Experimental and Clinical Endocrinology & Diabetes最新文献_第7页

Comparability of C-Peptide Measurements - Current Status and Clinical Relevance. c肽测量的可比性-现状和临床相关性。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-03-01 DOI: 10.1055/a-1998-6889

Sebastian Hörber, Matthias Orth, Andreas Fritsche, Andreas Peter

{"title":"Comparability of C-Peptide Measurements - Current Status and Clinical Relevance.","authors":"Sebastian Hörber, Matthias Orth, Andreas Fritsche, Andreas Peter","doi":"10.1055/a-1998-6889","DOIUrl":"https://doi.org/10.1055/a-1998-6889","url":null,"abstract":"C-peptide is an increasingly used and established marker for beta cell function by assessing endogenous insulin secretion. Accurate and comparable C-peptide measurements are needed in clinical practice and research studies. For example, to calculate HOMA-indices, the C-peptide/glucose ratio, and the classification of recently published novel subgroups of diabetes and prediabetes have used C-peptide measurements. Although the process for standardization of C-peptide measurements is advanced, its full implementation is still missing; therefore, the current status of the comparability of C-peptide measurements using different immunoassays is unclear. Here we compared five widely used C-peptide immunoassays on different analyzers (Abbott ALINITY i, DiaSorin Liaison XL, Roche Cobas e411, Siemens Healthineers ADVIA Centaur XPT, and Immulite 2000 XPi) using serum samples covering the clinically relevant C-peptide concentration range. Although all investigated immunoassays are traceable to the international reference reagent for C-peptide (NIBSC code: 84/510), results of C-peptide measurements showed significant differences between analyzers in the entire concentration range, especially with increasing C-peptide concentrations. The mean bias was largest (36.6%) between results of the immunoassays by Roche and Siemens Healthineers (ADVIA Centaur XPT), and both assays revealed large discrepancies compared to immunoassays by Abbott, DiaSorin, and Siemens Healthineers (Immulite 2000 XPi). In contrast, the three latter assays showed similar C-peptide results (mean bias: 2.3% to 4.2%). Consequently, C-peptide discrepancies might affect clinical diagnosis and the interpretation of study results. Therefore, there is an urgent need to implement and finalize the standardization process of C-peptide measurements to improve patient care and the comparability of research studies.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 3","pages":"173-178"},"PeriodicalIF":1.8,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/5d/10-1055-a-1998-6889.PMC9998184.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9447968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription. E2F2通过调节CDCA7L转录促进糖尿病足溃疡创面愈合

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-03-01 DOI: 10.1055/a-1989-1918

Meimei Xiao, Jiusong Wang, Yanming Chen

{"title":"E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription.","authors":"Meimei Xiao, Jiusong Wang, Yanming Chen","doi":"10.1055/a-1989-1918","DOIUrl":"https://doi.org/10.1055/a-1989-1918","url":null,"abstract":"Objective: The E2F2 transcription factor can accelerate cell proliferation and wound healing. However, its mechanism of action in a diabetic foot ulcer (DFU) remains unclear. Therefore, this study explores the influence of E2F2 on wound healing in DFU by examining cell division cycle-associated 7-like (CDCA7L) expression.Methods: CDCA7L and E2F2 expression in DFU tissues were analyzed with databases. CDCA7L and E2F2 expression were altered in human umbilical vein endothelial cells (HUVECs) and spontaneously transformed human keratinocyte cell culture (HaCaT) cells. Cell viability, migration, colony formation, and angiogenesis were evaluated. Binding of E2F2 to the CDCA7L promoter was examined. Subsequently, a diabetes mellitus (DM) mouse model was established and treated with full-thickness excision followed by CDCA7L overexpression. Wound healing in these mice was observed and recorded, and vascular endothelial growth factor receptor 2 (VEGFR2) and hematopoietic progenitor cell antigen CD34 (CD34) expression were determined. E2F2 and CDCA7L expression levels in cells and mice were evaluated. The expression of growth factors was tested.Results: CDCA7L expression was downregulated in DFU tissues and wound tissues from DM mice. Mechanistically, E2F2 bound to the CDCA7L promoter to upregulate CDCA7L expression. E2F2 overexpression enhanced viability, migration, and growth factor expression in HaCaT cells and HUVECs, and augmented HUVEC angiogenesis and HaCaT cell proliferation, which was nullified by silencing CDCA7L. In DM mice, CDCA7L overexpression facilitated wound healing and elevated the expression level of growth factors.Conclusions: E2F2 facilitated cell proliferation and migration and fostered wound healing in DFU cells through binding to the CDCA7L promoter.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 3","pages":"162-172"},"PeriodicalIF":1.8,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9097571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of Flash Glucose Monitoring in Hemodialysis Patients With and Without Diabetes Mellitus. 伴有和不伴有糖尿病的血液透析患者血糖监测的准确性。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-03-01 DOI: 10.1055/a-1978-0226

Michèle Weber, Matthias Hannes Diebold, Peter Wiesli, Andreas David Kistler

{"title":"Accuracy of Flash Glucose Monitoring in Hemodialysis Patients With and Without Diabetes Mellitus.","authors":"Michèle Weber, Matthias Hannes Diebold, Peter Wiesli, Andreas David Kistler","doi":"10.1055/a-1978-0226","DOIUrl":"https://doi.org/10.1055/a-1978-0226","url":null,"abstract":"Aims: Glucose and insulin metabolism are altered in hemodialysis patients, and diabetes management is difficult in these patients. We aimed to validate flash glucose monitoring (FGM) in hemodialysis patients with and without diabetes mellitus as an attractive option for glucose monitoring not requiring regular self-punctures.Methods: We measured interstitial glucose using a FreeStyle Libre device in eight hemodialysis patients with and seven without diabetes mellitus over 14 days and compared the results to simultaneously performed self-monitoring of capillary blood glucose (SMBG).Results: In 720 paired measurements, mean flash glucose values were significantly lower than self-measured capillary values (6.17±2.52 vs. 7.15±2.41 mmol/L, p=1.3 E-86). Overall, the mean absolute relative difference was 17.4%, and the mean absolute difference was 1.20 mmol/L. The systematic error was significantly larger in patients without vs. with diabetes (- 1.17 vs. - 0.82 mmol/L) and on dialysis vs. interdialytic days (-1.09 vs. -0.90 mmol/L). Compared to venous blood glucose (72 paired measurements), the systematic error of FGM was even larger (5.89±2.44 mmol/L vs. 7.78±7.25 mmol/L, p=3.74E-22). Several strategies to reduce the systematic error were evaluated, including the addition of +1.0 mmol/L as a correction term to all FGM values, which significantly improved accuracy.Conclusions: FGM systematically underestimates blood glucose in hemodialysis patients but, taking this systematic error into account, the system may be useful for glucose monitoring in hemodialysis patients with or without diabetes.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 3","pages":"132-141"},"PeriodicalIF":1.8,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/d2/10-1055-a-1978-0226.PMC9998185.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9088415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes and Pregnancy. 糖尿病和怀孕。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-02-01 DOI: 10.1055/a-1946-3648

Michael Hummel, Martin Füchtenbusch, Wilgard Battefeld, Christoph Bührer, Tanja Groten, Thomas Haak, Franz Kainer, Alexandra Kautzky-Willer, Andreas Lechner, Thomas Meissner, Christine Nagel-Reuper, Ute Schäfer-Graf, Thorsten Siegmund

{"title":"Diabetes and Pregnancy.","authors":"Michael Hummel, Martin Füchtenbusch, Wilgard Battefeld, Christoph Bührer, Tanja Groten, Thomas Haak, Franz Kainer, Alexandra Kautzky-Willer, Andreas Lechner, Thomas Meissner, Christine Nagel-Reuper, Ute Schäfer-Graf, Thorsten Siegmund","doi":"10.1055/a-1946-3648","DOIUrl":"https://doi.org/10.1055/a-1946-3648","url":null,"abstract":"Affiliations 1 Internal Medicine Group Practice and Diabetological Practice, Rosenheim, Germany 2 Research Group Diabetes e.V. at Helmholtz Center Munich, Munich, Germany 3 Diabetes Center am Marienplatz Munich, Munich, Germany 4 Diabetology and Endocrinology, Medical Care Center Kempten-Allgäu, Kempten, Germany 5 Department of Neonatology, Charité – Medical University of Berlin, Berlin, Germany 6 Department of Obstetrics and Maternal Health, University Hospital Jena, Jena, Germany 7 Diabetes Center Mergentheim, Bad Mergentheim, Germany 8 Department of Obstetrics and Prenatal Medicine, Hallerwiese Hospital, Nuremberg, Germany 9 Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria 10 Department of Internal Medicine IV, Diabetes Center, Ludwigs-Maximilians-University Munich, Munich, Germany 11 Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital Düsseldorf, Düsseldorf, Germany 12 Diabetes Practice Northeim, Northeim, Germany 13 Berlin Diabetes Center for Pregnant Women, St. Joseph Hospital Berlin Tempelhof, Berlin, Germany 14 Diabetes, Hormone, and Metabolism Center, Private Practice at Isar Clinic, Munich, Germany Bibliography Exp Clin Endocrinol Diabetes DOI 10.1055/a-1946-3648 ISSN 0947-7349 © 2023. Thieme. All rights reserved. Georg Thieme Verlag, Rüdigerstraße 14, 70469 Stuttgart, Germany","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 1-02","pages":"4-12"},"PeriodicalIF":1.8,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9426650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diabetic Neuropathy. 糖尿病神经病变。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-02-01 DOI: 10.1055/a-1946-3813

Dan Ziegler, Jutta Keller, Christoph Maier, Jürgen Pannek

引用次数: 1

Psychosocial Factors and Diabetes. 心理社会因素与糖尿病。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-02-01 DOI: 10.1055/a-1946-3863

Bernhard Kulzer, Christian Albus, Stephan Herpertz, Johannes Kruse, Karin Lange, Florian Lederbogen, Frank Petrak

引用次数: 2

Nephropathy in Diabetes. 糖尿病肾病。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-02-01 DOI: 10.1055/a-1946-3783

Ludwig Merker, Thomas Ebert, Martina Guthoff, Berend Isermann

引用次数: 1

Gestational Diabetes Mellitus (GDM), Diagnostics, Therapy and Follow-up Care. 妊娠期糖尿病(GDM)，诊断，治疗和随访护理。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-02-01 DOI: 10.1055/a-1946-3713

Ute Schäfer-Graf, Katharina Laubner, Sandra Hummel, Ulrich Gembruch, Tanja Groten, Franz Kainer, Melita Grieshop, Dagmar Bancher-Todesca, Mila Cervar-Zivakovic, Irene Hösli, Matthias Kaltheuner, Reinhold Gellner, Alexandra Kautzky-Willer, Christoph Bührer

{"title":"Gestational Diabetes Mellitus (GDM), Diagnostics, Therapy and Follow-up Care.","authors":"Ute Schäfer-Graf, Katharina Laubner, Sandra Hummel, Ulrich Gembruch, Tanja Groten, Franz Kainer, Melita Grieshop, Dagmar Bancher-Todesca, Mila Cervar-Zivakovic, Irene Hösli, Matthias Kaltheuner, Reinhold Gellner, Alexandra Kautzky-Willer, Christoph Bührer","doi":"10.1055/a-1946-3713","DOIUrl":"https://doi.org/10.1055/a-1946-3713","url":null,"abstract":"Affiliations 1 Berlin Diabetes Center for pregnant women, Department of Gynecology and Obstetrics, St. Joseph Hospital, Berlin, Germany 2 Department of Internal Medicine II, Department of Endocrinology and Diabetology, University Hospital Freiburg, Freiburg, Germany 3 Institute for Diabetes Research, Research Center for Health and Environment (GmbH), Helmholtz Zentrum München, München, Germany 4 Department of Gynecology, Obstetrics and Prenatal Medicine, University Hospital Bonn, Bonn, Germany 5 Department of Obstetrics, University Hospital Jena, Jena, Germany 6 Department of Obstetrics and Prenatal Medicine, Hallerwiese Hospital, Nuremberg, Germany 7 Protestant University of Applied Science, Berlin, Germany 8 Döbling Private Hospital, Vienna, Austria 9 Division of Obstetrics, Department of Gynecology and Obstetrics, LKH-University Hospital Graz, Graz, Austria 10 Department of Obstetrics and Gynecology, University Hospital Basel, Basel, Switzerland 11 Joint practice Dres. Kaltheuner/v. Boxberg, Leverkusen, Germany 12 Department of Gastroenterology and Hepatology, University Hospital Münster, Münster, Germany 13 Gender Medicine Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria 14 Department of Neonatology, Charité – Medical University Berlin, Berlin, Germany Bibliography Exp Clin Endocrinol Diabetes DOI 10.1055/a-1946-3713 ISSN 0947-7349 © 2023. Thieme. All rights reserved. Georg Thieme Verlag, Rüdigerstraße 14, 70469 Stuttgart, Germany","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 1-02","pages":"13-23"},"PeriodicalIF":1.8,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9795947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diabetic Foot Syndrome. 糖尿病足综合症。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-02-01 DOI: 10.1055/a-1946-3838

Stephan Morbach, Michael Eckhard, Ralf Lobmann, Eckhard Müller, Heinrich Reike, Alexander Risse, Gerhard Rümenapf, Maximilian Spraul

引用次数: 3

Nutritional Recommendations for People with Type 1 Diabetes Mellitus. 1型糖尿病患者的营养建议

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-02-01 DOI: 10.1055/a-1946-3753

Diana Rubin, Anja Bosy-Westphal, Stefan Kabisch, Peter Kronsbein, Marie-Christine Simon, Astrid Tombek, Katharina S Weber, Thomas Skurk

引用次数: 1