[The effect of heparin on the process of colony formation from bone marrow mononuclears in a diffusion chamber].

Abstract

In the experiments on Wistar rats to whom heparin was injected intravenously in the tail vein in doses of 50, 100 and 250 U, there were studied the colony-forming ability of the hemopoietic cells, the precursors of the bone marrow, and the colony-stimulating activity of the plasma of the heparinized animals 1, 3, 6, 12 and 24 hours after the drug administration. Heparin was found to increase the proliferative activity of the committed myelopoietic cells-precursors on a diffusion microchamber (GM-CFUdc) stimulating the mononuclears and elevating the level of the colony-stimulating activity of the plasma of the experimental animals.