Folia neuropathologica最新文献

{"title":"Down-regulation of PGAM5 attenuates spinal cord injury-induced neuronal injury by inhibiting ASK-1/p38/NF-kB signaling.","authors":"Junjie Guan, Xin Xu, Runze Zhang, Yingchu Gu, Xiangdong Chen","doi":"10.5114/fn.2024.141372","DOIUrl":"10.5114/fn.2024.141372","url":null,"abstract":"<p><strong>Introduction: </strong>The morbidity and mortality of spinal cord injury (SCI) are increasing year by year. It is of vital importance to ascertain the mechanism of SCI. Phosphoglycerate mutase family member 5 (PGAM5) is viewed as a molecular marker of SCI, but its specific role in SCI is elusive.</p><p><strong>Material and methods: </strong>Following establishment of the SCI mouse model, the pathological examination of the spinal cord was initially assessed using H&E staining. PGAM5 expression in spinal cord tissues was appraised utilizing immunohistochemistry and RT-qPCR. Subsequently, after the expression of PGAM5 in SCI mice was inhibited by adenovirus transfection, the degree of SCI was determined, and the motor ability of hind limbs was estimated with the BBB score. In addition, the apoptosis of neurons, microglia activation and the generation of inflammatory cytokines in the spinal cord of mice were detected. Next, at the cellular level, PGAM5 expression was inhibited in the BV2 microglial cells induced by lipopolysaccharide (LPS), so as to explore the effects of down-regulation of PGAM5 on the activation, inflammation and apoptosis of neurons. Finally, western blot was applied for the appraisement of apoptosis signal-regulating kinase-1 (ASK-1)/p38/nuclear factor-kappa B (NF-kB) signaling-associated proteins.</p><p><strong>Results: </strong>PGAM5 expression in SCI mice was found to be raised. PGAM5 expression in SCI mice was found to be raised. Inhibition of PGAM5 expression in SCI mice can significantly reduce spinal cord pathological injury, SCI-induced neuronal apoptosis, microglial cell activation and inflammation. The above regulatory process might be realized through the ASK-1/p38/NF-kB signaling pathway mediated by PGAM5.</p><p><strong>Conclusions: </strong>Down-regulation of PGAM5 attenuated SCI-induced neuronal injury by inhibiting ASK-1/p38/NF-kB signaling.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":" ","pages":"166-175"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer's disease-related a-synuclein gene expression in CA3 subfield of hippocampus in post-ischemic brain during 2-year survival.","authors":"Ryszard Pluta, Anna Bogucka-Kocka, Jacek Bogucki, Janusz Kocki, Stanisław Czuczwar","doi":"10.5114/fn.2025.152012","DOIUrl":"https://doi.org/10.5114/fn.2025.152012","url":null,"abstract":"<p><p>In this study, we investigated whether changes in the expression of the a-synuclein gene occur and participate in post-ischemic brain neurodegeneration of Alzheimer's disease phenotype. The current study assessed the expression of the a-synuclein gene by RT-PCR after 10-minute brain ischemia in rats in CA3 area with survival at 2, 7, and 30 days and 6, 12, 18, and 24 months. Reduced gene expression was observed at 2 days, 6, and 24 months after ischemia. In the remaining observation periods, i.e., 7 and 30 days and 12 and 18 months, its expression was significantly above control values. In post-ischemic brain, where survival times ranged from 2 days to 2 years, we noted biphasic changes in overexpression of the a-synuclein gene in the CA3 area of the hippocampus. The presented data correlate very well with previous studies, which found an increase in protein levels in the brain and strong immunostaining for a-synuclein after ischemia. Finally, the results clearly indicate that changes in the expression of the a-synuclein gene play an important role in acute and secondary brain injury and the development of brain neurodegeneration after ischemia of Alzheimer's disease phenotype. Overall, studies show that a-synuclein is an attractive target for the development of new therapies to minimize ischemic brain damage and neurological dysfunction.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"63 2","pages":"120-126"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild malformation of cortical development with oligodendroglial hyperplasia in frontal lobe epilepsy (MOGHE): a report of the first case in Bulgaria.","authors":"Dimitar Metodiev, Krassimir Minkin, Petia Dimova, Ingmar Blumcke, Roland Coras, Margarita Ruseva, Rumiana Ganeva, Dimitar Parvanov, Marin Penkov, Sevdalin Nachev","doi":"10.5114/fn.2024.138751","DOIUrl":"10.5114/fn.2024.138751","url":null,"abstract":"<p><p>Herein, we report the first case of mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE) in Bulgaria. It is a newly recognised clinico-pathological entity with medically intractable focal epilepsy in paediatric patients. The patient of interest is a 9-year-old boy who has been suffering from refractory epilepsy since the age of three. Positron emission tomography revealed a consistent hypometabolism with maximum in the orbitofrontal and fronto-opercular cortex, as well as in the adjacent anterior insula and the anterior temporal regions. A left frontal corticotomy anterior from the precentral sulcus, left insulectomy and temporal disconnection were performed. Pathomorphological examination of the material from the resected brain tissues demonstrated oligodendroglial hyperplasia with blurring of grey-white-matter boundaries and presence of subcortical heterotopic neurones. Eighteen months post-surgically the patient is seizure-free and drug-free. The observed oligodendroglial hyperplasia with increased proliferative activity and heterotopic neurones in the white matter with blurring of grey-white-matter junctions are the histopathological hallmarks of MOGHE. More new cases are needed to establish further data about this distinct entity in frontal lobe epilepsy.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":" ","pages":"209-216"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological and neuroradiological presentation in an immuno-deficiency patient with central nervous system recurrence of Burkitt lymphoma: an extremely rare case with complete remission achieved twice after GMALL-B-ALL/NHL2002 and R-MIV protocols.","authors":"Piotr Glinka, Michał Sobstyl, Grzegorz Rymkiewicz, Karol Karamon, Monika Skowronek-Płachta, Albert Acewicz, Katarzyna Błachnio, Robert Konecki, Marcin Chmielewski","doi":"10.5114/fn.2025.152574","DOIUrl":"10.5114/fn.2025.152574","url":null,"abstract":"<p><p>Burkitt lymphoma (BL) is a specific, rare (1-2% of all cases of lymphoma) and aggressive type of B-cell non-Hodgkin lymphoma. If BL recurs during treatment, it usually becomes drug-resistant to subsequent treatment regimens and the prognosis is very poor. We present an extremely rare case of recurrent BL infiltrating the central nervous system (CNS) in a 27-year-old HIV-infected patient who had completed GMALL-B-ALL/NHL2002 protocol treatment 4 months earlier. Radiological and neuropathological examinations of cerebral recurrence of BL, followed by specialized oncological treatment, were discussed. Currently, with antiretroviral therapy and intensive immunochemotherapy for the immunodeficiency-associated BL variant, disease recurrence in the CNS is extremely rare. The magnetic resonance imaging (MRI) findings and laboratory tests are unspecific, as shown in the present case. The final diagnosis can be established properly by performing image-guided stereotactic biopsy or flow cytometry with cytology examination of cerebrospinal fluid. After confirmation of isolated cerebral recurrence of BL, the patient received intensive treatment according to the R-MIV protocol and achieved a second complete remission.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"63 2","pages":"198-208"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of miR-3188 with patient prognosis and mechanistic inhibition of glioma proliferation, invasion, and migration by targeting MAPK1.","authors":"Pengcheng Feng, Cuiming Yan, Yishen Gao, Hao Cui, Tongbo Ning, Liang Chang","doi":"10.5114/fn.2025.149378","DOIUrl":"https://doi.org/10.5114/fn.2025.149378","url":null,"abstract":"<p><strong>Introduction: </strong>Glioma, as the deadliest malignant tumor, is one of the most difficult problems in medicine. This study aims to further elucidate the molecular mechanism of glioma development and explore possible miRNAs as targets for glioma prognosis and molecular therapy.</p><p><strong>Material and methods: </strong>RT-qPCR was used to determine the expression of miR-3188 in glioma tissues and cells. The relationship between miR-3188 and pathological features, as well as its prognostic importance, were examined using the chisquare test and Cox regression analysis. The dual luciferase reporting assay was utilized to confirm the targeting of miR-3188 and MAPK1. Transwell assay and Cell Counting Kit-8 (CCK-8) assays were used to identify the roles that miR-3188 plays in cell metastasis and proliferation, respectively.</p><p><strong>Results: </strong>Research has revealed downregulation of miR-3188 in the tissues and cells of glioma, which is strongly correlated with the tumor size, Karnofsky Performance Status (KPS) score, World Health Organization (WHO) grade, and patients' survival rate in glioma. Four downstream target genes were screened by bioinformatics analysis, among which MAPK1 was abnormally expressed in glioma, and was negatively correlated with miR-3188. When miR-3188 was overexpressed, the malignant behavioral activity of glioma cells was significantly decreased; however, the inhibitory effect was reversed when MAPK1 was overexpressed.</p><p><strong>Conclusions: </strong>miR-3188 is a potential predictor of malignant development and poor prognosis in glioma patients and targets MAPK1 to inhibit the progression of glioma.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"63 1","pages":"39-50"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of lncRNA SNHG22 targeting miR-27b-3p on regulation of glioma progression and prognosis.","authors":"Jin Feng, Hongzhi Liu","doi":"10.5114/fn.2024.144178","DOIUrl":"https://doi.org/10.5114/fn.2024.144178","url":null,"abstract":"<p><strong>Introduction: </strong>Glioma is a highly aggressive malignant tumor with high mortality, which is prone to metastasis and recurrence. This study investigated the biological function and related mechanism of action of the long non-coding RNA SNHG22 (lncRNA SNHG22; SNHG22) on glioma cells and its prognostic value.</p><p><strong>Material and methods: </strong>The relative expression levels of SNHG22 and miR-27b-3p in the included glioma patients were detected by real-time quantitative PCR (RT-qPCR). The cell counting kit-8 (CCK-8) proliferation assay and Transwell assay confirmed the effect of knockdown of SNHG22 on the biological function of glioma cells. Luciferase activity characterized the mechanism of SNHG22 targeting miR-27b-3p. Additionally, Kaplan-Meier and multivariate Cox analyses were performed to evaluate the effect of SNHG22 on patient survival.</p><p><strong>Results: </strong>In glioma tissues and cells, compared to normal samples as controls, SNHG22 expression was increased and the expression of miR-27b-3p was decreased. Silencing SNHG22 suppressed the proliferation, migration and invasion levels of glioma cells. SNHG22 directly targets miR-27b-3p to regulate tumor progression. Low expression of SNHG22 was more conducive to the survival of patients than high expression of SNHG22.</p><p><strong>Conclusions: </strong>The lncRNA SNHG22 regulated the progression of glioma by targeting miR-27b-3p, which reflected the prognostic potential of SNHG22 and provided a meaningful theoretical reference for the treatment of glioma patients.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"63 1","pages":"79-86"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The early predictive value of maternal serum PAPP-A concentration at 11-14 weeks of pregnancy for preeclampsia.","authors":"Qing Wang, Weiping Zhang, Wushan Li, Chunmei Yu","doi":"10.5114/fn.2024.140447","DOIUrl":"10.5114/fn.2024.140447","url":null,"abstract":"<p><strong>Introduction: </strong>To determine the expression and clinical significance of maternal serum pregnancy-associated plasma protein A (PAPP-A) in pregnant women with different degrees of preeclampsia at 11-14 weeks of gestation.</p><p><strong>Material and methods: </strong>The clinical data of 65 pregnant women with preeclampsia admitted to our hospital from January 2020 to October 2022 were retrospectively analysed. Another 45 normal pregnant women who came to our hospital for prenatal examination and delivery during the same period were selected as the healthy control group. The serum contents of PAPP-A, a-fetoprotein (AFP) and free estriol (uE3) in each group were compared. The correlation between PAPP-A and AFP as well as uE3 was analysed by Pearson analysis. The clinical value of serological indexes in diagnosing preeclampsia was analysed using ROC curve.</p><p><strong>Results: </strong>The levels of PAPP-A and uE3 in pregnant women in the preeclampsia group were lower, while the contents of AFP were higher than these in the healthy control group ( p < 0.01). The pregnant women with severe preeclampsia had lower levels of PAPP-A and uE3 with higher levels of AFP compared to these with mild preeclampsia ( p < 0.001). Pearson correlation analysis showed that serum PAPP-A was negatively correlated with AFP (r = -0.246, p < 0.05) and positively correlated with uE3 (r = 0.398, p < 0.01) in preeclampsia patients. ROC curve analysis demonstrated that the area under the curve (AUC) of PAPP-A, AFP and uE3 to assist in the diagnosis of preeclampsia was 0.740, 0.738 and 0.806, respectively. The AUC of the combination of PAPP-A, AFP and uE3 to assist in the diagnosis was 0.912, with a sensitivity of 90.38% and a specificity of 80.33%. The clinical assisted diagnostic value of combined detection was high.</p><p><strong>Conclusions: </strong>The serum level of PAPP-A in pregnant women with preeclampsia in the early pregnancy was significantly lower and related to the severity of the disease. The combination of routine detection for AFP and uE3 had a good predictive value for preeclampsia, which was helpful to take relevant interventions to reduce the incidence of preeclampsia as early as possible, and had a positive impact on protecting maternal and infant health.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":" ","pages":"176-184"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropathological findings in essential tremor.","authors":"Ioannis Mavroudis, Foivos Petridis","doi":"10.5114/fn.2024.140569","DOIUrl":"10.5114/fn.2024.140569","url":null,"abstract":"<p><p>Essential tremor (ET) is one of the most common neurological conditions and the most common movement disorder. The pathophysiological mechanisms that underlie this entity have not yet been described. However, recent post-mortem brain studies have provided useful insight into the underlying pathology of ET. Two brain areas have been consistently found to present neuropathological alterations in patients with ET: the brainstem, for presence of Lewy bodies or neuronal depletion, and the cerebellum, regarding Purkinje cells' morphology and density. In the present study we aim to review the literature on the main neuropathological findings in ET brains.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":" ","pages":"11-18"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nab-paclitaxel: A revolution in the nano-therapeutic approach to IDH-wildtype glioblastoma.","authors":"Maria Fareed Siddiqui, Amber Hassan, Muzna Tahir, Fahad Okal, Saleh Baeesa, Alaa Alkhotani, Zayd Jasaniah, Ahmad Fallatah, Eyad Faizo, Dahlia Mirdad, Bashayer A Althaqafi, Maher Kurdi","doi":"10.5114/fn.2025.152517","DOIUrl":"https://doi.org/10.5114/fn.2025.152517","url":null,"abstract":"<p><p>Paclitaxel (PTX) is a potent chemotherapy drug commonly used to treat various solid tumours, including breast and ovarian cancers. However, its effectiveness in treating IDH-wildtype glioblastoma has been limited due to challenges crossing the blood-brain barrier (BBB). Glioblastoma remains one of the most difficult cancers to treat, with a median survival of 15 months from diagnosis. Recent advancements in nanotechnology have led to innovative PTX delivery systems that enhance its bioavailability and enable targeted brain therapy. These include nanoparticles composed of biocompatible materials that enhance drug solubility and targeting while addressing BBB permeability. Examples include albumin-bound PTX (Abraxane), self-assembled nanoparticles from natural bioactive molecules, poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles, and hydrophilic nano-prodrugs, each showing promise in enhancing the therapeutic impact of PTX. These systems utilize biocompatible nanoparticles that enhance drug solubility, targeting, and BBB permeability. Numerous ongoing clinical trials and preclinical studies are exploring the efficacy of these nanocarrier systems in overcoming drug resistance and improving patient outcomes. The latest advancements in PTX-based nanotherapeutics for glioblastoma focus on overcoming the BBB, developing nanoparticle delivery systems, and evaluating the clinical significance of these developments.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"63 2","pages":"107-119"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis and comparison of immunohistochemical features of surgically treated primary-metastatic brain tumours.","authors":"Sule Gokturk, Yasin Göktürk, Nihal Kaya, Arzu Erdem Taşdemir","doi":"10.5114/fn.2025.149487","DOIUrl":"https://doi.org/10.5114/fn.2025.149487","url":null,"abstract":"<p><strong>Introduction: </strong>Malignant tumours diagnosed in the central nervous system are among the leading causes of death from cancer. Central nervous system tumours are the 10th most frequent cause of mortality due to cancer. Immunohistochemistry has become an important tool in the diagnosis of brain tumours. Brain tissue and meninges tumours comprise a heterogeneous group with diverse biological behaviour, treatment management, and different prognoses. Although conventional haematoxylin-eosin staining is crucial for diagnosis, diagnostic neuropathology has benefited from the inclusion of immunohistochemistry and recent advances in the field over the past 20 years. GFAP, S100, IDH, OLIG 2, EMA, ATRX, P53 and Ki67 are the most frequently used immunohistochemical markers globally, which we also highlighted in our study.</p><p><strong>Material and methods: </strong>Ninety-seven cases including primary-metastatic intracranial tumours, operated on in the Neurosurgery Clinic and diagnosed in the Medical Pathology Laboratory between 2018 and 2023 years, were examined retrospectively from the archive. Haematoxylin-eosin slides were re-evaluated under the light microscope by 2 double-blind pathologists and immunohistochemical features and characteristics of tumours were examined. Data were analysed using the program SPSS 22. Differences were accepted as statistically significant at p < 0.05.</p><p><strong>Results: </strong>According to the analysis of results, 46 (47.4%) of the 97 included patients were female and 51 (52.6%) were male. The most common tumour types were meningioma with 31 (32%) and high-grade neuroglial tumours with 31 (32%). GFAP, OLIG2, ATRX, and P53 values were found to be significantly higher in high-grade neuroglial tumours. While S 100 and EMA values were especially high in meningiomas, a positive correlation was found with IDH value in low-grade neuroglial tumours. The study showed that the median Ki67 value was significantly higher in high-grade neuroglial tumours and metastatic tumours.</p><p><strong>Conclusions: </strong>Intracranial tumours cause significant morbidity and mortality in patients. Diagnostic, prognostic and predictive biomarkers evaluated in patient biopsy specimens and/or body fluids are important in neuropathological oncology. By regularly updating our biomarkers and following new treatment approaches, we can improve survival with rapid diagnosis and appropriate treatment in central nervous system tumours after surgery.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"63 1","pages":"30-38"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}