Fundamental Toxicological Sciences最新文献

A trial to predict skin irritancy of cosmetic products using cytotoxicity tests 使用细胞毒性试验预测化妆品皮肤刺激性的试验

Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.113

Minori Mezaki, Chika Manabe, Junichiro Nagumo, T. Yoshimura, T. Nagahama, H. Itagaki, A. Takaoka

引用次数: 0

mRNA expression profile of cytokines in rat primary alveolar macrophages treated with multiwalled carbon nanotube (MWCNT) 多壁碳纳米管(MWCNT)处理大鼠原代肺泡巨噬细胞细胞因子mRNA表达谱

Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.27

N. Sultana, K. Fukamachi, Jiegou Xu, H. Tsuda, M. Suzui

引用次数: 2

Toxicological effects of repeated subcutaneous administration of corn oil for 4 weeks in rats 大鼠皮下重复注射玉米油4周的毒理学效应

Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.169

Takayasu Moroki, Fumika Akizawa, Satoshi Kondo, Sakura Fujiwara, T. Yoshikawa, Y. Inoue

引用次数: 0

Effects of continuous thiamine intake on onset and progression of type 2 diabetes in leptin-receptor deficient mice 持续摄入硫胺素对瘦素受体缺乏小鼠2型糖尿病发病和进展的影响

Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.83

Y. Kohda

引用次数: 0

Effect of blood collection tubes containing separation gels on the measurement of drug concentrations in clinical toxicology 含分离凝胶采血管对临床毒理学中药物浓度测定的影响

Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.179

Mayuu Tokudome, Asuka Kaizaki-Miitsumoto, S. Numazawa

引用次数: 0

DNA damage mediated by 4,4'-methylenebis(2-chloroaniline) cannot be detected via the DNA damage marker γH2AX: A case study 4,4'-亚甲基双(2-氯苯胺)介导的DNA损伤不能通过DNA损伤标记γH2AX检测:一个案例研究

Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.21

Saho Kobayashi, H. Kashiwagi

引用次数: 0

Effects of expression of the 10-formyltetrahydrofolate metabolizing enzyme ALDH1L1 on pyrimidine nucleotide synthesis and the salvage pathway 10-甲酰基四氢叶酸代谢酶ALDH1L1表达对嘧啶核苷酸合成和挽救途径的影响

Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.241

Masato Sasaki, Fumie Itoh, Nobuyuki Shibata

{"title":"Effects of expression of the 10-formyltetrahydrofolate metabolizing enzyme ALDH1L1 on pyrimidine nucleotide synthesis and the salvage pathway","authors":"Masato Sasaki, Fumie Itoh, Nobuyuki Shibata","doi":"10.2131/fts.10.241","DOIUrl":"https://doi.org/10.2131/fts.10.241","url":null,"abstract":"Proliferating cells, such as tumor cells, require nucleotides for DNA replication. Mammalian cells are equipped with de novo purine and pyrimidine nucleotide biosynthesis pathways, and a salvage pathway that recycles purine bases, to supply nucleotides for the same. To avoid imbalance in intracellular nucleotide levels, de novo nucleotide biosynthesis pathway is regulated by feedback mechanisms, such as synthase inhibition by nucleotide products. Recently, we reported that the aldehyde dehydrogenase 1 family member L1 (ALDH1L1) consumes 10-formyltetrahydrofolate (10-fTHF), which is utilized by the de novo purine nucleotide synthesis, and results in the accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (ZMP) during purine biosynthesis. Given that ZMP inhibits pyrimidine nucleotide synthesis, in the present study, we examined the effects of ZMP using brequinar, a dihydroorotate dehydrogenase inhibitor. ALDH1L1-mediated ZMP accumulation was unaffected by brequinar, and no effect was observed when brequinar was combined with 5-aminoimidazole-4-carboxamide riboside (AICAr), a nucleoside of ZMP. Furthermore, we examined involvement in the salvage pathway, because attenuation of de novo purine nucleotide synthesis may require a supply of purine nucleotides from the salvage pathway. The guanine analog, 6-thioguanine, and the 2'-deoxycytidine analog, cytarabine, were used in the assessment of dependency on the salvage pathway. We found that neither ALDH1L1-mediated ZMP accumulation nor the presence of AICAr affected the salvage pathway. Collectively, these results suggest that these purine and pyrimidine analogs can be useful for the treatment of tumor cells, regardless of ALDH1L1 expression.","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135158355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety studies of LAURESH® a standardized Laurus nobilis leaf extract LAURESH®标准月桂叶提取物的安全性研究

Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.143

C. Wong, Yukiko Kobayashi, Jinwei Yang

引用次数: 0

Derivation of human health hazard assessment values of 1,2-dichloroethane under the Japan Chemical Substances Control Law 根据《日本化学物质控制法》推导1,2-二氯乙烷的人体健康危害评估值

Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.91

Akira Kawashima, Kaoru Inoue, K. Ushida, K. Kai, Hiroshi Suzuki, Lucia Satiko Yoshida-Yamashita, A. Hirose, K. Masumura

引用次数: 0

K16ApoE inhibits the activity of acetylcholinesterase but is not the primary toxicological mechanism in mice K16ApoE抑制小鼠乙酰胆碱酯酶活性，但不是主要的毒理学机制

Fundamental Toxicological Sciences Pub Date : 2023-01-01 DOI: 10.2131/fts.10.125

Linlin Shao, T. Michelena

引用次数: 0