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Fundamental Toxicological Sciences最新文献

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Investigation of the maximum feasible volume of subretinal injections into rat and cynomolgus monkey eyes 大鼠和食蟹猴眼视网膜下注射最大可行体积的探讨
Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.199
Megumi Sakata, Tomoaki Araki, Masayuki Tomohiro
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引用次数: 0
A survey of on the use of genotoxicity and carcinogenicity testing packages for ophthalmic drug development 眼科药物开发中遗传毒性和致癌性检测包装的使用情况调查
Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.105
Haruna Tahara, Yu Haranosono
{"title":"A survey of on the use of genotoxicity and carcinogenicity testing packages for ophthalmic drug development","authors":"Haruna Tahara, Yu Haranosono","doi":"10.2131/fts.10.105","DOIUrl":"https://doi.org/10.2131/fts.10.105","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87442082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 90-day dose toxicity study of 2-(2H-benzotriazol-2-yl)-6-dodecyl-4-methylphenol in rats 2-(2h -苯并三唑-2-基)-6-十二烷基-4-甲基苯酚对大鼠90天剂量毒性研究
Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.59
M. Kuwagata, Masaru Tsuboi, Toshime Igarashi, Mariko Tsurumoto, Takuya Nishimura, Y. Taquahashi, S. Kitajima
{"title":"A 90-day dose toxicity study of 2-(2H-benzotriazol-2-yl)-6-dodecyl-4-methylphenol in rats","authors":"M. Kuwagata, Masaru Tsuboi, Toshime Igarashi, Mariko Tsurumoto, Takuya Nishimura, Y. Taquahashi, S. Kitajima","doi":"10.2131/fts.10.59","DOIUrl":"https://doi.org/10.2131/fts.10.59","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76362675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PPAR gamma negatively regulates the expression of TRPM8 in normal epidermal cells but mutually regulate their expressions with TRPM8 by feed-back loop regulation in squamous carcinoma cells PPAR γ在正常表皮细胞中负向调节TRPM8的表达，但在鳞癌细胞中与TRPM8通过反馈回路相互调节表达
Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.1
T. Fujino, Mizuki Nakamura, Saki Ohkawa
{"title":"PPAR gamma negatively regulates the expression of TRPM8 in normal epidermal cells but mutually regulate their expressions with TRPM8 by feed-back loop regulation in squamous carcinoma cells","authors":"T. Fujino, Mizuki Nakamura, Saki Ohkawa","doi":"10.2131/fts.10.1","DOIUrl":"https://doi.org/10.2131/fts.10.1","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83190553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An application of the magnetometer detection system to Crl:CD1 (ICR) mice for head twitch response induced by hallucinogenic 5-HT2A agonists 磁力计检测系统在致幻剂5-HT2A激动剂诱导的ICR小鼠抽头反应中的应用
Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.189
Mari Nakamura, Motoki Hojo, Ayaka Kawai, K. Ikushima, A. Nagasawa, Hideyo Takahashi, Kosho Makino, Toshinari Suzuki, Jin Suzuki, A. Inomata
{"title":"An application of the magnetometer detection system to Crl:CD1 (ICR) mice for head twitch response induced by hallucinogenic 5-HT2A agonists","authors":"Mari Nakamura, Motoki Hojo, Ayaka Kawai, K. Ikushima, A. Nagasawa, Hideyo Takahashi, Kosho Makino, Toshinari Suzuki, Jin Suzuki, A. Inomata","doi":"10.2131/fts.10.189","DOIUrl":"https://doi.org/10.2131/fts.10.189","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76358939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 90-day repeated oral dose toxicity study of 2-Butylbenzo[d]isothiazol-3(2H)-one in rats 大鼠90天重复口服2-丁基苯并[d]异噻唑-3(2H)- 1的毒性研究
Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.69
M. Kuwagata, Masaru Tsuboi, Toshime Igarashi, Mariko Tsurumoto, Takuya Nishimura, Y. Taquahashi, S. Kitajima
{"title":"A 90-day repeated oral dose toxicity study of 2-Butylbenzo[d]isothiazol-3(2H)-one in rats","authors":"M. Kuwagata, Masaru Tsuboi, Toshime Igarashi, Mariko Tsurumoto, Takuya Nishimura, Y. Taquahashi, S. Kitajima","doi":"10.2131/fts.10.69","DOIUrl":"https://doi.org/10.2131/fts.10.69","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75306680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paternal exposure to methylphenidate induces ADHD-like behavioral phenotypes and altered gene expressions in mouse offspring 父亲暴露于哌甲酯诱导小鼠后代adhd样行为表型和基因表达改变
Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.7
Ryota Nakano, Asuka Kaizaki-Mitsumoto, S. Numazawa
{"title":"Paternal exposure to methylphenidate induces ADHD-like behavioral phenotypes and altered gene expressions in mouse offspring","authors":"Ryota Nakano, Asuka Kaizaki-Mitsumoto, S. Numazawa","doi":"10.2131/fts.10.7","DOIUrl":"https://doi.org/10.2131/fts.10.7","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75320825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryopreserved human hepatocytes culture optimization on polymethylpentene oxygen permeable membranes for drug screening purposes 聚甲基戊烯透氧膜对人肝细胞低温培养药物筛选的优化
Fundamental Toxicological Sciences Pub Date : 2022-01-01 DOI: 10.2131/fts.9.135
Mathieu Danoy, Benedikt Scheidecker, Hiroshi Arakawa, Katsuhiro Esashika, Naoki Ishida, Hiroyasu Ito, Hisaaki Yanai, Jun Takahashi, Masaki Nishikawa, Yukio Kato, Y. Sakai
{"title":"Cryopreserved human hepatocytes culture optimization on polymethylpentene oxygen permeable membranes for drug screening purposes","authors":"Mathieu Danoy, Benedikt Scheidecker, Hiroshi Arakawa, Katsuhiro Esashika, Naoki Ishida, Hiroyasu Ito, Hisaaki Yanai, Jun Takahashi, Masaki Nishikawa, Yukio Kato, Y. Sakai","doi":"10.2131/fts.9.135","DOIUrl":"https://doi.org/10.2131/fts.9.135","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73824051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leaf extracts from Camellia sinensis and Argania spinosa suppress oxidative stress and chemokine release in human 3-dimensional cultured epidermis exposed to PM2.5 collected with cyclonic separation 油茶和阿卡尼亚叶提取物对暴露于PM2.5的人体三维培养表皮氧化应激和趋化因子释放有抑制作用
Fundamental Toxicological Sciences Pub Date : 2022-01-01 DOI: 10.2131/fts.9.117
M. Kono, T. Okuda, M. Takaishi, H. Ikeda, Nami Ishihara, Y. Ishihara
{"title":"Leaf extracts from Camellia sinensis and Argania spinosa suppress oxidative stress and chemokine release in human 3-dimensional cultured epidermis exposed to PM2.5 collected with cyclonic separation","authors":"M. Kono, T. Okuda, M. Takaishi, H. Ikeda, Nami Ishihara, Y. Ishihara","doi":"10.2131/fts.9.117","DOIUrl":"https://doi.org/10.2131/fts.9.117","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83021264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Absence of in vivo mutagenicity of 4,4'-oxybis(benzenesulfonohydrazide) in liver and glandular stomach of MutaTM Mouse 4,4′-氧双(苯磺酰肼)对MutaTM小鼠肝脏和腺胃的体内无致突变性
Fundamental Toxicological Sciences Pub Date : 2022-01-01 DOI: 10.2131/fts.9.31
T. Iso, Masakatsu Natsume, Yasumasa Murata, Y. Shigeta, N. Hirose, T. Umano, Katsuyoshi Horibata, K. Masumura, K. Sugiyama, M. Matsumoto, A. Hirose
{"title":"Absence of in vivo mutagenicity of 4,4'-oxybis(benzenesulfonohydrazide) in liver and glandular stomach of MutaTM Mouse","authors":"T. Iso, Masakatsu Natsume, Yasumasa Murata, Y. Shigeta, N. Hirose, T. Umano, Katsuyoshi Horibata, K. Masumura, K. Sugiyama, M. Matsumoto, A. Hirose","doi":"10.2131/fts.9.31","DOIUrl":"https://doi.org/10.2131/fts.9.31","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81523713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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