Giornale italiano di cardiologia最新文献

{"title":"Terapia intensiva cardiovascolare a cura di Andrea Farina e Stefano Savonitto.","authors":"Giuseppe Di Pasquale","doi":"10.1714/4687.47030","DOIUrl":"https://doi.org/10.1714/4687.47030","url":null,"abstract":"","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"27 5","pages":"380"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Fast-track model for the management of patients with non-ST-elevation acute coronary syndrome. Hub-Spoke experience in Umbria].","authors":"Andrea Santucci, Rocco Sclafani, Salvatore Notaristefano, Alessandro Aimi, Elisabetta Bordoni, Maurizio Del Pinto, Andrea Broccatelli, Claudia Castellani, Donatella Severini, Adriano Murrone, Euro Capponi, Paolo Verdecchia, Claudio Cavallini","doi":"10.1714/4687.47027","DOIUrl":"https://doi.org/10.1714/4687.47027","url":null,"abstract":"<p><strong>Background: </strong>Optimization of the management of patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) in terms of relationships between centers with and without cardiac catheterization facilities is still open to debate. We investigated the practical application of a fast-track model for the management of patients with NSTE-ACS in the Perugia Hub Hospital Area (Italy).</p><p><strong>Methods: </strong>The protocol involved invasive coronary angiography (ICA) at the Hub center after the patient had been transported safely by ambulance with a doctor and nurses from the Spoke center to the Hub center's catheterization laboratory, and then transferred back to the original facility at the end of the procedure in a similar manner. We defined an efficacy outcome (percentage of patients admitted to Spoke centers who, as described above, underwent ICA within 72 h after admission) and a safety outcome (major adverse events during the procedure, transport, and in the first 24 h after return to the Spoke center).</p><p><strong>Results: </strong>Overall, 1048 patients with NSTE-ACS between January 2020 and June 2025 were included in the study. Of these, 91% underwent ICA within the 72 h timeframe. A total of 644 patients (61.5%) underwent immediate percutaneous coronary intervention (PCI) at the Hub center, and 91 of these were retained at the Hub center due to the complexity of their clinical condition. Four serious adverse events occurred: one cardiovascular death due to cardiogenic shock, one severe femoral hematoma, and two acute stent thromboses occurring 5 and 6 h after the procedure, respectively, which required emergency referral for primary PCI.</p><p><strong>Conclusions: </strong>The above fast-track protocol proved feasible and associated with both logistical benefits and high patient safety. Rapid access to coronary revascularization and immediate return transport to the center of origin were guaranteed in this patient population.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"27 5","pages":"360-367"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147767325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cholesterol metabolism in patients with cancer: pathophysiology, therapeutic options, and future perspectives].","authors":"Irma Bisceglia, Lorenzo Tinti, Daniele Pastori, Maria Laura Canale, Vincenzo Quagliariello, Nicola Maurea, Stefano Oliva, Domenico Gabrielli, Furio Colivicchi, Massimiliano Camilli","doi":"10.1714/4687.47024","DOIUrl":"https://doi.org/10.1714/4687.47024","url":null,"abstract":"<p><p>Cholesterol is an essential component of cellular membranes and a precursor of biologically active molecules that are fundamental in maintaining organism homeostasis. Interest on the role of cholesterol and lipid-lowering agents in cancer patients has progressively grown, following the evidence that cholesterol metabolism is altered in tumor cells. Intracellular cholesterol levels clearly influence oncogenic signaling pathways, while lipid-lowering drugs offer cardioprotective effects for individuals undergoing potentially cardiotoxic therapies. In this review, we aimed at summarizing the evidences on lipid metabolism alterations in cancer cells, the effects of various antineoplastic drugs on lipid metabolism, and the potential role of lipid-lowering therapies in patients with cancer, with a particular focus on more recently introduced agents such as PCSK9 inhibitors and bempedoic acid.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"27 5","pages":"328-335"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Therapeutic inertia: physician, patient, and system-related factors and possible intervention strategies].","authors":"Marco Vatri, Elisabetta Angelino, Marco Ambrosetti, Andrea Faggiano, Pompilio Faggiano, Francesco Fattirolli","doi":"10.1714/4687.47022","DOIUrl":"https://doi.org/10.1714/4687.47022","url":null,"abstract":"<p><p>Therapeutic inertia is the result of a complex interaction between multiple factors. In the recent years, some authors suggested that the burden of responsibility for therapeutic inertia is shared, with 50% due to physician-related factors, 30% to patient-related factors, and the remaining 20% to healthcare system barriers. This view is misleading because it fails to capture the deep interconnection between the various elements and how they feed into each other in a vicious circle that influences therapeutic action. The physician's decision-making is influenced by cognitive biases, mental shortcuts, and contextual pressures that can lead to systematic errors. Within the different care settings, the patient is never a passive actor; their fears, perceptions and behaviors play a crucial role in factors that influence clinical reasoning and give rise to interactions in which avoiding conflict leads to a loss of therapeutic opportunities. At least four recurring clinical profiles can be identified, which can be defined as \"phenotypes of therapeutic inertia\": uninformed, hesitant, rigid, overwhelmed. Each phenotype is characterized by a different level of self-awareness and is supported by cognitive biases as well as specific relational difficulties with different types of patients. Identifying the phenotypes of inertia is only the first step: the crucial question for clinical practice is whether and how they can be modified. There are no single solutions: it is therefore a matter of developing an interpretative grid to recognize recurring patterns of inertia in clinical practice and identify the most effective corrective strategies.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"27 5","pages":"318-323"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Sudden cardiac death risk after newly diagnosed cardiomyopathy: insights from the SCD-PROTECT study and implications for clinical practice].","authors":"Andrea Matteucci, Stefania Angela Di Fusco, Alessandro Alonzo, Antonella Spinelli, Gaetano Marino, Silvio Fedele, Federico Nardi, Furio Colivicchi","doi":"10.1714/4687.47020","DOIUrl":"https://doi.org/10.1714/4687.47020","url":null,"abstract":"","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"27 5","pages":"313-316"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[ANMCO-SICPED consensus document on cardio-oncological transition in childhood cancer survivors].","authors":"Elena Bennati, Maria Laura Canale, Alice Pozza, Stefano Oliva, Andrea Tedeschi, Alessandra Greco, Gabriele Egidy Assenza, Anna Balducci, Maria Elena Derchi, Rachele Adorisio, Marcello Chinali, Massimo Chessa, Domenico Gabrielli, Silvia Favilli, Furio Colivicchi, Federico Nardi, Massimo Grimaldi, Fabrizio Oliva, Gabriele Rinelli","doi":"10.1714/4687.47029","DOIUrl":"https://doi.org/10.1714/4687.47029","url":null,"abstract":"<p><p>New cancer treatments led to a clear survival gain in childhood cancer patients in recent decades, but cardiovascular disease among long-term survivors represents the leading non-cancer cause of morbidity and mortality. The population of childhood, adolescent, and young adult (CAYA) cancer survivors is growing fast and is characterized by an increased cardiovascular risk, therefore requiring long-term cardiovascular surveillance for early diagnosis and timely treatment of cardiotoxicity. To increase follow-up adherence and implement preventive strategies, it is essential to ensure the transition process from pediatric to adult care. This document is the result of the collaboration between ANMCO and SICPED to ensure long-term care for CAYA cancer survivors and to guide clinicians in the transition phase.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"27 5","pages":"372-379"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The ANMCO and Heart Care Foundation commitment to primary cardiovascular prevention].","authors":"Stefania Angela Di Fusco, Daniela Aschieri, Ilaria Battistoni, Claudio Bilato, Giovanna Geraci, Vered Gil Ad, Attilio Iacovoni, Fabiana Lucà, Barbara Mabritto, Massimo Milli, Pietro Scicchitano, Francesco Vigorito, Roberto Ceravolo, Michele Massimo Gulizia, Furio Colivicchi, Domenico Gabrielli, Fabrizio Oliva, Federico Nardi, Massimo Grimaldi","doi":"10.1714/4696.47085","DOIUrl":"https://doi.org/10.1714/4696.47085","url":null,"abstract":"<p><p>Primary cardiovascular prevention was one of the main topics discussed during the 2025 ANMCO General States. The focus on this theme is due to the evidence that, although in high-income countries cardiovascular mortality has declined over the decades, the downward trend has slowed in the last years. Cardiovascular disease remains a leading cause of death worldwide, and a substantial proportion of cardiovascular events, including deaths, occurs in individuals with no previous history of disease. In this paper, the initiatives that ANMCO implements with the Heart Care Foundation to spread the culture of primary prevention are presented: from days dedicated to cardiovascular disease screening to training campaigns in schools and information and awareness campaigns through various digital tools (web pages, social media). Another aspect that ANMCO focuses on to foster cardiovascular prevention is the implementation of the One Health approach promoted by the World Health Organization. A healthy diet like the Mediterranean diet represents not only a lifestyle that promotes cardiovascular prevention but also an approach to health that respects and protects the environment. In addition, there are the \"silent killers\", environmental factors such as air pollution, noise and light pollution, and chemical pollution of land and water, all emerging risk factors that should be considered as targets of a One Health approach.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"27 5 Suppl. 1","pages":"e19-e25"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Integrated multidisciplinary management of heart failure patients with implantable devices].","authors":"Sara Doimo, Matteo Casula, Alberto D'Alleva, Simone Cappannelli, Filippo Angelini, Veronica Dusi, Sebastiano Lumera, Fabrizio Luigi Pizzetti, Mauro Gori, Marco Marini, Raul Limonta, Denitza Tinti, Samuela Carigi, Claudio Bilato, Carlo Pignalberi, Furio Colivicchi, Federico Nardi, Massimo Grimaldi, Fabrizio Oliva, Raimondo Calvanese","doi":"10.1714/4687.47025","DOIUrl":"https://doi.org/10.1714/4687.47025","url":null,"abstract":"<p><p>The growing number of heart failure patients with cardiac implantable electronic devices (CIEDs) requires a systematic integration of telemonitoring data into a multidisciplinary care pathway. This review critically appraises the emerging evidence on the latest predictive algorithms embedded in CIEDs and delineates the pivotal roles of nurses/technicians remote-monitoring specialists and case managers as the operational interface between the patient and the clinical team. This review also proposes an organizational model that integrates the pacemaker/device clinic with the heart failure clinic, aiming to detect the subclinical phase of the disease, improve quality of life, reduce hospitalizations, and optimize healthcare system costs.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"27 5","pages":"336-347"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Sudden cardiac death in Italy: prevention and intervention strategies].","authors":"Fabiana Lucà, Daniela Aschieri, Ilaria Battistoni, Claudio Bilato, Stefania Angela Di Fusco, Giovanna Geraci, Vered Gil Ad, Attilio Iacovoni, Barbara Mabritto, Massimo Milli, Pietro Scicchitano, Francesco Vigorito, Michele Massimo Gulizia, Furio Colivicchi, Domenico Gabrielli, Fabrizio Oliva, Federico Nardi, Massimo Grimaldi","doi":"10.1714/4696.47086","DOIUrl":"https://doi.org/10.1714/4696.47086","url":null,"abstract":"<p><p>Sudden cardiac death remains a major clinical and social challenge. The number of cases still remains higher in Italy, both involving patients suffering from overt heart disease and those otherwise healthy. The heterogeneous mechanisms leading to cardiac arrest call for a comprehensive preventive strategy plan that combines clinical assessment, advanced diagnostic tools, and public health initiatives. The need for counteracting a transient period of elevated risk - as in post-infarction - forces to the use of a wearable cardioverter-defibrillator as it provides temporary protection while awaiting definitive reassessment. On the contrary, when cardiac arrest affects young and apparently healthy individuals, preventive efforts necessarily extend to their families to identify inherited conditions that would otherwise remain unrecognized. In the out-of-hospital setting, survival largely depends on the actions taken within the first few minutes. Therefore accessible defibrillators, widespread community training, and the active involvement of law enforcement agencies and schools can significantly enhance the response to out-of-hospital cardiac arrest. This paper ultimately outlines a roadmap that integrates clinical risk stratification, the expansion of territorial networks, broad training initiatives, and consistent institutional coordination. The goal is to establish a coherent national framework that can reduce regional disparities, enhance the early identification of at-risk individuals, and improve survival rates after cardiac arrest.</p>","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"27 5 Suppl. 1","pages":"e26-e33"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Implementing artificial intelligence in cardiology: how the paradigm should evolve to really widely impact on routine clinical practice?]","authors":"Gian Luigi Nicolosi","doi":"10.1714/4687.47023","DOIUrl":"https://doi.org/10.1714/4687.47023","url":null,"abstract":"","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"27 5","pages":"324-327"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}