{"title":"[Ten questions about infective endocarditis].","authors":"Federico Fortuni, Giuseppe Ciliberti, Nina Ajmone Marsan, Victoria Delgado, Luca Franchin, Michele Magnesa, Antonella Spinelli, Enrica Vitale, Stefano Cangemi, Stefano Cornara, Domenico Gabrielli, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva","doi":"10.1714/4336.43212","DOIUrl":"https://doi.org/10.1714/4336.43212","url":null,"abstract":"<p><p>Infective endocarditis (IE) is an infective process involving the endocardium and, more frequently, the native heart valves, valvular prostheses and cardiac implantable electronic devices. IE can manifest with various non-specific symptoms making the diagnosis challenging. This condition is associated with high in-hospital and long-term mortality. Therefore, it is particularly important to prevent it by implementing an adequate antibiotic prophylaxis especially in patients at high risk undergoing invasive procedures. Moreover, it is pivotal to promptly diagnose IE, detect the presence of local and systemic complications, establish appropriate antibiotic therapy and identify the indication and timing for surgical treatment. In this focused review, we will provide answers to the most common questions regarding the epidemiology, causes, prophylaxis, diagnosis and antibiotic and surgical treatment of IE.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"25 10","pages":"699-710"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Last thing on my mind: cardiac metastases].","authors":"Marco Giardino, Elisabetta Tonet","doi":"10.1714/4336.43222","DOIUrl":"https://doi.org/10.1714/4336.43222","url":null,"abstract":"","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"25 10","pages":"e"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Laura Canale, Alessandra Greco, Alessandro Inno, Andrea Tedeschi, Marzia De Biasio, Stefano Oliva, Irma Bisceglia, Nicola Maurea, Luigi Tarantini, Giuseppina Gallucci, Michele Massimo Gulizia, Fabio Maria Turazza, Fabiana Lucà, Stefania Angela Di Fusco, Carmine Riccio, Alessandro Navazio, Leonardo De Luca, Domenico Gabrielli, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva
{"title":"[Atherosclerosis, cancer and immune checkpoint inhibitors].","authors":"Maria Laura Canale, Alessandra Greco, Alessandro Inno, Andrea Tedeschi, Marzia De Biasio, Stefano Oliva, Irma Bisceglia, Nicola Maurea, Luigi Tarantini, Giuseppina Gallucci, Michele Massimo Gulizia, Fabio Maria Turazza, Fabiana Lucà, Stefania Angela Di Fusco, Carmine Riccio, Alessandro Navazio, Leonardo De Luca, Domenico Gabrielli, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva","doi":"10.1714/4336.43213","DOIUrl":"10.1714/4336.43213","url":null,"abstract":"<p><p>Immunotherapy has revolutionized the treatment of various cancers leading to a clear survival benefit with cured or long-surviving patients. Atherosclerosis and cancer share risk factors and molecular mechanisms and have as their common thread a state of chronic inflammation linked to a deregulation of the immune system. A growing body of evidence is accumulating on the potential worsening effect of immune checkpoint inhibitors on atherosclerosis, with subsequent worsening of patients' long-term cardiovascular risk. The molecular pathways implicated in the growth and deregulation of atherosclerotic plaques seem to be the same (CTLA-4, PD-1, PD-L1) as those on which the anti-tumor effect is exerted. Owing to the increasing number of cancer patients treated with immunotherapy and the improved survival with the possibility of prolonged disease control, it is necessary to know the potential increase in cardiovascular risk for atherosclerosis-related events and to establish all prevention measures to reduce it.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"25 10","pages":"711-719"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Hematologic malignancies and increased cardiovascular risk: a new issue to be considered for patient follow-up].","authors":"Vincenzo Toschi, Maddalena Lettino","doi":"10.1714/4336.43214","DOIUrl":"10.1714/4336.43214","url":null,"abstract":"<p><p>The last decade has seen a significant increase in the number of long survivors after a hematologic cancer, both children and adults, due to significant improvement in treatment. This exciting result, however, has been associated with an increase in the occurrence of previously unknown cardiovascular complications, including acute myocardial infarction, stroke, heart failure, deep vein thrombosis and pulmonary embolism. These adverse outcomes are due to both the hematologic cancer per se and to antineoplastic therapy. Cancer-dependent complications are caused by a shift of blood and endothelial cells to a prothrombotic and proinflammatory phenotype associated also with cancer-related somatic gene mutations. Antineoplastic therapy, instead, can lead to adverse outcomes due to an increase in oxidative stress resulting from the effects of reactive oxygen and nitrogen species which can induce alterations of mitochondria and other intracellular organelles. In addition, cardiovascular complications following a hematologic malignancy are also due to the interaction between cancer and traditional cardiovascular risk factors such as smoking, hypertension, obesity and diabetes. Clinicians should take all of these factors into account, and adapt their usual follow-up schemes accordingly in patients who have survived a hematologic cancer.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"25 10","pages":"720-727"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Secondary prevention in patients with transient ischemic attack or stroke due to carotid atherosclerosis].","authors":"Maurizio Paciaroni","doi":"10.1714/4336.43215","DOIUrl":"https://doi.org/10.1714/4336.43215","url":null,"abstract":"<p><p>For patients presenting with a cerebral episode of vascular origin whose pathogenetic mechanism is due to large vessel disease affecting the carotid arteries, different intervention strategies for secondary prophylaxis are available: medical (single or dual antiplatelet therapy), surgical or endovascular. In this review, these strategies will be described, along with suggestions for appropriate application in clinical practice. These suggestions may vary depending on whether early or long-term secondary prophylaxis is considered.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"25 10","pages":"728-734"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[ECG, pain, and the importance of details].","authors":"Giulio Falasconi, Massimo Slavich","doi":"10.1714/4336.43211","DOIUrl":"10.1714/4336.43211","url":null,"abstract":"","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"25 10","pages":"698"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Shortage of specialists in cardiology and interaction between hospitals: some considerations].","authors":"Andrea Rubboli","doi":"10.1714/4336.43220","DOIUrl":"10.1714/4336.43220","url":null,"abstract":"","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"25 10","pages":"763"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Primary cardiac angiosarcoma: an unexpected presentation].","authors":"Marco Martinelli, Georgette Khoury, Massimo Principi, Elettra Tinella, Fabio Loreti, Stefano Ascani, Camilla Cresta, Elisa Rossi","doi":"10.1714/4336.43218","DOIUrl":"10.1714/4336.43218","url":null,"abstract":"<p><p>Among cardiac tumors, angiosarcoma is the most common primary malignancy, with a relatively higher prevalence in young male adults and a weak dominance in the right atrium as a primary site of growth. It is characterized by rapid infiltration of cardiac structures and possible metastasis to mediastinal and distant organs. The patient may be asymptomatic until advanced phases. It therefore has a poor prognosis. Diagnosis requires the use of multimodality imaging, including echocardiography, computed tomography (CT), cardiac magnetic resonance and positron emission tomography. The definitive diagnosis is based on histological examination. We report the case of a young male adult who was referred to the cardiology department for a syncopal event 5 h after cocaine assumption. During the diagnostic work-up, a chest X-ray was performed, showing multiple pulmonary lesions, which were evaluated with a chest CT highlighting the presence of a cardiac mass in the right atrium and ventricle. For this reason, a complete cardiological evaluation was performed. The clinical and instrumental suspicion of a malignant cardiac tumor was confirmed by multimodality imaging and finally by histological examination.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"25 10","pages":"752-755"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Artificial intelligence and scientific publishing].","authors":"Giuseppe Di Pasquale","doi":"10.1714/4336.43210","DOIUrl":"10.1714/4336.43210","url":null,"abstract":"","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"25 10","pages":"695-697"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefania Paolillo, Maria Stella Graziani, Ciro Indolfi, Martina Zaninotto, Paolo Calabrò, Ferruccio Ceriotti, Francesco Barillà, Aldo Clerico, Marco Matteo Ciccone, Tommaso Trenti, Italo Porto, Marcello Ciaccio, Arturo Cesaro, Sara Fontanarosa, Mario Plebani, Pasquale Perrone Filardi
{"title":"[Hypercholesterolemia and laboratory reports: joint document from the Italian Society of Cardiology (SIC) and the Italian Society of Clinical Biochemistry and Clinical Molecular Biology - Lab Medicine (SIBioC)].","authors":"Stefania Paolillo, Maria Stella Graziani, Ciro Indolfi, Martina Zaninotto, Paolo Calabrò, Ferruccio Ceriotti, Francesco Barillà, Aldo Clerico, Marco Matteo Ciccone, Tommaso Trenti, Italo Porto, Marcello Ciaccio, Arturo Cesaro, Sara Fontanarosa, Mario Plebani, Pasquale Perrone Filardi","doi":"10.1714/4336.43219","DOIUrl":"10.1714/4336.43219","url":null,"abstract":"<p><p>Dyslipidemia is one of the most important risk factors for the development of atherosclerotic disease and its control, through well-proven therapies, allows an optimal risk management over time. LDL-cholesterol targets are well defined by international guidelines and based on individual cardiovascular risk. As guidelines evolve, also laboratory reports need to do the same, including lipid reference values by cardiovascular risk classes, to avoid misunderstandings and inappropriate lipid-lowering therapy withdrawal. The aim of the present joint document from the Italian Society of Cardiology (SIC) and the Italian Society of Clinical Biochemistry and Clinical Molecular Biology - Lab Medicine (SIBioC) is to analyze the importance of cardiovascular risk estimation, therapeutical targets, and crucial elements about dyslipidemia in laboratory tests, as well as to suggest a shared proposal for the report of lipid profile parameters to be applied to all clinical scenarios of our daily practice.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"25 10","pages":"756-762"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}