Reviewing the function of macrophages in liver disease.

IF 3.8 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Lanlan Chen, Adrien Guillot, Frank Tacke
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引用次数: 0

Abstract

Introduction: The liver is a central metabolic organ, but is also hosting a unique immune microenvironment to sustain homeostasis and proper defense measures against injury threats in healthy individuals. Liver macrophages, mostly represented by the tissue-resident Kupffer cells and bone marrow- or monocyte-derived macrophages, are intricately involved in various aspects of liver homeostasis and disease, including tissue injury, inflammation, fibrogenesis and repair mechanisms.

Areas covered: We review recent findings on defining the liver macrophage landscape and their functions in liver diseases with the aim of highlighting potential targets for therapeutic interventions. A comprehensive literature search in PubMed and Google Scholar was conducted to identify relevant literature up to date.

Expert opinion: Liver macrophages orchestrate key homeostatic and pathogenic processes in the liver. Thus, targeting liver macrophages represents an attractive strategy for drug development, e.g. to ameliorate liver inflammation, steatohepatitis or fibrosis. However, translation from fundamental research to therapies remains challenging due to the versatile nature of the liver macrophage compartment. Recent and major technical advances such as single-cell and spatially-resolved omics approaches deepened our understanding of macrophage biology at a molecular level. Yet, further studies are needed to identify suitable, etiology- and stage-dependent strategies for the treatment of liver diseases.

巨噬细胞在肝脏疾病中的作用综述。
简介:肝脏是一个中心代谢器官,但也承载着一个独特的免疫微环境,以维持体内平衡,并对健康个体的伤害威胁采取适当的防御措施。肝巨噬细胞主要以组织内的库普弗细胞和骨髓或单核细胞来源的巨噬细胞为代表,它们复杂地参与肝脏稳态和疾病的各个方面,包括组织损伤、炎症、纤维化和修复机制。涵盖领域:我们回顾了肝脏巨噬细胞景观及其在肝脏疾病中的功能的最新发现,旨在突出治疗干预的潜在靶点。在PubMed和b谷歌Scholar中进行了全面的文献检索,以确定最新的相关文献。专家意见:肝巨噬细胞在肝脏中协调关键的稳态和致病过程。因此,靶向肝巨噬细胞代表了一种有吸引力的药物开发策略,例如改善肝脏炎症,脂肪性肝炎或纤维化。然而,由于肝巨噬细胞室的多功能性,从基础研究到治疗的转化仍然具有挑战性。最近的重大技术进步,如单细胞和空间分辨组学方法,加深了我们在分子水平上对巨噬细胞生物学的理解。然而,需要进一步的研究来确定适合的、病因和阶段依赖的肝病治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Expert Review of Gastroenterology & Hepatology
Expert Review of Gastroenterology & Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
6.80
自引率
2.60%
发文量
86
审稿时长
6-12 weeks
期刊介绍: The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology.
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