Frontiers in Molecular Biosciences最新文献

{"title":"Correction: Editorial: Structural studies of bacteria and viruses.","authors":"","doi":"10.3389/fmolb.2025.1697351","DOIUrl":"https://doi.org/10.3389/fmolb.2025.1697351","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fmolb.2025.1605596.].</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1697351"},"PeriodicalIF":3.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress: from molecular studies to clinical intervention strategies.","authors":"Qing Gao, Linlin Jiang, Yuting Sun, Xuedong An, Wenjie Sun, Shanshan Tang, Xiaomin Kang, Xuefei Zhao, Zehua Li, Chenran Liu, Hangyu Ji, Fengmei Lian","doi":"10.3389/fmolb.2025.1638042","DOIUrl":"10.3389/fmolb.2025.1638042","url":null,"abstract":"<p><p>The imbalance between the generation of free radicals and the body's capacity to counteract their damaging effects on proteins, lipids, and nucleic acids is known as oxidative stress. Since it is essential for controlling many biological functions, this imbalance is intimately associated with the development and course of many diseases. In this study, we first outlined the submechanisms of oxidative stress, concentrating on the antioxidant system and reactive oxygen species. We also discussed common detection methods that can be beneficial for both clinical and scientific purposes. We examined prevalent diseases such as cardiovascular issues, diabetes, cancer, and neurodegenerative disorders to highlight the significant impact of oxidative stress. Additionally, we provided a list of common antioxidants to assist in clinical treatment and further exploration of underlying mechanisms. Our findings indicate that the molecular mechanisms of oxidative stress have been more thoroughly investigated, underscoring its scientific and clinical importance in understanding disease development and potential interventions. We propose that ongoing, in-depth research centered on oxidative stress could offer new insights for clinical interventions and mechanism exploration.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1638042"},"PeriodicalIF":3.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12443558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive lipoprotein and glycoprotein characterization in rheumatoid arthritis plasma and association with clinical markers.","authors":"Konstantina Ismini Tsezou, Mohan Ghorasaini, Aswin Verhoeven, Aikaterini Iliou, Dimitra Benaki, Panayiotis G Vlachoyiannopoulos, Martin Giera, Emmanuel Mikros","doi":"10.3389/fmolb.2025.1627273","DOIUrl":"10.3389/fmolb.2025.1627273","url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and pain. This study investigates plasma lipoprotein and glycoprotein profiles in RA patients to identify clinically relevant markers for disease monitoring.</p><p><strong>Methods: </strong>Lipoprotein composition and subfractions were analyzed in plasma from 161 RA patients and 46 controls using proton nuclear magnetic resonance (¹H NMR) spectroscopy (Lipoprotein Subclass Analysis (B.I.LISA) platform) along with N-acetylglycoprotein signals GlycA and GlycB. Lipoprotein subclasses and glycoproteins in RA and disease-modifying anti-rheumatic drug (DMARD)-naive RA patients were compared to controls, and comprehensive profiles were evaluated in activity and remission. Correlations with disease activity score (DAS28), inflammation marker C-reactive protein (CRP), and Visual Analogue Scale (VAS) of pain were assessed using regression models, adjusting for age, gender, and CVD.</p><p><strong>Results: </strong>RA patients exhibited a distinct lipoprotein and glycoprotein profile, with increased triglycerides, cholesterol, apolipoproteins (A1, A2, B100), and changes in LDL, HDL, GlycA, and GlycB. Glycoproteins were significantly higher in DMARD-naive RA (AUC ≈ 0.9) validating these NMR signals as biomarkers of inflammation. Patients in remission had higher small dense HDL and lower LDL-triglycerides than those with high disease activity. VAS correlated with LDL-triglycerides, while DAS28 correlated with small dense LDL-triglycerides and glycoproteins, inversely with large LDL, small HDL lipids. H4A1 alone characterizes RA remission (AUC ≈ 0.8).</p><p><strong>Conclusion: </strong>Lipoprotein profiles in RA correlate with disease activity, inflammation, and pain. Large HDL, intermediate LDL and glycoproteins serve for RA monitoring as well as potential molecular markers of pain.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1627273"},"PeriodicalIF":3.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12443556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interaction of Cu(II) and Zn(II) with peptide fragment of HSPB1 and its analogs.","authors":"Agnieszka Szebesczyk, Domenica Musumeci, Ettore Napolitano, Halyna Kukhtenko, Paulina Iwaniak","doi":"10.3389/fmolb.2025.1593661","DOIUrl":"10.3389/fmolb.2025.1593661","url":null,"abstract":"<p><strong>Introduction: </strong>Copper (II) and zinc (II) ions are essential microelements in the human body, interacting with numerous biologically active molecules, including proteins and peptides. The precise identification of binding sites, complete with the detailed characterization of binding amino acid residues, is of great importance. This is particularly significant in the context of uncovering the mechanisms of diseases associated with single nucleotide polymorphisms (SNPs), and consequently, developing effective treatments.</p><p><strong>Methods: </strong>Two methodological approaches were applied to study the complexation behavior. In the first, ligand and metal ions were mixed at low pH, and complexes formed upon gradual pH increase (via NaOH addition). The formation of different complex forms at changing pH was observed, and stability constants were determined. Spectroscopic data allowed prediction of coordination modes linked to structural changes. The second approach involved complex formation in buffered solutions at fixed pH. Here, metal ion solution was added to partially deprotonated ligands, potentially influencing the complexation behavior compared to the first method.</p><p><strong>Results and discussion: </strong>This study highlights the importance of His-131 and Glu-126 residues in Cu²⁺ and Zn²⁺ ion binding by peptide fragments of the HSPB1 protein. These residues are essential for both the stability of the complexes and the nature of their interaction with the metal ions. Analytical methods exploring complexation behavior across a pH range of 2-10 and in buffer solutions provide a comprehensive view of the thermodynamic properties of the studied systems. This enables the prediction of their behavior under diverse conditions.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1593661"},"PeriodicalIF":3.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased serum anti-ceramide antibodies and decreased sphingosine-1-phosphate levels in patients with obstructive sleep apnea syndrome as potential markers of endothelial dysfunction.","authors":"Andrzej Wiśniewski, Elżbieta Wiśniewska, Łukasz Lewandowski, Izabela Nowak, Monika Kosacka","doi":"10.3389/fmolb.2025.1644828","DOIUrl":"10.3389/fmolb.2025.1644828","url":null,"abstract":"<p><strong>Objective: </strong>Sphingosine-1-phosphate (S1P) and ceramide are bioactive sphingolipids that have been associated with some obstructive sleep apnea (OSA) comorbidities like coronary artery disease (CAD), insulin resistance, diabetes mellitus, hypertension, cardiac dysfunction, and ischemic stroke. On the other hand, S1P and ceramide play key roles in maintaining endothelial homeostasis, which is impaired by repetitive hypoxia/reoxygenation and sleep fragmentation characteristic of OSA. Since the exact role of S1P and ceramide in OSA is still poorly explored, the present study aimed to compare the levels of S1P and anti-ceramide antibodies (ceramide-Ab) in OSA patients and controls.</p><p><strong>Methods: </strong>We recruited 153 subjects (104 patients and 49 controls). The concentrations of anti-ceramide antibodies and S1P were measured using the ELISA technique.</p><p><strong>Results: </strong>We detected significantly higher levels of anti-ceramide antibodies in the OSA group than in the control group (median 318.0 vs. 247.7 ng/mL, p < 0.0001). By contrast, S1P levels were markedly higher in the controls than in the OSA patients (median 1,006.0 vs. 573.9 ng/mL, p < 0.0001). No correlation was observed between either ceramide-Ab or S1P concentrations and the following variables: OSA severity (AHI), desaturation index (DI), BMI, average SaO₂, minimum SaO₂, and C-reactive protein (CRP). Additionally, we noted a positive correlation between BMI and AHI (Spearman r = 0.5051, p < 0.0001), as well as between BMI and DI (Spearman r = 0.55, p < 0.0001). Conversely, BMI negatively correlated with mean SaO₂ (Spearman r = - 0.58, p < 0.0001) and with minimum SaO₂ (Spearman r = - 0.44, p < 0.0001). A middle-strong positive correlation was observed between BMI and serum level of CRP (Spearman r = 0.60, p < 0.0001).</p><p><strong>Conclusion: </strong>We demonstrated that anti-ceramide antibody levels were significantly increased, whereas S1P levels were decreased in patients with obstructive sleep apnea in comparison to healthy subjects. These results suggest that the balance between ceramide and S1P (known as sphingolipid rheostat) may be dysregulated in the course of OSA. We suggest that ceramide-Ab might become a valuable positive biomarker of the disease with S1P as a negative biomarker.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1644828"},"PeriodicalIF":3.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local sequence context at <i>KRAS</i> codons modulates DNA repair efficiency: insights from molecular dynamics simulations.","authors":"James Davies, Georgina E Menzies","doi":"10.3389/fmolb.2025.1654434","DOIUrl":"10.3389/fmolb.2025.1654434","url":null,"abstract":"<p><strong>Introduction: </strong>Benzo[a]pyrene diol-epoxide (BPDE)-induced DNA adducts contribute to the disproportionate mutagenesis of codon 12 in the <i>KRAS</i> gene, driven by preferential DNA damage and impaired repair. Codon susceptibility, however, extends beyond oncogenic hotspots, suggesting that BPDE lesions may serve as biomarkers of individual DNA repair capacity and cancer risk. While the genotoxic effects of tobacco smoke are well characterised, their influence on DNA repair remains underexplored.</p><p><strong>Methods: </strong>Here, we modelled BPDE-adducted <i>KRAS</i> sequences at codons 12 and 14, which have been suggested to exhibit differential repair rates, to assess local helical distortion and its impact on nucleotide excision repair (NER).</p><p><strong>Results: </strong>We show that BPDE adduction at codon 12 induces distinct DNA distortion compared to codon 14, appearing closer to the canonical DNA structure and therefore potentially evading DNA repair, resulting in altered Rad4 binding and compromised lesion recognition.</p><p><strong>Discussion: </strong>Our findings link the mutational hotspot at <i>KRAS</i> codon 12 to impaired NER and highlight the critical role of local sequence context in repair efficiency. These results provide new insights into the interplay between sequence-dependent DNA structure and repair, with implications for mutation accumulation and cancer development.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1654434"},"PeriodicalIF":3.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and application of a preset dilution factor strategy for human chorionic gonadotropin testing in clinical laboratory.","authors":"Shu Chen, Qin Li, Huaqiang Liao, Mingcai Zhao, Jie Chen, Hongyu Chen, Guangjun Xiao","doi":"10.3389/fmolb.2025.1648421","DOIUrl":"10.3389/fmolb.2025.1648421","url":null,"abstract":"<p><strong>Introduction: </strong>Automated dilution has improved the efficiency of human chorionic gonadotropin (hCG) testing, however, challenges persist regarding the cost implications of repeated testing. This study proposes the concept of cost-effective optimization, which aims to further optimize testing efficiency while maintaining controllable costs, and establishes an automated process with preset dilution factors for the hCG testing.</p><p><strong>Materials and methods: </strong>The hCG testing process at Suining Central Hospital was optimized using the Aptio™ Automation Solution (Siemens Healthineers, Erlangen, Germany) integrated with Siemens Atellica® IM1600 analyzer. A novel middleware program was developed within the DataLink V2.0 (Siemens Healthineers, Erlangen, Germany) to automate dilution factor assignment. Relevant data such as dilution factors, sample reception time and review time were captured for statistical purposes to analyze the accuracy, ability to shorten TAT, and economic benefits of hCG testing.</p><p><strong>Results: </strong>After 8 months of continuous improvement, implementation of automated hCG dilution attained 91.19% compliance rate with 19.7% reduction in in-laboratory TAT. The process achieved 75.60% compliance against the 90 min benchmark, while the preset dilution process generated 15.03% mean cost savings per test.</p><p><strong>Conclusion: </strong>In this study, a preset dilution factor program was utilized to establish an automated dilution process, achieving accurate and rapid prediction of hCG. These strategies not only improve efficiency, but also effectively reduce costs, enabling the expansion of testing items and facilitating the implementation in laboratories. Furthermore, they also help to shorten the in-hospital TAT for patients, and improve the hospital's service quality.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1648421"},"PeriodicalIF":3.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytonutrients and their neuroprotective role in brain disorders.","authors":"Krishnendu Adhikary, Krishnendu Ganguly, Riya Sarkar, Md Abubakar, Pradipta Banerjee, Prithviraj Karak","doi":"10.3389/fmolb.2025.1607330","DOIUrl":"10.3389/fmolb.2025.1607330","url":null,"abstract":"<p><p>In the twenty-first century, cognitive impairment is a significant health problem. Function is substantially impaired by a number of neuropsychiatric and neurodegenerative diseases, such as Parkinsonism, schizophrenia, major depressive disorder, Alzheimer's disease and other types of cognitive impairment, cerebrovascular disabilities, seizure-related disorders, and brain traumas. Over time, a number of chemical messengers and signaling molecules have been identified as potential targets for treatment, and tests have been performed against these targets using both conventional and novel chemicals. Phytochemicals derived from medicinal plants are essential for preserving the chemical balance of the central nervous system because they change the activity of major inhibitory receptors that receive neurotransmitters. Many herbs have been used in conventional medicine to treat cognitive problems. Although the presence of receptors that are responsible or transporters for compounds called polyphenols and other phytochemicals in brain regions remains to be determined, multiple target substances seem to be a promising class of treatment options for treating disorders with multifactorial origins. Additional studies suggest that flavonoids possess significant anti-inflammatory properties in the brain, making them a promising therapeutic option for conditions such as ischemic or hemorrhagic stroke, as well as chronic neuroinflammatory disorders like Parkinson's and Alzheimer's disease. This review highlights how phytochemicals contribute to the protection against brain disorders and explores the underlying mechanisms involved in their action. It also emphasizes the core biological processes, providing deeper insight into the therapeutic potential of phytochemicals in the treatment of neurological conditions.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1607330"},"PeriodicalIF":3.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between composite inflammatory indicators and the clinicopathological characteristics of differentiated thyroid carcinoma.","authors":"Li-Yuan Yang, Li-Peng Yang","doi":"10.3389/fmolb.2025.1660379","DOIUrl":"10.3389/fmolb.2025.1660379","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined the associations between composite inflammatory indicators-including the Monocyte-to-Lymphocyte Ratio (MLR), Systemic Inflammation Response Index (SIRI), and Systemic Immune-Inflammation Index (SII)-and the clinicopathological characteristics in patients with Differentiated Thyroid Carcinoma (DTC). To provide a novel insight into refining patient selection criteria for active surveillance (AS) strategies in DTC patients.</p><p><strong>Methods: </strong>This retrospective study analyzed preoperative MLR, SIRI, and SII values in 231 DTC patients treated at Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine between January 2021 and February 2023. Comparisons of these inflammatory indicators were performed across subgroups stratified by clinicopathological characteristics. Subsequently, patients were categorized into low-expression and high-expression groups based on the median values of MLR, SIRI, and SII, followed by comparative analyses of clinicopathological features between the two groups.</p><p><strong>Results: </strong>Comparative Analysis: SIRI levels were significantly elevated (P < 0.05) in patients with larger maximum tumor diameter, higher Ki-67 index, lymph node metastasis (LNM), capsular invasion and bilateral thyroid tumors. Similarly, SII levels were significantly elevated (P < 0.05) in patients with larger maximum tumor diameter, aggressive pathologic variants, LNM, and capsular invasion. In contrast, the MLR showed no significant associations with any of the clinicopathological subgroups analyzed (all P > 0.05). Subgroup Analysis: Compared to the high-MLR group, the low-MLR group showed a significantly lower prevalence of psammoma bodies, and lower incidence of multifocal tumors (all P < 0.05). SIRI Group Comparisons: The high-SIRI group exhibited significantly larger maximum tumor diameter, higher rates of lymphovascular invasion compared to those in the low-SIRI group (P < 0.05). SII Group Comparisons: The high-SII group demonstrated a significantly higher prevalence of aggressive pathologic variants compared to the low-SII group (P < 0.05).</p><p><strong>Conclusion: </strong>Patients with DTC presenting elevated preoperative levels of MLR, SIRI, and SII demonstrated a significantly higher incidence of multiple adverse clinicopathological features postoperatively compared to those with lower baseline inflammatory indicators levels. These findings suggest that MLR, SIRI, and SII may serve as predictive biomarkers for adverse tumor clinicopathological characteristics in DTC.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1660379"},"PeriodicalIF":3.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer's disease.","authors":"Roberta Marongiu, Jimcy Platholi, Laibaik Park, Fangmin Yu, Garrett Sommer, Clara Woods, Teresa A Milner, Michael J Glass","doi":"10.3389/fmolb.2025.1684511","DOIUrl":"10.3389/fmolb.2025.1684511","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fmolb.2025.1597130.].</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1684511"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}