Expert Review of Gastroenterology & Hepatology最新文献_第2页

Advancements in the prevention and management of postoperative Crohn's disease recurrence. 克罗恩病术后复发的预防和治疗进展。

IF 3.8 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-06-05 DOI: 10.1080/17474124.2025.2514721

Shravya R Pothula, Miguel Regueiro, Benjamin H Click

{"title":"Advancements in the prevention and management of postoperative Crohn's disease recurrence.","authors":"Shravya R Pothula, Miguel Regueiro, Benjamin H Click","doi":"10.1080/17474124.2025.2514721","DOIUrl":"https://doi.org/10.1080/17474124.2025.2514721","url":null,"abstract":"Introduction: Postoperative recurrence of Crohn's disease after surgery remains common. The aim of this article is to present a comprehensive review of recent advancements in postoperative prognostication, surveillance, and the therapeutic prophylaxis.Areas covered: Reduction in postoperative recurrence risk is a multifactorial process requiring risk stratification, prophylactic therapeutics, and postoperative monitoring. Recent studies have explored the clinical utility of risk stratification paradigms. There are many ongoing trials including SOPRANO-CD which aims to evaluate and compare postoperative medical prophylaxis to endoscopy-driven management and POMEROL to determine optimal management strategy for moderate endoscopic disease activity. Postoperative disease activity monitoring including intestinal ultrasound, fecal calprotectin, and cross-sectional enterography offer a cost-effective and noninvasive alternative to ileocolonoscopy with new guideline recommendations for fecal calprotectin in the postoperative period. Data is emerging on outcomes between postoperative prophylactic versus endoscopy driven management algorithms. Tissue transcriptomics and serum proteomics provide a noninvasive surrogate measure of disease activity by detecting biomarkers of inflammation.Expert opinion: Through the advancements in risk stratification, monitoring modalities and algorithms, and postoperative therapeutics, there is reduction in the rate of postoperative Crohn's recurrence.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"1-13"},"PeriodicalIF":3.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovations in the diagnosis, treatment, and management of disorders of gut-brain interaction (DGBI). 肠脑相互作用紊乱（DGBI）的诊断、治疗和管理方面的创新。

IF 3.8 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-06-01 Epub Date: 2025-05-21 DOI: 10.1080/17474124.2025.2508967

Patrycja Krynicka, George Koulaouzidis, Wojciech Marlicz, Anastasios Koulaouzidis

{"title":"Innovations in the diagnosis, treatment, and management of disorders of gut-brain interaction (DGBI).","authors":"Patrycja Krynicka, George Koulaouzidis, Wojciech Marlicz, Anastasios Koulaouzidis","doi":"10.1080/17474124.2025.2508967","DOIUrl":"10.1080/17474124.2025.2508967","url":null,"abstract":"Introduction: Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are the most prevalent disorders of gut-brain interaction (DGBI), frequently overlapping and associated with complex pathophysiological mechanisms. Increasing evidence implicates gut microbiota alterations in driving symptoms via immune activation, altered motility, gut vascular barrier and gut-brain axis disruption.Areas covered: This review explores the role of gut microbiota in FD and IBS pathogenesis and symptomatology. A comprehensive literature search was conducted using PubMed, EMBASE, and Google Scholar databases, including studies published between January 2013 and March 2025. Particular focus is given to microbiota-targeted therapies such as prebiotics, probiotics, synbiotics, postbiotics, and fecal microbiota transplantation (FMT). The review also discusses multidimensional treatment strategies combining dietary and lifestyle modification, cognitive-behavioral therapy, and pharmacological neuromodulation. Recent advances in diagnostic methods, including capsule-based microbiota sampling and digital tools for remote psychogastroenterology care, are highlighted.Expert opinion: Despite scientific progress, current DGBI management remains insufficiently personalized. Future approaches should integrate individualized microbiota profiling with targeted interventions and utilize innovative diagnostic and digital health technologies to enhance clinical outcomes in FD and IBS.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"657-670"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From simplicity to precision: the balloon expulsion test in the diagnosis of anorectal disorders. 从简单到精确：气囊排出试验在肛肠疾病诊断中的应用。

IF 3.8 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-06-01 Epub Date: 2025-06-13 DOI: 10.1080/17474124.2025.2513510

Javier Chahuán, Hugo Monrroy, Mauricio Pizarro, José María Remes-Troche

{"title":"From simplicity to precision: the balloon expulsion test in the diagnosis of anorectal disorders.","authors":"Javier Chahuán, Hugo Monrroy, Mauricio Pizarro, José María Remes-Troche","doi":"10.1080/17474124.2025.2513510","DOIUrl":"10.1080/17474124.2025.2513510","url":null,"abstract":"Introduction: Anorectal disorders, such as chronic constipation and fecal incontinence, significantly impact patients' quality of life. Accurate diagnosis is essential for effective treatment, and the balloon expulsion test (BET) has emerged as a simple yet valuable tool in evaluating anorectal function. Despite its simplicity, variations in technique and interpretation have led to ongoing debates regarding its diagnostic precision. To support this review, a PubMed search was conducted using the terms balloon, expulsion, test, evacuation, and disorders, focusing on the most relevant articles published over the past 25 years.Areas covered: This review explores the evolution of the BET, highlighting its role in diagnosing defecatory disorders. It examines various methodologies, standardization efforts, and the test's sensitivity and specificity compared to other diagnostic modalities like anorectal manometry and defecography.Expert opinion: The balloon expulsion test remains a cornerstone in the functional assessment of anorectal disorders due to its simplicity, cost-effectiveness, and accessibility. However, standardized protocols are essential to improve diagnostic accuracy and reproducibility. Future research should focus on refining BET techniques and integrating them with advanced diagnostic tools to enhance patient outcomes and guide personalized treatment strategies.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"685-695"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver transplantation allocation: how can we optimize utilization of organ transplants? 肝移植分配：如何优化器官移植的利用？

IF 3.8 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-06-01 DOI: 10.1080/17474124.2025.2514722

Thomas M Hunold, Neehar D Parikh

引用次数: 0

Characterizing Crohn's disease phenotypes through pan-enteric capsule endoscopy. 通过泛肠胶囊内窥镜观察克罗恩病的表型特征。

IF 3.8 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.1080/17474124.2025.2509800

Luca Scarallo, Giusy Russo, Paolo Lionetti, Salvatore Oliva

引用次数: 0

Reviewing the function of macrophages in liver disease. 巨噬细胞在肝脏疾病中的作用综述。

IF 3.8 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-06-01 Epub Date: 2025-05-21 DOI: 10.1080/17474124.2025.2508963

Lanlan Chen, Adrien Guillot, Frank Tacke

{"title":"Reviewing the function of macrophages in liver disease.","authors":"Lanlan Chen, Adrien Guillot, Frank Tacke","doi":"10.1080/17474124.2025.2508963","DOIUrl":"10.1080/17474124.2025.2508963","url":null,"abstract":"Introduction: The liver is a central metabolic organ, but is also hosting a unique immune microenvironment to sustain homeostasis and proper defense measures against injury threats in healthy individuals. Liver macrophages, mostly represented by the tissue-resident Kupffer cells and bone marrow- or monocyte-derived macrophages, are intricately involved in various aspects of liver homeostasis and disease, including tissue injury, inflammation, fibrogenesis and repair mechanisms.Areas covered: We review recent findings on defining the liver macrophage landscape and their functions in liver diseases with the aim of highlighting potential targets for therapeutic interventions. A comprehensive literature search in PubMed and Google Scholar was conducted to identify relevant literature up to date.Expert opinion: Liver macrophages orchestrate key homeostatic and pathogenic processes in the liver. Thus, targeting liver macrophages represents an attractive strategy for drug development, e.g. to ameliorate liver inflammation, steatohepatitis or fibrosis. However, translation from fundamental research to therapies remains challenging due to the versatile nature of the liver macrophage compartment. Recent and major technical advances such as single-cell and spatially-resolved omics approaches deepened our understanding of macrophage biology at a molecular level. Yet, further studies are needed to identify suitable, etiology- and stage-dependent strategies for the treatment of liver diseases.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"621-637"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The serrated pathway and colorectal cancer: what the gastroenterologist should know. 锯齿状通路与结直肠癌：胃肠病学家应该知道的。

IF 3.8 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1080/17474124.2025.2509797

Rachael Hagen, Amitabh Srivastava, Joseph C Anderson

{"title":"The serrated pathway and colorectal cancer: what the gastroenterologist should know.","authors":"Rachael Hagen, Amitabh Srivastava, Joseph C Anderson","doi":"10.1080/17474124.2025.2509797","DOIUrl":"10.1080/17474124.2025.2509797","url":null,"abstract":"Introduction: Serrated polyps can progress to colorectal cancer (CRC), through a pathway that is distinct from the conventional adenoma-carcinoma sequence. This pathway includes hyperplastic polyps (HPs), sessile serrated polyps (SSPs), and traditional serrated adenomas (TSAs).Areas covered: Our review includes the histology and pathological challenges, carcinogenesis, risk factors, detection, emerging technologies, resection, and surveillance.Expert opinion: Serrated polyp management presents many detection, diagnosis, resection, and surveillance challenges. Missed serrated polyps contribute to preventable CRCs. A new SSP detection rate benchmark will guide endoscopists with a goal when improving detection. Furthermore, new SSP-specific surveillance strategies may also aid in reducing CRC burden. Histologic differentiation remains a challenge, underscoring the need for standardized pathology practices and exploring novel ways to stratify risk independent of histology, given interobserver variation. Moreover, the clinical significance of proximal HPs requires further clarification. Which HPs < 1 cm require closer surveillance intervals? Molecular profiling may help identify markers that separate proximal low risk from high-risk HP. The best approach for resection of serrated polyps also needs to be clarified. There is also a lack of robust longitudinal outcome data to guide surveillance recommendations since current guidelines are based on low quality of evidence.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"593-606"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A narrative literature review of the incidence and prevalence of safety outcomes in patients with ulcerative colitis. 溃疡性结肠炎患者安全性结局的发生率和患病率的叙述性文献综述。

IF 3.8 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-06-01 Epub Date: 2025-05-13 DOI: 10.1080/17474124.2025.2501224

Milena Gianfrancesco, Abiola Awofeso, Diogo Branquinho, Xiang Guo, Aoibhinn McDonnell, Wilco Jacobs, Miguel Regueiro

{"title":"A narrative literature review of the incidence and prevalence of safety outcomes in patients with ulcerative colitis.","authors":"Milena Gianfrancesco, Abiola Awofeso, Diogo Branquinho, Xiang Guo, Aoibhinn McDonnell, Wilco Jacobs, Miguel Regueiro","doi":"10.1080/17474124.2025.2501224","DOIUrl":"10.1080/17474124.2025.2501224","url":null,"abstract":"Introduction: Information on rates of safety outcomes in patients with ulcerative colitis [UC] is helpful to better understand the benefit-risk profile of more recent therapies approved for UC.Areas covered: This narrative review provides an updated examination of the incidence and prevalence of safety outcomes in the UC patient population. Incidence and prevalence estimates were determined for outcomes including cardiac conduction disorders, infections, and malignancies from published literature [2013-2023].Expert opinion: While information for certain outcomes was more frequently recorded, such as herpes viral infection (incidence rate [IR] 0.0-4.47 per 100 person-years [PY]) and malignancies [all; IR 0.0-1.77 per 100 PY], rarer outcome estimates such as bradycardia [IR 0.2 per 100 PY] and macular edema [IR 0.2 per 100 PY] were limited. Our knowledge of certain, uncommon safety outcomes and concomitant medical conditions in the UC population remains limited given the lack of data available. Even though larger cohorts with longer follow-up are warranted, estimates provided in this review will contribute to an improved understanding of the safety profile of UC therapies.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"639-656"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of inflammatory bowel disease: a holistic approach beyond pharmacotherapy. 炎症性肠病的管理：超越药物治疗的整体方法。

IF 3.8 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-06-01 Epub Date: 2025-05-20 DOI: 10.1080/17474124.2025.2508970

Najwa F Mourad, Jana G Hashash, Viraj C Kariyawasam, Fadi H Mourad

{"title":"Management of inflammatory bowel disease: a holistic approach beyond pharmacotherapy.","authors":"Najwa F Mourad, Jana G Hashash, Viraj C Kariyawasam, Fadi H Mourad","doi":"10.1080/17474124.2025.2508970","DOIUrl":"10.1080/17474124.2025.2508970","url":null,"abstract":"Introduction: Inflammatory bowel diseases (IBD) management extends beyond pharmacotherapy, incorporating psychosocial support, patient education, physical activity, and dietary strategies. These components are often overlooked despite their impact on quality of life (QoL) and treatment adherence. This review explores the role of non-pharmacological strategies in optimizing IBD care.Areas covered: This article examines the significance of patient-physician communication, disease-specific education, mental health support, exercise, and diet in IBD management. A strong patient-physician relationship fosters trust and adherence to treatment. Knowledge empowers patients, improving long-term control. Psychosocial challenges, including anxiety, depression, and fatigue, further complicate disease management, highlighting the need for timely interventions. Physical activity and dietary interventions play essential roles in reducing sarcopenia and malnutrition, though standardized guidelines are lacking. Literature was reviewed to assess their effectiveness and clinical integration.Expert opinion: Holistic, multidisciplinary care should be standard in IBD management. Education, mental health screening, and structured diet and exercise plans must be integrated into routine care. Medical training should emphasize communication skills and patient-centered strategies. Future research should establish evidence-based guidelines for implementing these approaches effectively, ensuring improved long-term outcomes for IBD patients.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"671-683"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The clinical implications of trial endpoints in immunotherapy for hepatocellular carcinoma. 肝细胞癌免疫治疗试验终点的临床意义

IF 3.8 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-06-01 Epub Date: 2025-05-12 DOI: 10.1080/17474124.2025.2500369

Xun Zhao, Talia Dufault, Gonzalo Sapisochin, Anna Saborowski, Arndt Vogel

{"title":"The clinical implications of trial endpoints in immunotherapy for hepatocellular carcinoma.","authors":"Xun Zhao, Talia Dufault, Gonzalo Sapisochin, Anna Saborowski, Arndt Vogel","doi":"10.1080/17474124.2025.2500369","DOIUrl":"10.1080/17474124.2025.2500369","url":null,"abstract":"Introduction: Investigative work in the treatment of hepatocellular carcinoma is rapidly growing with the advent of immunotherapy. Nonetheless, trial endpoints and, more importantly, clinically meaningful endpoints need to be accurately chosen depending on the phase of trial and the patient population studied. We provide a scoping review focusing on trial endpoints on the use of immunotherapy in hepatocellular carcinoma.Areas covered: We searched PubMed and Google Scholar for prospective phase II and III trials using immunotherapy, whether in the neoadjuvant, adjuvant, bridging, downstaging, or palliative settings, while discussing the clinical implications of trial endpoints.Expert opinion: The field of immune oncology is rapidly progressing and has become the standard of care in advanced hepatocellular carcinoma. However, the role of immunotherapy in the treatment of early and intermediate stage hepatocellular carcinoma is yet to be defined. Prospective trials for all stages of disease must strive for endpoints that are not only statistically significant but also clinically consequential. Whereas overall response rate may be a reasonable trial endpoint in phase II trials, phase III trials should rather aim for the improvement of overall survival or quality of life to have clinically meaningful impacts.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"607-619"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0