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[The experimental effect of the copolymer of 1-vinyl-3-methyl imidazole iodide with maleic acid diethyl ester on blood coagulability]. [1-乙烯基-3-甲基咪唑碘化物与马来酸二乙酯共聚物对血液凝固性能的实验影响]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
G V Afanas'eva, A A Antonovich, V S Efimov, A I Smirnov
{"title":"[The experimental effect of the copolymer of 1-vinyl-3-methyl imidazole iodide with maleic acid diethyl ester on blood coagulability].","authors":"G V Afanas'eva,&nbsp;A A Antonovich,&nbsp;V S Efimov,&nbsp;A I Smirnov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The antiheparin activity and acute toxicity of the copolymer of 1-vinyl-3-methyl inidazol iodide (VMII) with diethyl ether of maleic acid (DEMA) were investigated. It was shown that the injection of DEMA group to the molecule of VMII polymer was adequate for storage of a high antiheparin activity of the polymer with the structure. This composition of the copolymer has a low acute toxicity and high selectivity to heparin in the blood. Thrombocytopenia effect is absent.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12963200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of yohimbine and idazoxan on the systemic and regional hemodynamics of waking rats]. 育亨宾和咪唑嗪对清醒大鼠全身和局部血流动力学的影响。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
M N Ivashev, O S Medvedev, A D Giulumian
{"title":"[The effect of yohimbine and idazoxan on the systemic and regional hemodynamics of waking rats].","authors":"M N Ivashev,&nbsp;O S Medvedev,&nbsp;A D Giulumian","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of yohimbine and idazoxane (0.5 and 5 mg/kg, intravenously) on the systemic and regional hemodynamics were studied in conscious Wistar rats by the microsphere technique. The both drugs induced an elevation of the arterial blood pressure and the heart rate. The administration of yohimbine and idazoxane in a dose of 0.5 mg/kg produced a more pronounced increase in the cerebral and coronary blood flow that a higher dose (5.0 mg/kg). The blood flow in the small intestine, kidneys and testis was decreased by a high dose of the studied alpha-blockers. It was suggested that the direct action of alpha 2-blockers on the vessel smooth muscle cells in responsible for the increase in the blood flow whereas blockade of alpha 2-receptors on the sympathetic terminals produces the decrease in the blood flow.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The experimental anti-arrhythmia properties of the histamine H1 receptor blockader fencarol]. 组胺H1受体阻滞剂芬卡罗抗心律失常的实验研究。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
G M Iakovlev, V I Skorobogatov, A S Svistov, M I Mironova
{"title":"[The experimental anti-arrhythmia properties of the histamine H1 receptor blockader fencarol].","authors":"G M Iakovlev,&nbsp;V I Skorobogatov,&nbsp;A S Svistov,&nbsp;M I Mironova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Phencarol, a blocker of H1-histamine receptors, is used as an antihistaminic agent. The antiarrhythmic effect of phencarol was detected and studied on experimental models of arrhythmias in non-anesthetized rabbits in a dose of 5 mg/kg intravenously. The drug was shown to possess the pronounced antiarrhythmic and protective properties on the models of calcium-chloride-, adrenaline- and strophanthine-induced arrhythmias and to exert no influence on aconitine-induced arrhythmia. Phencarol was demonstrated to have no cardiodepressive effect.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Immunodepressants used in immune system pathology. II. Methotrexate, vinblastine, antilymphocyte serum and prednisolone]. 免疫系统病理学中使用的免疫抑制剂。2甲氨蝶呤，长春碱，抗淋巴细胞血清和强的松龙]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
Iu K Napolov, K B Borisov
{"title":"[Immunodepressants used in immune system pathology. II. Methotrexate, vinblastine, antilymphocyte serum and prednisolone].","authors":"Iu K Napolov,&nbsp;K B Borisov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12962261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The anti-inflammatory and analgesic activities of antiphlogistic complexes with glycyrrhizic acid]. [甘草酸抗炎复合物的抗炎镇痛作用]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
A I Bondarev, S A Bashkatov, V A Davydova, F S Zarudiĭ, D N Lazareva, T G Tolstikova, L A Baltina, G A Tolstikov, Iu I Murinov, I A Rusakov
{"title":"[The anti-inflammatory and analgesic activities of antiphlogistic complexes with glycyrrhizic acid].","authors":"A I Bondarev,&nbsp;S A Bashkatov,&nbsp;V A Davydova,&nbsp;F S Zarudiĭ,&nbsp;D N Lazareva,&nbsp;T G Tolstikova,&nbsp;L A Baltina,&nbsp;G A Tolstikov,&nbsp;Iu I Murinov,&nbsp;I A Rusakov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12962314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of microencapsulation on the pharmacological activity of theophylline and euphylline]. 微胶囊化对茶碱和幼嫩碱药理活性的影响。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
I N Andreeva, A S Saraf, V A Makarov
{"title":"[The effect of microencapsulation on the pharmacological activity of theophylline and euphylline].","authors":"I N Andreeva,&nbsp;A S Saraf,&nbsp;V A Makarov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12963199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of heparin on the process of colony formation from bone marrow mononuclears in a diffusion chamber]. [肝素对扩散室骨髓单核细胞集落形成过程的影响]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
G K Popov, M S Bel'skiĭ, A G Pochinskiĭ
{"title":"[The effect of heparin on the process of colony formation from bone marrow mononuclears in a diffusion chamber].","authors":"G K Popov,&nbsp;M S Bel'skiĭ,&nbsp;A G Pochinskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the experiments on Wistar rats to whom heparin was injected intravenously in the tail vein in doses of 50, 100 and 250 U, there were studied the colony-forming ability of the hemopoietic cells, the precursors of the bone marrow, and the colony-stimulating activity of the plasma of the heparinized animals 1, 3, 6, 12 and 24 hours after the drug administration. Heparin was found to increase the proliferative activity of the committed myelopoietic cells-precursors on a diffusion microchamber (GM-CFUdc) stimulating the mononuclears and elevating the level of the colony-stimulating activity of the plasma of the experimental animals.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12963201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The action of 3-indolepyruvate in quinolinate-induced convulsions in mice]. [3-吲哚乙酸酯在喹啉酸引起的小鼠惊厥中的作用]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
S Mirzaev, I V Ryzhov
{"title":"[The action of 3-indolepyruvate in quinolinate-induced convulsions in mice].","authors":"S Mirzaev,&nbsp;I V Ryzhov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The experiments on 286 mice of two lines (SHR and C57BL/6) showed that 3-indoipyruvate, a natural keto analogue of tryptophan and a precursor of serotonin and kynurenic acid) possesses the selective dose-dependent (100-500 mg/kg, intraperitoneally) protective effect against quinolinate-induced convulsions. At prolonged administration (50-100 mg/kg for 10 days twice a day) its efficiency drastically increased. It is supposed that the mechanism of the anticonvulsant action of 3-indolpyruvate involves an enhancement of synthesis of kynurenic acid, a blocker of N-methyl-D-aspartate receptors, and at chronic administration--also an increase of sensitivity and density of these receptors.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13001867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Drug derivatives of xanthine]. 黄嘌呤的药物衍生物。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
Iu F Krylov, E I Karamysheva
{"title":"[Drug derivatives of xanthine].","authors":"Iu F Krylov,&nbsp;E I Karamysheva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data on the pharmacological effects of xanthines and their use in pharmacotherapy, particularly, in regulation of cellular hemostasis to correct disorders of microcirculation are summarized. The possible mechanisms of hemostasis regulation by xanthines and the most promising ways of search for new antiaggregation drugs in this series are considered.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12962259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The antiamnesic properties of antidepressants]. [抗抑郁药的抗遗忘特性]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
M D Mashkovskiĭ, N I Andreeva, V A Parshin, S M Golovina
{"title":"[The antiamnesic properties of antidepressants].","authors":"M D Mashkovskiĭ,&nbsp;N I Andreeva,&nbsp;V A Parshin,&nbsp;S M Golovina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The experiments on albino rats demonstrated that antidepressants pyrazidol, imipramine, incazane, moclobemide and to a lesser degree azaphen reduce the amnesic effects of electroshock and scopolamine in the rats with the acquired conditioned reaction of passive avoidance. The studied antidepressants decrease also the disturbing action of alcohol on the learning of rats of the conditioned reaction of active avoidance.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12962315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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