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Fundamental Toxicological Sciences最新文献

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Influence of skin condition on the skin penetration of dextran 4000 and ovalbumin 皮肤状况对葡聚糖4000和卵清蛋白皮肤渗透的影响
Fundamental Toxicological Sciences Pub Date : 2020-01-01 DOI: 10.2131/fts.7.281
M. Fujii, Miko Imai, Hiroki Kuwabara, Minori Awano, K. Hashizaki, H. Taguchi
{"title":"Influence of skin condition on the skin penetration of dextran 4000 and ovalbumin","authors":"M. Fujii, Miko Imai, Hiroki Kuwabara, Minori Awano, K. Hashizaki, H. Taguchi","doi":"10.2131/fts.7.281","DOIUrl":"https://doi.org/10.2131/fts.7.281","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"15 1","pages":"281-286"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85156772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Arsenite inhibits gene expression of perlecan, syndecan-1, -2, -3 and biglycan in cultured vascular endothelial cells 亚砷酸盐抑制培养血管内皮细胞中perlecan、syndecan-1、-2、-3和biglycan基因的表达
Fundamental Toxicological Sciences Pub Date : 2020-01-01 DOI: 10.2131/fts.7.77
Dong-pan Wu, Tsuyoshi Nakano, Y. Tsuneoka, Tsutomu Takahashi, Y. Shinoda, T. Kaji, Y. Fujiwara
{"title":"Arsenite inhibits gene expression of perlecan, syndecan-1, -2, -3 and biglycan in cultured vascular endothelial cells","authors":"Dong-pan Wu, Tsuyoshi Nakano, Y. Tsuneoka, Tsutomu Takahashi, Y. Shinoda, T. Kaji, Y. Fujiwara","doi":"10.2131/fts.7.77","DOIUrl":"https://doi.org/10.2131/fts.7.77","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"26 1","pages":"77-83"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77937297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Maltosyltrehalose Syrup: Bacterial reverse mutation test, and 90-day feeding and 90-day repeated oral dose toxicity studies in rats 麦芽糖海藻糖糖浆:细菌反向突变试验，大鼠90天喂养和90天重复口服剂量毒性研究
Fundamental Toxicological Sciences Pub Date : 2020-01-01 DOI: 10.2131/fts.7.141
S. Matsumoto, T. Hashimoto, Chie Ushio, Keisuke Namekawa, A. Richards
{"title":"Maltosyltrehalose Syrup: Bacterial reverse mutation test, and 90-day feeding and 90-day repeated oral dose toxicity studies in rats","authors":"S. Matsumoto, T. Hashimoto, Chie Ushio, Keisuke Namekawa, A. Richards","doi":"10.2131/fts.7.141","DOIUrl":"https://doi.org/10.2131/fts.7.141","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"108 1","pages":"141-152"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82708096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of estrogen on fatty-acid-induced cytotoxicity in mouse Neuro-2a neural cells 雌激素对脂肪酸诱导小鼠神经-2a神经细胞毒性的影响
Fundamental Toxicological Sciences Pub Date : 2020-01-01 DOI: 10.2131/fts.7.115
M. Ogawa, Takahiro Kyoya, Takahiro Kimura, M. Terada
{"title":"Effects of estrogen on fatty-acid-induced cytotoxicity in mouse Neuro-2a neural cells","authors":"M. Ogawa, Takahiro Kyoya, Takahiro Kimura, M. Terada","doi":"10.2131/fts.7.115","DOIUrl":"https://doi.org/10.2131/fts.7.115","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"14 1","pages":"115-121"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88623721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Repeated 28-day and 13-week dose toxicity studies of oils prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis) in rats 日本巨扇贝(Patinopecten yessoensis)内脏油对大鼠28天和13周的重复剂量毒性研究
Fundamental Toxicological Sciences Pub Date : 2020-01-01 DOI: 10.2131/fts.7.177
Koki Sugimoto, Eito Shimizu, Nozomi Hagihara, Ryota Hosomi, K. Fukunaga, Munehiro Yoshida, T. Yoshioka, Koretarō Takahashi
{"title":"Repeated 28-day and 13-week dose toxicity studies of oils prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis) in rats","authors":"Koki Sugimoto, Eito Shimizu, Nozomi Hagihara, Ryota Hosomi, K. Fukunaga, Munehiro Yoshida, T. Yoshioka, Koretarō Takahashi","doi":"10.2131/fts.7.177","DOIUrl":"https://doi.org/10.2131/fts.7.177","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"51 1","pages":"177-188"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72617617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
In vitro toxicity studies of epoxyoleic acid and diepoxylinoleic acid 环氧油酸和二聚亚油酸的体外毒性研究
Fundamental Toxicological Sciences Pub Date : 2020-01-01 DOI: 10.2131/fts.7.123
Takashi Kitaguchi, Masaharu Tanaka, Takahiro Matsuda, Taisei Mizota, K. Ohno, Kazuhiro Kobayashi, Y. Ogra, Mitsuru Tanaka
{"title":"In vitro toxicity studies of epoxyoleic acid and diepoxylinoleic acid","authors":"Takashi Kitaguchi, Masaharu Tanaka, Takahiro Matsuda, Taisei Mizota, K. Ohno, Kazuhiro Kobayashi, Y. Ogra, Mitsuru Tanaka","doi":"10.2131/fts.7.123","DOIUrl":"https://doi.org/10.2131/fts.7.123","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"44 1","pages":"123-132"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74065147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinoic acid dramatically enhances cytotoxicity of equol against human monoblastic U937 cells, but not against human peripheral neutrophils 视黄酸显著增强马雌酚对人单核细胞U937的细胞毒性，但对人外周血中性粒细胞没有作用
Fundamental Toxicological Sciences Pub Date : 2020-01-01 DOI: 10.2131/fts.7.201
H. Kikuchi, Kaori Harata, C. Kawai, H. Madhyastha, A. Yamauchi, F. Kuribayashi
{"title":"Retinoic acid dramatically enhances cytotoxicity of equol against human monoblastic U937 cells, but not against human peripheral neutrophils","authors":"H. Kikuchi, Kaori Harata, C. Kawai, H. Madhyastha, A. Yamauchi, F. Kuribayashi","doi":"10.2131/fts.7.201","DOIUrl":"https://doi.org/10.2131/fts.7.201","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"1 1","pages":"201-206"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88782987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxicological evaluation of DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine) DSPC(1,2-二硬脂酰-sn-甘油-3-磷酸胆碱)的毒理学评价
Fundamental Toxicological Sciences Pub Date : 2020-01-01 DOI: 10.2131/fts.7.55
O. Ohgoda, I. Robinson
{"title":"Toxicological evaluation of DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine)","authors":"O. Ohgoda, I. Robinson","doi":"10.2131/fts.7.55","DOIUrl":"https://doi.org/10.2131/fts.7.55","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"26 1","pages":"55-76"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84711720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Combined repeated-dose and reproductive/developmental oral toxicity of 3-methylpentane, isooctane, and isononane in rats 3-甲基戊烷、异辛烷和异壬烷对大鼠的复合重复剂量和生殖/发育口服毒性
Fundamental Toxicological Sciences Pub Date : 2020-01-01 DOI: 10.2131/fts.7.259
A. Kawashima, Kaoru Inoue, Y. Yoshizaki, K. Ushida, K. Kai, Hiroshi Suzuki, M. Takano, S. Fujii, Kaoru Yabe, M. Matsumoto, Takashi Yamada, A. Hirose
{"title":"Combined repeated-dose and reproductive/developmental oral toxicity of 3-methylpentane, isooctane, and isononane in rats","authors":"A. Kawashima, Kaoru Inoue, Y. Yoshizaki, K. Ushida, K. Kai, Hiroshi Suzuki, M. Takano, S. Fujii, Kaoru Yabe, M. Matsumoto, Takashi Yamada, A. Hirose","doi":"10.2131/fts.7.259","DOIUrl":"https://doi.org/10.2131/fts.7.259","url":null,"abstract":"ABSTRACT — 3-Methylpentane, isooctane, and isononane are acyclic branched saturated hydrocarbons with carbon numbers C6, C8, and C9, respectively. To assess human risk, we conducted a combined repeated-dose and reproductive/developmental oral toxicity studies in rats. [Organization for Economic Co-operation and Development (OECD) Test Guideline 422]. Each hydrocarbon was administered by gavage to rats at three doses (plus a control group). All three chemicals targeted the liver and kidney. An increase in liver weight without hepatic injury was observed as the adaptive response to the chemical treatments. Males treated by each chemical showed α2u-globulin nephropathy, which is a rat-specific finding that bears no human relevance. Reproduction/developmental toxicity parameters showed no treatment-related effects in parents or offspring at any dose for the three chemicals, except for the retardation of offspring bodyweight development which may be a secondary effect of a maternal systemic condition or direct effect on offspring in isononane. No observed adverse effect levels (NOAELs) of repeated toxicity in either sex were determined to be 300 mg/kg/day for 3-methylpentane, 100 mg/kg/day for isooctane, and 250 mg/kg/day for isononane. NOAELs of reproductive/developmental toxicity in parents and offspring were determined to be 1000 mg/kg/day for 3-methylpentane, and 300 mg/kg/day for isooctane. For isononane, NOAELs were determined to be 1000 mg/kg/day for reproduction, and 250 mg/kg/day for offspring development. These results provide new toxicological information and support the category assessment of published reports that evaluate the acyclic branched saturated hydrocarbons as low-toxicity substances.","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"13 1","pages":"259-279"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83619975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Lack of combined effect of continuous exposure to α-glycosyl isoquercitrin from fetal stages to adulthood and voluntary exercise or environmental enrichment on learning and behaviors in rats 胎儿期至成年期持续暴露于α-糖基异槲皮苷与自愿运动或环境富集对大鼠学习和行为的联合影响缺乏
Fundamental Toxicological Sciences Pub Date : 2020-01-01 DOI: 10.2131/fts.7.241
Yasunori Masubuchi, Satomi Kikuchi, Hiromu Okano, Yasunori Takahashi, K. Takashima, Ryota Ojiro, Qian Tang, Toshinori Yoshida, Mihoko Koyanagi, R. Maronpot, S. Hayashi, M. Shibutani
{"title":"Lack of combined effect of continuous exposure to α-glycosyl isoquercitrin from fetal stages to adulthood and voluntary exercise or environmental enrichment on learning and behaviors in rats","authors":"Yasunori Masubuchi, Satomi Kikuchi, Hiromu Okano, Yasunori Takahashi, K. Takashima, Ryota Ojiro, Qian Tang, Toshinori Yoshida, Mihoko Koyanagi, R. Maronpot, S. Hayashi, M. Shibutani","doi":"10.2131/fts.7.241","DOIUrl":"https://doi.org/10.2131/fts.7.241","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"96 1","pages":"241-248"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80220786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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