers in Cambodia. 柬埔寨公共部门医护人员对乙型肝炎和丙型肝炎的认识、态度、做法和流行率以及乙型肝炎疫苗接种覆盖率。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01097

Youlet By, Linh-Vi Le, Sovanthida Suy, Monidarin Chou, Po-Lin Chan, Kanika Heng, Socheata Phou, Chanthou Ny, Serongkea Deng, Chan Leakhena Phoeung, Sovatha Mam, Laurent Ferradini, François-Xavier Babin, Vonthanak Saphonn

{"title":"Knowledge, attitudes, practices and prevalence of hepatitis B and C and hepatitis B vaccination coverage among public sector healthcare workers in Cambodia.","authors":"Youlet By, Linh-Vi Le, Sovanthida Suy, Monidarin Chou, Po-Lin Chan, Kanika Heng, Socheata Phou, Chanthou Ny, Serongkea Deng, Chan Leakhena Phoeung, Sovatha Mam, Laurent Ferradini, François-Xavier Babin, Vonthanak Saphonn","doi":"10.35772/ghm.2023.01097","DOIUrl":"10.35772/ghm.2023.01097","url":null,"abstract":"Healthcare workers (HCWs) are a key population at high risk for hepatitis B (HBV) and hepatitis C (HCV) infections. We aim to study HBV vaccination coverage, seroprevalence, knowledge, attitudes, and practices towards HBV and HCV infections among HCWs in public sector in Cambodia. A nationally representative cross-sectional study was implemented in 2019, among Cambodian HCWs. A standardized questionnaire was administered to randomly selected HCWs whose blood was then sampled. We used univariate and multivariate regression to determine predictors of outcomes. Among 755 participants, we found 4.9% positive HBsAg and 2.3% positive anti-HCV Ab. HBV vaccination coverage was 59.3%. Lack of knowledge was found on the route of transmission, HBV vaccination, diagnosis and treatment of HBV and HCV. 67% of HCWs thought that all patients should be screened for HBV and HCV and about 30% of them would refuse to take care of infected patients. 58% of HCWs always recapped the needle after use. In univariate analysis, older age-group (> 50 years) is more likely to have positive anti-HCV (OR: 9.48; 95% CI: 2.36-38.18). HCWs who were younger, female or having higher education or having ever been tested, were more likely to have gotten HBV vaccinated. Multivariate analysis reconfirmed these predictors of getting vaccinated. Study findings indicated an urgent need of a national policy for Cambodian HCWs given the high prevalence of hepatitis among this group. Policy should include an effective in-service training program to improve knowledge and practices, a testing and vaccination program for HCWs and it should emphasize stigma intervention towards people living with HBV/HCV.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"108-116"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crisis management for the future: Building a platform to provide information on emerging and re-emerging infectious diseases from normal times in Japan. 面向未来的危机管理：建立一个平台，提供有关日本平时新出现和再次出现的传染病的信息。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01089

Eisuke Adachi, Amato Otani, Hiroshi Yotsuyanagi, Masayuki Saijo, Tomoya Saito

引用次数: 0

Prevalence, characteristics, and virologic correlations of hepatitis delta (D) among patients with hepatitis B surface antigen in Mongolia. 蒙古乙型肝炎表面抗原患者中三角肝炎 (D) 的流行率、特征和病毒学相关性。

IF 2.6

Global health & medicine Pub Date : 2024-04-30 DOI: 10.35772/ghm.2023.01080

Sarantuya Gidaagaya, Akinori Rokuhara, Masaya Sugiyama, Sumiya Dorj, Batnasan Barsuren, Bira Namdag, Batmunkh Munkhbat, Shinichi Oka, Masashi Mizokami

{"title":"Prevalence, characteristics, and virologic correlations of hepatitis delta (D) among patients with hepatitis B surface antigen in Mongolia.","authors":"Sarantuya Gidaagaya, Akinori Rokuhara, Masaya Sugiyama, Sumiya Dorj, Batnasan Barsuren, Bira Namdag, Batmunkh Munkhbat, Shinichi Oka, Masashi Mizokami","doi":"10.35772/ghm.2023.01080","DOIUrl":"https://doi.org/10.35772/ghm.2023.01080","url":null,"abstract":"Clinical and biochemical features of hepatitis delta virus (HDV) infections in Mongolia remain largely unknown. We aimed to investigate the clinical characteristics of HDV patients in Mongolia using several markers. The 143 hepatitis B surface antigen (HBsAg)-positive patients were divided into 122 HDV-positive and 21 HDV-negative patients by HDV RNA positivity. Subgroup analysis was performed between hepatitis B e antigen (HBeAg)-positive and -negative HDV-positive patients. Liver function, quantitative HBsAg (qHBsAg), anti-HDV Immunoglobulin (Ig) M, Mac-2 binding protein glycosylation isomer (M2BPGi), hepatitis B virus (HBV) DNA level, and HDV RNA level were tested. HDV RNA was positive in 85.3% (122/143) of patients showing anti-HDV IgG. Liver disease activity was higher in HDV-positive patients than in HDV-negative patients. The HDV-positive group included a higher proportion of patients with high qHBsAg and M2BPGi levels (p < 0.001). The positivity rate for anti-HDV IgM was significantly higher in the HDV-positive group (p < 0.001). HDV RNA levels showed an inverse correlation with qHBsAg levels in HBeAg-positive-HDV-positive patients (r = -0.49, p = 0.034), and a positive correlation with qHBsAg levels in HBeAg-negative patients (r = 0.35, p < 0.001). Hepatitis B virus (HBV) DNA and HDV RNA levels did not show any correlation. M2BPGi levels likewise did not correlate with HDV RNA levels. A high positivity rate for HDV RNA was observed for HBV patients in Mongolia using the highly sensitive HDV RNA assay. The positivity rate for anti-HDV IgM was high in HDV RNA-positive patients. Severity of liver disease and M2BPGi levels were both high in the HDV RNA-positive group.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 2","pages":"101-107"},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0