Gene最新文献

{"title":"Combined genomic profiling by exome sequencing analysis and optical genome mapping reveals bi-allelic somatic inactivation of SMAD4 in pediatric colon adenocarcinoma","authors":"Mari C. Morán-Espinosa , Aldo Zaragoza-Fernández , Karem Yohaly Pérez-López , Cristian Jesús Huchim-Peña , Pedro Velarde-Hernández , María Argelia Escobar-Sánchez , Rodrigo Moreno-Salgado , Rocío Sánchez-Urbina , Hector Diaz-Garcia , Guillermo Aquino Jarquin , Javier T. Granados-Riverón","doi":"10.1016/j.gene.2025.149891","DOIUrl":"10.1016/j.gene.2025.149891","url":null,"abstract":"","PeriodicalId":12499,"journal":{"name":"Gene","volume":"978 ","pages":"Article 149891"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145523202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Omics discovery and clinical validation of IGFBP2, B2M, and CST3 as a serum biomarker panel for diabetic kidney disease progression","authors":"Jianbo Wu ,&nbsp;Tong Yin ,&nbsp;Zhiguo Zhang ,&nbsp;Ruili Yin ,&nbsp;Elsayed Metwally ,&nbsp;Kun Li ,&nbsp;Yongsong Xu ,&nbsp;Hongling Zhao ,&nbsp;Shuwen Zheng ,&nbsp;Lingling Wei ,&nbsp;Lijie Zhang ,&nbsp;Yan Wang ,&nbsp;Longyan Yang","doi":"10.1016/j.gene.2025.149858","DOIUrl":"10.1016/j.gene.2025.149858","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic kidney disease (DKD) is a major microvascular complication of diabetes. Current diagnostic markers (e.g., UACR, eGFR) exhibit limitations in sensitivity and specificity, underscoring the need for novel approaches.</div></div><div><h3>Methods</h3><div>We integrated single-cell RNA sequencing (scRNA-seq) of kidney tissues from 30 individuals (18 healthy, 12 DKD) with serum proteomics data. Cellular heterogeneity and dysregulated pathways were analyzed using Seurat and pathway enrichment analyses. Intercellular communication networks were deciphered via tensor-cell2cell. A LASSO model identified hub genes, followed by robust validation across independent bulk RNA-seq cohorts (Nephrectomy and Nephroseq). Integration with proteomics prioritized three candidate biomarkers—IGFBP2, B2M, and CST3— which were further assessed in murine DKD models (STZ/HFD-induced) and clinical serum samples (n = 139). Drug-target interactions were predicted using ChEMBL and validated by molecular docking.</div></div><div><h3>Results</h3><div>(1) scRNA-seq revealed aberrant activation of immune pathways and enhanced tubule cell repair in DKD. (2) Cell-cell communication analysis identified 43 hub genes, with 8 genes showing consistent upregulation in glomerular and tubular compartments. (3) Integration of proteomics and transcriptomics pinpointed three serum biomarkers-IGFBP2, B2M, CST3. (4) Longitudinal validation in STZ-induced murine models (n = 16) and human clinical samples (n = 139) confirmed progressive, stage-dependent elevation of all three biomarkers, with late-stage DKD showing the most pronounced elevation versus controls (p &lt; 0.001). (5) Molecular docking predicted high-affinity binding of pramlintide acetate to CST3/IGFBP2 and rivipansel to B2M.</div></div><div><h3>Conclusion</h3><div>Through a multi-omics approach, we identified IGFBP2/B2M/CST3 as a non-invasive biomarker panel for DKD progression, highlighting their roles as both diagnostic markers and therapeutic targets.</div></div>","PeriodicalId":12499,"journal":{"name":"Gene","volume":"978 ","pages":"Article 149858"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pugionium cornutum PcHARBI1-5 (Harbinger Transposase Derived 1–5) facilitates early flowing and seed development in in Arabidopsis thaliana","authors":"Yunwei Zhao,&nbsp;Kaifan Shang,&nbsp;Ping Wang","doi":"10.1016/j.gene.2025.149914","DOIUrl":"10.1016/j.gene.2025.149914","url":null,"abstract":"<div><div><em>Pugionium cornutum</em> is a biennial herb belonging to the Brassicaceae family and is an endemic species of the Mongolian Plateau, exhibiting strong stress tolerance and notable medicinal value. In this study, the <em>PcHARBI1-5</em> gene was cloned from <em>P. cornutum</em> and functionally characterized through heterologous transformation in <em>Arabidopsis thaliana</em>. Transgenic overexpression lines (OE) and homologous knockout mutants (KO-1) were generated, and their phenotypic differences were systematically evaluated under controlled conditions. Overexpression of <em>PcHARBI1-5</em> significantly promoted early flowering in <em>Arabidopsis</em>, with transgenic plants flowering approximately four days earlier than wild-type controls, whereas the KO-1 mutant exhibited a delay of about three days. Furthermore, transgenic lines displayed enhanced agronomic performance, including longer roots, increased plant height, greater lateral branching, elongated siliques, and higher seed yield per plant. Gene expression analysis revealed that <em>PcHARBI1-5</em> modulates flowering time by down-regulating the floral repressor <em>FLC</em> and up-regulating key floral integrators <em>FT</em> and <em>SOC1</em>. Taken together, this study reports the successful cloning and functional validation of <em>PcHARBI1-5</em> from <em>P. cornutum</em>, demonstrating its pivotal role in accelerating flowering and improving multiple agronomic traits. These findings highlight <em>PcHARBI1-5</em> as a promising candidate gene for molecular breeding strategies aimed at developing early-maturing and high-yielding crop varieties.</div></div>","PeriodicalId":12499,"journal":{"name":"Gene","volume":"978 ","pages":"Article 149914"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145577704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De novo PKD1 splicing and missense variants in two familial ADPKD: Molecular characterization and genetic counseling implications","authors":"Juan Zhu ,&nbsp;Zi-yan Xu ,&nbsp;Hong-ping Yu ,&nbsp;Ruo-li Wang ,&nbsp;Yi-jia Luo ,&nbsp;Li-jun Xie ,&nbsp;Jian-hui Zhang ,&nbsp;Qian Chen ,&nbsp;Peng-fei Wang ,&nbsp;Dan-dan Ruan ,&nbsp;Jing Zou ,&nbsp;Yan-feng Zhou ,&nbsp;Li Chen ,&nbsp;Fang-meng Huang ,&nbsp;Mei-zhu Gao ,&nbsp;Li Zhang ,&nbsp;Yun-fei Li ,&nbsp;Zhu-ting Fang ,&nbsp;Li-sheng Liao ,&nbsp;Xi-kui Zhang ,&nbsp;Zhi-hai Zheng","doi":"10.1016/j.gene.2025.149902","DOIUrl":"10.1016/j.gene.2025.149902","url":null,"abstract":"<div><div>This study identifies two pedigrees with autosomal dominant polycystic kidney disease (ADPKD) caused by de novo PKD1 variants. Proband A carried a heterozygous splicing variant (c.9202-16G &gt; A), presenting with bilateral renal cysts. The miniGENE assay confirmed this variant causes aberrant splicing with a 60-base excision, leading to a frameshift and a predicted truncated protein. Proband B carried a missense variant (c.2180 T &gt; C; p.Leu727Pro), presenting with polycystic kidney and liver disease. Structural modeling revealed this variant severely disrupts local secondary structure and a critical spatial interaction, compromising protein stability. Functional analyses demonstrate that both de novo variants are pathogenic through distinct mechanisms, implicating aberrant splicing and structural disruption in ADPKD etiology.</div></div>","PeriodicalId":12499,"journal":{"name":"Gene","volume":"978 ","pages":"Article 149902"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the genetic blueprint: A transcriptomic approach to deciphering blue iris color formation in Nili-Ravi buffalo","authors":"Dong Wang ,&nbsp;Yixue Xu ,&nbsp;Chaobin Qin ,&nbsp;Xinhui Song ,&nbsp;Hui Li ,&nbsp;Xiaoxian Xu ,&nbsp;Muhammad Farhan Khan ,&nbsp;Kuiqing Cui ,&nbsp;Zhipeng Li ,&nbsp;Qingyou Liu","doi":"10.1016/j.gene.2025.149878","DOIUrl":"10.1016/j.gene.2025.149878","url":null,"abstract":"<div><div>Water buffalo are economically significant livestock worldwide, yet the genetic basis of the blue iris in Nili-Ravi buffalo remains elusive. We collected mixed iris–lens samples from two Murrah buffaloes (black iris) and two Nili-Ravi buffaloes (blue iris) and performed paired-end RNA-seq. After quality control, 64.53 Gb of high-quality data (Q30 ≥ 89.92 %) were obtained. Differential analysis (DESeq2,|log₂FoldChange| ≥ 2 and padj &lt; 0.05) revealed 1,289 differentially expressed genes and 248 differentially expressed lncRNAs between blue and black irises. GO and KEGG enrichment highlighted melanogenesis, tyrosine metabolism, cysteine metabolism, and phototransduction pathways. Key differential genes related to eye development and melanin production—including the hub mRNAs <em>KIT</em>, <em>MGST1</em>, <em>GNGT1</em>, and <em>TYRP1</em>—were identified. Network analysis further showed that lncRNA MSTRG.14079.1 directly targets protein tyrosine phosphatase receptor T (<em>PTPRT</em>), and this interaction is significantly down-regulated in blue irises. Together, our study provides the first molecular network underlying the blue iris phenotype and establishes a theoretical basis for using this non-invasive marker to enhance breeding efficiency in buffalo.</div></div>","PeriodicalId":12499,"journal":{"name":"Gene","volume":"978 ","pages":"Article 149878"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic diversity, natural selection, and immunological features of the Plasmodium vivax CyRPA protein: Implications for vaccine development","authors":"Diego Garzón-Ospina ,&nbsp;Sindy P. Buitrago ,&nbsp;Natalia Cepeda-Riaño ,&nbsp;Carlos J. Castro-Cavadía ,&nbsp;María Fernanda Yasnot-Acosta","doi":"10.1016/j.gene.2025.149894","DOIUrl":"10.1016/j.gene.2025.149894","url":null,"abstract":"<div><div>Malaria caused by <em>Plasmodium vivax</em> remains a significant public health challenge, with vaccine development hindered by factors such as antigenic diversity and immune evasion. The Cysteine-Rich Protective Antigen (CyRPA), a key protein involved in erythrocyte invasion, has emerged as a promising vaccine candidate. However, its genetic diversity and immunological properties have not been fully explored. This study aimed to analyze the genetic diversity, selective pressures, and antigenic potential of the <em>pvcyrpa</em> locus using 950 sequences, including 42 newly obtained isolates from Colombia. The <em>pvcyrpa</em> gene displayed high nucleotide diversity shaped by both natural selection and recombination. <em>In-silico</em> predictions identified B- and T-cell epitopes, encompassing mainly polymorphic regions, with strong binding affinities predicted for multiple HLA alleles. Notably, these epitopes overlapped with regions previously shown to elicit immune responses in natural infections, as reported in a recent study. Moreover, immune simulation of a multiepitope C-terminal construct predicted a robust humoral memory profile. Collectively, these genetic, epitope-mapping, and immune-simulation findings highlight the conserved C-terminal region of PvCyRPA as a strong, broadly reactive vaccine candidate, providing a rational basis for subsequent <em>in-vitro</em> and <em>in-vivo</em> validation.</div></div>","PeriodicalId":12499,"journal":{"name":"Gene","volume":"978 ","pages":"Article 149894"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145523126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mettl1 mitigates sepsis-induced cardiomyopathy via inhibition of FDX1-dependent cuproptosis","authors":"Wei Siang ,&nbsp;Wang Guoyun ,&nbsp;Feng Yan ,&nbsp;Lin Wenji","doi":"10.1016/j.gene.2025.149892","DOIUrl":"10.1016/j.gene.2025.149892","url":null,"abstract":"<div><div>Sepsis-induced cardiomyopathy (SICM) significantly contributes to sepsis-related mortality, yet its molecular mechanisms remain incompletely understood. Here, we identify cuproptosis—a copper-dependent mitochondrial cell death pathway—as a critical driver of SICM pathogenesis. In a murine SICM model induced by lipopolysaccharide (LPS), cardiac dysfunction was accompanied by myocardial copper accumulation and dysregulation of cuproptosis regulators. RNA sequencing (RNA-seq) analysis revealed cuproptosis as one of the top enriched pathways. Crucially, we demonstrate that the m7G methyltransferase Mettl1 functions as a cardioprotective factor. Mettl1 expression was upregulated in septic hearts and positively correlated with copper levels. <em>In vitro</em>, Mettl1 knockdown exacerbated LPS-induced cytotoxicity in cardiomyocytes and amplified intracellular copper overload. Mechanistically, Mettl1 deficiency potentiated LPS-triggered upregulation of FDX1—a key executor of cuproptosis—and suppressed PDHA1 expression. Our findings establish Mettl1 as a novel suppressor of cuproptosis that confers protection against sepsis-induced cardiotoxicity by restraining FDX1-mediated copper-dependent cell death. Targeting the Mettl1-FDX1 axis may offer a promising therapeutic strategy for SICM.</div></div>","PeriodicalId":12499,"journal":{"name":"Gene","volume":"978 ","pages":"Article 149892"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145511585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the molecular mechanism of dietary FCE supplementation in regulating chicken meat quality","authors":"Wei Zhao,&nbsp;Jinli Tian,&nbsp;Lijuan Yang,&nbsp;Lin Xue,&nbsp;Siyu Chen,&nbsp;Rinmin Ma,&nbsp;Yaling Gu,&nbsp;Dawei Wei,&nbsp;Juan Zhang","doi":"10.1016/j.gene.2025.149865","DOIUrl":"10.1016/j.gene.2025.149865","url":null,"abstract":"<div><div>Meat quality is a critical factor influencing the sales of chicken. Most plant extracts have been shown to improve meat quality in poultry. This study selected 120 similar-weight (1.5 ± 0.2 kg) 135-day-old Jingyuan chickens, divided them into four groups, and fed them different doses (CON, 0.3 % FCE, 0.6 % FCE, and 0.9 % FCE) of fresh corn extract (FCE) until they were 180-day-old chickens. Fifteen chickens were randomly selected from each group for slaughter performance and meat quality assessment. Combining the transcriptome and metabolome sequencing data of the breast (CON and 0.6 % FCE), the weighted co-expression network analysis (WGCNA) method was used to identify hub genes and key metabolites significantly related to meat quality. The results showed that the 0.6 % FCE group was significantly better than the other groups in terms of slaughter performance and meat quality. Transcriptomic analysis identified differentially expressed genes (DEGs) significantly enriched in mineral absorption, amino sugar and nucleotide sugar metabolism, and phosphonate and phosphinate metabolism. Based on WGCNA, six key DEGs significantly associated with meat quality were selected. Metabolomics analysis identified differentially expressed metabolites (DEMs) significantly enriched in the pathways of secondary bile acid biosynthesis, autophagy, pantothenate and CoA biosynthesis, and beta-alanine metabolism Pearson correlation analysis further revealed correlations between the six key DEGs (<em>YKT6</em>, <em>ENSGALG00010016848</em>, <em>GALK2</em>, <em>COMMD9</em>, <em>EIF2D</em>, and <em>GABPB2</em>) and five key DEMs (1H-Indole-4-carboxaldehyde, Leucylproline, Trimethoprim, Ursodeoxycholic acid, and N.epsilon.-Acetyl-L-lysine). Furthermore, the expression levels and content of these genes and metabolites in the breast muscle of Jingyuan chickens were also assessed.</div></div>","PeriodicalId":12499,"journal":{"name":"Gene","volume":"977 ","pages":"Article 149865"},"PeriodicalIF":2.4,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression analysis of androglobin and its influence on the transcriptome in cancer","authors":"Carina Osterhof ,&nbsp;Michel Seiwert ,&nbsp;Stefan Mündnich ,&nbsp;Teng Wei Koay ,&nbsp;Elena Porto ,&nbsp;Glen Kristiansen ,&nbsp;David Hoogewijs ,&nbsp;Thomas Hankeln","doi":"10.1016/j.gene.2025.149840","DOIUrl":"10.1016/j.gene.2025.149840","url":null,"abstract":"<div><div>Androglobin (ADGB) is a phylogenetically ancient multi-domain protein with an embedded globin domain, which binds heme and may therefore interact with gaseous molecules. Other globins like neuroglobin, cytoglobin and myoglobin have shown tumor-suppressor or oncogenic roles in a tissue-dependent way, and also ADGB has been suggested as being oncogenic in prostate and brain cancer models. However, <em>ADGB</em> expression in human tumor entities <em>in vivo</em> has not been investigated systematically so far. Here we mined transcriptome data from various cancer types and reveal that <em>ADGB</em> is typically downregulated in cancer cell lines, as well as in tumors from lung and testis, which express <em>ADGB</em> endogenously in healthy states. We show via bioinformatics analyses that in cell lines only a few <em>ADGB</em> exons are transcribed, or the gene locus was amplified, which greatly limits suitability of such cell lines as model systems for research into ADGB. Consistent with correlation analysis, we further demonstrate that RFX3 regulates <em>ADGB</em> promoter-driven luciferase activity as well as endogenous <em>ADGB</em> expression levels. Since recent literature postulated oncogenic effects of ADGB, we established stable <em>ADGB</em> overexpression (ADGB+) in A549 lung cancer cells. Our transcriptomic analysis of ADGB + cells indicate increased cell motility and restructuring of the extracellular matrix – both hallmarks of elevated malignancy. ADGB thus may display oncogenic potential <em>in vitro</em>. However, since human cancer entities show little to no <em>ADGB</em> transcription, a role for ADGB in tumorigenesis <em>in vivo</em> appears rather limited.</div></div>","PeriodicalId":12499,"journal":{"name":"Gene","volume":"977 ","pages":"Article 149840"},"PeriodicalIF":2.4,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional analysis of two component signaling system in Mycobacterium tuberculosis","authors":"Karthikeyan Sundaram ,&nbsp;Sridhar Rathinam","doi":"10.1016/j.gene.2025.149868","DOIUrl":"10.1016/j.gene.2025.149868","url":null,"abstract":"<div><div>Tuberculosis is a fatal infection transmitted through airborne droplet nuclei. The etiological agent is Mycobacterium tuberculosis, an acid-fast bacillus. Drug-resistant tuberculosis poses a global challenge, with specific mycobacterial genes intricately associated with drug resistance. Numerous factors are implicated in the etiology of the condition. This review specifically aims to examine ClpCP, an ATPase belonging to the AAA + protease family, and the genes of the two-component sensor system related with disease etiology. Mycobacterium TB depends significantly on protein degradation to regulate their quantity and quality, which is crucial for its proliferation and pathogenicity involving Clp. The two-component sensor system comprises histidine kinase (HK) and response regulator (RR), which governs responses to stress situations, starvation, nutritional abundance, persistence, hypoxia, dormancy, and primarily disease pathogenesis. Within the two-component system, there exist 12 pairs, including SenX3/RegX3, PhoP/PhoR, DosR/DosS, MtrA/MtrB, and PdtaS/PdtaR, alongside 6 response regulators Rv0195, Rv0260c, Rv0818, PdtaR, Rv2884, and Rv3143 encoded in the Mycobacterium tuberculosis genome. The PhoPR genes have been extensively researched, and the pathogenicity of Mycobacterium tuberculosis (MTB) is contingent upon the sensor kinase of the PhoPR two-component regulatory system, known as PhoR. This review will examine the roles of genes related to the factors associated with mycobacterial growth and pathogenesis.</div></div>","PeriodicalId":12499,"journal":{"name":"Gene","volume":"977 ","pages":"Article 149868"},"PeriodicalIF":2.4,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}