Giornale italiano di cardiologia最新文献_第2页

[Win ratio, win decision and win placebo]. [胜率，决定和安慰剂]。

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Giornale italiano di cardiologia Pub Date : 2025-10-01 DOI: 10.1714/4570.45747

Franco Cosmi

引用次数: 0

[ANMCO Position paper: ANMCO States General 2024 - Continuing to improve outcomes for patients with acute heart disease]. [ANMCO立场文件：ANMCO国家一般2024 -继续改善急性心脏病患者的预后]。

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Giornale italiano di cardiologia Pub Date : 2025-10-01 DOI: 10.1714/4570.45743

Gianni Casella, Emanuele Tizzani, Giuseppe Musumeci, Serafina Valente, Claudio Bilato, Marco Corda, Leonardo De Luca, Massimo Di Marco, Giovanna Geraci, Attilio Iacovoni, Massimo Milli, Alessandro Navazio, Vittorio Pascale, Carmine Riccio, Pietro Scicchitano, Federico Nardi, Domenico Gabrielli, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva

{"title":"[ANMCO Position paper: ANMCO States General 2024 - Continuing to improve outcomes for patients with acute heart disease].","authors":"Gianni Casella, Emanuele Tizzani, Giuseppe Musumeci, Serafina Valente, Claudio Bilato, Marco Corda, Leonardo De Luca, Massimo Di Marco, Giovanna Geraci, Attilio Iacovoni, Massimo Milli, Alessandro Navazio, Vittorio Pascale, Carmine Riccio, Pietro Scicchitano, Federico Nardi, Domenico Gabrielli, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva","doi":"10.1714/4570.45743","DOIUrl":"https://doi.org/10.1714/4570.45743","url":null,"abstract":"In recent years, there has been a constant reduction in mortality and morbidity in numerous cardiovascular diseases. The advent of hospital networks has allowed for a reduction in the timing of reperfusion treatment in patients with acute coronary syndromes (ACS). However, to date, only the network for ST-elevation myocardial infarction, according to the latest Cardiological Census, is widely spread in Italy. Instead, there are several other acute heart diseases for which there is no equally widespread network, and there is still great heterogeneity among regions. The data from the National Outcome Plan of AGENAS confirms these gaps, particularly for non-ST-elevation ACS and for cardiogenic shock. This observation is further complemented by the profound transformation that the intensive cardiac care units (ICCUs) have undergone in recent years. Today's ICCUs are no longer just places for treating ACS, but should also care for and monitor other acute heart diseases, in particular heart failure, cardiogenic shock, intermediate-to-high-risk pulmonary embolism, and multiple cardiac complication of non-cardiac organ damage as well. This evolution requires significant developments in clinical skills, technological resources, and healthcare organization. The purpose of this work is therefore to describe this clinical and organizational evolution and identify the necessary pathways, interactions with the territory and system indicators to implement them with the aim to improve the prognosis of patients with acute heart diseases as well.","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"26 10","pages":"776-779"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Efficacy and safety of bempedoic acid in the prevention of cardiovascular events: results of the CLEAR Outcomes study and subgroup analyses]. 【苯戊酸预防心血管事件的有效性和安全性：CLEAR Outcomes研究和亚组分析的结果】。

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Giornale italiano di cardiologia Pub Date : 2025-10-01 DOI: 10.1714/4570.45739

Furio Colivicchi, Marcello Arca, Stefania Angela Di Fusco, Angela Pirillo, Alessandro Alonzo, Federico Nardi, Alberico Luigi Catapano

{"title":"[Efficacy and safety of bempedoic acid in the prevention of cardiovascular events: results of the CLEAR Outcomes study and subgroup analyses].","authors":"Furio Colivicchi, Marcello Arca, Stefania Angela Di Fusco, Angela Pirillo, Alessandro Alonzo, Federico Nardi, Alberico Luigi Catapano","doi":"10.1714/4570.45739","DOIUrl":"https://doi.org/10.1714/4570.45739","url":null,"abstract":"Bempedoic acid is a lipid-lowering drug recently introduced into clinical practice. The CLEAR Outcomes randomized controlled clinical trial has confirmed the efficacy of bempedoic acid in reducing low-density lipoprotein cholesterol (LDL-C) levels and has shown that this reduction translates into a significant decrease in major adverse cardiovascular events (MACE). The clinical benefits were consistent with the benefits obtained with other lipid-lowering drugs that have the same efficacy in reducing LDL-C levels. Furthermore, the CLEAR Outcomes trial confirmed the safety of bempedoic acid. This study reported the same frequency of adverse events as observed in previous phase 3 trials. Pre-specified and post-hoc analyses of the CLEAR Outcomes trial showed that treatment with bempedoic acid confers a clinical benefit both in primary prevention and in patients with recurrent events, independent of gender and comorbidities such as diabetes, obesity and metabolic syndrome, and confirmed a potential additive benefit due to the favorable effects on the glycemic profile and high-sensitivity C-reactive protein. In patients with peripheral artery disease, bempedoic acid reduces both MACE and major adverse limb events. Based on the available evidence, the European Medicines Agency has updated the summary of product characteristics to include cardiovascular disease as a therapeutic indication in addition to hypercholesterolemia. Bempedoic acid is now approved in adults with established atherosclerotic cardiovascular disease or at high risk of a first cardiovascular event, to reduce cardiovascular risk by lowering LDL-C levels, in patients treated with the maximum tolerated statin dose (with or without ezetimibe), or in statin-intolerant patients who are not adequately controlled with ezetimibe alone.","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"26 10","pages":"747-756"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Flu vaccination in cardiovascular prevention: a low-cost therapy to be implemented]. [预防心血管疾病的流感疫苗：一种即将实施的低成本疗法]。

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Giornale italiano di cardiologia Pub Date : 2025-10-01 DOI: 10.1714/4570.45732

Giuseppe Di Pasquale

引用次数: 0

[Reply to "Heart failure with preserved systolic function: reflections from a provincial cardiologist"]. [回复“保留收缩功能的心力衰竭：一位省级心脏病专家的思考”]。

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Giornale italiano di cardiologia Pub Date : 2025-10-01 DOI: 10.1714/4570.45746

Attilio Iacovoni, Alessandro Navazio

引用次数: 0

[Heart failure with preserved systolic function: reflections from a provincial cardiologist]. [保留收缩功能的心力衰竭：一位省级心脏病专家的反思]。

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Giornale italiano di cardiologia Pub Date : 2025-10-01 DOI: 10.1714/4570.45745

Alberto Genovesi Ebert, Elio Venturini

引用次数: 0

[Multiple spontaneous coronary artery dissections: a multidisciplinary challenge in diagnosis and treatment]. 多发自发性冠状动脉夹层：诊断和治疗的多学科挑战。

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Giornale italiano di cardiologia Pub Date : 2025-10-01 DOI: 10.1714/4570.45742

Gianluca Pagnoni, Arianna Maini, Irma Marconi, Daniela Aschieri, Fabio Alfredo Sgura, Giuseppe Boriani, Francesca Coppi

{"title":"[Multiple spontaneous coronary artery dissections: a multidisciplinary challenge in diagnosis and treatment].","authors":"Gianluca Pagnoni, Arianna Maini, Irma Marconi, Daniela Aschieri, Fabio Alfredo Sgura, Giuseppe Boriani, Francesca Coppi","doi":"10.1714/4570.45742","DOIUrl":"https://doi.org/10.1714/4570.45742","url":null,"abstract":"Spontaneous coronary artery dissection (SCAD) is a rare but increasingly recognized cause of acute coronary syndrome, primarily affecting young women without traditional cardiovascular risk factors. We report the case of a 57-year-old woman with obesity and a history of smoking, admitted for acute respiratory failure due to pneumonia, complicated by cardiac arrest. Elevated troponin levels, along with subsequent ECG and echocardiographic findings suggestive of previous myocardial ischemia, led to the indication for coronary angiography. The angiogram revealed severe three-vessel coronary disease with three distinct SCADs involving the left anterior descending, right coronary, and circumflex arteries. Advanced imaging, including whole-body positron emission tomography, revealed active systemic vasculitis. A multidisciplinary approach led to initiation of immunosuppressive therapy with corticosteroids and tocilizumab, alongside conservative cardiac management with dual antiplatelet therapy. At 1-year follow-up, the patient showed significant improvement in left ventricular function and normalization of inflammatory markers. This case highlights the diagnostic and therapeutic complexity of multiple SCADs, particularly in the context of underlying systemic inflammatory diseases, and underscores the importance of individualized treatment strategies and multidisciplinary collaboration.","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"26 10","pages":"772-775"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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[The top ten novelties of the ESC guidelines for the management of myocarditis and pericarditis]. 【ESC心肌炎和心包炎治疗指南的十大创新】。

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Giornale italiano di cardiologia Pub Date : 2025-10-01 DOI: 10.1714/4570.45733

Massimo Imazio, Attilio Iacovoni

引用次数: 0

[State of the art and projects of the Italian Fabry Disease Cardiovascular Registry]. [意大利法布里病心血管登记处的技术现状和项目]。

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Giornale italiano di cardiologia Pub Date : 2025-09-01 DOI: 10.1714/4542.45431

Elena Biagini, Giuseppe Limongelli, Vanda Parisi, Francesco Cappelli, Francesca Graziani, Emanuele Monda, Iacopo Olivotto, Maurizio Pieroni, Marta Rubino, Raffaello Ditaranto, Serena Serratore, Maria Alessandra Schiavo, Gianfranco Sinagra, Ciro Indolfi, Pasquale Perrone Filardi

引用次数: 0

[When rarity duplicates: myocardial non-compaction and single coronary artery, an association not to be underestimated]. [当罕见重复时：心肌不压实和单一冠状动脉，一个不可低估的关联]。

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Giornale italiano di cardiologia Pub Date : 2025-09-01 DOI: 10.1714/4542.45434

Gianluca Pagnoni, Marco Loffi, Sean Rastelli, Anna Bartone, Malina Sintuzzi, Francesco Di Spigno, Alberto Monello, Daniela Aschieri

{"title":"[When rarity duplicates: myocardial non-compaction and single coronary artery, an association not to be underestimated].","authors":"Gianluca Pagnoni, Marco Loffi, Sean Rastelli, Anna Bartone, Malina Sintuzzi, Francesco Di Spigno, Alberto Monello, Daniela Aschieri","doi":"10.1714/4542.45434","DOIUrl":"https://doi.org/10.1714/4542.45434","url":null,"abstract":"Noncompaction myocardium (NCM) is a rare cardiac condition characterized by prominent trabeculation, associated with an increased risk of heart failure, arrhythmias, and embolism. We report the case of a 46-year-old man, smoker, with a family history of sudden cardiac death, who presented to the emergency department with progressive dyspnea. Echocardiography revealed dilated cardiomyopathy with severe biventricular dysfunction and marked apical trabeculation of the left ventricle. Coronary angiography showed a single coronary artery with anomalous origin of the right coronary artery from the mid-segment of the left anterior descending artery, without significant stenosis. Cardiac magnetic resonance imaging confirmed the NCM phenotype with a noncompacted-to-compacted myocardial ratio of 2.4. The simultaneous presence of NCM and single coronary artery is extremely rare in the literature. This phenotypic combination may suggest a common genetic predisposition and warrants targeted diagnostic investigations for optimal cardiovascular risk management.","PeriodicalId":12510,"journal":{"name":"Giornale italiano di cardiologia","volume":"26 9","pages":"698-700"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0