Fiziolohichnyi zhurnal最新文献_第3页

[MORPHOFUNCTIONAL STATE OF BLOOD CELLS AFTER CHRONIC EXPOSURE OF THE PROTEIN KINASES INHIBITOR MALEIMIDE DERIVATIVE]. [慢性暴露于蛋白激酶抑制剂马来酰亚胺衍生物后血细胞的形态功能状态]。

Fiziolohichnyi zhurnal Pub Date : 2015-01-01 DOI: 10.15407/FZ61.04.071

I. Byelinska, O. Lynchak, S. M. Tsyvinska, V. Rybalchenko

{"title":"[MORPHOFUNCTIONAL STATE OF BLOOD CELLS AFTER CHRONIC EXPOSURE OF THE PROTEIN KINASES INHIBITOR MALEIMIDE DERIVATIVE].","authors":"I. Byelinska, O. Lynchak, S. M. Tsyvinska, V. Rybalchenko","doi":"10.15407/FZ61.04.071","DOIUrl":"https://doi.org/10.15407/FZ61.04.071","url":null,"abstract":"The effect of the protein kinases inhibitor maleimide derivative (MI-1, 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrole-2,5-dione), inhibitor of VEGF-R1,2,3, FGF-R1, EGF-R(h), PDK1, Src(h), Syk(h), YES, ZAP70 et al. with antineoplastic activity, on blood cells parameters of rats after chronic exposure has been studied. Administration of MI-1 at doses 0.027 and 2.7 mg/kg (suppress colon carcinogenesis) for 20 and 26 weeks does not affect the morphofunctional state of red blood cells in healthy rats. This is confirmed by the lack of differences in the concentration of hemoglobin in blood, red blood cells count, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration, hematocrit and mean corpuscular volume, and the number of reticulocytes in blood after 20 and 26 weeks of exposure compared with the control group. MI-1 at indicated doses does not influence total leukocytes count and content (eosinophilic and neutrophilic granulocytes, lymphocytes, monocytes) and does not inhibit thrombocytopoiesis (platelet count remains unchanged). No negative effect of MI-1 on hematopoiesis is not limited (by the hemopoietic system) use of this compound as a potential antitumor drug","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87288636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

[INVESTIGATIONS OF SUBMICROSCOPIC ARCHITECTONICS SERTOLI AND LEYDIG CELLS AFTER HYDROCHLORIDE SEROTONIN DESTRUCTIVE IMPACT AND THE POSSIBILITY OF CORRECTION BY STIMULANTS OF METABOLIC PROCESSES]. [亚显微结构的研究后，盐酸血清素破坏性影响的支持细胞和间质细胞和可能纠正的兴奋剂代谢过程]。

Fiziolohichnyi zhurnal Pub Date : 2015-01-01 DOI: 10.15407/FZ61.04.085

N. Brechka, V. Nevzorov, V. Bondarenko, N. Malova, N. Selyukova

引用次数: 2

[MODELING IN VITRO PATHWAYS OF ACTIVATION OF LIPID PEROXIDATION AND PROTEIN IN CHRONIC KIDNEY DISEASE]. [慢性肾脏疾病中脂质过氧化和蛋白质激活的体外途径建模]。

Fiziolohichnyi zhurnal Pub Date : 2015-01-01 DOI: 10.15407/FZ61.04.092

L. Korol

引用次数: 2

[THE EFFECT OF EXOGENOUS MELATONIN ON BONE REMODELING]. [外源性褪黑素对骨重塑的影响]。

Fiziolohichnyi zhurnal Pub Date : 2015-01-01 DOI: 10.1615/INTJPHYSPATHOPHYS.V7.I2.60

V. Berezovskyĭ, I. G. Litovka, S. Veselskyi, R. Janko, U. A. Zhernoklev

引用次数: 0

[CHANGES IN THE BRAIN TESTOSTERONE METABOLISM AND SEXUAL BEHAVIOR IN MALE RATS PRENATALLY EXPOSED TO METHYLDOPA AND STRESS]. [产前暴露于甲基多巴和压力下的雄性大鼠脑睾酮代谢和性行为的变化]。

Fiziolohichnyi zhurnal Pub Date : 2015-01-01 DOI: 10.1615/INTJPHYSPATHOPHYS.V7.I3.50

A. Reznikov, N. Nosenko, L. Tarasenko, A. Limareva

{"title":"[CHANGES IN THE BRAIN TESTOSTERONE METABOLISM AND SEXUAL BEHAVIOR IN MALE RATS PRENATALLY EXPOSED TO METHYLDOPA AND STRESS].","authors":"A. Reznikov, N. Nosenko, L. Tarasenko, A. Limareva","doi":"10.1615/INTJPHYSPATHOPHYS.V7.I3.50","DOIUrl":"https://doi.org/10.1615/INTJPHYSPATHOPHYS.V7.I3.50","url":null,"abstract":"The changes of aromatase and 5α-reductase activities were studied in preoptic area (POA) and medial basal hypothalamus of 10-days-old and sexual behavior in 3-month-old male offsprings of rats exposed daily to noradrenaline antagonist methyldopa (400 mg/kg per os) 30 minutes prior to 1-hour immobilization during the last week of pregnancy (from 15th to 21st day). Prenatal stress caused aromatase activity lowering in the POA of developing brain and feminization (appearance of lordosis) and demasculinization of sexual behavior (prolongation of latent periods to the first mounting and first intromission as well as of the first ejaculation and postejaculation refractory period) in young male offspring. Oral methyldopa used prior to pregnant females stressing prevented early effect of prenatal stress on aromatase activity in the POA and normalized the male sexual behavior in young male rats by shortening both latent period to the first ejaculation and postejaculation refractory period, and an increase of numbers of ejaculation. The data obtained indicate that brain noradrenergic system plays significant role in the mechanisms of metabolic- and behavioral disturbances developing in male rats exposed to prenatal stress.","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74114233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[PHYSICAL EXERCISE TRAINING CAN- CELS CONSTITUTIVE NOS UNCOUPLING AND INDUCED VIOLATIONS OF CARDIAC HEMODYNAMICS IN HYPERTENSION (PART III)]. [体育锻炼训练可以抑制高血压患者的细胞组成性一氧化氮解偶联并诱导心脏血流动力学紊乱(第三部分)]。

Fiziolohichnyi zhurnal Pub Date : 2015-01-01 DOI: 10.15407/FZ61.04.011

N. Dorofeyeva, A. Kotsuruba, B. S. Kopjak, V. Sagach

{"title":"[PHYSICAL EXERCISE TRAINING CAN- CELS CONSTITUTIVE NOS UNCOUPLING AND INDUCED VIOLATIONS OF CARDIAC HEMODYNAMICS IN HYPERTENSION (PART III)].","authors":"N. Dorofeyeva, A. Kotsuruba, B. S. Kopjak, V. Sagach","doi":"10.15407/FZ61.04.011","DOIUrl":"https://doi.org/10.15407/FZ61.04.011","url":null,"abstract":"In the heart and heart mitochondria spontaneously hypertensive rats investigated the effect of physical exercise training (swimming in a moderate and excessive training mode) on the physiological indicators of cardiac hemodynamics and biochemical parameters that characterize the level of oxidative and nitrosative stress. The index of coupling Ca(2+)-dependent constitutive NO-synthases (cNOS = eNOS + nNOS) and biochemical index of dysfunction were calculated. It turned out that both modes of training is completely restored, and even exceed the reference values in untrained rats Wistar conjugate cNOS state and Ca(2+)-dependent synthesis of nitric oxide (NO). Intensity regime of exercise on the border of functionality have been ineffective for improving the functional state of the cardiovascular system and hypertension can provoke it further. Moderate physical training regime, on the contrary, improves the diastolic function of the heart due to an increase dP/dtmin, reducing end-diastolic pressure and a significant reduction in end-diastolic stiffness. Moderate exercise decreased peripheral resistance and cardiac afterload, as indicated by the decrease in end-systolic pressure and arterial stiffness, which contributed to more efficient and energy-saving of heart work. Improve physiological indicators of cardiac hemodynamics and functional state of the heart in moderate mode of training correlated with changes in both the calculated indices. Moderate mode of training is recommended as a simple physiological preconditioning method for the prevention of cardiac dysfunction, hypertension as a result of state uncoupling cNOS and the resulting excessive generation of superoxide and, conversely, inhibition of Ca(2+)-dependent synthesis of NO.","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87020898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[DETERMINATION OF THE OPTIMAL SAFE MODE OF PHYSICAL ACTIVITY FOR THE MILITARY SERVANTS UNDER CONDITIONS CLOSE TO FIGHTING]. [确定在接近战斗的条件下军人身体活动的最佳安全模式]。

Fiziolohichnyi zhurnal Pub Date : 2015-01-01 DOI: 10.15407/FZ61.06.069

A. Chernozub, Y. Radchenko

引用次数: 2

[EFFECT OF PROPARGYLGLYCINE UPON CARDIOHEMODYNAMICS IN OLD RATS]. 丙基甘氨酸对老年大鼠血流动力学的影响。

Fiziolohichnyi zhurnal Pub Date : 2015-01-01 DOI: 10.15407/FZ61.04.035

K. Drachuk, N. Dorofeyeva, A. Kotsjuruba, V. Sagach

引用次数: 2

[THE EFFECTS OF LYS-PLASMINOGEN ON HUMAN PLATELET SECRETION]. 溶酶型纤溶酶原对人血小板分泌的影响。

Fiziolohichnyi zhurnal Pub Date : 2015-01-01 DOI: 10.15407/FZ61.06.026

A. Tykhomyrov, D. Zhernosekov, Y. M. Roka-Moya, S. I. Diordieva, T. Grinenko

引用次数: 4

[ROLE PHOSPHOINOSITID SIGNALING PATHWAY IN OPIOIDS CONTROL OF P2X3 RECEPTORS IN THE PRIMARY SENSORY NEURONS]. [磷脂苷信号通路在阿片样物质控制初级感觉神经元p2x3受体中的作用]。

Fiziolohichnyi zhurnal Pub Date : 2015-01-01 DOI: 10.15407/FZ61.04.022

V. Kulyk, I. Chizhmakov, T. M. Volkova, O. Maximyuk, O. Krishtal

{"title":"[ROLE PHOSPHOINOSITID SIGNALING PATHWAY IN OPIOIDS CONTROL OF P2X3 RECEPTORS IN THE PRIMARY SENSORY NEURONS].","authors":"V. Kulyk, I. Chizhmakov, T. M. Volkova, O. Maximyuk, O. Krishtal","doi":"10.15407/FZ61.04.022","DOIUrl":"https://doi.org/10.15407/FZ61.04.022","url":null,"abstract":"Homomeric P2X3 receptors expressed in primary nociceptive neurons are crucial elements in the pain signal generation. In turn, opioid system regulates the intensity of this signal in both CNS and PNS. Here we describe the effects of opioids on P2X3 receptors in DRG neurons studied by using patch clamp technique. Activation of G-protein coupled opioid receptors by endogenous opioid Leu-enkephalin (Leu), resulted in the two opposite effects on P2X3 receptor-mediated currents (P2X3 currents). In particular, application of 1 µM Leu lead to the complete inhibition of P2X3 currents. However, after pretreatment of the neurons with a Gi/o-protein inhibitor pertussis toxin (PT), the same concentration of Leu caused facilitation of P2X3 currents. PLC inhibitor U-73122 at concentration of 1 µM completely eliminated both facilitating and inhibitory effects of Leu on P2X3 currents. Thus, opioid receptor agonists cause two oppositely directed effects on P2X3 receptors in DRG neurons of rats and both of them are mediated through PLC signaling pathway. Our results point to a possible molecular basis of the mechanism for the well-known transition inhibitory action of opioids (analgesia) to facilitating (hyperalgesia).","PeriodicalId":12306,"journal":{"name":"Fiziolohichnyi zhurnal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79610739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4