Fiziolohichnyi zhurnal最新文献_第7页

[The activity of interferon-dependent 2',5'-oligoadenylatesynthetase in rat thymus lymphoid cells under the action of ethanol and acetic zinc administration]. [乙醇和乙酸锌作用下大鼠胸腺淋巴样细胞干扰素依赖性2′，5′-寡聚腺苷酸合成酶的活性]。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.02.025

I. Kompanets, I. O. Stepanets', V. Voitenko, D. M. Hrebinyk, L. Ostapchenko

引用次数: 0

[The activity of muscles of the shoulder girdle and shoulder during the constant isometric efforts of the wrist]. [在手腕持续的等距运动过程中肩带和肩部肌肉的活动]。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.03.089

I. Vereshchaka, O. V. Lehedza, M. Dornovs'kyĭ, A. V. Horkovenko, V. I. Khorievin

引用次数: 0

[Morphofunctional state of reproductive system of ageing male rats in case of using nanocerium]. [使用纳米铈对老龄雄性大鼠生殖系统形态功能的影响]。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.01.011

N. Nosenko, N. Zholobak, L. I. Poliakova, P. Sinitsyn, A. A. Lymarieva, O. Shcherbakov, M. Spivak, O. H. Reznikov

引用次数: 6

[Effects of N-stearoylethanolamine on the emotionality and learning ability of rats]. n -硬脂酰乙醇胺对大鼠情绪和学习能力的影响。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.05.052

O. Bondarenko, N. Hula, M. Makarchuk, T. Horid’ko, O. Kovalenko

{"title":"[Effects of N-stearoylethanolamine on the emotionality and learning ability of rats].","authors":"O. Bondarenko, N. Hula, M. Makarchuk, T. Horid’ko, O. Kovalenko","doi":"10.15407/FZ60.05.052","DOIUrl":"https://doi.org/10.15407/FZ60.05.052","url":null,"abstract":"After administration of endocannabinoid-like compound N-stearoylethanolamine (NSE) at a dose of 0,1 and 5 mg/kg the anxiety level of rats in the elevated plus maze and learning ability of rats in the radial maze were investigated. It was revealed that NSE can change both innate and acquired behavior of rats. It was found that the administration of NSE decreased of anxious behavior in general, although number and duration of grooming were not affected. Administration of NSE at a dose of 5 mg/kg decreases of anxious behavior in rats but also decreases locomotor activity. Higher anxiolytic effect of the substance in the elevated plus maze and growth of learning ability in the radial maze were shown during 7 days' introduction of NSE at a dose of 0,1 mg/kg that administration of this substance at a dose of 5 mg/kg. Administration of NSE at a dose of 0.1 mg/kg significantly reduced the total number of errors in the radial maze compared to the control at the first day of conditioning with food reinforcement. The latent period of 3rd reinforcement's taking in animals in this group was lower on the 1st, 5th (P<0.05) and 6th (P <0.01) days. Nevertheless, it was found no significant differences in the behavior in rats treated with NSE in both doses throughout the study period. Therefore, NSE changes the behavior of rats and contributes to the improvement of cognitive function without negative effects specific to cannabinoid drugs.","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80201095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Renoprotective efficacy of different doses of statins in experimental acute renal failure]. 不同剂量他汀类药物对实验性急性肾功能衰竭的肾保护作用。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/fz60.02.075

V. H. Zeleniuk, I. I. Zamors'kyĭ, O. Horoshko

引用次数: 3

Expression of XBP1 in lymphocytes of the small intestine in rats under chronic social stress and modulation of intestinal microflora composition. 慢性社会应激大鼠小肠淋巴细胞XBP1的表达与肠道菌群组成的调节

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.02.038

I. Topol, A. Kamyshny, A. V. Abramov, Yu. M. Kolesnik

{"title":"Expression of XBP1 in lymphocytes of the small intestine in rats under chronic social stress and modulation of intestinal microflora composition.","authors":"I. Topol, A. Kamyshny, A. V. Abramov, Yu. M. Kolesnik","doi":"10.15407/FZ60.02.038","DOIUrl":"https://doi.org/10.15407/FZ60.02.038","url":null,"abstract":"The present study was conducted to investigate of the influence of chronic social stress and modulation of the composition of intestinal microflora on the distribution of Xbp(1+)-lymphocytes in the gut-associated lymphoid tissue of ileum of the rats. Structure of population of Xbp(1+)-cells has been studied by the analysis of serial histological sections using the method of indirect immunofluorescence with monoclonal antibodies to Xbp1 of rat. Chronic social stress development is accompanied with the reduction of total number of Xbp(1+)-lymphocytes in lymphoid structures of ileum (31% -3 fold reduction, p < 0.05), mostly expressed in lymphoidfollicles, and changes the concentration of Xbp1 protein in immunopositive cells. Modulation of the composition of intestinal microflora by antibiotics and probiotics under chronic social stress results in the increase of total number of Xbp1+ lymphocytes in gut-associated lymphoid tissue, the degree of it depends on the kind ofstress. The discovered alterations of Xbp1 expression under stress may be one of the triggers for development of autoimmune and inflammatory bowel diseases. Thus, increased understanding of the molecular actions and transcriptional networks regulated by XBP1 in immune cells may aid in the development of potential therapeutics targeting immune disorders.","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83069855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

[Analysis of the effect of N5, N10-methylenetetrahydrofolate reductase gene C(677)-->T polymorphism on the ischemic stroke development in persons with various risk factors]. [N5, n10 -亚甲基四氢叶酸还原酶基因C(677)—>T多态性对多种危险因素人群缺血性卒中发展的影响分析]。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.1615/INTJPHYSPATHOPHYS.V6.I2.20

V. Harbuzova, O. V. Polonikov, D. O. Stroi, O. Matlai, Iu O Ataman, V. A. Sukharieva, O. Ataman

{"title":"[Analysis of the effect of N5, N10-methylenetetrahydrofolate reductase gene C(677)-->T polymorphism on the ischemic stroke development in persons with various risk factors].","authors":"V. Harbuzova, O. V. Polonikov, D. O. Stroi, O. Matlai, Iu O Ataman, V. A. Sukharieva, O. Ataman","doi":"10.1615/INTJPHYSPATHOPHYS.V6.I2.20","DOIUrl":"https://doi.org/10.1615/INTJPHYSPATHOPHYS.V6.I2.20","url":null,"abstract":"The results ofMTHFR gene C(677)-->T (rs1801133) polymorphism determined in 170 patients with ischemic atherothrombotic stroke (IATS) and 124 healthy subjects (control group) are presented in the paper. It has been shown that in patients with IATS, the frequencies of main homozygotes (CC), heterozygotes (CT) and minor homozygotes (TT) are 52.4, 35.9, 11.8% (in control--46.0, 48.4, 5.6%, P = 0.044 by chi2-test). TT homozygotes have a greater chance of developing IATS than carriers of main C-allele (CT + CC) (OR = 2.3, CI = 0.911-5.449, P = 0.049). In the representatives of the Ukrainian population there is a relationship between the frequency of MTHFR gene C(677)-->T polymorphism genotypes and the risk of IATS. This connection is manifested in male patients, in persons with normal blood pressure, and in people who do not have the habit of smoking. The sex of the patients, body mass index, blood pressure and smoking affect the level of the studied polymorphism association with stroke.","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87203428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[Pathological remodeling of myocardium in spontaneous hypertensive rats with experimental diabetes mellitus: the role of mitochondrial dysfunction]. 【自发性高血压合并实验性糖尿病大鼠心肌病理重构:线粒体功能障碍的作用】。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.1615/INTJPHYSPATHOPHYS.V6.I2.60

Iu M Kolesnyk, M. I. Kolesnyk, A. V. Abramov

引用次数: 1

[The role of mitochondrial uniporter in calcium-homeostasis of the exorbital lacrimal gland secretory cells]. 线粒体单转运蛋白在眶外泪腺分泌细胞钙稳态中的作用。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.05.073

A. Kotliarova, V. M. Merlavs'kyĭ, O. Dorosh, V. V. Man'ko

{"title":"[The role of mitochondrial uniporter in calcium-homeostasis of the exorbital lacrimal gland secretory cells].","authors":"A. Kotliarova, V. M. Merlavs'kyĭ, O. Dorosh, V. V. Man'ko","doi":"10.15407/FZ60.05.073","DOIUrl":"https://doi.org/10.15407/FZ60.05.073","url":null,"abstract":"The role of mitochondrial calcium-uniporter in calcium-homeostasis maintenance and correlations of calcium-uniporter with other calcium-transport systems of the rat exorbital lacrimal gland secretory cells were studied. The experiments were performed on intact and digitonin-permeabilized cells. The interdependence of calcium-uniporter and other calcium-transporting systems functioning was estimated on the basis of additivity of their inhibitors/agonists effects, which was accompanied with a decrease in the Ca2+ content in the gland cells. It was found that in conditions of simultaneously inhibition of sarco endoplasmic reticulum Ca2+-ATPase (SERCA) and mitochondrial calcium-uniporter Ca2+ passively released from different calcium stores, because the effects of these calcium-transport systems inhibitors (thapsigargin and ruthenium red, respectively) were additive. Similarly, the processes of inositol-1,4,5-trisphosphate receptors (IP3Rs) activation and calcium-uniporter inhibition were additive. In contrast, the effects of ryanodine and ruthenium red on the Ca2+ content in cells were significantly non-additive. In addition, ryanodine at concentrations 1-3 μM reduced respiration rate of studied cells in dose-dependent manner, and this effect was persisted at cells preincubation with ruthenium red or tapsigargin. Thus, besides the activation of ryanodine receptors (RyRs) in endoplasmic reticulum, ryanodine inhibits Ca2+ influx to the mitochondrial matrix, that was insensitive to ruthenium red.","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85171666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[The changes of the motor function of the stomach and the colon under the action of the nanocrystalline cerium dioxide]. [纳米二氧化铈作用下胃和结肠运动功能的变化]。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.03.067

O. I. Iefimenko, I. Savchenko, T. Falalieieva, T. Berehova, O. Shcherbakov, V. Ivanov, N. Zholobak, Iu V Maliukin, M. Spivak

引用次数: 0