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[Ferakril--a local-action hemostatic]. [Ferakril——局部作用止血药]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
V Z Annenkova, V M Annenkova, G M Kononchuk, V B Kazimirovskaia, M G Voronkov
{"title":"[Ferakril--a local-action hemostatic].","authors":"V Z Annenkova,&nbsp;V M Annenkova,&nbsp;G M Kononchuk,&nbsp;V B Kazimirovskaia,&nbsp;M G Voronkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data of the preclinical and clinical study of feracryl, a local hemostatic, are presented. The drug's hemostatic activity, acute, subacute and chronic toxicity, anesthetic effect as well as antibacterial and antifungal activities were studied. The results of the clinical trial of the drug are given.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12963203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The anticoagulant and lipolysis-stimulating activity of polysaccharides from marine brown algae]. [海洋褐藻多糖的抗凝血和促脂肪分解活性]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
M Ia Rozkin, M N Levina, V S Efimov, A I Usov
{"title":"[The anticoagulant and lipolysis-stimulating activity of polysaccharides from marine brown algae].","authors":"M Ia Rozkin, M N Levina, V S Efimov, A I Usov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The search for the compounds inducing release of lipoprotein lipase in the blood flow was made in the series of sulfated polysaccharides of brown sea algae of the Japanese Sea--fucoidanes. The effects of the substances on the blood coagulability were studied. Single intravenous injections of the substances were followed by the combined but independent anticoagulant and lipolysis-stimulating effects. Fucoidane isolated from Pelvetia wrightii possessed the greatest lipolysis-stimulating activity along with a weak anticoagulant effect. The degree of the pharmacological effects of the studied compounds did not depend on the degree of sulfation of macromolecules of the polysaccharides. In contrast to heparin fucoidanes exhibited the maximum effect on lipolysis later, 120-180 minutes after the intravenous injection.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12963204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The pharmacodynamics of eicosapentaenoic and docosahexaenoic acids]. [二十碳五烯酸和二十二碳六烯酸的药效学]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
Iu F Krylov, I B Liubimov, A G Muliar
{"title":"[The pharmacodynamics of eicosapentaenoic and docosahexaenoic acids].","authors":"Iu F Krylov,&nbsp;I B Liubimov,&nbsp;A G Muliar","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13000437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The adequacy of a new method for assessing the vestibular protective effect of biologically active substances]. [评估生物活性物质前庭保护作用的新方法的充分性]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
N N Karkishchenko, N A Dimitriadi
{"title":"[The adequacy of a new method for assessing the vestibular protective effect of biologically active substances].","authors":"N N Karkishchenko,&nbsp;N A Dimitriadi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of some neuropsychotropic agents on changes in pain sensitivity in albino male rats under the action of complex accelerations were investigated. It was found that administration of drugs with the antimotion-sickness activity--scopolamine, phenamine, phenibut prevented the development of analgesia with the opiate component, the use of low-effective and non-effective with respect to suppression of vestibulo-vegetative disturbances agents--diazepam, ephedrine, haloperidol failed to exert such an effect.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12963197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A comparative evaluation of amphotericin pharmacokinetics in the skin and subcutaneous fatty tissue when used dermally and by phonophoresis]. [两性霉素在皮肤及皮下脂肪组织中的药代动力学比较研究]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
I M Romanenko
{"title":"[A comparative evaluation of amphotericin pharmacokinetics in the skin and subcutaneous fatty tissue when used dermally and by phonophoresis].","authors":"I M Romanenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During the combined use of the ointment with amphotericin B and ultrasound after 1, 3, 24, 48 and 72 hours there was detected a higher content of the drug in the skin and the subcutaneous fatty tissue as compared with the epicutaneous application of the ointment without ultrasound. The drug contents in the insonified and non-insonified samples increased by the 3rd hour after the application except the insonified skin, where the maximal values were noted after 1 hour; subsequently (after 24, 48 and 72 hours) amphotericin B concentration gradually decreased. It remained significantly higher in the insonified samples than in the non-insonified ones. The data ground the expediency of using the ointment with amphotericin B in combination with ultrasound in candidosis that is one of the ways of increasing the effectiveness of treatment of this disease.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12962316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The acute toxicity of dipidolor (piritramid) against a background of irradiation and the use of cytostatic preparations]. [双吡多啉(匹拉米)在辐照和使用细胞抑制剂的背景下的急性毒性]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
M V Tishchenko
{"title":"[The acute toxicity of dipidolor (piritramid) against a background of irradiation and the use of cytostatic preparations].","authors":"M V Tishchenko","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12962326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The history of the Department of Pharmacology of the 1st Moscow Medical Institute (1930-1956)]. [莫斯科第一医学院药学系的历史(1930-1956年)]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
D N Samoĭlov
{"title":"[The history of the Department of Pharmacology of the 1st Moscow Medical Institute (1930-1956)].","authors":"D N Samoĭlov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12962321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The M-receptor stimulation of phosphatidylinositol metabolism in the isolated rabbit heart]. [m受体刺激离体兔心脏磷脂酰肌醇代谢]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
V I Kocherga, N V Nesterenko, L K Kurchenko, V A Afanas'ev
{"title":"[The M-receptor stimulation of phosphatidylinositol metabolism in the isolated rabbit heart].","authors":"V I Kocherga,&nbsp;N V Nesterenko,&nbsp;L K Kurchenko,&nbsp;V A Afanas'ev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The activating effect of a M-receptor agonist carbachol on phosphatidylinositol metabolism under perfusion of the isolated rabbit heart with 32Pi was shown. An increase of the inclusion of 32P in phosphatidylinositol-4-phosphate and phosphatidylinositol-4-diphosphate was found. Simultaneously there was detected an elevation of the levels of products of hydrolysis of inositol phospholipids--inositol-1,4-diphosphate and inositol-1,4,5-triphosphate. There was noted the blocking action of carbachol on the contractile activity of the heart that manifested itself in a lowering of the systolic pressure in the left ventricle and a slowing of the contraction rate.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12963198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The use of a vibration photometric method for studying the pharmacological regulation of reversible erythrocyte aggregation]. [利用振动光度法研究可逆性红细胞聚集的药理调节]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
R T Tukhvatulin, T M Plotnikova, N I Komova, L K Novikova
{"title":"[The use of a vibration photometric method for studying the pharmacological regulation of reversible erythrocyte aggregation].","authors":"R T Tukhvatulin,&nbsp;T M Plotnikova,&nbsp;N I Komova,&nbsp;L K Novikova","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12888903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The dissimilar effects of the single and prolonged administration of melatonin on the hypnogenic action of hexenal in mice in relation to the dose and the time of day]. [单次和长期服用褪黑素对小鼠己烯醛催眠作用的不同影响与剂量和时间有关]。
Farmakologiia i toksikologiia Pub Date : 1991-09-01
E B Arushanian, P Botvev Orkhiĭ
{"title":"[The dissimilar effects of the single and prolonged administration of melatonin on the hypnogenic action of hexenal in mice in relation to the dose and the time of day].","authors":"E B Arushanian,&nbsp;P Botvev Orkhiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>At the acute administration the pineal hormone melatonin depending on the dose (0.01-10 mg/kg) potentiated the hypnogenic effect of hexenal (hexobarbital sodium) in mice both in the daytime and at night. When low doses of the hormone were chronically administered in the light phase of the day, there was noted a decrease of the duration of barbiturate anesthesia. A similar result was found during its round-the-clock evaluation against the background of 0.1 mg/kg of melatonin (a single dose) in the late daytime hours and on the contrary a sharp enhancement of hexenal action before switching on the light. The relationship between the circadian fluctuations of the hypnogenic effect of barbiturates and the periodical character of the epiphysis activity is suggested.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12962325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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