Experimental Dermatology最新文献

{"title":"The First Reported Japanese Case of PNPLA1-Nonsyndromic Epidermal Differentiation Disorder (PNPLA1-nEDD) Associated With an Unreported 92-Base-Pair Duplication Variant","authors":"Shiori Kato,&nbsp;Takuya Takeichi,&nbsp;Keisuke Jojima,&nbsp;Maiko Kato,&nbsp;Michiya Omi,&nbsp;Kana Tanahashi,&nbsp;Atsushi Otsuka,&nbsp;Yoshinao Muro,&nbsp;Akio Kihara,&nbsp;Masashi Akiyama","doi":"10.1111/exd.70130","DOIUrl":"https://doi.org/10.1111/exd.70130","url":null,"abstract":"<div>\u0000 \u0000 <p>Autosomal recessive congenital ichthyosis (ARCI) is a rare inherited skin disorder marked by generalised scaling and erythema. Very recently, diseases formerly diagnosed as ichthyosis, including ARCI, have been renamed nonsyndromic epidermal differentiation disorders (nEDDs). Although pathogenic variants in various genes, including <i>PNPLA1</i>, have been identified as causes, regional and ethnic differences exist in their prevalence. <i>PNPLA1</i> encodes a unique transacylase essential for acylceramide synthesis, a critical component of the skin barrier. Here, we describe the first reported Japanese case of a <i>PNPLA1</i>-related nonsyndromic epidermal differentiation disorder (<i>PNPLA1</i>-nEDD) caused by a homozygous 92-base-pair duplication variant (c.36_127dup, p.Leu43Profs*46) in <i>PNPLA1</i>. Lipidomic analysis of the stratum corneum revealed marked reductions in ω-<i>O</i>-acylceramides and protein-bound ceramides, alongside the accumulation of non-acylated ceramides—indicating a failure in acylceramide synthesis. This ceramide profile supports the conclusion that the <i>PNPLA1</i> duplication causes a loss of function. Our findings emphasise the importance of <i>PNPLA1</i> in the genetic screening of nEDD cases in Japan, regardless of clinical subtype, due to the absence of genotype–phenotype correlations and to broad phenotypic variability.</p>\u0000 </div>","PeriodicalId":12243,"journal":{"name":"Experimental Dermatology","volume":"34 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Stress Overactivates IL-23/Th17 Inflammatory Axis and Increases cDC2 in Imiquimod-Induced Psoriasis Models of C57BL/6 Mice","authors":"Jue Tang,&nbsp;Siqi Zhao,&nbsp;Yanqian Su,&nbsp;Huijuan Shi,&nbsp;Xuan Li,&nbsp;Xuan Zhang,&nbsp;Jing Wang,&nbsp;Xinping Jin,&nbsp;Yanling He","doi":"10.1111/exd.70128","DOIUrl":"https://doi.org/10.1111/exd.70128","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Psychological stress often accompanies psoriasis, and both conditions involve an overactive IL-23/Th17 inflammatory axis. However, the mechanism behind the comorbidity of psoriasis and psychological stress remains unclear. This study established a mouse model of comorbid psoriasis and psychological stress to investigate the impact on skin inflammation and the IL-23/Th17 axis. Chronic restraint stress and imiquimod cream were used to induce psychological stress and psoriasis. Behavioural tests included the open-field test and elevated plus maze, while psoriasis severity was assessed using the Psoriasis Severity Index and histopathology. Flow cytometry measured cDC2 populations in the lesion and spleen, and ELISA quantified levels of key inflammatory factors in serum and lesions. Mice with psoriasis alone showed anxiety symptoms, which were significantly exacerbated in the comorbid group. The comorbid group exhibited more severe lesions, with elevated levels of IL-23 and IL-17A in both serum and lesions compared to the psoriasis-only group. The number of CD11c⁺ cDCs in the dermis and the proportion of cDC2s in the lesion and spleen were also significantly higher in the comorbid group. Psychological stress intensifies anxiety symptoms and exacerbates the inflammatory response in the skin and systemic tissues of mice with comorbid psoriasis and psychological stress. This occurs via the overactivation of the IL-23/Th17 inflammatory axis, leading to increased mobilisation of cDC2s and higher levels of inflammatory mediators like IL-23 and IL-17A, thus chronicling inflammation. These findings enhance our understanding of the mechanisms linking psoriasis and psychological disorders, paving the way for identifying potential therapeutic targets.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12243,"journal":{"name":"Experimental Dermatology","volume":"34 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: New Target for Skin Cancer","authors":"Motoki Nakamura,&nbsp;Dai Ogata","doi":"10.1111/exd.70127","DOIUrl":"https://doi.org/10.1111/exd.70127","url":null,"abstract":"<div>\u0000 \u0000 <p>Skin cancer encompasses a diverse spectrum of malignancies with increasing global incidence and persistent clinical challenges. Despite advances in therapies such as immune checkpoint inhibitors and targeted agents, many patients—especially those with rare subtypes or immunologically ‘cold’ tumours—face limited options and poor outcomes. This special issue of Experimental Dermatology, titled ‘New Target for Skin Cancer’, highlights 29 original articles that reflect the evolving landscape of dermatologic oncology. The collection spans six key themes: molecular and genetic mechanisms, tumour microenvironment and immunology, novel diagnostic biomarkers, emerging therapeutic strategies, rare cancer subtypes and technological innovations. Studies presented include identification of small nucleolar RNAs and metabolic pathways as prognostic markers, analysis of tertiary lymphoid structures and the use of spatial omics and artificial intelligence for diagnostic refinement. Promising therapeutic strategies discussed involve antibody-drug conjugates, oncolytic viruses and stromal-targeting agents. Several articles focus on underrepresented cancers such as extramammary Paget's disease and dermatofibrosarcoma protuberans, underscoring the need for more inclusive research. Technological advances such as ex vivo functional drug screening and mobile health platforms are also explored as tools to personalise and expand access to care. Collectively, these contributions illustrate how interdisciplinary integration of molecular biology, immunology, engineering and AI is reshaping both research and clinical practice in skin cancer. This issue serves as both a comprehensive update on current progress and a forward-looking roadmap for future innovations aimed at improving patient outcomes across all skin cancer types.</p>\u0000 </div>","PeriodicalId":12243,"journal":{"name":"Experimental Dermatology","volume":"34 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144299886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive Skin Syndrome in the Chinese Population—A Critical Discussion of Current Knowledge, Clinical Implications and Research Needs","authors":"Thomas Jaenicke,&nbsp;Tao Zhang,&nbsp;Ehrhardt Proksch,&nbsp;Jean Krutmann,&nbsp;Thomas Luger","doi":"10.1111/exd.70124","DOIUrl":"https://doi.org/10.1111/exd.70124","url":null,"abstract":"<p>It has been suggested that East Asians, especially Han Chinese, are more susceptible to developing sensitive skin syndrome (SSS). To address this topic, we have conducted a systematic review of the existing literature about SSS. From this, we conclude that, in comparison to other ethnicities, the prevalence of SSS in the Chinese population is not higher, but that it has sharply increased over the last two decades. We believe that this development might be best explained by increased exposure of the Chinese populace to well-known triggering factors of SSS. The current scientific literature does not provide sufficient direct scientific evidence that Chinese are more susceptible to developing SSS due to the skin's intrinsic properties. We conclude this review article by discussing possible clinical consequences, care protocols and cosmetic and pharmaceutical strategies for individuals with SSS.</p>","PeriodicalId":12243,"journal":{"name":"Experimental Dermatology","volume":"34 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/exd.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Pressing: An Easy and Reliable Method to Induce Acute Hair Greying in Mice and Useful for Studying Canities","authors":"Yoshihiro Kawai,&nbsp;Ichitaro Niibe,&nbsp;Takashi Matsuzaki","doi":"10.1111/exd.70126","DOIUrl":"https://doi.org/10.1111/exd.70126","url":null,"abstract":"<p>Grey hair is a hallmark of aging, and its restoration is a major concern. Using aged mice for studying hair greying has disadvantages, such as individual variability and time requirements. In this study, we developed a simple method to induce acute and less variable hair greying in mice. After induction of the hair cycle anagen in black mice, the dorsal skin was pinched and pressed from both sides using a pair of C-shaped neodymium magnets cushioned with a thin silicone rubber. This pressure was maintained for 8 h. Grey hair was consistently observed on the skin just below the area where the skin press was applied and sporadically inside, but not outside, the area in all treated mice. No obvious differences were observed in hair characteristics (length, thickness, shape, and hair-type ratio) between the induced grey hair and normal black hair, except for a slight delay in hair emergence. The sporadic greying pattern resembled that of age-related hair depigmentation. The grey pattern was stable through three consecutive hair cycles, and melanocyte stem cells were observed in the bulge area of the grey hair, suggesting that the skin press method offers a reliable model for studying the mechanisms and treatment of canities.</p>","PeriodicalId":12243,"journal":{"name":"Experimental Dermatology","volume":"34 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/exd.70126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial Transcriptomics Shows a Distinctive Tumour Microenvironment in the Invasive Versus Premalignant Portion of Early Cutaneous Squamous Cell Carcinoma","authors":"Jeong-An Gim,&nbsp;Chungyeul Kim,&nbsp;Hyun Jyung Oh,&nbsp;Ko Eun Kim,&nbsp;Jiehyun Jeon,&nbsp;Aeree Kim,&nbsp;Yoo Sang Baek","doi":"10.1111/exd.70125","DOIUrl":"https://doi.org/10.1111/exd.70125","url":null,"abstract":"<p>Cutaneous squamous cell carcinoma (SCC) is known for its stepwise progression from healthy skin to premalignant actinic keratosis (AK), followed by a malignant transformation to SCC. Unfortunately, less attention has been paid to changes in gene expression in the tumour microenvironment during this process. We retrospectively selected early-stage cutaneous SCC tissue samples containing both invasive and premalignant portions and conducted a spatial transcriptomic experiment using a NanoString GeoMx Digital Spatial Profiler (DSP). First, we selected invasive and premalignant regions of interest (ROIs) for each tissue. We then compared the gene expression patterns between the two portions (invasive versus premalignant) of the three segments: tumour cells, immune cells and fibroblasts, in each ROI. As a result, early-stage cutaneous SCC tissue samples from 17 patients were selected for this study. We identified 29, 14 and 15 differentially expressed genes (DEGs) between the invasive and premalignant portions of the tumour cells, immune cells and fibroblasts, respectively. The top three genes with the highest absolute log₂ fold-change were <i>CCDC88C</i>, <i>GJD3</i> and <i>COMP</i> in tumour cells; <i>SVEP1</i>, <i>TSLP</i> and <i>PPP2R5C</i> in immune cells; and <i>SPAG6</i>, <i>PPP1CA</i> and <i>CCDC68</i> in fibroblasts. Notably, several genes, such as <i>COMP</i>, <i>SVEP1</i> and <i>SPAG6</i>, have been linked to the development and function of cancer-associated fibroblasts. Functional enrichment analysis revealed that several pathways were altered in tumour and immune cells. In conclusion, distinctive changes in gene expression patterns were observed as AK progressed to SCC.</p>","PeriodicalId":12243,"journal":{"name":"Experimental Dermatology","volume":"34 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/exd.70125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144206651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAK1/2 Inhibitors Alleviate the Damage of Intercellular Adhesion by Reducing Endoplasmic Reticulum Stress-Induced Apoptosis in Pemphigus Vulgaris","authors":"Xi Chen,&nbsp;Mei-Nian Xu,&nbsp;Zheng-Quan Wu,&nbsp;Rong Huang,&nbsp;Hong-Yan Lu,&nbsp;Xiaoming Peng,&nbsp;Kang Zeng,&nbsp;Chang-Xing Li","doi":"10.1111/exd.70121","DOIUrl":"https://doi.org/10.1111/exd.70121","url":null,"abstract":"<div>\u0000 \u0000 <p>Pemphigus vulgaris (PV), a severe autoimmune disease with high morbidity and mortality, necessitates innovative therapies to improve outcomes while minimising the adverse effects of conventional immunosuppressants. Immunohistochemical analysis revealed elevated phosphorylated Janus kinase (p-JAK)1 and p-JAK2 expression in PV lesions, complemented by transcriptome data showing JAK/STAT pathway dysregulation. Using a PV acantholysis model, we demonstrated that Ruxolitinib, a JAK1/2 inhibitor, significantly reduced keratinocyte apoptosis, enhanced cell adhesion, and alleviated endoplasmic reticulum (ER) stress. Additionally, Ruxolitinib mitigated tunicamycin-induced ER stress and apoptosis in HaCaT cells. These findings establish a crucial role for JAK1/2 in PV pathogenesis, demonstrating that their inhibition alleviates ER stress, reduces apoptosis, and improves cell adhesion. Our results provide a theoretical foundation for the clinical application of JAK inhibitors in PV treatment.</p>\u0000 </div>","PeriodicalId":12243,"journal":{"name":"Experimental Dermatology","volume":"34 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nemolizumab Improves Pruritus in Patients With Intrinsic Atopic Dermatitis Lacking Atopic Predisposition: A Single-Centre Pilot Retrospective Cohort Study","authors":"Emi Sato,&nbsp;Hisatomi Arima,&nbsp;Keita Tsutsui,&nbsp;Hiroki Shimizu,&nbsp;Kotaro Ito,&nbsp;Mayuko Iwata,&nbsp;Shinichi Imafuku","doi":"10.1111/exd.70120","DOIUrl":"https://doi.org/10.1111/exd.70120","url":null,"abstract":"<div>\u0000 \u0000 <p>Interleukin (IL)-31 is a key therapeutic target for severe pruritus in atopic dermatitis (AD). Nemolizumab, an IL-31 receptor A antibody, has been available in Japan since 2022 for treating AD-related pruritus. This retrospective study aimed to identify the characteristics of patients with AD for whom nemolizumab is appropriate and most effective, focusing on its efficacy in alleviating pruritus. We reviewed the clinical data of patients with AD who received 60 mg of nemolizumab between 2022 and 2024 at Fukuoka University Hospital. Patients who achieved a ≥ 4-point improvement on the Peak Pruritus Numerical Rating Scale (PP-NRS4) within 16 weeks were classified as responders. Background characteristics, including atopic predisposition and total serum immunoglobulin E (IgE) levels, were compared between responders and non-responders. Multivariate analysis was performed to identify treatment response predictors. Sixteen (64%) of the 25 patients treated with nemolizumab achieved PP-NRS4 within 16 weeks. Of the 25 patients, 14 had extrinsic AD with an atopic predisposition, although only 5 (36%) achieved PP-NRS4. All 11 patients with intrinsic AD achieved PP-NRS4 (<i>p</i> = 0.001). The median total serum IgE level was significantly lower in responders (74.5 IU/mL) than in non-responders (691.5 IU/mL, <i>p</i> = 0.0034). Multivariate analysis revealed that higher baseline IgE levels were associated with poorer PP-NRS4 outcomes (standardised <i>β</i> = −0.63033, <i>p</i> = 0.0154). Serum total IgE levels, indicative of an atopic predisposition, are critical predictors of nemolizumab efficacy in alleviating pruritus. These findings underscore the importance of patient selection based on IgE levels for optimising nemolizumab therapy in AD.</p>\u0000 </div>","PeriodicalId":12243,"journal":{"name":"Experimental Dermatology","volume":"34 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Memory T-Cell Phenotype in Cutaneous T-Cell Lymphoma Is Modified by Germline Gene Gametocyte Specific Factor 1","authors":"Amelia Martínez Villarreal,&nbsp;Jennifer Gantchev,&nbsp;Pingxing Xie,&nbsp;Philippe Lefrançois,&nbsp;Brandon Ramchatesingh,&nbsp;Ivan V. Litvinov","doi":"10.1111/exd.70123","DOIUrl":"https://doi.org/10.1111/exd.70123","url":null,"abstract":"<p>Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of lymphoproliferative disorders characterised by skin infiltration by malignant memory T cells. While most patients will present with an indolent disease, others will follow a highly aggressive clinical course. Currently, defining disease prognosis remains challenging. Ectopic expression of gametocyte-specific factor 1 (GTSF1) has emerged as a potential prognostic biomarker. However, its contribution to CTCL carcinogenesis remains unknown. Here, we report that GTSF1 contributes to carcinogenesis by partially modifying the memory/effector phenotype of the malignant T cells. GTSF1 knockdown in CTCL cells led to T-cell activation and production of IFNγ and TNFα. Advanced stages of the disease are associated with decreased production of these cytokines. Notably, we show that patients classified with high expression of GTSF1 are associated with a worse disease prognosis. Taken together, our findings indicate that GTSF1 expression in CTCL cells allows them to acquire memory T-cell phenotype. Malignant memory T cells have a decreased production of immune-responsive cytokines, leading to a diminished immune response and disease progression. GTSF1 is an important candidate as a prognostic biomarker. Furthermore, understanding the specific function of GTSF1 might help develop novel targeted treatment options for CTCL patients.</p>","PeriodicalId":12243,"journal":{"name":"Experimental Dermatology","volume":"34 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/exd.70123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extension of Secukinumab and Ixekizumab Dose for Moderate-To-Severe Psoriasis in Low Disease Activity Intervals","authors":"Caiyu Wang,&nbsp;Yanhua Liu,&nbsp;Yang Yang,&nbsp;Jiao Ning,&nbsp;Xiaoyi Xing,&nbsp;Ping Jian,&nbsp;Ziyuan Wang,&nbsp;Guangquan Xu,&nbsp;Zhongrui Xu,&nbsp;Jian Zhou,&nbsp;Xiaoming Liu,&nbsp;Chen Yu,&nbsp;Gang Wang","doi":"10.1111/exd.70122","DOIUrl":"https://doi.org/10.1111/exd.70122","url":null,"abstract":"<div>\u0000 \u0000 <p>Biological agents targeting IL-17A, such as secukinumab and ixekizumab, are highly effective in treating psoriasis, often achieving low disease activity or remission. However, frequent injections, side effects and high costs pose significant challenges. Extending dosing intervals for patients with stable disease and partial response may address these issues while maintaining efficacy, yet standardised dose reduction guidelines remain absent. This study aimed to evaluate the efficacy and safety of reduced dosing regimens of secukinumab and ixekizumab during the maintenance phase of psoriasis treatment. From 2020 to 2023, patients completing induction and maintenance phases with prescribed regimens, achieving a PASI (Psoriasis Area and Severity Index) score below 1 and PASI90 or PASI100 response, underwent clinician evaluations for extended dosing intervals. Secukinumab dosing was adjusted from 300 mg (or 150 mg) Q4W to Q8W, and ixekizumab from 80 mg Q4W to Q8W. Patients were monitored over 36 weeks, with data collected throughout the observation period to assess feasibility and safety. A total of 64 patients with moderate-to-severe plaque psoriasis were enrolled. Following extended dosing intervals, 75.4% maintained a PASI90 response at 12 weeks, with 67.7% sustaining it at 36 weeks. Similarly, 69.8% achieved PASI100 at 12 weeks, and 61.2% maintained this response at 36 weeks. These findings demonstrate that dose reduction strategies for secukinumab and ixekizumab in moderate-to-severe psoriasis can reduce treatment burden while maintaining high therapeutic efficacy, offering valuable insights to guide clinical guidelines and address current knowledge gaps.</p>\u0000 </div>","PeriodicalId":12243,"journal":{"name":"Experimental Dermatology","volume":"34 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}