Frontiers in Cell and Developmental Biology最新文献

{"title":"Metabolic reprogramming in efferocytosis.","authors":"Qing Yan, Kuo Li, Lu Chen, Aowei Wang, Yingying Xi, Hui Xiao, Lei Yuan","doi":"10.3389/fcell.2025.1677028","DOIUrl":"10.3389/fcell.2025.1677028","url":null,"abstract":"<p><p>Efferocytosis refers to the process by which phagocytes specifically identify and eliminate apoptotic cells. This process is essential for both maintaining tissue homeostasis and suppressing inflammatory responses, as well as facilitating tissue repair. When phagocytes internalize apoptotic cells, which act as \"nutrient packages,\" they undergo significant metabolic reprogramming. This reprogramming not only supplies energy and biosynthetic precursors necessary for engulfment but also critically influences the functional phenotype of phagocytes through complex molecular networks. These networks ultimately determine whether phagocytes adopt an anti-inflammatory resolution or a pathological pro-inflammatory state. This article offers a comprehensive analysis of the molecular regulatory mechanisms that underpin metabolic reprogramming during efferocytosis, aiming to elucidate the intricate regulatory networks formed by the interaction of metabolites as signaling molecules and classical signaling pathways. We examine how the three primary metabolic pathways-glucose, lipid, and amino acid metabolisms-are regulated by signals from efferocytosis and, in turn, modulate phagocyte function. A deeper understanding of the interplay between metabolic reprogramming and efferocytosis will provide a theoretical foundation and novel targets for treating diseases associated with impaired clearance of apoptotic cells.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1677028"},"PeriodicalIF":4.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of mitochondrial dynamics in cardiomyocytes: implications for cardiac health and disease.","authors":"Tengxu Zhang, Ziwei Li, Ying Xu, Chaoqun Xu, Hao Wang, Tao Rui","doi":"10.3389/fcell.2025.1652683","DOIUrl":"10.3389/fcell.2025.1652683","url":null,"abstract":"<p><p>Mitochondrial dynamics, involving fission and fusion, are vital for maintaining mitochondrial quality, shape, and function in heart cells. This review explores how key regulators-Dynamin-related protein 1 (Drp1), mitofusins 1 and 2 (Mfn1/2), and Optic Atrophy 1 (OPA1)-control these processes in the heart. Drp1 facilitates fission, while Mfn1/2 and OPA1 mediate outer and inner membrane fusion. Their activities are finely tuned by modifications, gene regulation, and stress pathways. Disruptions in these dynamics can impair functions like energy production, calcium balance, ROS management, and mitophagy, contributing to heart diseases. Abnormal fission and fusion are also linked to conditions such as sepsis, ischemia/reperfusion injury, and diabetic cardiomyopathy. This review aims to offer a thorough analysis of recent advancements in the understanding of dysregulated mitochondrial dynamics and their contribution to cardiac pathology. Additionally, it evaluates emerging therapeutic strategies that target the balance between mitochondrial division and fusion. We posit that precise modulation of the activities of Drp1, Mfn1/2, and OPA1 presents significant potential for the treatment of cardiac diseases. However, achieving tissue specificity and temporal control remains a critical challenge for clinical translation.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1652683"},"PeriodicalIF":4.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Cooperative targeting of NF-κB enhances ferroptosis-driven HCC therapy with Alisertib and Donafenib.","authors":"Qiong Zhou, Rui Wang","doi":"10.3389/fcell.2025.1685448","DOIUrl":"https://doi.org/10.3389/fcell.2025.1685448","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fcell.2025.1637767.].</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1685448"},"PeriodicalIF":4.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotopographic control of actin waves and growth cone navigation in developing neurons.","authors":"Spandan Pathak, Kate M O'Neill, Emily K Robinson, Matt J Hourwitz, Corey Herr, John T Fourkas, Edward Giniger, Wolfgang Losert","doi":"10.3389/fcell.2025.1631520","DOIUrl":"10.3389/fcell.2025.1631520","url":null,"abstract":"<p><p>The development of axons and dendrites (neurites) in a neural circuit relies on the dynamic interplay of cytoskeletal components, especially actin, and the integration of diverse environmental cues. Building on prior findings that actin dynamics can serve as a primary sensor of physical guidance cues, this work investigates the role of nanotopography in modulating and guiding actin waves and neurite-tip dynamics during early neural circuit development. Although actin dynamics is well known to contribute to pathfinding in wide axonal tips, typically referred to as growth cones, we also observe dynamic actin remodeling throughout neurites and at other, narrower, neurite tips. We find that actin-wave speeds do not change significantly in the first 2 weeks of neurite development on flat substrates, but decrease over the same period in neurites on nanoridges. The ability of nanoridges to guide actin waves and the neurite-tip direction also decreases as neurites mature, both for narrow tips and wide growth cones. This change in responsiveness to physical guidance cues with neuronal maturation may impact the regenerative capacity of developing neural cells that are inserted into mature brains.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1631520"},"PeriodicalIF":4.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation.","authors":"Lifeng Gan, Peiyue Luo, Junrong Zou, Wei Li, Qi Chen, Le Cheng, Fangtao Zhang, Haidong Zhong, Yiran Lu, Liying Zheng, Biao Qian","doi":"10.3389/fcell.2025.1684892","DOIUrl":"https://doi.org/10.3389/fcell.2025.1684892","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fcell.2025.1611889.].</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1684892"},"PeriodicalIF":4.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic taste receptors in animal physiology: evolutionary conservation and functional diversification.","authors":"Kejin Chen, Xinyu Liang, Hongyu Yi, Guixiang Yu, Qi Wu","doi":"10.3389/fcell.2025.1660529","DOIUrl":"10.3389/fcell.2025.1660529","url":null,"abstract":"<p><p>Taste perception is crucial for animals to assess food's nutritional value while avoiding toxic substances. Recent decades have unveiled the presence of taste receptors beyond the oral cavity, expressed in diverse non-gustatory tissues including gastrointestinal, cardiovascular, reproductive, and neural tissues. These ectopically expressed taste receptors are implicated in a multitude of physiological processes such as the regulation of hormone secretion, nutrient sensing and digestive processes, pathogen defense, and modulation of locomotor abilities. Moreover, these receptors present potential pharmacological targets for therapeutic interventions in diseases related to the respiratory, digestive, and cardiovascular systems. In this review, we summarize the recent advances in understanding the distribution and functions of extraoral taste receptors in mammals, teleosts, insects, and nematodes, emphasizing the commonalities and variations among different species. The emerging paradigm positions taste receptors as polymodal sensors integrating environmental cues with physiological homeostasis beyond their canonical gustatory functions, offering new perspectives on sensory system evolution and organismal adaptation.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1660529"},"PeriodicalIF":4.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional microarchitecture of the human placental villous tree in health and disease.","authors":"Nirav Barapatre, Hans-Georg Frank","doi":"10.3389/fcell.2025.1639740","DOIUrl":"10.3389/fcell.2025.1639740","url":null,"abstract":"<p><strong>Background: </strong>Placental dysfunction plays a central role in pregnancy complications such as fetal growth restriction (FGR), preeclampsia (PE), and gestational diabetes mellitus (GDM). Recent advances in 3D microscopy and stereological analysis have revealed microanatomical changes not detectable by conventional histology.</p><p><strong>Objective: </strong>To summarise key morphological and cellular alterations in the human placenta across FGR, PE, and GDM, with a focus on architecture of the villous tree, proliferative trophoblast dynamics, and sex-specific adaptations.</p><p><strong>Methods: </strong>A synthesis of quantitative 3D histological studies was undertaken, focusing on villous compartment volumes, trophoblast proliferation markers (PCNA), nuclear distribution patterns, and branching indices in placentas from affected and control pregnancies.</p><p><strong>Results: </strong>FGR placentas exhibit central loss of contractile villi (C-villi), increased syncytial nuclear density, and abolished sexual dimorphism. In PE, peripheral villous volume (NC-villi) is reduced, with marked increased proliferation of trophoblast in female placentas and disrupted nuclear spacing. GDM placentas show a global reduction in villous branching and altered proliferative dynamics of villous trophoblast, particularly in females, already in the absence of placental macrosomia.</p><p><strong>Conclusion: </strong>Despite distinct clinical profiles, FGR, PE, and GDM exhibit specific yet partially overlapping placental microstructural pathologies, characterised by trophoblast dysregulation and sex-specific adaptations. These findings underscore the significance of fetal sex and quantitative three-dimensional morphometry in advancing our understanding of placental disease mechanisms.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1639740"},"PeriodicalIF":4.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogels incorporating active compounds from traditional Chinese medicine for diabetic wound healing: mechanistic pathways and bioengineering progress.","authors":"Rui Zhang, Suk Fei Tan, Ye Wang, Junxue Wu, Chao Zhang","doi":"10.3389/fcell.2025.1666646","DOIUrl":"10.3389/fcell.2025.1666646","url":null,"abstract":"<p><p>Diabetic wounds, especially foot ulcers, pose significant clinical challenges due to persistent inflammation, oxidative stress, impaired angiogenesis, and a high risk of infection. Advanced therapeutic strategies are needed to actively modulate the wound microenvironment. Hydrogels incorporating bioactive compounds derived from Traditional Chinese Medicine (TCM), such as curcumin, baicalein, glycyrrhetinic acid, Astragalus polysaccharides, and Ganoderma lucidum polysaccharides, offer a promising integrative approach. These hydrogels combine the biological activities of TCM compounds with the advantages of a moist, biocompatible wound dressing. This review highlights recent advancement (2020-2025) in TCM-based hydrogels for diabetic wound healing focusing on the design of these materials (e.g., curcumin, baicalein, glycyrrhetinic acid, Astragalus and Ganoderma polysaccharides) and the development of stimuli-responsive delivery systems (e.g., pH, enzymes, temperature, glucose and possibly magnetic/electric fields). TCM-derived compounds can not only form or reinforce hydrogel networks but also impart therapeutic functions by modulating key cellular pathways involved in anti-inflammatory (NF-κB) and antioxidant responses (Nrf2/HO-1), angiogenesis (VEGF, PI3K/Akt), and tissue regeneration (TGF-β/Smad). Challenges in translating TCM-based hydrogles into clinical use, such as pharmacokinetic variability and stability of the active compounds, are also discussed. Furthermore, representative studies are critically compared to elucidate how different TCM-hydrogel systems enchance wound healing outcomes by improving tissue regeneration, accelerating wound closure, and combating infection through responsive release and localized delivery mechanism. TCM-based hydrogels offer a novel, multi-functional platforms to diabetic wounds. They represent a novel paradigm in chronic wound management. Continued interdisciplinary research and clinical translation of these integrative biomaterials could significantly advance precision regenerative therapy for diabetic patients.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1666646"},"PeriodicalIF":4.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic modifications in developmental coordination disorder: association between DNA methylation and motor performance.","authors":"Fangfang Huang, Huizhen Li, Haizhen You, Yuantao Su, Huijuan Peng, Wenchong Du, Jing Hua","doi":"10.3389/fcell.2025.1647365","DOIUrl":"10.3389/fcell.2025.1647365","url":null,"abstract":"<p><strong>Objective: </strong>Developmental Coordination Disorder (DCD) is a common neurodevelopmental condition characterized by impaired motor coordination. However, the biological mechanisms underlying DCD remain largely unclear. This study aimed to investigate the potential role of DNA methylation in the pathogenesis of DCD.</p><p><strong>Methods: </strong>Genome-wide DNA methylation analysis was conducted using peripheral blood samples from children with and without DCD. Forty-two key differentially methylated probes (DMPs) were selected for targeted validation using MethylTarget™ sequencing.</p><p><strong>Results: </strong>A total of 416 DMPs were detected. Using the Bumphunter and ProbeLasso algorithms, 48 and 22 differentially methylated regions (DMRs) were identified, respectively. Among the key DMPs, methylation levels at cg18187326 (<i>FAM45A</i>) and cg11968956 (<i>FAM184A</i>) were significantly associated with both total motor and gross motor scores. In addition, cg03597174 (<i>SEZ6</i>) was negatively associated, while cg05986449 (<i>GPD2</i>) was positively associated with gross motor function.</p><p><strong>Conclusion: </strong>These findings provide preliminary evidence that specific DNA methylation alterations may influence early motor development and potentially contribute to the pathogenesis of DCD. DNA methylation markers may serve as novel biomarkers for early diagnosis and targeted intervention in children with DCD.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1647365"},"PeriodicalIF":4.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in cataract grading system: a LOCS III-based hybrid model achieving high-precision classification.","authors":"Gege Tang, Jie Zhang, Yingqi Du, Dexun Jiang, Yanhua Qi, Nan Zhou","doi":"10.3389/fcell.2025.1669696","DOIUrl":"10.3389/fcell.2025.1669696","url":null,"abstract":"<p><strong>Purpose: </strong>To design an artificial intelligence (AI) algorithm based on the Lens Opacities Classification System III (LOCS III) to realize automatic diagnosis of cataracts and classification of its.</p><p><strong>Methods: </strong>This retrospective study develops an AI-based neural network to diagnose cataracts and grade lens opacity. According to the LOCS III, cataracts are classified into Nuclear Opalescence (NO), Nuclear Color (NC), Cortical(C) and Posterior subcapsular(P). The newly developed neural network system uses grayscale, binarization, cluster analysis, \"dilation-corrosion\" and other methods to process and analyze the images, then the study need to test and evaluate the generalization ability of the system.</p><p><strong>Results: </strong>The new neural network system can identify 100% of lens anatomy. It has an accuracy of 92.28%-100% in the diagnosis of nuclear cataract, cortical cataract and posterior subcapsular cataract. The classification accuracy rate of the system for cataract NO, NC, C, P is between 90.88% and 100%, the Area Under the Curve (AUC) is between 96.68% and 100%.</p><p><strong>Conclusion: </strong>A novel cataract diagnostic and grading system can be developed based on the AI recognition algorithm, which establishes an automatic cataract diagnosis and grading scheme. The system facilitates rapid and accurate cataract diagnosis and grading.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1669696"},"PeriodicalIF":4.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}