D Pittrow, H U Wittchen, P Bramlage, R Dikow, W Kirch, H Lehnert, E Ritz
{"title":"[Nephropathy: an overview for daily practice].","authors":"D Pittrow, H U Wittchen, P Bramlage, R Dikow, W Kirch, H Lehnert, E Ritz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The examination of renal function in the daily practice may give important information on the risk status of a given patient. For example, the diagnosis of microalbuminuria carries high predictive value for a future cardiovascular risk of patients with hypertension, diabetes, congestive heart failure, as well as myocardial infarction. The findings of the Hypertension and Diabetes Screening and Awareness Study (HYDRA) indicate that screening for microalbuminuria is performed not often enough in patients with diabetes or hypertension, respectively, and a positive screening finding often does not trigger necessary consequences as for additional diagnosis or therapy.</p>","PeriodicalId":12358,"journal":{"name":"Fortschritte der Medizin. Originalien","volume":"121 Suppl 1 ","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"2003-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24171073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H U Wittchen, P Krause, M Höfler, H Pfister, B Küpper, D Pittrow, P Bramlage, T Unger, A M Sharma, E Ritz, B Göke, H Lehnert, D Tschöpe, W Kirch
{"title":"[Aim, design and methods of the \"Hypertension and diabetes screening and awareness\" -- (HYDRA) study].","authors":"H U Wittchen, P Krause, M Höfler, H Pfister, B Küpper, D Pittrow, P Bramlage, T Unger, A M Sharma, E Ritz, B Göke, H Lehnert, D Tschöpe, W Kirch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Aim of the study is a comprehensive clinical-epidemiological description of the prevalence of arterial hypertension and diabetes among primary care patients along with an assessment of doctor's recognition rates and prescription behaviour. The paper describes methods and design of the study and provides background information on the sampling process, instruments used as well as characteristics of doctors and patients. The study is based on a nationally representative sample of 1,912 primary care doctors and 45,000 patients that attended the doctors' office on the target days. The patients were also characterized by laboratory tests. The first stage of study consisted of a comprehensive description of the doctors' characteristics in terms of psychosocial, qualification- and provider aspects as well as attitudes towards hypertension and diabetes and their management. In the second stage all patients completed a questionnaire to describe their health behaviour and attitudes as well as the treatment history and therapy. In the third stage all patients were characterized by their doctors in terms of their diagnostic status and their past and current interventions.</p>","PeriodicalId":12358,"journal":{"name":"Fortschritte der Medizin. Originalien","volume":"121 Suppl 1 ","pages":"2-11"},"PeriodicalIF":0.0,"publicationDate":"2003-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24172912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P Bramlage, H U Wittchen, D Pittrow, R Dikow, W Kirch, H Lehnert, E Ritz
{"title":"[Diabetes, hypertension and microalbuminuria in primary care].","authors":"P Bramlage, H U Wittchen, D Pittrow, R Dikow, W Kirch, H Lehnert, E Ritz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Microalbuminuria has been widely appreciated in recent years to be a valuable risk marker for an increased cardiovascular disease morbidity and mortality. Thus guidelines for the treatment of type-2-diabetes in Germany and the US recommend an annual screening as soon as the diagnosis of diabetes is established and a quarterly control when microalbuminuria is present. While nationally representative epidemiologic data from the US have been available, data from Germany, especially from the primary care sector are missing. This is especially important in light of the gatekeeper function of the primary care physician. The \"Hypertension and Diabetes Risk Screening Study\" (HYDRA) has been identifying 37.8% of patients with hypertension and diabetes to have a positive dipstick test for microalbuminuria on the study day while only 12.5% of these are diagnosed by the doctor as having nephropathy. These patients additionally show a high burden of associated comorbidities and thus call for early detection and intervention especially because effective therapy is available. Although screening for microalbuminuria is recommended in the guidelines the value of a routine screening for microalbuminuria in primary care is under recognized.</p>","PeriodicalId":12358,"journal":{"name":"Fortschritte der Medizin. Originalien","volume":"121 Suppl 1 ","pages":"33-8"},"PeriodicalIF":0.0,"publicationDate":"2003-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24171072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P Bramlage, H U Wittchen, D Pittrow, R Dikow, W Kirch, H Lehnert, E Ritz
{"title":"[Microalbuminuria is an early marker for increased morbidity and mortality].","authors":"P Bramlage, H U Wittchen, D Pittrow, R Dikow, W Kirch, H Lehnert, E Ritz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent studies have shown the beneficial effects of a blockade of the renin-angiotensin system (RAS) not only for blood pressure reduction but also end organ protection. One of the markers that is closely correlated with the increased cardiovascular risk is microalbuminuria. A common mediator for the development of both, microalbuminuria and end organ damage seems to be Angiotensin II, the blockade of which apparently reduces microalbuminuria as well as end organ damage. Therefore we had a closer look into pathophysiology of microalbuminuria and the relevance for end organ damage and discuss current medical strategies to alleviate these diseases.</p>","PeriodicalId":12358,"journal":{"name":"Fortschritte der Medizin. Originalien","volume":"121 Suppl 1 ","pages":"28-32"},"PeriodicalIF":0.0,"publicationDate":"2003-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24171071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P Krause, H U Wittchen, B Küpper, D Pittrow, T Unger, A M Sharma, E Ritz, B Göke, H Lehnert, D Tschöpe, W Kirch, H Pfister, P Bramlage, M Höfler
{"title":"[Management of diabetes and hypertension: how do primary care physicians judge their performance?].","authors":"P Krause, H U Wittchen, B Küpper, D Pittrow, T Unger, A M Sharma, E Ritz, B Göke, H Lehnert, D Tschöpe, W Kirch, H Pfister, P Bramlage, M Höfler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With regard to the management of hypertension and diabetes, HYDRA reveals that doctors report multiple problems in their everyday practice. Being confronted with an average of 73 patients a day, with almost every second having either diabetes or hypertension, frequently associated with multiple comorbid conditions, the core obstacle is the time factor. Doctors do not have sufficient time to perform diagnostic tests and especially no time for non-drug interventions of any type. Further available treatment guidelines are only used in 1 out of 2 doctors. Further they seem not to affect doctors performance significantly.</p>","PeriodicalId":12358,"journal":{"name":"Fortschritte der Medizin. Originalien","volume":"121 Suppl 1 ","pages":"12-8"},"PeriodicalIF":0.0,"publicationDate":"2003-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24172913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[\"Hypertension and diabetes screening and awareness\" -- (HYDRA) study].","authors":"H U Wittchen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12358,"journal":{"name":"Fortschritte der Medizin. Originalien","volume":"121 Suppl 1 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2003-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24172911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H U Wittchen, P Krause, M Höfler, H Pfister, E Ritz, B Göke, H Lehnert, D Tschöpe, W Kirch, D Pittrow, A M Sharma, P Bramlage, B Küpper, T Unger
{"title":"[Hypertension, diabetes mellitus and comorbidity in primary care].","authors":"H U Wittchen, P Krause, M Höfler, H Pfister, E Ritz, B Göke, H Lehnert, D Tschöpe, W Kirch, D Pittrow, A M Sharma, P Bramlage, B Küpper, T Unger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Almost every second patient seeing a primary care doctor suffers from arterial hypertension and about every fifth has diabetes mellitus. These diseases often occur at the same time. They are associated in more than 80% of the cases with other severe concomitant and subsequent diseases (heart attack, stroke, renal failure, neuropathy etc.). The magnitude especially of subsequent and concomitant diseases, the dimension of the personal suffering and the immense diagnostic and therapeutic challenges for the doctors have been massively underestimated so far. The article informs about the prevalence of the above disease, and structure of the problem. Before the background of an extremely high patient load seen by German General Physicians, the mainstay challenge is highlighted how to achieve further improvements of the quality of care on the basis of scientific guidelines alone, without a concomitant change in the system structure.</p>","PeriodicalId":12358,"journal":{"name":"Fortschritte der Medizin. Originalien","volume":"121 Suppl 1 ","pages":"19-27"},"PeriodicalIF":0.0,"publicationDate":"2003-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24171070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The effect of ginkgo biloba on healthy elderly subjects].","authors":"A Cieza, P Maier, E Pöppel","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and aim: </strong>Over the past 25 years, numerous studies have confirmed the positive effect of the special ginkgo extract EGb 761 on the mental ability and emotional well-being of patients with cognitive disorders of vascular genesis, and Alzheimer-type dementia. The following study investigated the short-term effect of the special ginkgo extract EGb 761 on the subjective emotional well-being of healthy elderly subjects. STUDY POPULATION AND METHOD: The study was designed as a randomized double-blind, monocenter study with parallel groups. It included 66 healthy subjects of both sexes aged between 50 and 65 with no age-related cognitive impairments. For a period of 4 weeks, 34 subjects received a daily dose of 240 mg EGb 761, and 32 a placebo. Prior to starting medication and after 28 days of treatment, subjects completed the following scales and questionnaires to establish subjective emotional well-being: the Profile of Mood States (POMS), the Self Rating Depression Scale (SDS), three Visual Analog Scales to assess the quality of life (VAS-QoL), general health (VAS-GH) and mental health (VAS-MH), and a new instrument for assessing changes in general subjective well-being, the Subjective Intensity Score Mood (SIS Mood). Depending on the underlying distribution of the variables analyzed, parametric (t-tests) or nonparametric tests (U-tests) were performed to compare mean values and distributions both within and between the treatment groups.</p><p><strong>Results: </strong>The final examination revealed a statistically significant difference between the two groups for the VAS mental health and quality of life, as also for SIS Mood at the telephone interview in week 2. A comparison of baseline with the final examination within the groups showed a statistically significant improvement in the EGb 761 group for the variables: depression, fatigue, anger and SDS. For none of the variables investigated was a worsening observed in the EGb 761 group.</p><p><strong>Conclusions: </strong>The results suggest a positive effect of EGb 761 on the subjective emotional well-being of healthy elderly persons.</p>","PeriodicalId":12358,"journal":{"name":"Fortschritte der Medizin. Originalien","volume":"121 1","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24495430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Audimont--a scientific research expedition to Mount Cho Oyu in the Himalayas].","authors":"K Mees, A Behnisch, M Suckfüll","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Even though hearing and vestibular disorders at high altitude have been reported since 1938, their reasons are still unknown. During the Audimont Research Expedition the risk for cochlear and vestibular sensory cells has been quantified by otoacoustic emissions and videonystagmography. Vestibular disorders could not be observed up to 7050 meters. However, the outer hair cells in the inner ear showed a reduction of emissions at increasing height. The pattern of the inner ear reply, depending on the altitude, complies with an increase of the perilymphatic pressure. As the perilymphatic space corresponds directly to the subarachnoid space, the limitation of hearing thus appears to be a direct consequence of raised intracranial pressure.</p>","PeriodicalId":12358,"journal":{"name":"Fortschritte der Medizin. Originalien","volume":"121 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24495429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Treatment of chronic wounds with an alginate dressing containing calcium zinc and manganese].","authors":"U E Ziegler, K Schmidt, H P Keller, A Thiede","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Treatment of chronic wounds comprises adequate debridement, reduction in the bacterial burden, and application of a dressing to absorb excess exudate.</p><p><strong>Methods: </strong>In a prospectively documented, multicenter observational study involving 1285 chronic wounds of varying etiologies, carried out in 314 doctor's offices in Germany, the effect of the new alginate dressing, containing calcium zinc and manganese was investigated.</p><p><strong>Results: </strong>After twelve weeks of treatment with the dressing, 95% of all wounds had improved appreciably, and 52.5% had healed completely. The drop out rate was 4.4% and side effects were observed in 2.6% of the cases. 73.8% of the patients reported markedly improved tolerability in comparison with previous treatment. 604 patients (47.0%) considered handling of the dressing to be \"much better\", and 411 (32.0%) to be \"better\" than previous treatment. The frequency of dressing changes decreased from 5.2 to 3.2 a week.</p>","PeriodicalId":12358,"journal":{"name":"Fortschritte der Medizin. Originalien","volume":"121 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24495936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}