2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG)最新文献_第5页

Gastric cancer detection based on Colorectal Cancer transfer learning 基于结直肠癌迁移学习的胃癌检测

2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG) Pub Date : 2023-06-22 DOI: 10.1109/ENBENG58165.2023.10175323

Sara Nóbrega, Alexandre Neto, Miguel Coimbra, António Cunha

引用次数: 1

VitalSticker: A novel multimodal physiological wearable patch device for health monitoring VitalSticker:一种用于健康监测的新型多模态生理可穿戴贴片设备

2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG) Pub Date : 2023-06-22 DOI: 10.1109/ENBENG58165.2023.10175348

Francisco Manuel Pinto Vieira, Mafalda Alexandra Ferreira, D. Dias, J. P. Cunha

{"title":"VitalSticker: A novel multimodal physiological wearable patch device for health monitoring","authors":"Francisco Manuel Pinto Vieira, Mafalda Alexandra Ferreira, D. Dias, J. P. Cunha","doi":"10.1109/ENBENG58165.2023.10175348","DOIUrl":"https://doi.org/10.1109/ENBENG58165.2023.10175348","url":null,"abstract":"Wearable Health Devices (WHDs) are increasingly becoming an integral part of daily life and significantly contributing to self-monitoring in healthcare. WHDs have a wide range of applications, ranging from sports to clinical settings, where the monitoring of cardiovascular health, particularly through ECG, plays a crucial role. This study introduces a unique WHD called VitalSticker, which exhibits distinctive features such as having a comfortable tiny patch form-factor to be attached to the chest, collecting multiple vital signs with medical-grade quality (ECG, respiration, temperature and actigraphy) and seamlessly sending data to a companion app. This paper encompasses a detailed description of the hardware, firmware, and case design of the WHD. A study was conducted to assess the quality of the ECG signal acquired by VitalSticker, comparing it with the signal obtained from a CE medical-grade certified ambulatory device. The results demonstrate that our VitalSticker achieves similar medical-grade quality when compared to the reference device, surpassing its counterpart in several specifications. Furthermore, this study presents the successful implementation of an ECG baseline wander correction filter that runs on the tiny on-board wearable microcontroller without introducing any artifacts into the ECG signal, reducing the need for further processing for this outside the wearable patch.","PeriodicalId":125330,"journal":{"name":"2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG)","volume":"63 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132638982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sunglasses: calculation for corneal exposure and influx of UV through the pupil 太阳镜:计算角膜暴露和通过瞳孔进入的紫外线

2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG) Pub Date : 2023-06-22 DOI: 10.1109/ENBENG58165.2023.10175352

Mauro Masili, L. Ventura

{"title":"Sunglasses: calculation for corneal exposure and influx of UV through the pupil","authors":"Mauro Masili, L. Ventura","doi":"10.1109/ENBENG58165.2023.10175352","DOIUrl":"https://doi.org/10.1109/ENBENG58165.2023.10175352","url":null,"abstract":"UV protection is crucial for sunglasses, and the World Health Organization and the International Commission on Non-Ionizing Radiation Protection have set safe limits for UV radiation exposure. We conducted a study using the SMARTS2 model to calculate solar UV irradiance on a vertical surface simulating sunglasses. The radiant exposure on the eye's surface was calculated for the 280nm-400nm range, following ICNIRP recommendations. Results showed that the tested lens failed to meet the UV-A safe limit, even after the aging process. Incorporating ICNIRP safe limits into standards is necessary for better UV protection. While the importance of UV protection when wearing sunglasses is emphasized, there is a lack of quantification regarding pupil dilation. We estimated pupil diameter and calculated UV influx through the pupil, considering surrounding luminance. Pupil diameter ranged from 2mm to 7.8mm, adjusting to brightness changes. At midday, when the sun is less direct, the pupil is larger. Wearing and not wearing sunglasses exhibited opposite behaviors, highlighting the need to understand how light attenuation affects pupil diameter through transmittance spectra analysis.","PeriodicalId":125330,"journal":{"name":"2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133895656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new simple machine that converts torque into steady-state pressure in solids 一种新的简单机器，可以将扭矩转化为固体中的稳态压力

2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG) Pub Date : 2023-06-22 DOI: 10.1109/ENBENG58165.2023.10175336

C. Andreucci, Elza M. M. Fonseca, R. N. Jorge

{"title":"A new simple machine that converts torque into steady-state pressure in solids","authors":"C. Andreucci, Elza M. M. Fonseca, R. N. Jorge","doi":"10.1109/ENBENG58165.2023.10175336","DOIUrl":"https://doi.org/10.1109/ENBENG58165.2023.10175336","url":null,"abstract":"The proposed new mechanism, BKS, converts the movement of rotation into linear movement, torque into compression by increasing the density of the mass on which it acts decreasing its original volume under measured conditions. The chosen material for BKS must be more resistant than the material on which it will be applied, making it possible to drill it. To do this, it makes the collected mass smaller than the original by cutting and breaking its original structure, forming granular solids, moving them like fluids into the internal volume of the BKS due to the insertion torque applied, increasing the coefficient of friction between these materials. This is an innovative simple machine that can compact particles within its internal volume, making the material collected denser under mechanical pressure. Previous experimental studies from the authors have shown that the BKS modifies its original surface, incorporating inside its volume the same material on which's applied, standardizing inner volume measurement under given precise conditions. With the introduction of this new simple machine, the possibility to create and develop new mechanical and biomechanical devices is expanded by applying the mechanical advantage determined in this work.","PeriodicalId":125330,"journal":{"name":"2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130928247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Compressive loading affects endothelial cell migration: a numerical study 压缩载荷影响内皮细胞迁移:一项数值研究

2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG) Pub Date : 2023-06-22 DOI: 10.1109/ENBENG58165.2023.10175357

A. Guerra, J. Belinha, C. Salgado, Ferando Jorge Monteiro, R. N. Jorge

{"title":"Compressive loading affects endothelial cell migration: a numerical study","authors":"A. Guerra, J. Belinha, C. Salgado, Ferando Jorge Monteiro, R. N. Jorge","doi":"10.1109/ENBENG58165.2023.10175357","DOIUrl":"https://doi.org/10.1109/ENBENG58165.2023.10175357","url":null,"abstract":"This study aims to investigate the impact of compressive loading on endothelial cell migration pattern in angiogenesis using a meshless discretization technique, combined with a reaction-diffusion formulation. In silico models are highly valuable for understanding the dynamics of biological systems, and numerical models allow for testing different laboratory protocols and deducing which ones produce the best outcomes. In the proposed model, angiogenesis was simulated in response to a reaction-diffusion equation for vascular endothelial growth factor (VEGF) in a 5×5 mm2 square domain and using the Radial Point Interpolation Method (RPIM). The compressive loading was applied as a hydrostatic pressure of around 0.0067 MPa, in a specific zone in the domain to simulate the domain stress-strain interactions. The effect of compressive loading on angiogenesis sprouting patterns is analysed, and the results show that compression load affects the VEGF diffusion gradient and increases the VEGF concentration in the region where the compression was applied, causing the capillary to move away from the VEGF release region. Overall, this study sheds light on the role of mechanical stimuli in angiogenesis and provides a basis for further research in this area.","PeriodicalId":125330,"journal":{"name":"2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126522332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic device for controlled ocular drug delivery 用于眼部药物控制的微流控装置

2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG) Pub Date : 2023-06-22 DOI: 10.1109/ENBENG58165.2023.10175343

Carlos Carreira, E. Delgado, V. Silvério

{"title":"Microfluidic device for controlled ocular drug delivery","authors":"Carlos Carreira, E. Delgado, V. Silvério","doi":"10.1109/ENBENG58165.2023.10175343","DOIUrl":"https://doi.org/10.1109/ENBENG58165.2023.10175343","url":null,"abstract":"Proper drug concentration in the treatment of ocular disease is challenging. To alleviate this, we developed a 10 × 5 mm2 device for controlled delivery of drugs to the eye consisting of a 320 µm) hyaluronic acid (HA) laden hydrogel covered on one side by monolayer of graphene. The hydrogel composition contains HA due to its lubricating and wound healing properties, biocompatibility and safety. The HA was tested at 0.5, 1, and 2 percent w/v. Graphene was added to allow slow release of the active component and to act as an impermeable layer. As part of a proof-of-concept study, inserts were tested in vivo on a healthy dog after the owner provided written informed consent. They were inserted in the cul-de-sac of one eye with the graphene layer facing the outer eyelid and the hydrogel remaining in contact with the conjunctiva and lower cornea. The results show only a slight increase in clinical signs of conjunctivitis in the last two trials, while the patient did not experience any visible discomfort. In the first two trials, the insert remained in the cul-de-sac for almost 6 hours before being expelled, with the last trial lasting longer than 1 hour. The inserts were found to be well tolerated, but in terms of biofunctionality, further studies are needed to increase the residence time and to further optimise the shape and positioning of the device. The clinical use of the device is anticipated to have a positive impact on the lives of patients afflicted by dry eye disease.","PeriodicalId":125330,"journal":{"name":"2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG)","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133482017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New approach for rapid detection of bioactive compounds using MIR spectroscopy and machine learning algorithms 使用MIR光谱和机器学习算法快速检测生物活性化合物的新方法

2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG) Pub Date : 2023-06-22 DOI: 10.1109/ENBENG58165.2023.10175326

P. Sampaio, F. Duarte, C. Calado

{"title":"New approach for rapid detection of bioactive compounds using MIR spectroscopy and machine learning algorithms","authors":"P. Sampaio, F. Duarte, C. Calado","doi":"10.1109/ENBENG58165.2023.10175326","DOIUrl":"https://doi.org/10.1109/ENBENG58165.2023.10175326","url":null,"abstract":"Nowadays, microbial infections and resistance to antibiotic drugs are the biggest challenges, which threaten the health of societies. Due to several pharmacological activities associated with Cynara cardunculus, such as hepatoprotective, antioxidative, anticarcinogenic, hypocholesterolemic, antibacterial, anti-HIV, among others, extracts from seeds, leaves, and flowers were tested in Escherichia coli cells. The sensibility of the Mid-infrared (MIR) spectroscopy allowed to perform a detailed analysis of the antimicrobial action of extracts in terms of their biomolecular changes. A comparative model based on several commercial antibiotics such as metronidazole, kanamycin, clarithromycin, chloramphenicol, and ampicillin, was developed. The clustering analysis was performed using unsupervised algorithms such as Principal Component Analysis (PCA), and Kohonen Self-Organizing Maps (SOM). The extracts characterized with antioxidant activity were clustered with antibiotics and presented a promissory antimicrobial activity. According to this preliminary result, it is possible to use the MIR spectroscopy and machine learning algorithm to discover promissory bio compounds characterized by antimicrobial properties, allowing to develop a platform to discover new bioactive molecules, reducing time and costs.","PeriodicalId":125330,"journal":{"name":"2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114324460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Numerical Study of the Heat Distribution Generated by a Microheater in an Organ-on-a-Chip Chamber 芯片上器官腔室微加热器热分布的数值研究

2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG) Pub Date : 2023-06-22 DOI: 10.1109/ENBENG58165.2023.10175328

G. M. Ferreira, P. Sousa, V. Pinto, S. Catarino, P. Sousa, G. Minas

{"title":"A Numerical Study of the Heat Distribution Generated by a Microheater in an Organ-on-a-Chip Chamber","authors":"G. M. Ferreira, P. Sousa, V. Pinto, S. Catarino, P. Sousa, G. Minas","doi":"10.1109/ENBENG58165.2023.10175328","DOIUrl":"https://doi.org/10.1109/ENBENG58165.2023.10175328","url":null,"abstract":"In an organ-on-a-chip (OoC), temperature must be kept stable for a well-controlled and human representative microenvironment. This work presents the numerical simulation of a microheater to be integrated in a polydimethylsiloxane chamber that will comprise an OoC. Numerical simulations were performed to evaluate the heat distribution, considering the fluid flow and its direction, the microheater and substrate materials, and the thickness of the oxide layer (electric insulator), on top of the microheater. Silicon (Si) and glass for the substrate, and platinum (Pt) and aluminium (Al) for the microheater materials were evaluated. Results showed that the Si substrate assured better heat uniformity than glass, although reaching lower temperature values, for the same input power. For the microheater, although Al achieved better heat uniformity than Pt, it needed higher current to reach the same temperatures (ranging from 35-45°C). The oxide layer thickness did not affect the achieved temperature. The Si substrate/Pt microheater microsystem was able to heat the fluid chamber up to the 35-45°C range, with current consumption from 0.06 A to 0.1 A, respectively, showing good heat uniformity and low power consumption. Regarding the fluid flow, the domain temperature decreases as the flow rate increases, for the same actuation conditions. It was also analysed the effect of the flux direction and it was observed that, at 120 $mumathrm{L}/min$, it did not affect the heat distribution in the chamber.","PeriodicalId":125330,"journal":{"name":"2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121944388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessing Information Transfer and Modification in Plateau Waves of Intracranial Pressure 颅内压平台波的信息传递与修正评估

2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG) Pub Date : 2023-06-22 DOI: 10.1109/ENBENG58165.2023.10175369

Hélder Pinto, C. Dias, A. P. Rocha

{"title":"Assessing Information Transfer and Modification in Plateau Waves of Intracranial Pressure","authors":"Hélder Pinto, C. Dias, A. P. Rocha","doi":"10.1109/ENBENG58165.2023.10175369","DOIUrl":"https://doi.org/10.1109/ENBENG58165.2023.10175369","url":null,"abstract":"Plateau waves (PW) of Intracranial Pressure occur mostly in patients with Traumatic Brain Injury (TBI) and preserved cerebral autoregulation. This cerebral vascular phenomenon is associated with an intense systemic stress response that can be evidenced by Heart Rate Variability (HRV), as a mirror of the autonomic nervous system dysfunction. The Network Physiology framework allows the multivariate and simultaneous analysis of the information processed in multiple interacting dynamical systems. In this study, we used the multiscale representation of Transfer Entropy (TE) within the network of interactions among slow waves and respiratory waves of Mean Arterial Pressure (MAP) and Intracranial Pressure (ICP), with the RR intervals. The decomposition into redundant and synergistic contributions, is obtained using a Vector AutoRegressive Fractionally Integrated (VARFI) framework for Gaussian processes. This recent method allows to assess directed interactions and to quantify the information flow accounting for the coexistence of short-term dynamics and long-range correlations. The results indicate that PWs are an extremely critical phenomenon with high persistence where the information transfer from MAP to RR is reduced. Moreover, the prevalence of synergistic interactions between MAP and ICP is observed, specially in the range of slow waves. The used approach enhanced the description of HRV during PW and was able to highlight the dependence of the information transfer on the balance between short-term and long-range correlations in this complex stress situation.","PeriodicalId":125330,"journal":{"name":"2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG)","volume":"177 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131680343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Low Resource Skeleton Maturation Estimation System for Automatic Hand X-Ray Assessment in Pediatric Applications 一种用于小儿手部x线自动评估的低资源骨骼成熟度评估系统

2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG) Pub Date : 2023-06-22 DOI: 10.1109/ENBENG58165.2023.10175334

Ana Campos, Maria Silva, R. Azeredo, L. Coelho, Sara S. Reis, Sílvia Abreu

{"title":"A Low Resource Skeleton Maturation Estimation System for Automatic Hand X-Ray Assessment in Pediatric Applications","authors":"Ana Campos, Maria Silva, R. Azeredo, L. Coelho, Sara S. Reis, Sílvia Abreu","doi":"10.1109/ENBENG58165.2023.10175334","DOIUrl":"https://doi.org/10.1109/ENBENG58165.2023.10175334","url":null,"abstract":"The assessment of differences between skeletal age and chronological age in childhood is often based on the comparison of the patient's left hand x-ray with a reference atlas, performed by a experienced professional. This procedure involves a manual image analysis, that can be subject to inter rater variability posing several problems for clinical applications. In this paper a new methodology for skeleton maturation estimation based on automatic hand X-ray assessment for pediatric applications on a low resource devices (e.g. mobile device) is proposed. The pipeline covers hand-area estimation and bone-area estimation to achieve maturation scores which are then indexed with references images, separately for male and female. The proposed approach is based on simple image processing functions always bearing in mind the application on a mobile context. The involved steps are thoroughly presented and all the used functions are explained. The performance of the system was then evaluated using the complete pipeline. The obtained results pointed to an average error rate of 15,38±3,31%, which is subject to improvements. In particular, contrast enhancement in some lower quality images still offers some challenges.","PeriodicalId":125330,"journal":{"name":"2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129358992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0