Experimental and Clinical Endocrinology & Diabetes最新文献_第10页

Video Consultation for Parents with a Child Newly Diagnosed with Type 1 Diabetes: A Qualitative Study. 儿童新诊断为1型糖尿病的家长视频咨询:一项定性研究。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-08-01 Epub Date: 2021-10-20 DOI: 10.1055/a-1655-5471

Jana Doerdelmann, Fabian-Simon Frielitz, Karin Lange, Tanja Meinsen, Sandra Reimers, Tanja Ottersberg, Alexander Katalinic, Olaf Hiort, Simone von Sengbusch

{"title":"Video Consultation for Parents with a Child Newly Diagnosed with Type 1 Diabetes: A Qualitative Study.","authors":"Jana Doerdelmann, Fabian-Simon Frielitz, Karin Lange, Tanja Meinsen, Sandra Reimers, Tanja Ottersberg, Alexander Katalinic, Olaf Hiort, Simone von Sengbusch","doi":"10.1055/a-1655-5471","DOIUrl":"https://doi.org/10.1055/a-1655-5471","url":null,"abstract":"Aims: With the exception of the coronavirus pandemic, video consultations have not been a part of the standard care for children with diabetes in Germany. The \"Virtual Diabetes Outpatient Clinic for Children and Adolescents 2.0\" (VIDIKI 2.0) study investigated the effect of monthly and supplementary video consultations on standard care over one year. The qualitative substudy investigated the experiences of families with a child newly diagnosed with type 1 diabetes mellitus (T1DM) who received at least four weekly supplementary video consultations.Methods: Guideline-based qualitative interviews were conducted with seven families with children under the age of eight and T1DM onset shortly before study entry. The answers were analyzed using a qualitative content analysis approach, particularly inductive category formation.Results: Families of patients with T1DM onset have questions, almost daily, concerning various aspects of insulin therapy. The offer of high-frequency video consultations can reduce the number of trips to the diabetes team, facilitate the organization of daily life and increase the sense of security.Conclusion: Video consultations as a supplementary offer of health care, especially after diabetes onset, were considered very helpful by the affected families. High-frequency video consultations may provide a tool to overcome existing deficiencies in specialized diabetes care.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"130 8","pages":"519-524"},"PeriodicalIF":1.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39560142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Idiopathic Frozen Shoulder in Individuals with Diabetes: Association with Metabolic Control, Obesity, Antidiabetic Treatment and Demographic Characteristics in Adults with Type 1 or 2 Diabetes from the DPV Registry. 糖尿病患者的特发性肩周炎:与1型或2型糖尿病成人的代谢控制、肥胖、抗糖尿病治疗和人口统计学特征的关联

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-07-01 Epub Date: 2021-08-23 DOI: 10.1055/a-1543-8559

Alexander J Eckert, Maike Plaumann, Sigrid Pehlke, Christof Beck, Steffen Mühldorfer, Uwe Weickert, Markus Laimer, Martin Pfeifer, Lars Stechemesser, ReinhardW Holl

{"title":"Idiopathic Frozen Shoulder in Individuals with Diabetes: Association with Metabolic Control, Obesity, Antidiabetic Treatment and Demographic Characteristics in Adults with Type 1 or 2 Diabetes from the DPV Registry.","authors":"Alexander J Eckert, Maike Plaumann, Sigrid Pehlke, Christof Beck, Steffen Mühldorfer, Uwe Weickert, Markus Laimer, Martin Pfeifer, Lars Stechemesser, ReinhardW Holl","doi":"10.1055/a-1543-8559","DOIUrl":"https://doi.org/10.1055/a-1543-8559","url":null,"abstract":"Aims: To examine the association of frozen shoulder (FS) with demographic and diabetes-related outcomes in individuals with type 1 (T1D) or type 2 (T2D) diabetes aged ≥30 years.Materials and methods: Multivariable logistic regression models, adjusted for demographics were used to calculate the proportion of FS in association with age, gender, diabetes duration, body mass index (BMI), haemoglobin A1C (HbA1c) and diabetes treatment.Results: The unadjusted percentage of FS was higher in T1D compared to T2D (0.22% vs. 0.06%). In T1D, adjusted regression models revealed higher prevalence of FS in women than men (0.26 [0.20-0.34] % vs. 0.15 [0.11-0.21] %, p=0.010). No significant relationship of age and BMI with FS was found in both diabetes types. Longer diabetes duration was associated with a higher proportion of FS in T1D (p<0.001) and T2D (p=0.004). In T1D, HbA1c >7% was related to a higher proportion of FS compared to HbA1c ≤7% (0.25 [0.19-0.32] vs. 0.12 [0.08-0.20] %, p=0.007), while an inverse relationship was found in T2D (HbA1c ≤7%: 0.08 [0.07-0.10] vs. HbA1c >7%: 0.05 [0.04-0.06] %, p=0.001).Conclusions: Different associations of FS with gender and HbA1c were observed for T1D and T2D; however, longer diabetes duration increases the risk for FS independent of diabetes type. Musculoskeletal diseases are still underreported in individuals with diabetes and awareness should be raised for FS as a specific diabetes complication.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"130 7","pages":"468-474"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39337587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Prevalence of Atherosclerotic Cardiovascular Disease, Heart Failure, and Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus: A Primary Care Research Network-based Study. 2型糖尿病患者动脉粥样硬化性心血管疾病、心力衰竭和慢性肾脏疾病的患病率:一项基于初级保健研究网络的研究

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-07-01 Epub Date: 2021-06-21 DOI: 10.1055/a-1508-3912

Geert Goderis, Bert Vaes, Pavlos Mamouris, Eline van Craeyveld, Chantal Mathieu

{"title":"Prevalence of Atherosclerotic Cardiovascular Disease, Heart Failure, and Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus: A Primary Care Research Network-based Study.","authors":"Geert Goderis, Bert Vaes, Pavlos Mamouris, Eline van Craeyveld, Chantal Mathieu","doi":"10.1055/a-1508-3912","DOIUrl":"https://doi.org/10.1055/a-1508-3912","url":null,"abstract":"Aims: This study aims to assess the prevalence of atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), chronic kidney disease (CKD), and their combined presence in type 2 diabetes (T2D) patients in primary care for whom the 2019 ADA/EASD consensus update \"Management of Hyperglycemia in Type 2 Diabetes\" recommends GLP-1 receptor agonists (GLP-1RA) or sodium-glucose cotransporter-2 inhibitors (SGLT-I) as first-line medications after metformin.Methods: Data were obtained in 2015 from Intego, a morbidity registration network of 111 general practitioners (GPs) working in 48 practices and including 123 261 registered patients.Results: Of 123 261 patients, 9616 had T2D. Of these patients, 4200 (43.7%) presented with ASCVD and/or CKD and/or HF. Specifically, 3348 (34.8%) patients had ASCVD, 388 (4.0%) had heart failure, and 1402 (14.6%) had CKD. Compared to patients without any of these comorbidities, patients with at least 1 of these conditions were older (69.7 ±12.6 vs. 63.1±12.5 years), had higher LDL-C values (104.2±35.8 mg/dl vs. 97.2±37.7) and less frequently achieved the systolic blood pressure target of 140 mm Hg (53 vs. 61%) (all p<0.001). Comorbid patients also had significantly more other comorbidities, such as dementia or cancer; received more recommended medications, such as statins; and received less metformin. Most patients with HF (325; 3.4%) had ASCVD (114; 1.2%), CKD (76; 0.8%), or both (135; 1.4%). In total, 478 patients with CKD (5.0%) also had ASCVD.Conclusions: At the primary care level, 44% of T2D patients suffer from ASCVD, CKD, and/or HF, and thus qualify for GLP-1RA or SGLT2-I therapy.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"130 7","pages":"447-453"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39253102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Is Telemedicine the Preferred Visit Modality in Patients with Type 1 Diabetes? 远程医疗是1型糖尿病患者首选的就诊方式吗?

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-07-01 Epub Date: 2021-07-22 DOI: 10.1055/a-1532-4610

Alena Kirzhner, Taiba Zornitzki, Viviana Ostrovsky, Hilla Knobler, Tal Schiller

{"title":"Is Telemedicine the Preferred Visit Modality in Patients with Type 1 Diabetes?","authors":"Alena Kirzhner, Taiba Zornitzki, Viviana Ostrovsky, Hilla Knobler, Tal Schiller","doi":"10.1055/a-1532-4610","DOIUrl":"https://doi.org/10.1055/a-1532-4610","url":null,"abstract":"Background: The COVID-19 pandemic limits access to diabetes clinics. Remote communication by phone calls and WhatsApp messages became available in the past years. However, the current need to avoid face-to-face meetings necessitates further expansion of telemedicine services. There are limited data whether the option of virtual meetings is a preferred therapeutic modality for patients with type 1 diabetes (T1D).Objective: To assess in a cohort of T1D patients, their preference and perception of telemedicine.Methods: T1D patients who are followed in a hospital-affiliated diabetes clinic were asked to fill a structured questionnaire aimed to determine their attitude towards telemedicine and their preference of virtual versus conventional visits. The questionnaire was offered to consecutive T1D patients who visited the clinic between August to October 2020.Results: Seventy one T1D patients that fulfilled the questionnaire were included. Median age was 38 years, 39% were male, and median duration of diabetes was 18 years. Fourteen percent of the participants preferred only virtual visits, 24% only conventional visits and 62% preferred a combination of these modalities. Sex, origin, education, duration of diabetes, mode of insulin treatment and distance from the clinic were not associated with patients' preference, but older patients (≥ 61 years) tended to prefer conventional visits. Sixty-six percent felt confident in their ability to download data from their personal medical devices.Conclusions: Patients from a wide range of treatment modalities are willing to use telemedicine. However, virtual meetings cannot fully replace conventional visits in T1D especially in the older age group.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"130 7","pages":"462-467"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39209522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A Risk Assessment Tool for Identifying Osteoporosis in Older Women with Type 2 Diabetes Mellitus. 老年女性2型糖尿病骨质疏松症的风险评估工具

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-07-01 Epub Date: 2021-12-15 DOI: 10.1055/a-1702-5168

Fenghui Pan, Wenxia Cui, Lei Gao, Xiaoting Shi, Mingrui Zhang, Man Li, Haiyan Yang, Yun Hu

{"title":"A Risk Assessment Tool for Identifying Osteoporosis in Older Women with Type 2 Diabetes Mellitus.","authors":"Fenghui Pan, Wenxia Cui, Lei Gao, Xiaoting Shi, Mingrui Zhang, Man Li, Haiyan Yang, Yun Hu","doi":"10.1055/a-1702-5168","DOIUrl":"https://doi.org/10.1055/a-1702-5168","url":null,"abstract":"Purpose: To develop a simple and clinically useful assessment tool for osteoporosis in older women with type 2 diabetes mellitus (T2DM).Methods: A total of 601 women over 60 years of age with T2DM were enrolled in this study. The levels of serum sex hormones and bone metabolism markers were compared between the osteoporosis and non-osteoporosis groups. The least absolute shrinkage and selection operator regularization (LASSO) model was applied to generate a risk assessment tool. The risk score formula was evaluated using receiver operating characteristic analysis and the relationship between the risk score and the bone mineral density (BMD) and T-value were investigated.Results: Serum sex hormone-binding globulin (SHBG), cross-linked C-telopeptide of type 1 collagen (CTX), and osteocalcin (OC) were significantly higher in the osteoporosis group. After adjustment for age and body mass index (BMI), SHBG was found to be correlated with the T-value or BMD. Then, a risk score was specifically generated with age, BMI, SHBG, and CTX using the LASSO model. The risk score was significantly negatively correlated with the T-value and BMD of the lumbar spine, femoral neck, and total hip (all P<0.05).Conclusion: A risk score using age, BMI, SHBG, and CTX performs well for identifying osteoporosis in older women with T2DM.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"130 7","pages":"426-433"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39729367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diurnal Salivary Cortisol Profiles in Patients with Cushing's Syndrome. 库欣综合征患者的日唾液皮质醇谱。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-07-01 Epub Date: 2022-01-17 DOI: 10.1055/a-1719-5381

Leah T Braun, Frederick Vogel, Stephanie Zopp, German Rubinstein, Katharina Schilbach, Heike Künzel, Felix Beuschlein, Martin Reincke

{"title":"Diurnal Salivary Cortisol Profiles in Patients with Cushing's Syndrome.","authors":"Leah T Braun, Frederick Vogel, Stephanie Zopp, German Rubinstein, Katharina Schilbach, Heike Künzel, Felix Beuschlein, Martin Reincke","doi":"10.1055/a-1719-5381","DOIUrl":"https://doi.org/10.1055/a-1719-5381","url":null,"abstract":"Background: Quantification of salivary cortisol is one of the highly sensitive and specific screening parameters for Cushing's syndrome (CS). However, only late-night salivary cortisol is part of the standard screening procedure. In this study, we aimed to analyze salivary cortisol day profiles in patients with different types of CS to test whether specific patterns might be relevant for diagnosis and subtyping.Material and methods: Among 428 patients including those with confirmed Cushing's syndrome (N=111, of those 75 with Cushing's disease, 27 patients with adrenal CS and nine patients with ectopic CS), autonomous cortisol secretion (N=39) or exclusion of CS (control group, N=278) salivary cortisol was measured five times a day.Results: At each of the five time points, salivary cortisol was significantly higher in patients with CS compared to the control group (p≤0.001). Using the entire profile instead of one single salivary cortisol at 11 p.m. improved diagnostic accuracy (85 vs. 91%) slightly. Patients with ACTH-dependent CS had higher salivary cortisol levels than patients with adrenal CS. Also, morning cortisol was significantly higher in patients with ectopic CS than in patients with Cushing's disease (p=0.04). Nevertheless, there was a strong overlap between diurnal profiles, and the diagnostic yield for subtyping was low.Discussion: The study results show that using diurnal salivary cortisol profiles for CS diagnosis results in a limited increase in diagnostic accuracy. With significant differences between Cushing subtypes, cortisol profiles are not useful in everyday clinical practice for subtyping of CS.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"130 7","pages":"434-438"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39704470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Out-of-Hospital Management of Diabetic Emergencies in Germany: Structural and Process Quality. 德国糖尿病急诊的院外管理:结构和过程质量。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-07-01 Epub Date: 2021-07-20 DOI: 10.1055/a-1523-7562

David J F Holstein, Judith D Holstein, Daniel Fischer, Meinhard Mende, Brian M Frier, Andreas Holstein

{"title":"Out-of-Hospital Management of Diabetic Emergencies in Germany: Structural and Process Quality.","authors":"David J F Holstein, Judith D Holstein, Daniel Fischer, Meinhard Mende, Brian M Frier, Andreas Holstein","doi":"10.1055/a-1523-7562","DOIUrl":"https://doi.org/10.1055/a-1523-7562","url":null,"abstract":"Aims: To collect and analyse representative data of structural and process quality in the management of diabetic emergencies in Germany in 2020.Methods: A standardised questionnaire comprising detailed items concerning clinically relevant parameters on the structural and process quality of out-of-hospital management of diabetic emergencies was sent nationwide to medical directors of emergency medical service districts (EMSDs). Results were compared with those from a similar study conducted in 2001.Results: The return rate of the questionnaires represented 126 EMSDs, serving a total population of > 40.1 million. Only 4% of ambulances carried glucagon (6% in 2001). In 2020, blood glucose determination increased significantly to 71% of all emergency interventions and to 29% of suspected cardiac emergencies (24% and 15%, respectively, in 2001). In 100% of EMSDs severe hypoglycaemia (SH) was treated by paramedics by administering intravenous dextrose before the arrival of a doctor compared to 63% in 2001. The potential value of nasal glucagon was acknowledged by 43% of responders. In selected patients, treatment of SH was conducted without hospital admission in 78% of EMDs (60% in 2001). Fifty-three percent of medical directors acknowledged the need for further training in diabetic emergencies (47% in 2001). Cooperation for medical education between emergency teams and a diabetes centre was reported by 14% (41% in 2001).Conclusion: Structural and process quality of the management of diabetic emergencies in Germany has improved considerably since 2001. Persisting deficiencies could be improved by providing better medical equipment in ambulances and ongoing education to the entire emergency teams.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"130 7","pages":"454-461"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39201932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Insight into the Mechanism of Metabolic Surgery Causing the Diversity in Glycemic Status in Type 2 Diabetes. 代谢手术导致2型糖尿病患者血糖状态差异机制的新见解

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-07-01 Epub Date: 2022-01-03 DOI: 10.1055/a-1708-3214

Mengxiao Zhou, Lijuan Wang, Lujin Zhou, Xiaotong Chang, Xiaobo Zhu

引用次数: 1

Evaluation of Meal Carbohydrate Counting Errors in Patients with Type 1 Diabetes. 1型糖尿病患者膳食碳水化合物计数误差的评价。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-07-01 Epub Date: 2021-05-25 DOI: 10.1055/a-1493-2324

Sina Buck, Collin Krauss, Delia Waldenmaier, Christina Liebing, Nina Jendrike, Josef Högel, Boris M Pfeiffer, Cornelia Haug, Guido Freckmann

{"title":"Evaluation of Meal Carbohydrate Counting Errors in Patients with Type 1 Diabetes.","authors":"Sina Buck, Collin Krauss, Delia Waldenmaier, Christina Liebing, Nina Jendrike, Josef Högel, Boris M Pfeiffer, Cornelia Haug, Guido Freckmann","doi":"10.1055/a-1493-2324","DOIUrl":"https://doi.org/10.1055/a-1493-2324","url":null,"abstract":"Aim: Correct estimation of meal carbohydrate content is a prerequisite for successful intensified insulin therapy in patients with diabetes. In this survey, the counting error in adult patients with type 1 diabetes was investigated.Methods: Seventy-four patients with type 1 diabetes estimated the carbohydrate content of 24 standardized test meals. The test meals were categorized into 1 of 3 groups with different carbohydrate content: low, medium, and high. Estimation results were compared with the meals' actual carbohydrate content as determined by calculation based on weighing. A subgroup of the participants estimated the test meals for a second (n=35) and a third time (n=22) with a mean period of 11 months between the estimations.Results: During the first estimation, the carbohydrate content was underestimated by -28% (-50, 0) of the actual carbohydrate content. Particularly meals with high mean carbohydrate content were underestimated by -34% (-56, -13). Median counting error improved significantly when estimations were performed for a second time (p<0.001).Conclusions: Participants generally underestimated the carbohydrate content of the test meals, especially in meals with higher carbohydrate content. Repetition of estimation resulted in significant improvements in estimation accuracy and is important for the maintenance of correct carbohydrate estimations. The ability to estimate the carbohydrate content of a meal should be checked and trained regularly in patients with diabetes.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"130 7","pages":"475-483"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39017797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Neuropeptides, Inflammation, Biofilms, and diabetic Foot Ulcers. 神经肽、炎症、生物膜和糖尿病足溃疡。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-07-01 Epub Date: 2021-07-05 DOI: 10.1055/a-1493-0458

Shaoling Yang, Liye Hu, Rui Han, Yiwen Yang

{"title":"Neuropeptides, Inflammation, Biofilms, and diabetic Foot Ulcers.","authors":"Shaoling Yang, Liye Hu, Rui Han, Yiwen Yang","doi":"10.1055/a-1493-0458","DOIUrl":"https://doi.org/10.1055/a-1493-0458","url":null,"abstract":"A diabetic foot ulcer (DFU) is a serious complication in patients with diabetes mellitus (DM). A DFU is the most common cause of non-traumatic limb amputation, and patients with DFUs have increased mortality rates within 5 years after amputation. DFUs also increase the risk of cardiovascular and cerebrovascular diseases; therefore, with the increasing incidence and prevalence of diabetic foot wounds, DFUs are gradually becoming a major public health problem. The pathophysiology of DFUs is complicated and remains unclear. In recent years, many studies have demonstrated that the pathophysiology of DFUs is especially associated with neuropeptides, inflammation, and biofilms. Neuropeptides, especially substance P (SP) and calcitonin gene-related peptide (CGRP), play an important role in wound healing. SP and CGRP accelerate the healing of cutaneous wounds by promoting neovascularization, inhibiting the release of certain proinflammatory chemokines, regulating macrophage polarization, and so on. However, the expression of SP and CGRP was downregulated in DM and DFUs. DFUs are characterized by a sustained inflammatory phase. Immune cells such as neutrophils and macrophages are involved in the sustained inflammatory phase in DFUs by extracellular traps (NETs) and dysregulated macrophage polarization, which delays wound healing. Furthermore, DFUs are at increased risk of biofilm formation. Biofilms disturb wound healing by inducing a chronic inflammatory response, inhibiting macrophage phagocytosis and keratinocyte proliferation migration, and transferring antimicrobial resistance genes. To understand the relationships among neuropeptides, inflammation, biofilms, and DFUs, this review highlights the recent scientific advances that provide possible pathophysiological insights into the delayed healing of DFUs.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"130 7","pages":"439-446"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39072278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7