Experimental and Clinical Endocrinology & Diabetes最新文献_第3页

Incidence of Stroke in People With Diabetes Compared to Those Without Diabetes: A Systematic Review. 糖尿病患者与非糖尿病患者中风发生率的比较：一项系统综述。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-09-01 Epub Date: 2023-06-06 DOI: 10.1055/a-2106-4732

Tatjana Kvitkina, Maria Narres, Heiner Claessen, Maria-Inti Metzendorf, Bernd Richter, Andrea Icks

{"title":"Incidence of Stroke in People With Diabetes Compared to Those Without Diabetes: A Systematic Review.","authors":"Tatjana Kvitkina, Maria Narres, Heiner Claessen, Maria-Inti Metzendorf, Bernd Richter, Andrea Icks","doi":"10.1055/a-2106-4732","DOIUrl":"10.1055/a-2106-4732","url":null,"abstract":"Background: One of the goals of the St. Vincent Declaration was to reduce serious complications of diabetes, including strokes. However, it remains uncertain whether this goal has been achieved.Study aim: To evaluate the incidence of stroke in the diabetic population and its differences regarding sex, ethnicity, age, and region, to compare the incidence rate in people with and without diabetes, and to investigate time trends.Materials and methods: A systematic review was conducted according to the guidelines for meta-analysis of observational studies in epidemiology (the MOOSE group) and the PRISMA group guidelines.Results: Nineteen of the 6.470 studies retrieved were included in the analysis. The incidence of stroke in the population with diabetes ranged from 238 per 100,000 person-years in Germany in 2014 to 1191 during the 1990s in the United Kingdom. The relative risk comparing people with diabetes to those without diabetes varied between 1.0 and 2.84 for total stroke, 1.0 and 3.7 for ischemic stroke, and 0.68 and 1.6 for hemorrhagic stroke. Differences between fatal and non-fatal stroke were significant, depending on the time period and the population. We found decreasing time trends in people with diabetes and stable incidence rates of stroke over time in people without diabetes.Conclusion: The considerable differences between results can partly be explained by differences in study designs, statistical methods, definitions of stroke, and methods used to identify patients with diabetes. The lack of evidence arising from these differences ought to be rectified by new studies.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 9","pages":"476-490"},"PeriodicalIF":1.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/40/10-1055-a-2106-4732.PMC10506631.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10350939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Aldosteronism Prevalence - An Unfolding Story. 原发性醛固酮增多症的流行-一个正在展开的故事。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-08-01 DOI: 10.1055/a-2066-2696

Suranut Charoensri, Adina Turcu

引用次数: 1

Adrenal Vein Sampling in the Young - Necessary or Not? 青少年肾上腺静脉取样是否必要?

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-08-01 DOI: 10.1055/a-2099-3525

Eleftheria Gkaniatsa, Oskar Ragnarsson

引用次数: 1

Primary Aldosteronism and Drug Resistant Hypertension: A "Chicken-Egg" Story. 原发性醛固酮增多症和耐药高血压:一个“先有鸡还是先有蛋”的故事。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-08-01 DOI: 10.1055/a-2073-3202

Livia Lenzini, Giovanni Pintus, Teresa Maria Seccia, Giacomo Rossitto, Gian Paolo Rossi

{"title":"Primary Aldosteronism and Drug Resistant Hypertension: A \"Chicken-Egg\" Story.","authors":"Livia Lenzini, Giovanni Pintus, Teresa Maria Seccia, Giacomo Rossitto, Gian Paolo Rossi","doi":"10.1055/a-2073-3202","DOIUrl":"https://doi.org/10.1055/a-2073-3202","url":null,"abstract":"Drug-resistant arterial hypertension (RH) is a major risk factor for cardiovascular disease, often due to overlooked underlying causes. Identification of such causes poses significant clinical challenges. In this setting, primary aldosteronism (PA) is a frequent cause of RH and its prevalence in RH patients is likely higher than 20%.The pathophysiological link between PA and the development and maintenance of RH involves target organ damage and the cellular and extracellular effects of aldosterone excess that promote pro-inflammatory and pro-fibrotic changes in the kidney and vasculature.The feasibility of adrenal vein sampling in PA patients with RH, and the clinical benefit achieved by adrenalectomy, further emphasize the need to implement systematic screening for this common form of secondary hypertension in the management of a high-risk population as RH patients.: We herein review the current knowledge of the factors that contribute to the RH phenotype with a focus on PA and discuss the issues regarding the screening for PA in this setting and the therapeutic approaches (surgical and medical) aimed at resolving RH caused by PA.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 7-08","pages":"409-417"},"PeriodicalIF":1.8,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9981571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role of Adrenal Vein Sampling in Guiding Surgical Decision in Primary Aldosteronism. 肾上腺静脉取样对原发性醛固酮增多症手术决策的指导作用。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-08-01 DOI: 10.1055/a-2106-4663

Nada Younes, Stéphanie Larose, Isabelle Bourdeau, Eric Therasse, André Lacroix

{"title":"Role of Adrenal Vein Sampling in Guiding Surgical Decision in Primary Aldosteronism.","authors":"Nada Younes, Stéphanie Larose, Isabelle Bourdeau, Eric Therasse, André Lacroix","doi":"10.1055/a-2106-4663","DOIUrl":"https://doi.org/10.1055/a-2106-4663","url":null,"abstract":"Adrenal vein sampling (AVS) is recommended for subtyping primary aldosteronism (PA) to identify lateralized or bilateral sources of aldosterone excess, allowing for better decision-making in regard to medical or surgical management on a case-by-case basis. To date, no consensus exists on protocols to be used during AVS, especially concerning sampling techniques, the timing of sampling, and whether or not to use adrenocorticotropic hormone (ACTH) stimulation. Interpretation criteria for selectivity, lateralization, and contralateral suppression vary from one expert center to another, with some favoring strict cut-offs to others being more permissive. Clinical and biochemical post-operative outcomes can also be influenced by AVS criteria utilized to indicate surgical therapy.In this review, we reanalyze studies on AVS highlighting the recent pathological findings of frequent micronodular hyperplasia adjacent to a dominant aldosteronoma (APA) overlapping with bilateral idiopathic hyperaldosteronism (IHA) etiologies, as opposed to the less frequent unilateral single aldosteronoma. The variable expression of melanocortin type 2 receptors in the nodules and hyperplasia may explain the frequent discordance in lateralization ratios between unstimulated and ACTH- stimulated samples. We conclude that aldosterone values collected during simultaneous bilateral sampling, both at baseline and post-ACTH stimulation, are required to adequately evaluate selectivity, lateralization, and contralateral suppression during AVS, to better identify all patients with PA that can benefit from a surgical indication. Recommended cut-offs for each ratio are also presented.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 7-08","pages":"418-434"},"PeriodicalIF":1.8,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9986832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Progress in Primary Aldosteronism 7: No better time to meet! 原发性醛固酮增多症的进展7:没有更好的时间见面!

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-08-01 DOI: 10.1055/a-2129-3672

Martin Reincke, William E Rainey, Tracy Ann Williams

{"title":"Progress in Primary Aldosteronism 7: No better time to meet!","authors":"Martin Reincke, William E Rainey, Tracy Ann Williams","doi":"10.1055/a-2129-3672","DOIUrl":"https://doi.org/10.1055/a-2129-3672","url":null,"abstract":"Fourteen years ago, in July 2009, we held the first Progress in Primary Aldosteronism (PIPA) meeting in Munich. Our idea was that a meeting dedicated to primary aldosteronism (PA) would facilitate collaborative research and scientific exchange in the field. Since then, five more PIPA meetings in 2011, 2013, 2015, 2017 and 2019 gathered scientists from around the world and led to the Progress in Primary Aldosteronism special issues in Hormone and Metabolic Research (2011, 2015, 2017, 2020) and in the European Journal of Endocrinology (2013) that covered current knowledge by PIPA participants. Also, numerous collaborative projects were initiated at these conferences. Then, in 2020, the COVID-19 outbreak caused an unprecedented challenge to humanity, science and research. Worldwide public and private initiatives were undertaken to fight the pandemic, and for 2 long years, everyone was stuck in a black hole. Research related to the COVID-19 emergency increased dramatically, and increasing resources were directed towards pandemic-related research areas. Research in many fields, not directly related to the pandemic, suffered or was partially displaced [1]. Due to the pandemic, we were unable to hold our biennial PIPA meeting in 2021.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 7-08","pages":"383-385"},"PeriodicalIF":1.8,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10420680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiofrequency Ablation in Primary Aldosteronism. 射频消融治疗原发性醛固酮增多症。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-08-01 DOI: 10.1055/a-2128-5811

Yun-Ni Lee, William Martyn Drake

引用次数: 1

Improving Detection Rates for Primary Aldosteronism. 提高原发性醛固酮增多症的检出率。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-08-01 DOI: 10.1055/a-2048-6213

Renata Libianto, Michael Stowasser, Grant Russell, Peter J Fuller, Jun Yang

引用次数: 1

An Abbreviated History of Aldosterone Metabolism, Current and Future Challenges. 醛固酮代谢简史，当前和未来的挑战。

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-08-01 DOI: 10.1055/a-2054-1062

Celso E Gomez-Sanchez, Elise P Gomez-Sanchez

{"title":"An Abbreviated History of Aldosterone Metabolism, Current and Future Challenges.","authors":"Celso E Gomez-Sanchez, Elise P Gomez-Sanchez","doi":"10.1055/a-2054-1062","DOIUrl":"https://doi.org/10.1055/a-2054-1062","url":null,"abstract":"The initial isolation of adrenal steroids from large quantities of animal adrenals resulted in an amorphous fraction resistant to crystallization and identification and had potent effects on electrolyte transport. Aldosterone was eventually isolated and identified in the fraction and was soon shown to cause hypertension when in excess. The autonomous and excessive production of aldosterone, primary aldosteronism, is the most common cause of secondary hypertension. Aldosterone is metabolized in the liver and kidney, and its metabolites are conjugated with glucuronic acid for excretion. The most common liver metabolite is 3α,5β-tetrahydroaldosterone-3-glucuronide, while that of the kidney is aldosterone-18-oxo-glucuronide. In terms of their value, especially the aldosterone-18-oxo-glucuronide, is commonly used for the diagnosis of primary aldosteronism because they provide an integrated value of the total daily production of aldosterone. Conversion of aldosterone to 18-oxo-glucuronide is impeded by drugs, like some common non-steroidal anti-inflammatory drugs that compete for UDP-glucuronosyltransferase-2B7, the most important glucuronosyltransferase for aldosterone metabolism. Tetrahydroaldosterone is the most abundant metabolite and the most reliable for the diagnosis of primary aldosteronism, but it is not commonly measured.","PeriodicalId":12241,"journal":{"name":"Experimental and Clinical Endocrinology & Diabetes","volume":"131 7-08","pages":"386-393"},"PeriodicalIF":1.8,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9983999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Metabolic and Endocrine Complications of Long-COVID-19: A Review. 长期covid -19的代谢和内分泌并发症:综述

IF 1.8 4区医学

Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-06-01 DOI: 10.1055/a-2063-8697

Thushari Bandara, Harshal A Deshmukh, Mohammed Abdalla, Thozhukat Sathyapalan

引用次数: 0