Experimental and Clinical Endocrinology & Diabetes最新文献

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Pituitary Surgery in Germany - Findings from the European Pituitary Adenoma Surgery Survey. 德国垂体手术-来自欧洲垂体腺瘤手术调查的结果。
IF 1.8 4区 医学
Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-06-01 DOI: 10.1055/a-2061-1284
Malte Ottenhausen, Jens Conrad, Darius Kalasauskas, David Netuka, Florian Ringel
{"title":"Pituitary Surgery in Germany - Findings from the European Pituitary Adenoma Surgery Survey.","authors":"Malte Ottenhausen,&nbsp;Jens Conrad,&nbsp;Darius Kalasauskas,&nbsp;David Netuka,&nbsp;Florian Ringel","doi":"10.1055/a-2061-1284","DOIUrl":"https://doi.org/10.1055/a-2061-1284","url":null,"abstract":"<p><strong>Background: </strong>Surgery is, next to medical and radiation therapy, the mainstay therapy for pituitary adenomas. While scientific consensus regarding the key aspects of pituitary surgery exists among neurosurgeons, procedures are not standardized and might vary significantly between hospitals and surgeons.</p><p><strong>Objective: </strong>To provide an overview of how neurosurgical departments in Germany manage pituitary surgery.</p><p><strong>Methods: </strong>Responses from the European Pituitary Adenoma Surgery Survey were analyzed. The survey contained 60 questions regarding demographics, training, surgical and endocrinological aspects, and patient management.</p><p><strong>Results: </strong>Sixty neurosurgical centers from Germany responded to the survey. Among the centers, 35.3% (n=18) exclusively use the microscopic and 31.1% (n=14) the endoscopic technique; all other centers (n=28) use both approaches. Of responding centers, 20% (n=12) perform less than 10 transsphenoidal pituitary surgeries per year, and 1.7% (n=1), more than 100 operations. The number of transcranial pituitary operations is significantly smaller, with 53.3% of centers performing only 0-2 per year, 35% performing 3-5, and only one center (1.7%) performing more than 15 transcranial operations per year. In 8 centers (13.3%), surgeries are always performed together with an ENT surgeon; in 29 centers (48.4%) ENT surgeons are never involved. In most centers (n=54, 90%) intraoperative MRI is not available. Image guidance (with preoperative CT and/or MRI data) is used by 91.7% of respondents (n=55). Forty-two centers (72.4%) routinely prescribe hydrocortisone after pituitary surgery, and 75% (n=45) have pituitary board meetings with endocrinologists, radiologists, and radiosurgeons. Fifty-two (86.7%) respondents perform the first follow-up scan by MRI 3-4 months after surgery.</p><p><strong>Conclusions: </strong>The data showed differences as well as similarities between centers and could help to discuss the standardization of methods and the formation of networks and certification to improve patient care.</p>","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 6","pages":"362-366"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9992314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Prehospital Blood Glucose Levels and Outcomes in Patients With COVID-19 Infection: A Retrospective Cohort Study. COVID-19感染患者院前血糖水平与预后之间的关系:一项回顾性队列研究
IF 1.8 4区 医学
Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-06-01 DOI: 10.1055/a-2068-6821
Christophe A Fehlmann, Laurent Suppan, Christophe Gaudet-Blavignac, Nadia Elia, Karim Gariani
{"title":"Association Between Prehospital Blood Glucose Levels and Outcomes in Patients With COVID-19 Infection: A Retrospective Cohort Study.","authors":"Christophe A Fehlmann,&nbsp;Laurent Suppan,&nbsp;Christophe Gaudet-Blavignac,&nbsp;Nadia Elia,&nbsp;Karim Gariani","doi":"10.1055/a-2068-6821","DOIUrl":"https://doi.org/10.1055/a-2068-6821","url":null,"abstract":"<p><strong>Background: </strong>Hyperglycaemia is associated with worse outcomes in many settings. However, the association between dysglycaemia and adverse outcomes remains debated in COVID-19 patients. This study determined the association of prehospital blood glucose levels with acute medical unit (intensive care unit or high dependency unit) admission and mortality among COVID-19-infected patients.</p><p><strong>Methods: </strong>This was a single-centre, retrospective cohort study based on patients cared for by the prehospital medical mobile unit from a Swiss university hospital between March 2020 and April 2021. All adult patients with confirmed or suspected COVID-19 infection during the study period were included. Data were obtained from the prehospital medical files. The main exposure was prehospital blood glucose level. A 7.8 mmol/L cut-off was used to define high blood glucose level. Restricted cubic splines were also used to analyse the exposure as a continuous variable. The primary endpoint was acute medical unit admission; secondary endpoints were 7-day and 30-day mortality. Multivariable logistic regressions were performed to compute odds ratios.</p><p><strong>Results: </strong>A total of 276 patients were included. The mean prehospital blood glucose level was 8.8 mmol/l, and 123 patients presented high blood glucose levels. The overall acute medical unit admission rate was 31.2%, with no statistically significant difference according to prehospital blood glucose levels. The mortality rate was 13.8% at 7 days and 25% at 30 days. The 30-day mortality rate was higher in patients with high prehospital blood glucose levels, with an adjusted odds ratio of 2.5 (1.3-4.8).</p><p><strong>Conclusions: </strong>In patients with acute COVID-19 infection, prehospital blood glucose levels do not seem to be associated with acute medical unit admission. However, there was an increased risk of 30-day mortality in COVID-19 patients who presented high prehospital blood glucose levels.</p>","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 6","pages":"338-344"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/60/10-1055-a-2068-6821.PMC10437172.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10046194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Prevalence of Primary Aldosteronism in Screening Populations: Is Hypokalaemia Important? 筛查人群中原发性醛固酮增多症的患病率:低钾血症重要吗?
IF 1.8 4区 医学
Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-06-01 DOI: 10.1055/a-2075-0735
David M Williams, Ayesha Shaikh, Ellen Williams, Aiman Maroof, Therese Michael, Kusuma Boregowda
{"title":"The Prevalence of Primary Aldosteronism in Screening Populations: Is Hypokalaemia Important?","authors":"David M Williams,&nbsp;Ayesha Shaikh,&nbsp;Ellen Williams,&nbsp;Aiman Maroof,&nbsp;Therese Michael,&nbsp;Kusuma Boregowda","doi":"10.1055/a-2075-0735","DOIUrl":"https://doi.org/10.1055/a-2075-0735","url":null,"abstract":"Dear Editor, We read with great interest the article by Asbach et al., ‘Prevalence of Primary Aldosteronism in Newly Diagnosed Hypertensive Patients in Primary Care’, published in Experimental and Clinical Endocrinology & Diabetes [1]. The authors reported that of 200 patients with newly-diagnosed hypertension in 27 primary care centres, 42 (21.0 %) had an elevated aldosterone-to-renin ratio (ARR), of which 11/33 (33.3 %) were subsequently confirmed to have primary aldosteronism (PA). This gave a 5.5 % prevalence of PA in people with newly-diagnosed hypertension. Curiously, none of the patients with confirmed PA were hypokalaemic at screening, and hypokalaemia prevalence did not differ at screening between those with normal or pathological ARR.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 6","pages":"375-376"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10054119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined Training Improves Executive Functions Without Changing Brain-Derived Neurotrophic Factor Levels of Middle-Aged and Older Adults with Type 2 Diabetes. 联合训练在不改变中老年2型糖尿病患者脑源性神经营养因子水平的情况下改善执行功能
IF 1.8 4区 医学
Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-06-01 DOI: 10.1055/a-2069-4050
João Gabriel Silveira-Rodrigues, Nathálya Gardênia de Holanda Nogueira Marinho, Larissa Oliveira Faria, Daniele S Pereira, Danusa Dias Soares
{"title":"Combined Training Improves Executive Functions Without Changing Brain-Derived Neurotrophic Factor Levels of Middle-Aged and Older Adults with Type 2 Diabetes.","authors":"João Gabriel Silveira-Rodrigues,&nbsp;Nathálya Gardênia de Holanda Nogueira Marinho,&nbsp;Larissa Oliveira Faria,&nbsp;Daniele S Pereira,&nbsp;Danusa Dias Soares","doi":"10.1055/a-2069-4050","DOIUrl":"https://doi.org/10.1055/a-2069-4050","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) provokes executive function and long-term memory decrements, and aerobic plus resistance training (combined training) may alleviate this T2DM-related cognitive impairment. Brain-derived neurotrophic factor (BDNF) levels have been found to be related to cognitive performance.</p><p><strong>Aim: </strong>To analyze the effects of 8-week combined training on executive functions and circulating BDNF levels of subjects with T2DM and verify the association between BDNF levels and combined training-induced changes in executive functions and long-term memory.</p><p><strong>Methods: </strong>Thirty-five (63±8 years old) subjects of both sexes were allocated to combined training (<i>n</i>=17<i>,</i> thrice weekly for 8 weeks) or the control group (<i>n</i>=18). Executive functions (evaluated through Trail making test, Stroop color task, and Digit Span), long-term memory (evaluated through the Taylor Complex Figure Test simplified), and plasma samples were compared pre- and post-intervention.</p><p><strong>Results: </strong>Combined training improved executive function z-score compared to control (<i>d=</i>1.31). Otherwise, BDNF levels were not statistically altered (combined training group: 179±88 pg/mL <i>vs.</i> 148±108 pg/mL; control group: 163±71 pg/mL <i>vs.</i> 141±84 pg/mL, <i>p</i>>0.05). However, pre-training BDNF levels explained 50.4% of the longitudinal improvements in composite executive function z-score (<i>r</i>=0.71, <i>p</i><0.01), 33.6% of inhibitory control (<i>r=</i>0.58; <i>p</i>=0.02), and 31.4% of cognitive flexibility (<i>r=</i>0.56, <i>p=</i>0.04) in the combined training group.</p><p><strong>Conclusion: </strong>Combined training improved executive functions independently of alterations in resting BDNF levels after 8 weeks. Furthermore, pre-training BDNF levels explained one-half of the variance in combined training-induced improvements in executive functions.</p>","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 6","pages":"345-353"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9636743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetes and Migration. 糖尿病和移民。
IF 1.8 4区 医学
Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-06-01 DOI: 10.1055/a-1946-3878
Sebahat Şat, Kadriye Aydınkoç-Tuzcu, Faize Berger, Alain Barakat, Ina Danquah, Karin Schindler, Peter Fasching
{"title":"Diabetes and Migration.","authors":"Sebahat Şat,&nbsp;Kadriye Aydınkoç-Tuzcu,&nbsp;Faize Berger,&nbsp;Alain Barakat,&nbsp;Ina Danquah,&nbsp;Karin Schindler,&nbsp;Peter Fasching","doi":"10.1055/a-1946-3878","DOIUrl":"https://doi.org/10.1055/a-1946-3878","url":null,"abstract":"Affiliations 1 MVZ DaVita Rhine-Ruhr, Düsseldorf, Germany 2 German Diabetes Association (DDG) Working Group on Diabetes and Migrants 3 Wilhelminenspital of the City of Vienna, 5th Medical Department of Endocrinology, Rheumatology and Acute Geriatrics, Vienna, Austria 4 Austrian Diabetes Association (ÖGD) Working Group on Migration and Diabetes 5 Diabetes Center Duisburg-Mitte (DZDM), Duisburg, Germany 6 Heidelberg Institute of Global Health (HIGH), Medical Faculty and University Hospital Heidelberg, Heidelberg University, Heidelberg, Germany 7 Medical University of Vienna, Department of Internal Medicine III, Clinical Department of Endocrino logy and Metabolism, Vienna, Austria","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 6","pages":"319-337"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9642424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Dietary Niacin Intake with Diabetes in Adults in the United States. 美国成人饮食中烟酸摄入与糖尿病的关系。
IF 1.8 4区 医学
Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-06-01 DOI: 10.1055/a-2038-0476
Chan Liu, Wenjuan Duan, Wenming Xu
{"title":"Association of Dietary Niacin Intake with Diabetes in Adults in the United States.","authors":"Chan Liu,&nbsp;Wenjuan Duan,&nbsp;Wenming Xu","doi":"10.1055/a-2038-0476","DOIUrl":"https://doi.org/10.1055/a-2038-0476","url":null,"abstract":"<p><strong>Objective: </strong>Previous studies have shown inconsistent associations between niacin supplementation and diabetes, and little is known about the relationship between dietary niacin intake and the risk of diabetes in the general population. Our study aimed to explore the association between dietary niacin intake and the risk of diabetes in the adult population in the United States.</p><p><strong>Methods: </strong>Data from the 2005-2016 National Health and Nutrition Examination Surveys were analyzed. Diabetes was diagnosed according to the American Diabetes Association criteria. Multivariate logistic regression models were used to estimate the association between dietary niacin intake and diabetes. Covariates included age, sex, race, family income, educational level, drinking status, smoking status, marital status, and physical activity.</p><p><strong>Results: </strong>This study included 24494 participants, of which 13.63% had diabetes. In the fully adjusted model, a high niacin intake was significantly associated with a reduced risk of diabetes in a dose-dependent manner. When extreme quintiles of niacin intake were compared, the multivariable-adjusted odds ratio was 0.66 (95% confidence interval: 0.49, 0.88) for diabetes, and per ten-unit increment in dietary niacin intake was associated with a 14% lower risk of diabetes. When niacin intake was less than 15.01 mg/d, a ten-unit increment in niacin intake was associated with a 24% higher risk of diabetes. However, the effect was not statistically significant.</p><p><strong>Conclusions: </strong>Our results suggest that the consumption of adequate amounts of niacin can reduce the risk of diabetes. Furthermore, this protective effect disappeared when the niacin intake was insufficient (less than 15.01 mg/d).</p>","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 6","pages":"354-361"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10008424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Aldosterone with Mortality in the General Population. 醛固酮与一般人群死亡率的关系。
IF 1.8 4区 医学
Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-05-01 DOI: 10.1055/a-2035-6179
Cornelia Then, Christian Herder, Margit Heier, Christa Meisinger, Wolfgang Koenig, Wolfgang Rathmann, Chaterina Sujana, Michael Roden, Martin Bidlingmaier, Jochen Seissler, Barbara Thorand, Annette Peters, Martin Reincke
{"title":"Association of Aldosterone with Mortality in the General Population.","authors":"Cornelia Then,&nbsp;Christian Herder,&nbsp;Margit Heier,&nbsp;Christa Meisinger,&nbsp;Wolfgang Koenig,&nbsp;Wolfgang Rathmann,&nbsp;Chaterina Sujana,&nbsp;Michael Roden,&nbsp;Martin Bidlingmaier,&nbsp;Jochen Seissler,&nbsp;Barbara Thorand,&nbsp;Annette Peters,&nbsp;Martin Reincke","doi":"10.1055/a-2035-6179","DOIUrl":"https://doi.org/10.1055/a-2035-6179","url":null,"abstract":"<p><strong>Introduction: </strong>Aldosterone excess is linked to cardiovascular events and mortality as well as to low-grade inflammation in the context of metabolic diseases. Whether mildly elevated aldosterone levels in the general population promote cardiovascular risk is still under debate. We analyzed the association of plasma aldosterone concentrations with incident cardiovascular events, cardiovascular and all-cause mortality as well as with biomarkers of subclinical inflammation in the population-based KORA F4 study.</p><p><strong>Methods: </strong>Plasma aldosterone concentrations were measured with an in-house immunoflurometric assay. The analyses included 2935 participants (n=1076 for selected biomarkers of subclinical inflammation) with a median follow-up of 8.7 (8.2; 9.1) years. The associations were estimated using Cox proportional hazard and linear regression models adjusted for renin, sex, age, body mass index, arterial hypertension, diabetes, estimated glomerular filtration rate, low- and high-density lipoprotein cholesterol, physical activity, smoking, use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, diuretics and calcium channel blockers.</p><p><strong>Results: </strong>Aldosterone was significantly associated with all-cause mortality (hazard ratio per standard deviation increase: 1.20; 95% confidence interval 1.04-1.37), but not with cardiovascular mortality, incident cardiovascular events, or with biomarkers of subclinical inflammation.</p><p><strong>Conclusions: </strong>Aldosterone was associated with all-cause mortality in the population-based KORA F4 study, but the previously described associations of excess aldosterone with cardiovascular complications and biomarkers of subclinical inflammation could not be shown.</p>","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 5","pages":"307-313"},"PeriodicalIF":1.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9475416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of Hypoglycemia in Diabetic Patients During Colonoscopy Preparation. 糖尿病患者在结肠镜检查准备期间低血糖的预测。
IF 1.8 4区 医学
Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-05-01 DOI: 10.1055/a-2044-0685
Xiaohua Lu, Lingqiao Xie, Wane Zhao, Chuangbiao Zhang, Xixi Luo, Yan Zhou
{"title":"Prediction of Hypoglycemia in Diabetic Patients During Colonoscopy Preparation.","authors":"Xiaohua Lu,&nbsp;Lingqiao Xie,&nbsp;Wane Zhao,&nbsp;Chuangbiao Zhang,&nbsp;Xixi Luo,&nbsp;Yan Zhou","doi":"10.1055/a-2044-0685","DOIUrl":"https://doi.org/10.1055/a-2044-0685","url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinical outcomes and establish a predictive model of hypoglycemia during colonoscopy preparation for diabetic patients.</p><p><strong>Methods: </strong>Three-hundred ninety-four patients with diabetes who received colonoscopy were retrospectively enrolled in this study and assigned to hypoglycemia or non-hypoglycemia groups. Information about clinical characteristics and outcomes during colonoscopy preparation was collected and compared between the two groups. Logistic regression analysis was applied to identify the risk factors of hypoglycemia. These risk factors were used to construct a hypoglycemia predictive model verified by the receiver operating characteristic (ROC) curve and Hosmer-Lemeshow goodness fit test.</p><p><strong>Results: </strong>Among 394 participants, 66 (16.8%) underwent a total of 88 hypoglycemia attacks during the bowel preparation. Grade 1 hypoglycemia (≤3.9 mmol/L) comprised 90.9% (80/88) of all hypoglycemia attacks and grade 2 hypoglycemia accounted for 9.1% (8/88), signifying that grade 1 hypoglycemia is the most common type. No severe hypoglycemia was identified. The incidence of nocturnal hypoglycemia was 15.9%. Logistic regression analyses revealed that the main risk factors of hypoglycemia during colonoscopy preparation were postprandial C-peptide, serum triglyceride, gender, type of diabetes mellitus, and insulin injection frequencies. The area under the ROC curve of the hypoglycemia prediction model was 0.777 (95% CI: 0.720-0.833).</p><p><strong>Conclusion: </strong>Diabetic patients are prone to develop mild to moderate hypoglycemia during colonoscopy preparation. This study proposes a predictive model that could provide a reference for identifying patients with a high risk of hypoglycemia during colonoscopy preparation.</p>","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 5","pages":"274-281"},"PeriodicalIF":1.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9489223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Dietary Sodium and Protein Intake on Glomerular Filtration Rate in Subjects with Type 2 Diabetes Treated with Sodium-Glucose Cotransporter 2 Inhibitors. 膳食钠和蛋白质摄入对钠-葡萄糖共转运蛋白2抑制剂治疗2型糖尿病患者肾小球滤过率的影响
IF 1.8 4区 医学
Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-05-01 DOI: 10.1055/a-2041-1516
Costanza Gaudio, Marta Seghieri, Chiara Merciai, Claudia Colombi, Giuseppe Spatoliatore, Cristiana Maria Baggiore, Alberto Rosati
{"title":"Effects of Dietary Sodium and Protein Intake on Glomerular Filtration Rate in Subjects with Type 2 Diabetes Treated with Sodium-Glucose Cotransporter 2 Inhibitors.","authors":"Costanza Gaudio,&nbsp;Marta Seghieri,&nbsp;Chiara Merciai,&nbsp;Claudia Colombi,&nbsp;Giuseppe Spatoliatore,&nbsp;Cristiana Maria Baggiore,&nbsp;Alberto Rosati","doi":"10.1055/a-2041-1516","DOIUrl":"https://doi.org/10.1055/a-2041-1516","url":null,"abstract":"<p><strong>Background: </strong>Approximately one-fourth of patients treated with sodium-glucose cotransporter 2 inhibitors (SGLT2i) experience an acute estimated glomerular filtration rate (eGFR) reduction of more than 10% (\"dippers\"). High sodium and protein intake can increase intraglomerular pressure and predispose to a decline in renal function. We investigated whether measured creatinine clearance (CrCl) is a sensitive enough method to detect the initial dip of GFR and if dietary sodium and protein intake might influence the extent of the early change in GFR.</p><p><strong>Methods: </strong>28 subjects with type 2 diabetes (T2D) were enrolled. For sodium and urea determination, 24-h urinary samples were collected to estimate sodium and protein intake respectively before and 1, 3 and 6 months after SGLT2i initiation.</p><p><strong>Results: </strong>Mean CrCl was 83.23±25.52 mL/min/1.73 m<sup>2</sup> (eGFR 67.32±16.07) and dropped by 19% at month 1 (eGFR by 6%). Dippers were 64 and 40%, according to CrCl and eGFR, respectively. Exploring the potential correlation between changes in renal function and salt intake, ΔCrCl and baseline urinary sodium were inversely related at month 1 (<i>r</i>=-0,61; <i>p</i><0.01), at month 3 (<i>r</i>=-0.51; <i>p</i>=0.01) and month 6 (<i>r</i>=-0,48; <i>p</i><0.05). Likewise, an inverse correlation between ΔCrCl and baseline urinary urea was demonstrated at months 1 and 3 (<i>r</i>=-0.46; <i>p</i><0.05 for both); at month 6, a similar trend was observed (<i>r</i>=-0.47; <i>p</i>=0.054).</p><p><strong>Conclusions: </strong>The present study suggests that a higher dietary sodium and protein intake may amplify the extent of the early dip in GFR, as detected with measured CrCl, in diabetic patients undergoing SGLT2i treatment.</p>","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 5","pages":"254-259"},"PeriodicalIF":1.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9475429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mind the gap: Measured and Calculated Osmolarity are Not Interchangeable in Diabetic Hyperglycemic Emergencies. 注意差距:在糖尿病高血糖紧急情况下,测量和计算的渗透压不能互换。
IF 1.8 4区 医学
Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-05-01 DOI: 10.1055/a-2039-0978
Sebastiaan Paul Blank, Ruth Miriam Blank
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