Fiziolohichnyi zhurnal最新文献_第6页

[The effect of water with modified isotope content on the parameters of free radical oxidation in vivo]. [改性同位素水对体内自由基氧化参数的影响]。

Fiziolohichnyi zhurnal Pub Date : 2014-01-15 DOI: 10.15407/FZ59.06.049

A. Basov, M. Baryshev, S. Dzhimak, I. Bykov, R. Sepiashvili, I. I. Pavliuchenko

引用次数: 2

[Effects of the prenatal hypoxia on the hypothalamic-pituitary-adrenal axis function and working memory in rats]. [产前缺氧对大鼠下丘脑-垂体-肾上腺轴功能及工作记忆的影响]

Fiziolohichnyi zhurnal Pub Date : 2014-01-15 DOI: 10.15407/fz59.06.116

E. I. Tiul'kova, L. Vataeva, T. Glushchenko, S. Pivina

引用次数: 0

[Carcinogenic aspects of indeterministic effects of ionizing radiation]. [电离辐射不确定效应的致癌方面]。

Fiziolohichnyi zhurnal Pub Date : 2014-01-15 DOI: 10.15407/FZ59.06.155

Tkachenko Mm, Liubarets Tf

引用次数: 0

[Hematological effects of the protein kinase inhibitor maleimide derivative in dimethylhydrazin E-induced colorectal carcinogenesis of rats]. [蛋白激酶抑制剂马来酰亚胺衍生物在二甲基肼e诱导的大鼠结直肠癌中的血液学作用]。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.04.040

I. V. Bielins'ka, O. Lynchak, T. V. Rybal'chenko, O. Hurniak

{"title":"[Hematological effects of the protein kinase inhibitor maleimide derivative in dimethylhydrazin E-induced colorectal carcinogenesis of rats].","authors":"I. V. Bielins'ka, O. Lynchak, T. V. Rybal'chenko, O. Hurniak","doi":"10.15407/FZ60.04.040","DOIUrl":"https://doi.org/10.15407/FZ60.04.040","url":null,"abstract":"The effect of the protein kinase inhibitor maleimide derivative (MI-, 1, 1-(4-Cl-benzyl)-3-CI-4-(CF3-phenylamino)- 1H-pyrrole-2,5-dione) on blood cells of rats with 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis has been studied. Administration of MI-I1 at 2.7 mg/kg for 20 weeks on DMH-induced carcinogenesis prevents anemia, which is a consequence of cancer and complicates it. This is confirmed by a reduction in the numberofreticulocytes (0,19(0,15;0,21)x 10(12)/1)and restoration of mean corpuscular hemoglobin (18,02 (17,44;19,03) pg) and mean corpuscular hemoglobin concentration (309,42 (292,38;318,27) g/L) to a control value (0,17 (0,15;0,19), 18,31 (17,95;18,45), 310,78 (306,25;316,18), respectively) in contrast to the group DMH (0,28 (0,24;0,39); 17,50 (17,00;17,96); 288,10 (284,71;303,73), respectively). MI-I normalizes the number of monocytes (1,40 (0,95;2,50)x 10(9)/L) and platelets (646,32 (575,23;700,50)xl10(9)/L) in the blood after 26 weeks ofexperiment; in the DMH group, the values are significantly higher (1,97 (1,52;2,58), 783,90 (687,64;922,27), respectively) as compared to control group (1,23 (0,94; 1,68), 629,34 (590,19;711,48), respectively). MI- 1 reduces the involvement of these cells in the tumors progression and metastasis. Reduction of the monocytosis and thrombocytosis may be mediated by: 1) a decrease in the number and size of tumors and, consequently, the influence of their cytokines on hematopoietic tissue; 2) suppression of proliferation and differentiation of hematopoietic progenitor cells through inhibiting of receptor protein kinases of vascular endothelial and epidermal growth factors and non-receptor PDKI-, Src- and Syk- kinases, that are involved in hematopoiesis and carcinogenesis.","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91226148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

[Evaluating the effectiveness of the antioxidant properties of lipophilic plant products in liposome model test systems in vitro]. [在体外脂质体模型试验系统中评估亲脂性植物产品抗氧化性能的有效性]。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.02.088

I. Bykov, E. E. Esaulenko, R. Sepiashvili, M. A. Khil'chuk

引用次数: 0

Acute L-glutamine deprivation affects the expression of TP53-related protein genes in U87 glioma cells. 急性l -谷氨酰胺剥夺影响U87胶质瘤细胞中tp53相关蛋白基因的表达。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.04.011

D. Minchenko, S. V. Danilovskyi, I. V. Kryvdiuk, N. A. Hlushchak, O. V. Kovalevska, L. L. Karbovskyi, O. Minchenko

{"title":"Acute L-glutamine deprivation affects the expression of TP53-related protein genes in U87 glioma cells.","authors":"D. Minchenko, S. V. Danilovskyi, I. V. Kryvdiuk, N. A. Hlushchak, O. V. Kovalevska, L. L. Karbovskyi, O. Minchenko","doi":"10.15407/FZ60.04.011","DOIUrl":"https://doi.org/10.15407/FZ60.04.011","url":null,"abstract":"We have studied the effect of acute L-glutamine deprivation on the expression oftumor protein 53 (TP53)-related genes such as TOPORS (topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase), TP53BPI (TP53 bindingprotein 1), TP53TG1 (TP53 inducible gene 1), SESN1 (p53 regulatedPA26 nuclear protein), NME6 (NME/NM23 nucleoside diphosphate kinase 6), and ZMAT3 (zinc finger Matrin-type 3) in glioma cells with ERN1 knockdown. It was shown that blockade of ERN1 finction in U87 glioma cells is induced the expression of RYBP and SESN1 genes, but decreased the expression of TP53BP1, TP53TG1, TOPORS, NME6, genes. Moreover, the expression levels ofRYBPI SESN1, TP53BP1, and ZMAT3 genes is increased in control glioma cells by L-glutamine deprivation condition but blockade of ERN1 signaling enzyme function significantly enhances this effect on the expression all of these genes. At the same time, the ERN1 knockdown eliminates the response TP53TG1 and TOPORS genes to L-glutamine deprivation condition. Results of this investigation clearly demonstrate that the expression most of genes encoding TP53-related factors depends upon acute L-glutamine deprivation condition as well as upon ERN1, the major signaling system of the endoplasmic reticulum stress.","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74923976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

[Morphological changes of the vision organ among winterers in Ukrainian Antarctic station "Academician Vernadskiĭ"]. [乌克兰南极站“韦尔纳德斯基院士”冬季候鸟视觉器官的形态学变化]。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.01.070

D. Varyvonchyk, S. Rykov, A. O. Saliukov, A. B. Mishenin, H. I. Pyshnov, Ie V Moĭseienko

{"title":"[Morphological changes of the vision organ among winterers in Ukrainian Antarctic station \"Academician Vernadskiĭ\"].","authors":"D. Varyvonchyk, S. Rykov, A. O. Saliukov, A. B. Mishenin, H. I. Pyshnov, Ie V Moĭseienko","doi":"10.15407/FZ60.01.070","DOIUrl":"https://doi.org/10.15407/FZ60.01.070","url":null,"abstract":"The study revealed that the Antarctic territory in the area of the Ukrainian Antarctic station \"Academician Vernadsky\" can be referred to the zone of the \"super high\", risk in developing ophthalmological pathology, caused by ultraviolet radiation. The results of the comprehensive dynamic study of 24 winterers of the XVI and XVII Ukrainian Antarctic expeditions (2011-2013) showed the developing of specific changes in the organ of vision under the exposure to the excessive natural ultraviolet radiation (UVR), such as parenchymatous-endothelial keratopathy, nuclear-posteriorcapsular phacopathy, maculopathy. Morphological changes were recorded using the cornea densitometry method: a decrease of the central cornea thickness by 14.3%, a decrease of the density and the number of endothelial cells of hexagonal type by 10.1% and 16.6%, respectively (P < 0.05). Using densitometry method, we detected morphological changes in the lens. Specifically, we found an increase of the optic lens density: in median zone by 10.1%, in maximal zone by 21.6%, in posterior part by 13.1%, P < 0.05. The results of densitometry recordings point to the development of local opacity in the posterior lens parts (in the nucleus and in the capsule). The data of the computed quantitative macula perimetry showed a significant decrease of light sensitivity of retina conicalis cells by 6 times (P < 0.05). The morphological signs of the endured acute solar retinopathy were found in more than 50% winterers. The revealed pathological changes can be considered as pre-, subclinical manifestations of the cornea dystrophy, cataracts and maculodystrophy, caused by specific action of the natural UVR, thus demanding the elaboration of the combined preventive measures.","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79103258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

[Effects of decarboxylated L-arginine on morphofunctional characteristics of the erythron in experimental diabetes mellitus in rats]. [脱羧l -精氨酸对实验性糖尿病大鼠红细胞形态功能的影响]。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.04.070

I. Ferents, I. Brodiak, M. Liuta, O. R. Kulachkovs'kyĭ, N. Sybirna

引用次数: 1

[Effect of quercetin on proteasome activity in the aorta and heart tissues of spontaneously hypertensive rats]. 槲皮素对自发性高血压大鼠主动脉及心脏组织蛋白酶体活性的影响

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.03.003

S. V. Honcharov, H. Portnichenko, L. V. Tumanovs'ka, D. O. Pashevin, M. Kuzmenko, O. Moibenko, V. Dosenko

{"title":"[Effect of quercetin on proteasome activity in the aorta and heart tissues of spontaneously hypertensive rats].","authors":"S. V. Honcharov, H. Portnichenko, L. V. Tumanovs'ka, D. O. Pashevin, M. Kuzmenko, O. Moibenko, V. Dosenko","doi":"10.15407/FZ60.03.003","DOIUrl":"https://doi.org/10.15407/FZ60.03.003","url":null,"abstract":"To determine the role of proteasome proteolysis in the pathogenesis of hypertension, we have studied the proteolytic activity of the proteasome in the aorta and heart tissues of rats with spontaneous hypertension (line SHR), and used quercetin, the drug that can inhibit the activity of this multicatalytic complex. In the aorta of SHR, the activities of the proteasome were not significantly different from that observed in Wistar rats. At the same time, in the heart tissues the trypsin-like (at 40%, P > 0.05), and chymotrypsin-like (by 1.7 times, P < 0.03) activities were significantly less in SHR. Significant morphological changes (fibrosis of the left ventricle was 4.7%, aorta intima width was increased and heart weight index was higher by 21.6% (3.7 +/- 0.6 mg/g) compared with Wistar rats (2.9 +/- 0,4 mg/g, P < 0.004) were observed in these animals functional disorders (reduced stroke volume by 3 times (P < 0.0001), ejection fraction by 2.5 times (P < 0.0001), increased end diastolic pressure by 6.5 times (P < 0.005), end systolic pressure by 15% (P < 0.004)) were revealed. Pharmacological drug \"Qvercetin\" effectively inhibited trypsin-like and chymotrypsin-like proteasome activities in the aorta (2.7-fold (P < 0.005) and 2-fold (P < 0.003), correspondingly) and trypsin-like, and peptidyl-glutamyl peptide-hydrolyzing-like activities (2.4-fold, P > 0.05 and 9.3-fold, P < 0.02, correspondingly) activities in the heart, leading to a significant improvement of morphological and functional parameters of the heart. Whereas the drug \"Qvercetin\" that is widely used in clinical practice (especially in therapy of acute myocardial infarction) it could be recommended for the use in prevention of cardiac remodeling with high level of blood pressure.","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91193838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Experimental correction of metabolic changes in mouth at long-term hypoacidity by multiprobiotic "Symbiter acidophilic". 复合益生菌“Symbiter嗜酸菌”对长期低酸性口腔代谢变化的实验校正。

Fiziolohichnyi zhurnal Pub Date : 2014-01-01 DOI: 10.15407/FZ60.05.099

A. Manko, K. Neporada, A. Sukhomlyn, J. Ghasemzadeh, T. Beregova, D. Yankovskiy

引用次数: 2