[THE EFFECT OF EXOGENOUS MELATONIN ON BONE REMODELING].

Abstract

It was investigated in spring 28-day experiment the administration of pharmacological doses (5 mg/kg) of melatonin to 3-month male rats with high and low levels of energy metabolismat remodeling of bone tissue. It was shown the decrease in activity of osteoblast and increase of osteoclast activity regardless of energy metabolism intensity, increase in concentration of glycosaminoglycans and free amino acids. This indicates the inhibition of physiological bone remodeling and helps to maintain the integrity of the organic matrix and the inorganic component of the fixation of the connective tissue - hydroxyapatite crystals.