Expert Review of Gastroenterology & Hepatology最新文献_第7页

The impact of a multidisciplinary team evaluation on the diagnosis and management of acute and chronic pancreatitis in a tertiary referral center. 多学科团队评估对三级转诊中心急性和慢性胰腺炎诊断和管理的影响。

IF 3.3 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1080/17474124.2026.2629615

Gaetano Lauri, Matteo Tacelli, Gabriele Capurso

{"title":"The impact of a multidisciplinary team evaluation on the diagnosis and management of acute and chronic pancreatitis in a tertiary referral center.","authors":"Gaetano Lauri, Matteo Tacelli, Gabriele Capurso","doi":"10.1080/17474124.2026.2629615","DOIUrl":"10.1080/17474124.2026.2629615","url":null,"abstract":"Background: Multidisciplinary team meetings (MTM) are crucial in benign conditions such as acute pancreatitis (AP) and chronic pancreatitis (CP). Our aim was to evaluate the impact of MTM on the diagnosis and management of AP and CP in a tertiary referral center.Research design and methods: This retrospective study analyzed 232 patients with AP/CP discussed with biweekly MTM (10/2020-06/2024). The patients were classified according to etiology or complication management, recording diagnostic and therapeutic outcomes over six months.Results: Of 536 referred patients, 232 were analyzed (142 AP, 90 CP). In AP subgroup, MTM revised etiology in 34.4% of cases and identified a cause in 45.5% of idiopathic AP. MTM also ensured successful management of AP complications in 100% of cases, including endoscopic or surgical interventions for pseudocysts and walled-off necrosis. In CP, the diagnosis was revised in 38.9%, with a cause identified in 45.5% of idiopathic cases. MTM effectively guided CP complication management, with 55% of cases managed surgically and 10% endoscopically. MTM identified 6 cases of low-grade pancreatic intraepithelial neoplasia and 9 previously undiagnosed pancreatic ductal adenocarcinomas (PDAC) across both cohorts.Conclusions: In high-volume centers, MTM enhance diagnostic accuracy and optimize the tailored management of benign pancreatic diseases.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"191-199"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leucine-rich alpha-2 glycoprotein as a blood biomarker in inflammatory bowel disease: clinical implications and future perspectives. 富亮氨酸α -2糖蛋白作为炎症性肠病的血液生物标志物：临床意义和未来展望

IF 3.3 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2026-02-01 Epub Date: 2026-02-18 DOI: 10.1080/17474124.2026.2628012

Takayuki Yamamoto

{"title":"Leucine-rich alpha-2 glycoprotein as a blood biomarker in inflammatory bowel disease: clinical implications and future perspectives.","authors":"Takayuki Yamamoto","doi":"10.1080/17474124.2026.2628012","DOIUrl":"10.1080/17474124.2026.2628012","url":null,"abstract":"Introduction: Reliable biomarkers for monitoring inflammatory bowel disease (IBD) remain an unmet clinical need, particularly in patients receiving biologic therapies where C-reactive protein (CRP) responses may be attenuated. Leucine-rich alpha-2 glycoprotein (LRG) is a novel acute-phase reactant regulated by multiple cytokines, potentially less dependent on interleukin-6 than CRP.Areas covered: This narrative review synthesizes recent Japanese real-world data and emerging international literature on LRG, outlining its biological characteristics, early clinical applications, and evidence in ulcerative colitis and Crohn's disease. Key topics include correlations with clinical, endoscopic, and histologic activity; proposed cutoff values; comparisons with conventional biomarkers; diagnostic performance in small bowel disease; and its role in therapeutic monitoring, including postoperative assessment.Expert opinion: LRG shows strong correlations with mucosal and transmural inflammation across IBD phenotypes, retains sensitivity in biologic-treated patients or those with normal CRP, and predicts treatment response. Its rapid turnaround and noninvasive nature make it well suited to treat-to-target strategies. However, most evidence originates from Japan, limiting generalizability until confirmed in large, multicenter international cohorts. Broader adoption will require assay standardization, validation across diverse populations, and integration into composite indices to optimize individualized care. If validated globally, LRG could transform precision monitoring and enhance outcomes in clinical practice.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"147-156"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and use of IBD therapies during pregnancy and lactation. 妊娠和哺乳期IBD治疗的安全性和使用。

IF 3.3 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2026-02-01 Epub Date: 2026-01-13 DOI: 10.1080/17474124.2026.2615447

L G Rabinowitz, A Gade, T Deyhim, J D Feuerstein

{"title":"Safety and use of IBD therapies during pregnancy and lactation.","authors":"L G Rabinowitz, A Gade, T Deyhim, J D Feuerstein","doi":"10.1080/17474124.2026.2615447","DOIUrl":"10.1080/17474124.2026.2615447","url":null,"abstract":"Introduction: Inflammatory bowel disease (IBD) commonly affects young women and frequently overlaps with peak reproductive years. Despite this overlap, there remains limited data on the safety and efficacy of IBD treatments during pregnancy and lactation, and many gastroenterology trainees report limited exposure to managing pregnant patients with IBD. Optimal management of IBD in pregnancy ideally starts before conception, with a goal of at least 3 months of steroid-free remission. The preconception period is critical for patient education and therapeutic optimization for patients with IBD. Optimized management during pregnancy and lactation is necessary to prevent adverse maternal and fetal outcomes.Areas covered: In this review, we discuss latest evidence on the safety and efficacy of available IBD therapies during conception, pregnancy, and lactation. Medications discussed include 5-aminosalicylates, biologic therapies, calcineurin inhibitors, Janus kinase inhibitors, corticosteroids, immunomodulators, and sphingosine 1-phosphate receptor modulators.Expert opinion: While most IBD therapies can be safely continued during pregnancy and lactation. Patient education during the preconception period is critical for maintenance of remission during pregnancy and postpartum. Evidence-based research and representation of pregnant patients with IBD in future studies are necessary to address existing knowledge gaps to optimize maternal and neonatal outcomes.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"81-92"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Per-oral endoscopic myotomy (POEM) in achalasia: why length matters. 经口内窥镜下肌切开术治疗贲门失弛缓症：为什么长度很重要。

IF 3.3 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2026-02-01 Epub Date: 2026-02-05 DOI: 10.1080/17474124.2026.2620718

Anthony J Kang, John E Pandolfino, A Aziz Aadam

{"title":"Per-oral endoscopic myotomy (POEM) in achalasia: why length matters.","authors":"Anthony J Kang, John E Pandolfino, A Aziz Aadam","doi":"10.1080/17474124.2026.2620718","DOIUrl":"10.1080/17474124.2026.2620718","url":null,"abstract":"Introduction: Per-oral endoscopic myotomy (POEM) is a minimally-invasive, effective treatment option in patients with non-spastic and spastic achalasia, and is continuously evolving toward a personalized, tailored approach for patients.Areas covered: This article reviews the procedural aspects of POEM, its efficacy in the treatment of non-spastic and spastic achalasia, adverse events, and how it compares to other first-line therapies including pneumatic dilation and laparoscopic Heller myotomy with partial fundoplication. It also describes the evolution of tailored therapy in patients, including short-tailored myotomy in non-spastic achalasia and manometry-directed myotomy in spastic achalasia. This review is based on data from randomized controlled trials, systematic reviews, meta-analyses, and comparative studies from PubMed over the past 20 years, and primarily over the past 5-10 years.Expert opinion: POEM has continuously moved toward personalized medicine, offering tailored therapy to a patient's specific phenotype. Delivering effective therapy while minimizing the major disadvantages of POEM (e.g. gastroesophageal reflux, esophagitis, and blown-out myotomy) would be a milestone in achalasia therapy. A movement toward a short-tailored myotomy in non-spastic achalasia and manometry-directed therapy for spastic achalasia may provide these answers.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"93-105"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of yoga therapy in intestinal disorders. 瑜伽疗法对肠道疾病的影响。

IF 3.3 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2026-02-01 Epub Date: 2026-02-10 DOI: 10.1080/17474124.2026.2628016

Giovanni Santacroce, Alessandra Cocchi, Antonio Di Sabatino

{"title":"Impact of yoga therapy in intestinal disorders.","authors":"Giovanni Santacroce, Alessandra Cocchi, Antonio Di Sabatino","doi":"10.1080/17474124.2026.2628016","DOIUrl":"10.1080/17474124.2026.2628016","url":null,"abstract":"Introduction: Intestinal disorders such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and colorectal cancer (CRC) are rising in prevalence worldwide. Despite medical advances, many patients experience persistent symptoms and impaired quality of life (QoL), highlighting the need for integrative, non-pharmacological approaches.Areas covered: This review explores the physiological and clinical impact of yoga therapy in intestinal disorders, examining its effects on neural, intestinal, and microbial pathways. A structured literature search was conducted in PubMed for studies published from database inception to August 2025, to identify relevant clinical trials and meta-analyses across IBS, IBD, and CRC. Evidence suggests yoga improves symptom control, stress resilience, QoL, and may exert anti-inflammatory and neuromodulatory effects.Expert opinion: Yoga therapy presents a low-risk, potentially cost-effective adjunct to conventional care, with applicability across diverse gastrointestinal conditions. Future integration into clinical practice will depend on overcoming barriers such as protocol variability, lack of clinician awareness, and limited reimbursement. Advancements in biomarker research, digital therapeutics, and personalized treatment models will shape the field. In the next decades, yoga therapy may become a standard, personalized component of integrative care in gastroenterology.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"119-134"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to predict abnormal acid reflux: recent developments. 如何预测异常胃酸反流：最新进展。

IF 3.3 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2026-02-01 Epub Date: 2026-02-09 DOI: 10.1080/17474124.2026.2628950

Yu Kyung Cho, Donghoon Kang, Jae Myung Park

{"title":"How to predict abnormal acid reflux: recent developments.","authors":"Yu Kyung Cho, Donghoon Kang, Jae Myung Park","doi":"10.1080/17474124.2026.2628950","DOIUrl":"10.1080/17474124.2026.2628950","url":null,"abstract":"Introduction: Recent advances in physiology and technology have led to the identification of additional parameters that have the potential to enhance diagnostic accuracy and inform the management of Gastroesophageal reflux disease (GERD). Whilst traditional pH monitoring and acid exposure time (AET) remain central to diagnosis, recent advances have introduced novel physiological markers that improve diagnostic accuracy, especially in cases where results are inconclusive.Areas covered: This review summarizes recent advances in predicting abnormal acid reflux. Novel physiologic indices include baseline impedance as markers of mucosal integrity, and the post-reflux swallow-induced peristaltic wave (PSPW) as a measure of chemical clearance. High resolution esophageal manometry (HRM) provides indirect evidence through EGJ contractile integral (EGJ-CI), multiple rapid swallows, and straight leg raise testing. Finally, artificial intelligence (AI) offers powerful methods to automate reflux event detection, PSPW calculation, and endoscopic classification, reducing interobserver variability and supporting precision diagnosis.Expert opinion: While AET remains central, novel physiologic metrics and AI integration substantially enhance prediction of abnormal acid reflux, particularly in patients with borderline findings. The standardization of thresholds and validation in large multicentre studies is required for the establishment of these tools in clinical practice.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"171-189"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis of reference values of cardiorespiratory fitness and impact of interventions in patients with cirrhosis. 肝硬化患者心肺健康参考值及干预措施影响的meta分析。

IF 3.3 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2026-02-01 Epub Date: 2026-02-03 DOI: 10.1080/17474124.2026.2623009

Alexis Couret, Fabrice Rannou, Bruno Pereira, Martine Duclos, James A King, Sebastien Dharancy, Remi Nevière, Delphine Weil-Verhoeven, Gaël Ennequin, Armand Abergel

{"title":"Meta-analysis of reference values of cardiorespiratory fitness and impact of interventions in patients with cirrhosis.","authors":"Alexis Couret, Fabrice Rannou, Bruno Pereira, Martine Duclos, James A King, Sebastien Dharancy, Remi Nevière, Delphine Weil-Verhoeven, Gaël Ennequin, Armand Abergel","doi":"10.1080/17474124.2026.2623009","DOIUrl":"10.1080/17474124.2026.2623009","url":null,"abstract":"Introduction: Cirrhosis is associated with significant risk of comorbidity and early mortality. Cardiopulmonary exercise testing has the advantage of allowing cardiac, pulmonary and muscle function assessment and could have a better prognosis value than the usual assessment of cardiorespiratory function often evaluated at rest in patients with cirrhosis.Methods: We reviewed electronic databases (PubMed, Scopus, Embase, Google Scholar) for relevant literature running up to April 2024.Results: This review gathers the data from 3029 patients with cirrhosis from 62 studies. Patients with cirrhosis had lower cardiorespiratory fitness (CRF) than age-matched healthy subjects and reference values were meta-analyzed. VO2Peak (mL.min-1.kg-1) and anaerobic threshold (mL.min-1.kg-1) were significantly lower in Child-Pugh C compared to A (p = 0.009) and B (p < 0.001). Supervised exercise proved effective for improving VO2Peak (p < 0.001) before and after transplantation (p < 0.001), but not when conducted in a home-based setting (p = 0.569). Liver transplantation initially (at three months) results in a minor decrease in CRF, but over time (at 12 months) leads to an improvement in CRF.Conclusion: This meta-analysis provides reference values for CRF in patients with cirrhosis and shows the benefits of supervised physical exercise before and after liver transplantation. CRF could help clinicians to prioritize patients on the LT waiting list.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"157-170"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146061065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guideline comparison for fatty liver disease: European (EASL-EASD-EASO) and Asian (APASL) perspectives. 脂肪肝的指南比较：欧洲（EASL-EASD-EASO）和亚洲（APASL）的观点。

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2026-01-01 Epub Date: 2025-12-19 DOI: 10.1080/17474124.2025.2607008

Ludovico Abenavoli

{"title":"Guideline comparison for fatty liver disease: European (EASL-EASD-EASO) and Asian (APASL) perspectives.","authors":"Ludovico Abenavoli","doi":"10.1080/17474124.2025.2607008","DOIUrl":"10.1080/17474124.2025.2607008","url":null,"abstract":"Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) represent an increasing global health challenge for modern medicine. Europe and Asia have responded with region-specific guidelines -respectively, European Association for the Study of the Liver (EASL)-European Association for the Study of Diabetes (EASD)-European Association for the Study of Obesity (EASO) for MASLD and Asian Pacific Association for the Study of the Liver (APASL) for MAFLD- that reflect different epidemiology, clinical priorities and healthcare systems.Areas covered: We compare the two guidelines on the basis of three main points: 1) definitions and diagnostic strategies, 2) treatment and in particular lifestyle and pharmacological options, and 3) surveillance approaches.Expert opinion: Both guidelines agree on the central role of lifestyle management and early diagnosis. However, there are several differences in diagnosis, pharmacotherapy, and surveillance. The European approach supports targeted fibrosis assessment using fibrosis-4 and transient elastography. On the other hand, the Asian-Pacific framework provides broader coverage, including special populations. What our analysis suggests is a harmonization, to be reached via global consensus, that balances precision medicine with inclusivity and that supports collaborative, cross-regional research that focuses on closing the gaps of current knowledge.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"5-9"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional imaging: a game changer for biomarker discovery and treatment response among patients with hepatocellular carcinoma. 功能成像：肝细胞癌患者生物标志物发现和治疗反应的游戏规则改变者

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2026-01-01 Epub Date: 2025-12-25 DOI: 10.1080/17474124.2025.2607569

Shadi Afyouni, Ghazal Zandieh, Timothy M Pawlik, Ihab R Kamel

{"title":"Functional imaging: a game changer for biomarker discovery and treatment response among patients with hepatocellular carcinoma.","authors":"Shadi Afyouni, Ghazal Zandieh, Timothy M Pawlik, Ihab R Kamel","doi":"10.1080/17474124.2025.2607569","DOIUrl":"10.1080/17474124.2025.2607569","url":null,"abstract":"Introduction: Liver cancer, particularly hepatocellular carcinoma (HCC), is a leading cause of cancer-related mortality worldwide. Traditional imaging techniques including CT and MRI provide valuable anatomical data but often overlook the liver's functional heterogeneity, which is crucial for accurate diagnosis and personalized treatment.Areas covered: This review explores advancements in functional imaging modalities, including contrast-enhanced ultrasound (CEUS), diffusion-weighted imaging (DWI), dynamic contrast-enhanced MRI (DCE-MRI), and PET/CT, which provide detailed insights into tumor biology and treatment response in HCC. CEUS enables real-time assessment of hepatic microvascular perfusion with excellent temporal resolution and without ionizing radiation. DCE-MRI and perfusion CT permit time-resolved quantification of perfusion kinetics and vascular permeability, offering surrogate biomarkers of tumor angiogenesis and treatment response. PET/CT, through tracers captures regional variations in metabolism, reflecting tumor viability and functional reserve.Expert opinion: Collectively, these modalities advance precision imaging by linking physiological and metabolic information to morphologic findings, thereby improving diagnostic accuracy, risk stratification, and therapy monitoring in hepatocellular carcinoma.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"29-38"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathology and characteristics of colorectal polyps in a Sub-Saharan setting-implications for local colon cancer screening. 撒哈拉以南地区结直肠息肉的组织病理学和特征——对当地结肠癌筛查的意义。

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2026-01-01 Epub Date: 2025-12-09 DOI: 10.1080/17474124.2025.2600379

Amoako Duah, Dominic Amakye, Paddy Ssentongo, Kofi Clarke

{"title":"Histopathology and characteristics of colorectal polyps in a Sub-Saharan setting-implications for local colon cancer screening.","authors":"Amoako Duah, Dominic Amakye, Paddy Ssentongo, Kofi Clarke","doi":"10.1080/17474124.2025.2600379","DOIUrl":"10.1080/17474124.2025.2600379","url":null,"abstract":"Background: Colorectal cancer (CRC) is a leading cause of global cancer-related mortality and morbidity, with rising incidence in Sub-Saharan African countries over the past decade. This study aims to determine the prevalence, and describe location, as well as histopathology of polyps in patients undergoing colonoscopy in Ghana. The prevalence and polyp characteristics provide additional data and have implications for developing locally relevant screening guidelines.Research design and methods: Retrospective chart review of patients ≥18 years who completed a colonoscopy at the anonymized from 1 January 2021 to 31 December 2023.Results: 510 patients were included in the analysis. The mean age was 54.8 (±0.7 SD); 62% were males. Abnormal findings included hemorrhoids (47.1%), polyps (30.0%), diverticular disease (10.2%), and colonic mass (2.4%). Overall adenoma detection rate (ADR) was 26.1%. Histopathology showed 30.8% tubular adenoma, 30.1% hyperplastic polyps, and 16.0% tubulovillous adenoma. The highest burden of polyps was in the 60- to 80-year-old age group. The prevalence of CRC was 2.2% in our study.Conclusions: CRC prevalence rates remain relatively low in Sub-Saharan Africa. Access to screening is limited, and the numbers may be underestimated. A cost-effective screening strategy to improve early detection and outcomes is needed.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"57-62"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145700117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0