Global health & medicine最新文献_第5页

Prospective therapeutic studies of disseminated extranodal large B-cell lymphoma including intravascular large B-cell lymphoma. 播散性结节外大 B 细胞淋巴瘤（包括血管内大 B 细胞淋巴瘤）的前瞻性治疗研究。

IF 1.9

Global health & medicine Pub Date : 2024-08-31 DOI: 10.35772/ghm.2024.01021

Tomoyuki Sakai, Yusuke Ueda, Hiroto Yanagisawa, Kotaro Arita, Haruka Iwao, Kazunori Yamada, Shuichi Mizuta, Hiroshi Kawabata, Toshihiro Fukushima, Katsunori Tai, Shinji Kishi, Koji Morinaga, Jun Murakami, Hiroyuki Takamatsu, Yasushi Terasaki, Nobuyuki Yoshio, Yukio Kondo, Hirokazu Okumura, Sadaya Matano, Masaki Yamaguchi, Hiroshi Tsutani, Yasufumi Masaki

{"title":"Prospective therapeutic studies of disseminated extranodal large B-cell lymphoma including intravascular large B-cell lymphoma.","authors":"Tomoyuki Sakai, Yusuke Ueda, Hiroto Yanagisawa, Kotaro Arita, Haruka Iwao, Kazunori Yamada, Shuichi Mizuta, Hiroshi Kawabata, Toshihiro Fukushima, Katsunori Tai, Shinji Kishi, Koji Morinaga, Jun Murakami, Hiroyuki Takamatsu, Yasushi Terasaki, Nobuyuki Yoshio, Yukio Kondo, Hirokazu Okumura, Sadaya Matano, Masaki Yamaguchi, Hiroshi Tsutani, Yasufumi Masaki","doi":"10.35772/ghm.2024.01021","DOIUrl":"10.35772/ghm.2024.01021","url":null,"abstract":"This study aimed to establish a standard treatment for disseminated extranodal large B-cell lymphoma, including intravascular large B-cell lymphoma (DEN-LBCL/IVL), and to validate the clinical diagnostic criteria we proposed. Between 2006 and 2016, 22 patients were enrolled in a clinical trial conducted by the Hokuriku Hematology Oncology Study Group. The first cycle of chemotherapy consisted of dose-reduced cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) with delayed administration of rituximab. From the second to the sixth cycle, patients received conventional rituximab and CHOP therapy. The primary endpoint was overall survival (OS), while the secondary endpoints included the complete response (CR) rate and time to treatment failure (TTF). The results showed a CR rate of 73%, a median OS of 65 months, and a median TTF of 45 months. These findings indicate that patients with DEN-LBCL/IVL were effectively treated with our new chemoimmunotherapy regimen. Our clinical diagnostic criteria are useful for identifying patients who require early intervention.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 4","pages":"277-281"},"PeriodicalIF":1.9,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human papilloma virus (HPV)-related information acquisition and seeking behavior among infected women: A single center cross-sectional survey in Shanghai, China. 感染人乳头瘤病毒（HPV）的女性获取相关信息和寻求信息的行为：中国上海单中心横断面调查。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2023.01100

Xiehua Yuan, Linlin Lu, Ruhe Jiang, Yue Yu, Jing Zhou, Ling Wang, Yan Du

{"title":"Human papilloma virus (HPV)-related information acquisition and seeking behavior among infected women: A single center cross-sectional survey in Shanghai, China.","authors":"Xiehua Yuan, Linlin Lu, Ruhe Jiang, Yue Yu, Jing Zhou, Ling Wang, Yan Du","doi":"10.35772/ghm.2023.01100","DOIUrl":"10.35772/ghm.2023.01100","url":null,"abstract":"Lacking of adequate knowledge is an obstacle to effective prevention of cervical cancer, yet factors that affect the information acquisition and seeking behavior as well as the information communication process are not well studied. We assessed information acquisition and seeking behavior, as well as perceived barriers of doctor-patient communication regarding human papilloma virus (HPV)-related information of infected women. Among 437 participants, 405 (93%) expressed demands for HPV-related information, while only a small proportion (100/437, 22.9%) actively sought information and felt obstacles comprehending. Web-based channels were most frequently utilized and medical personnel were the most trusted information source. Patients' satisfaction was significantly correlated with doctor's patience (r = 0.581, p < 0.001) and emotional caring (r = 0.555, p < 0.001). Compared to patients not actively seeking information, those actively seeking information were more likely to be single (p = 0.005), had higher education (p = 0.009) and monthly individual-level income (p = 0.023), and was more likely to undergo regular cervical cancer screening (p = 0.003), and were already or willing to be vaccinated (p = 0.008). The actively seeking information group also achieved higher scores in HPV knowledge test (p = 0.007). Public health interventions targeting HPV-infected women using specifically designed educational materials may influence information seeking behavior, increase HPV literacy and knowledge, which could potentially increase HPV vaccine uptake and cervical cancer screening rate.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"212-217"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of liver resection in the era of advanced systemic therapy for hepatocellular carcinoma. 肝细胞癌晚期系统治疗时代的肝切除术作用。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2024.01002

Norihiro Kokudo, Takashi Kokudo, Peipei Song, Wei Tang

{"title":"Role of liver resection in the era of advanced systemic therapy for hepatocellular carcinoma.","authors":"Norihiro Kokudo, Takashi Kokudo, Peipei Song, Wei Tang","doi":"10.35772/ghm.2024.01002","DOIUrl":"10.35772/ghm.2024.01002","url":null,"abstract":"The recent dramatic progress in systemic therapy for hepatocellular carcinoma (HCC) provides the possibility of a combination of surgery and systemic therapy including adjuvant, neoadjuvant, or conversion settings. Since the turn of the century, at least three negative studies have tested adjuvant therapies after curative resection or ablation, including uracil-tegafur, which is an oral chemotherapeutic drug, sorafenib, and peretinoin, which a synthetic retinoid that may induce the apoptosis and differentiation of liver cancer cells. Using more potent immuno-checkpoint inhibitors (ICIs), at least 4 phase III trials of adjuvant immunotherapy are ongoing: nivolumab, durvalumab/ bevacizumab, pembrolizumab, and atezolizumab+bevacizumab. Very recently, the last trial indicated a significantly better recurrence-free survival (RFS) for adjuvant atezolizumab+bevacizumab. Another promising combination of surgery and systemic therapy is neoadjuvant therapy for potentially resectable cases or a conversion strategy for oncologically unresectable cases. There are 2 neoadjuvant trials for technically or oncologically unresectable HCCs ongoing in Japan: the LENS-HCC trial using lenvatinib and the RACB study using atezolizumab+bevacizumab. A longer follow-up may be needed, but the overall survival (OS) in resected cases seems much higher than that in unresectable cases. Recently, the Japan Liver Cancer Association (JLCA) and the Japanese Society of HPB Surgery (JSHPBS) created a joint working group on \"so-called borderline resectable HCC\". They obtained a Japanese consensus on this issue that has been published on the websites of JLCA and JSHPBS. The definition of resectability or borderline resectability provides a common language regarding advanced HCC for investigators and is a useful tool for future clinical trials.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"170-173"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Fertility-friendly hospitals": A key measure to promote long-term and balanced population development in China. "生育友好型医院"：促进中国人口长期均衡发展的关键举措。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2024.01027

Jingyi Ma, Fei Ma, Heng Zou

{"title":"\"Fertility-friendly hospitals\": A key measure to promote long-term and balanced population development in China.","authors":"Jingyi Ma, Fei Ma, Heng Zou","doi":"10.35772/ghm.2024.01027","DOIUrl":"10.35772/ghm.2024.01027","url":null,"abstract":"In response to the twin challenges of an aging population and declining birth rates, Zhejiang, China pioneered the concept of \"fertility-friendly hospitals\" in 2022 to support families and individuals in navigating the complexities of childbirth. Although fertility-friendly hospitals have not yet scaled up in number, their potential benefits and the challenges they face are evident. These facilities aim to provide comprehensive services from preconception to postnatal care, necessitating a high level of specialization and resource allocation, with an emphasis on patient education and participatory decision-making. Currently, there is an uneven distribution of resources across regions in China, with the density of maternal and child health care facilities in developed areas exceeding that of less developed regions by more than tenfold. The establishment of fertility-friendly hospitals will help to slow the pace of population aging and mitigate further declines in birth rates, thereby balancing the population composition and promoting long-term equitable social development. However, they also face challenges in balancing resources, improving the quality of services, and improving accessibility across different regions. As the concept is promoted and practiced, fertility-friendly hospitals are expected to become a significant force supporting Chinas population policy.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"218-221"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rescue of outflow block of the remnant left liver after extended right hemihepatectomy for resection of a tumor in the caudate lobe. 为切除尾状叶肿瘤而进行右半肝切除术后，残余左肝的流出道阻塞得以恢复。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2023.01105

Shohei Kawaguchi, Shiro Onozawa, Hirokazu Momose, Ryota Matsuki, Masaharu Kogure, Yutaka Suzuki, Yoshihiro Sakamoto

{"title":"Rescue of outflow block of the remnant left liver after extended right hemihepatectomy for resection of a tumor in the caudate lobe.","authors":"Shohei Kawaguchi, Shiro Onozawa, Hirokazu Momose, Ryota Matsuki, Masaharu Kogure, Yutaka Suzuki, Yoshihiro Sakamoto","doi":"10.35772/ghm.2023.01105","DOIUrl":"10.35772/ghm.2023.01105","url":null,"abstract":"Outflow block of the liver is a life-threatening event after living donor liver transplantation. Herein, we rescued a patient suffering from the outflow block of the remnant left hemiliver caused by bending of the left hepatic vein (LHV) after right hemihepatectomy plus caudate lobectomy combined with resection of the middle hepatic vein (MHV). A metastatic tumor sized 6 cm in the caudate lobe of the liver involving the root of the MHV was found in a 50's year old patient after resection of a right breast cancer eight years ago. Right hemihepatectomy and caudate lobectomy combined with resection of the MHV was performed using a two-stage hepatectomy (partial TIPE ALPPS). On day 1, the total bilirubin value increased to 4.5 mg/dL, and a dynamic computed tomography (CT) scan showed the bent LHV. On the diagnosis of outflow block of the left liver, a self-expandable metallic stent was placed in the LHV using an interventional approach, and the pressure in the LHV decreased from 27 cmH2O to 12 cmH2O. The bilirubin value decreased to 1.2 mg/dL on day 3. Outflow block of the LHV can happen after extended right hemihepatectomy with resection of the MHV. Early diagnosis and interventional stenting treatment can rescue the patient from congestive liver failure.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"222-224"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updated information concerning trends in suicide rates in elderly in China, 2002-2020. 2002-2020年中国老年人自杀率趋势的最新信息。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2024.01003

Sanmei Wen, Xinyue Wang, Rongfeng Zhou, Tetsuya Asakawa

{"title":"Updated information concerning trends in suicide rates in elderly in China, 2002-2020.","authors":"Sanmei Wen, Xinyue Wang, Rongfeng Zhou, Tetsuya Asakawa","doi":"10.35772/ghm.2024.01003","DOIUrl":"10.35772/ghm.2024.01003","url":null,"abstract":"The aim of this study was to investigate trends in suicide rates (SRs) among the elderly in China. Annual data on SRs among Chinese people ≥ the age of 65 were collected from China's Health Statistics Yearbook from 2002 to 2020. Then, data were stratified by age, region, and sex. Standardized SRs were calculated and analyzed using a conventional joinpoint regression model. Results revealed that overall, SRs among the elderly in China tended to decline from 2002-2020. Fluctuations in SRs, including in 2004-2005 due to the SARS epidemic, in 2009-2010 due to the economic crisis, and in 2019-2020 due to the COVID-19 pandemic, were also observed. Data suggested a relatively greater crude SR among the elderly (vs. young people), in males (vs. females), and in people living in a rural area (vs. those living in an urban area). SRs tended to rise with age. Joinpoint regression analysis identified joinpoints only for males ages 65-69 and over the age of 85 living in a rural area, suggesting that individuals in these groups are more sensitive to negative stimuli and more likely to commit suicide, necessitating closer attention. The findings from this study should help to make policy and devise measures against suicide in the future.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"204-211"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BACE1 inhibitor drugs for the treatment of Alzheimer's disease: Lessons learned, challenges to overcome, and future prospects^†. 治疗阿尔茨海默病的 BACE1 抑制剂药物：汲取的教训、克服的挑战和未来的前景†。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2024.01033

Arun K Ghosh

引用次数: 0

Comparison of oncological outcomes of upfront androgen receptor signaling inhibitors and combined androgen blockade in Japanese patients with metastatic castration-sensitive prostate cancer. 日本转移性阉割敏感性前列腺癌患者前期雄激素受体信号抑制剂与联合雄激素阻断治疗的肿瘤学疗效比较。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2024.01019

Michio Noda, Taketo Kawai, Kanade Hagiwara, Takahiro Yoshida, Kazuki Yanagida, Yuumi Tokura, Itsuki Yoshimura, Tomoyuki Kaneko, Tohru Nakagawa

{"title":"Comparison of oncological outcomes of upfront androgen receptor signaling inhibitors and combined androgen blockade in Japanese patients with metastatic castration-sensitive prostate cancer.","authors":"Michio Noda, Taketo Kawai, Kanade Hagiwara, Takahiro Yoshida, Kazuki Yanagida, Yuumi Tokura, Itsuki Yoshimura, Tomoyuki Kaneko, Tohru Nakagawa","doi":"10.35772/ghm.2024.01019","DOIUrl":"10.35772/ghm.2024.01019","url":null,"abstract":"In recent years, randomized controlled trials have demonstrated that upfront androgen receptor signaling inhibitors (ARSIs) prolong overall survival (OS) compared with androgen deprivation therapy (ADT) alone or combined androgen blockade (CAB) in patients with metastatic castration-sensitive prostate cancer (mCSPC). However, it remains unclear whether upfront ARSI is superior to CAB in Asian populations, among which the efficacy of ADT/CAB is considered relatively high. In this study, we compared the oncological outcomes of upfront ARSI and CAB in Japanese patients with mCSPC. Patients with mCSPC who underwent systemic therapy between May 2009 and October 2023 were enrolled retrospectively. Propensity score matching (PSM) was performed to compare the castration-resistant prostate cancer-free survival (CRPC-FS), cancer-specific survival (CSS), and OS between patients treated with upfront ARSI (ARSI group) and those treated with CAB (CAB group). In total, 30 and 142 patients were enrolled in the ARSI and CAB groups, respectively. After PSM (25 patients in each group), CRPC-FS was significantly longer in the ARSI group than in the CAB group (median: 36.7 vs. 12.3 months, hazard ratio: 0.44, 95% confidence interval: 0.20-0.97, p = 0.035). No significant differences were observed in CSS or OS between the two groups. In conclusion, when compared to CAB, upfront ARSI might have the potential to extend CRPC-FS among individuals in the Japanese population.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"199-203"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low preoperative hemoglobin A1c level is a predictor of perioperative infectious complications after esophagectomy: A retrospective, single-center study. 术前低血红蛋白 A1c 水平是食管切除术后围手术期感染并发症的预测因素：一项回顾性单中心研究。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2023.01113

Daiki Kato, Kazuhiko Yamada, Naoki Enomoto, Syusuke Yagi, Hanako Koda, Kyoko Nohara

{"title":"Low preoperative hemoglobin A1c level is a predictor of perioperative infectious complications after esophagectomy: A retrospective, single-center study.","authors":"Daiki Kato, Kazuhiko Yamada, Naoki Enomoto, Syusuke Yagi, Hanako Koda, Kyoko Nohara","doi":"10.35772/ghm.2023.01113","DOIUrl":"10.35772/ghm.2023.01113","url":null,"abstract":"This retrospective, single-center study aimed to evaluate the impact of blood glucose (BG) markers on perioperative complications after esophagectomy in a cohort of 176 patients. Study analyses included the correlation of daily maximum BG level and hemoglobin A1c (HbA1c) with clinicopathological factors. Maximum BG levels were significantly higher on postoperative day (POD) 0 than on PODs 2, 3, 5, and 7 (p < 0.05). Additionally, maximum BG levels on PODs 1, 2, and 7 were significantly higher in patients with preoperative HbA1c levels of ≥ 5.6% than in those with preoperative HbA1c levels of < 5.6% (p < 0.05 for all). The rates of any complications and infectious complications were higher in patients with preoperative HbA1c levels of < 5.6% than in those with preoperative HbA1c levels of ≥ 5.6% (p < 0.05 for both). A preoperative HbA1c level of < 5.6% was a significant predictor of infectious complications after esophagectomy by logistic regression analysis (p < 0.05). Maximum BG level after esophagectomy remained high in patients with high preoperative HbA1c levels, whereas a normal HbA1c level was an independent risk factor for infectious complications.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"190-198"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallbladder fossa nodularity in the liver as observed in alcoholic liver disease patients: Analysis based on hepatobiliary phase signal intensity on gadoxetate-enhanced MRI and extracellular volume fraction calculated from routine CT data. 酒精性肝病患者肝脏中的胆囊窝结节：根据钆喷酸增强核磁共振成像的肝胆相信号强度和常规 CT 数据计算的细胞外体积分数进行分析。

IF 1.9

Global health & medicine Pub Date : 2024-06-30 DOI: 10.35772/ghm.2023.01085

Keisuke Sato, Shinji Tanaka, Hiroshi Urakawa, Ryo Murayama, Eiko Hisatomi, Yukihisa Takayama, Kengo Yoshimitsu

{"title":"Gallbladder fossa nodularity in the liver as observed in alcoholic liver disease patients: Analysis based on hepatobiliary phase signal intensity on gadoxetate-enhanced MRI and extracellular volume fraction calculated from routine CT data.","authors":"Keisuke Sato, Shinji Tanaka, Hiroshi Urakawa, Ryo Murayama, Eiko Hisatomi, Yukihisa Takayama, Kengo Yoshimitsu","doi":"10.35772/ghm.2023.01085","DOIUrl":"10.35772/ghm.2023.01085","url":null,"abstract":"The purpose of this study is to further verify the concept utilizing signal intensity on hepatobiliary phase (HBP) of gadoxetate-enhanced MRI and extracellular volume fraction (ECV) calculated from CT data. Between Jan 2013 and September 2018, consecutive ALD patients who had both quadruple phase CT and gadoxetate-enhanced MRI within six months were retrospectively recruited. Those who had any intervention or disease involvement around gallbladder fossa were excluded. All images were reviewed and ECV was measured by two experienced radiologists. GBFN grades, and their HBP signal intensity or ECV relative to the surrounding background liver (BGL) were analyzed. There were 48 patients who met the inclusion criteria. There were GBFN grade 0/1/2/3 in 11/15/18/4 patients, respectively. The signal intensity on HBP relative to BGL were iso/slightly high/high in 30/15/3 patients, respectively, and ECV ratio (ECV of GBFN divided by that of BGL) was 0.88 ± 0.18, indicating there are more functioning hepatocytes and less fibrosis in GBFN than in BGL. The GBFN grades were significantly correlated to relative signal intensity at HBP (Spearman's rank correlation, p < 0.01, rho value 0.53), and ECV ratio (p < 0.01, rho value -0.45). Our results suggest GBFN in ALD would represent liver tissues with preserved liver function with less fibrosis, as compared to BGL, which are considered to support our hypothesis as shown above.","PeriodicalId":12556,"journal":{"name":"Global health & medicine","volume":"6 3","pages":"183-189"},"PeriodicalIF":1.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0