European Surgery最新文献

{"title":"Surgery positively translates the fruits of your mind","authors":"Martin Riegler","doi":"10.1007/s10353-023-00824-9","DOIUrl":"https://doi.org/10.1007/s10353-023-00824-9","url":null,"abstract":"","PeriodicalId":12253,"journal":{"name":"European Surgery","volume":"116 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of custom-made endograft simulation techniques: physical prototypes versus numerical simulations","authors":"Fadi Taher, Miriam Kliewer, Jean-Noel Albertini, Joris Vermunt, Raphael Doustaly, Corinna Walter, Markus Plimon, Jürgen Falkensammer, Herbert Langenberger, Afshin Assadian","doi":"10.1007/s10353-023-00819-6","DOIUrl":"https://doi.org/10.1007/s10353-023-00819-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>The technical success of fenestrated endovascular aortic repair (FEVAR) relies on the exact fit of the custom-made endograft in the patient. Numerical simulation software has been made available (PLANOP™, PrediSurge) to digitally test the intended endograft design.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The distance between opposite peaks of the proximal endograft sealing ring were measured on computed tomography (CT) scans of the test implantation within a 3D printed model, on numerical simulation software, and on postoperative CT (reference). Two types of modeling were used for the aorta in the numerical simulation software: rigid and deformable. This resulted in four measurements: (1) CT scan of the physical endograft prototype implanted in a rigid printed silicone model of the aorta, (2) rigid numerical or finite element (FE) simulation of the endograft implanted in a rigid aortic model, (3) numerical or FE simulation with a deformable virtual aortic model, and (4) patient postoperative CT.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Ten patients were included in the study. The mean distance between peaks was 26.8 mm in the postoperative CT scan (reference). The distance in the rigid printed model was 23.8 ± 2.0 mm <i>p</i> &lt; 0.003). The FE analysis with rigid aorta measured 23.8 ± 1.5 mm (<i>p</i> &lt; 0.006). Measurements performed on CT of the physical prototype test implanted in the printed silicone model of the aorta, and measurements from FE analysis with rigid modeling, were not significantly different. Measurements in a simulated deformable aorta were 27.4 ± 2.1 mm (<i>p </i> &lt; 0.521). A high correlation (<i>r</i> = 0.81, <i>p</i> &lt; 0.01) was found between measurements on postoperative CT and deformable aorta FE analysis.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Numerical simulation with a rigid aorta may be a suitable substitute for traditional test implantation of a non-sterile prototype within a 3D aortic model. This may help reduce time for graft planning and fabrication. The FE analysis with a deformable aorta was able to predict peak-to-peak distances at the proximal sealing ring more reliably. The effect on clinical outcomes and endoleak occurrence remains to be elucidated in future trials.</p>","PeriodicalId":12253,"journal":{"name":"European Surgery","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138567049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-139-5p mediates TGIF1 to regulate the TGFβ pathway and inhibit growth of esophageal squamous cell carcinoma cells","authors":"Xiaowu Fan","doi":"10.1007/s10353-023-00818-7","DOIUrl":"https://doi.org/10.1007/s10353-023-00818-7","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Esophageal squamous cell carcinoma (ESCC) is the most prevalent histological subtype of esophageal cancer. miR-139-5p has been shown to have abnormal expression in ESCC. We intend to probe into the roles of miR-139-5p in ESCC, thus providing references for investigating underlying therapeutic targets.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>miR-139-5p expression in esophageal carcinoma was predicted by the Starbase online website. miR-139-5p expression in human ESCC cell lines (KYSE-150, KYSE-410, KSE-30) and human esophageal epithelial cell line Het1A was determined by reverse transcription quantitative polymerase chain reaction (RT-qPCR). KYSE-150 cells were manipulated with miR-139-5p mimic to upregulate miR-139-5p. Cell colony formation, viability, apoptosis, migration, and invasion were assessed by colony formation assay, CCK‑8, flow cytometry, wound healing test, and Transwell. The targeted binding between miR-139-5p and TGIF1 was predicted on Starbase, Targetscan, and miRDB online websites and verified by Dual-Luciferase assay. Cells were transfected with miR-139-5p mimic and pcDNA3.1 TGIF1. The phosphorylation levels of TGFβ pathway-related proteins Smad2 and Smad3 were assessed by RT-qPCR and western blot.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>miR-139-5p was underexpressed in ESCC cells. miR-139-5p overexpression reduced ESCC cell viability, migration, and invasion, and promoted apoptosis. TGIF1 overexpression averted miR-139-5p mimic-inhibited ESCC cell growth. miR-139-5p overexpression decreased the phosphorylation levels of TGFβ pathway-related proteins Smad2 and Smad3, while the phosphorylation levels were increased by additional TGIF1 vector transfection.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>miR-139-5p mediates TGIF1 to regulate TGFβ pathway and inhibit ESCC cell growth.</p>","PeriodicalId":12253,"journal":{"name":"European Surgery","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138505963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"17th European Colorectal Congress – ECC, St.Gallen","authors":"","doi":"10.1007/s10353-023-00815-w","DOIUrl":"https://doi.org/10.1007/s10353-023-00815-w","url":null,"abstract":"","PeriodicalId":12253,"journal":{"name":"European Surgery","volume":" 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135241810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bariatrisch-metabolische Operationstechniken","authors":"Aline-Louise Schäfer, Heinz Wykypiel","doi":"10.1007/s10353-023-00811-0","DOIUrl":"https://doi.org/10.1007/s10353-023-00811-0","url":null,"abstract":"Zusammenfassung Bariatrisch-metabolische Operationen gelten als die effektivste Therapiemöglichkeit der morbiden Adipositas. In Langzeitstudien konnten sehr gute Erfolge bei der Reduktion des Übergewichts und bei der Behandlung Adipositas-assoziierter Komorbiditäten (u. a. arterielle Hypertonie, Diabetes mellitus Typ 2) gezeigt werden. Die bariatrischen Operationstechniken beruhen auf dem Wirkungsprinzip der Restriktion und Malabsorption. Die damit verbundenen metabolischen Effekte, die z. T. unabhängig vom Gewichtsverlust und der Kalorienreduktion schon früh postoperativ einsetzen, werden derzeit intensiv beforscht. Die am häufigsten angewandten restriktiven Verfahren sind Schlauchmagen, Magenband, Magenfaltung und Magenballon. Beim Magenbypass, der biliopankreatischen Diversion (mit und ohne duodenalem Switch) und dem „single anastomosis duodenal-ileal-bypass“ mit Sleeve werden die Wirkprinzipien kombiniert. Die Eingriffe werden üblicherweise laparoskopisch durchgeführt und haben akzeptable Komplikationsraten. Postoperativ sind lebenslange Stoffwechselkontrollen und Substitution mit Vitaminen und Spurenelementen (insbesondere bei malabsorptiven Verfahren) erforderlich, um einer Malnutrition vorzubeugen.","PeriodicalId":12253,"journal":{"name":"European Surgery","volume":"57 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136102696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive approaches in pancreatic cancer surgery","authors":"Steffen Deichmann, Ulrich Wellner, Louisa Bolm, Kim Honselmann, Rüdiger Braun, Thaer Abdalla, Tobias Keck","doi":"10.1007/s10353-023-00812-z","DOIUrl":"https://doi.org/10.1007/s10353-023-00812-z","url":null,"abstract":"Summary This literature review reflects the present evidence on minimally invasive pancreatic surgery, differentiating between distal pancreatic resection and pancreatoduodenectomy for pancreatic cancer. The review analyzed studies comparing minimally invasive and open pancreatic surgery in PubMed, the Cochrane Library, and the WHO Trial Register according to the following MeSH search strategy: MeSH items: pancreatic surgery, minimally invasive surgery, robotic surgery, laparoscopic surgery, pancreatoduodenectomy, and distal pancreatic resection. In systematic reviews and meta-analysis, minimally invasive distal pancreatectomy (MI-DP) has been shown to result in shorter hospital stays, less blood loss, and better quality of life than open distal resection (ODP) with similar morbidity and mortality. Meta-analyses have suggested similar oncological outcomes between the two approaches. Minimally invasive pancreatoduodenectomy (MI-PD) has been shown to offer advantages over open surgery, including shorter length of stay and less blood loss, by expert surgeons in several studies. However, these studies also reported longer operative times. As the procedure is technically demanding, only highly experienced pancreatic surgeons have performed MI-PD in most studies, so far limiting widespread recommendations. In addition, selection of cases for minimally invasive operations might currently influence the results. Registry studies from dedicated groups such as the European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS) and randomized controlled trials currently recruiting (DIPLOMA‑1 and 2, DISPACT-2) will bring more reliable data in the coming years. In conclusion, both MI-DP and MI-PD have shown some advantages over open surgery in terms of shorter hospital stays and reduced blood loss, but their effectiveness in terms of oncological outcomes is uncertain due to limited evidence. The study highlights the need for further randomized controlled trials with larger sample sizes and registry studies to further evaluate the safety, efficacy, and oncological outcomes of minimally invasive pancreatic resections.","PeriodicalId":12253,"journal":{"name":"European Surgery","volume":"921 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134975806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized treatment in localized pancreatic cancer","authors":"John P. Neoptolemos, Kai Hu, Peter Bailey, Christoph Springfeld, Baobao Cai, Yi Miao, Christoph Michalski, Carlos Carvalho, Thilo Hackert, Markus W. Büchler","doi":"10.1007/s10353-023-00814-x","DOIUrl":"https://doi.org/10.1007/s10353-023-00814-x","url":null,"abstract":"Summary The treatment elements used for pancreatic ductal adenocarcinoma (PDAC) include surgical resection, systemic cytotoxic agents, and targeted drugs. For second- and third-line therapies in PDAC, approximately 15% of patients have actionable mutations although only 2.5% receive matched targeted treatment but with a significant improvement in survival of around 16 months. For the majority of PDAC patients the current most effective strategy is surgical resection of the primary tumor and systemic combination chemotherapy. The chemotherapy regimens and the order of delivery relative to the resection reference point have been based to a large extent on randomized trials using a newly developed empirical staging (Em) system. Although the reductionist TNM based AJCC and UICC systems work well for pathology staging, they are less accurate and less manageable for treatment decision-making. This Em system defines locally resectable (EmR), borderline resectable (EmBR), and unresectable (EmUR) stages, plus the emerging entity of oligometastatic disease (EmOm). For EmR patients, 6 months of adjuvant chemotherapy achieves 5‑year survival rates of 30–50%. In EmBR short-course (2 months) neoadjuvant plus 6‑month adjuvant chemotherapy increases 12-month survival rates to around 77%, compared to 40% for upfront surgery, despite resection rates of 64–85% and 75%, respectively. Longer-course (4 months) neoadjuvant chemotherapy has also been shown to achieve an 18-month overall survival of 67%. In EmUR, induction therapy (3–6 months) may result in resections rates of 20–60% with significantly improved survival rates compared to no resection. For all stages including the polymetastatic (EmPm) setting, patients with good performance status receive combination chemotherapies based on either oxaliplatin (FOLFIRINOX or NALIRIFOX) or gemcitabine (GEM-CAP, or Gem-NabP). Molecular subtypes (Moffitt, Collisson, Bailey, and Cheng-Sen-Yue) are shown to be associated with treatment responses. Transcriptomic signatures have also been developed as classifiers for determining either oxaliplatin- or gemcitabine-based therapies (PurIST, Tiriac, GemPred+, and ESPAC) and are being evaluated in various studies. Most notably the ESPAC transcriptomic signature is being used as the treatment classifier in the experimental arms of the randomized ESPAC6 adjuvant trial in EmR patients and the ESPAC7 induction therapy trial in EmUR patients. Genomic and transcriptomic profiling at baseline and over time is an integral part of ESPAC6/7 to deepen our understanding of tumor plasticity during the course of therapy, identifying the intrinsic (persister cell) and acquired (genetic) tumor plasticity evolving over time and in reaction to different therapies in order to enable a scientific approach to overcoming clonal-resistance clades.","PeriodicalId":12253,"journal":{"name":"European Surgery","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135828493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgery assists cleaning the roots","authors":"M. Riegler","doi":"10.1007/s10353-023-00813-y","DOIUrl":"https://doi.org/10.1007/s10353-023-00813-y","url":null,"abstract":"","PeriodicalId":12253,"journal":{"name":"European Surgery","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135193177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unlikely path: hernia mesh migration","authors":"A. Ferreira, B. Castro, Catarina Ortigosa, Sílvia Costa, B. Pereira, Manuel Oliveira","doi":"10.1007/s10353-023-00807-w","DOIUrl":"https://doi.org/10.1007/s10353-023-00807-w","url":null,"abstract":"","PeriodicalId":12253,"journal":{"name":"European Surgery","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78701208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of conventional right colectomy and complete mesocolic excision technique—case–control analysis of short-term results","authors":"T. Sztipits, P. Mészáros, Z. Dubóczki, D. Wettstein, G. Oláh, Kornel Mezo, B. Budai, T. Mersich","doi":"10.1007/s10353-023-00804-z","DOIUrl":"https://doi.org/10.1007/s10353-023-00804-z","url":null,"abstract":"","PeriodicalId":12253,"journal":{"name":"European Surgery","volume":"60 1","pages":"134 - 141"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73086529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}