Evidence-based Complementary and Alternative Medicine最新文献

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RETRACTION: Ex Vivo Stromal Cell-Derived Factor 1-Mediated Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells into Hepatocytes Is Enhanced by Chinese Medicine Yiguanjian Drug-Containing Serum. 撤回:体外基质细胞衍生因子1介导的小鼠骨髓间充质干细胞向肝细胞的分化被中药益冠健含药血清增强。
4区 医学
Evidence-based Complementary and Alternative Medicine Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI: 10.1155/ecam/9812485
Evidence-Based Complementary And Alternative Medicine
{"title":"RETRACTION: <i>Ex Vivo</i> Stromal Cell-Derived Factor 1-Mediated Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells into Hepatocytes Is Enhanced by Chinese Medicine Yiguanjian Drug-Containing Serum.","authors":"Evidence-Based Complementary And Alternative Medicine","doi":"10.1155/ecam/9812485","DOIUrl":"10.1155/ecam/9812485","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2016/7380439.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2025 ","pages":"9812485"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to Exploring the Mechanism of Berberine Intervention in Ulcerative Colitis From the Perspective of Inflammation and Immunity Based on Systemic Pharmacology. 基于系统药理学的从炎症和免疫角度探讨小檗碱干预溃疡性结肠炎机制的修正。
4区 医学
Evidence-based Complementary and Alternative Medicine Pub Date : 2025-03-26 eCollection Date: 2025-01-01 DOI: 10.1155/ecam/9803142
Yan Jiang, Li Zhao, Qing Chen, Lihong Zhou
{"title":"Correction to Exploring the Mechanism of Berberine Intervention in Ulcerative Colitis From the Perspective of Inflammation and Immunity Based on Systemic Pharmacology.","authors":"Yan Jiang, Li Zhao, Qing Chen, Lihong Zhou","doi":"10.1155/ecam/9803142","DOIUrl":"https://doi.org/10.1155/ecam/9803142","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2021/9970240.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2025 ","pages":"9803142"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "PEI-PEG-Coated Mesoporous Silica Nanoparticles Enhance the Antitumor Activity of Tanshinone IIA and Serve as a Gene Transfer Vector". “pei - peg包被的介孔二氧化硅纳米颗粒增强丹参酮IIA的抗肿瘤活性并作为基因转移载体”的勘误。
4区 医学
Evidence-based Complementary and Alternative Medicine Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI: 10.1155/ecam/9763501
Yinxing Zhu, Miao Yue, Ting Guo, Fang Li, Zhifeng Li, Dazhuang Yang, Mei Lin
{"title":"Corrigendum to \"PEI-PEG-Coated Mesoporous Silica Nanoparticles Enhance the Antitumor Activity of Tanshinone IIA and Serve as a Gene Transfer Vector\".","authors":"Yinxing Zhu, Miao Yue, Ting Guo, Fang Li, Zhifeng Li, Dazhuang Yang, Mei Lin","doi":"10.1155/ecam/9763501","DOIUrl":"10.1155/ecam/9763501","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2021/6756763.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2025 ","pages":"9763501"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted: Antiulcerogenic Activity of Li-Zhong Decoction on Duodenal Ulcers Induced by Indomethacin in Rats: Involvement of TLR-2/MyD88 Signaling Pathway. 撤回:李中煎剂对吲哚美辛诱发大鼠十二指肠溃疡的抗溃疡活性:TLR-2/MyD88信号通路的参与
4区 医学
Evidence-based Complementary and Alternative Medicine Pub Date : 2024-07-25 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9831531
Evidence-Based Complementary And Alternative Medicine
{"title":"Retracted: Antiulcerogenic Activity of Li-Zhong Decoction on Duodenal Ulcers Induced by Indomethacin in Rats: Involvement of TLR-2/MyD88 Signaling Pathway.","authors":"Evidence-Based Complementary And Alternative Medicine","doi":"10.1155/2024/9831531","DOIUrl":"10.1155/2024/9831531","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2020/6538156.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2024 ","pages":"9831531"},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of In Vivo Antidiarrheal Activities of 80% Methanol Extract and Solvent Fractions of Peels of Colocasia esculenta (Araceae). 评估80%甲醇提取物和天南星果皮溶剂馏分的体内止泻活性。
4区 医学
Evidence-based Complementary and Alternative Medicine Pub Date : 2024-07-12 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2728282
Temesgen Obsa Terfa, Fekadu Abera Kebede, Monas Kitessa Beyene, Tilahun Tesfaye Abebe, Abebe Basazn Mekuria, Jibril Seid Yesuf
{"title":"Evaluation of In Vivo Antidiarrheal Activities of 80% Methanol Extract and Solvent Fractions of Peels of <i>Colocasia esculenta</i> (Araceae).","authors":"Temesgen Obsa Terfa, Fekadu Abera Kebede, Monas Kitessa Beyene, Tilahun Tesfaye Abebe, Abebe Basazn Mekuria, Jibril Seid Yesuf","doi":"10.1155/2024/2728282","DOIUrl":"10.1155/2024/2728282","url":null,"abstract":"<p><strong>Background: </strong>Diarrhea is the common gastrointestinal disorder accounting for 2.5 billion episodes and 1.5 million deaths annually. Limitations and inaccessibility of currently available medications are the main problem associated with treatment of diarrhea. Hence, medicinal plants are usually preferred to manage diarrhea because they may contain constituents with high activity and fewer side effects. Even though the dose, safety, and efficacy of <i>Colocasia esculenta</i> (L.) Schott are not substantiated scientifically, several societies use it for the treatment of diarrhea.</p><p><strong>Objective: </strong>This study was targeted at exploring the in vivo antidiarrheal activities of 80% methanol extract and solvent fractions of peels of <i>Colocasia esculenta</i> (L.) Schott in Swiss albino mice.</p><p><strong>Methods: </strong>The plant was collected and extracted with 80% methanol, followed by fractionation with distilled water, chloroform, and diethyl ether. Castor oil-induced diarrhea, enteropooling, and motility tests were used to evaluate antidiarrheal activity. The test groups received graded doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg. Negative controls received 10 ml/kg of 2% Tween 80 while positive controls received loperamide (3 mg/kg) or atropine (5 mg/kg).</p><p><strong>Results: </strong>The crude and solvent fractions of the plant extract have induced significant effects in reduction of the number and weight of wet stools at all tested doses. However, delay in onset of diarrhea was observed only at 400 mg/kg (<i>P</i> < 0.001) for both crude extract and solvent fractions. In antienteropooling test, 80% methanol extract and solvent fractions have significantly reduced the weight and volume of intestinal contents, especially at 200 mg/kg and 400 mg/kg. Regarding the antimotility test, the crude extract reduced motility at all tested doses, whereas the solvent fractions reduced intestinal motility mainly at 400 mg/kg (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>The study has revealed that the 80% methanol extract and solvent fractions of the plant possess antidiarrheal activities supporting the traditional antidiarrheal claims of the plant.</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2024 ","pages":"2728282"},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Helicobacter pylori Effects of Thymus caramanicus Jalas Essential Oils: A New Antimicrobial Approach. 胸腺caramanicus Jalas 精油的抗幽门螺旋杆菌作用:一种新的抗菌方法。
4区 医学
Evidence-based Complementary and Alternative Medicine Pub Date : 2024-06-10 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3627074
Sepehr Asadi, Ebrahim Rahimi, Amir Shakerian
{"title":"Anti-<i>Helicobacter pylori</i> Effects of <i>Thymus caramanicus</i> Jalas Essential Oils: A New Antimicrobial Approach.","authors":"Sepehr Asadi, Ebrahim Rahimi, Amir Shakerian","doi":"10.1155/2024/3627074","DOIUrl":"10.1155/2024/3627074","url":null,"abstract":"<p><strong>Background: </strong><i>Helicobacter pylori</i> are the principal causative factor in the etiological factors of chronic, active, or type B gastritis; peptic and duodenal ulcers; stomach carcinoma; and epithelial tissue lymphoid malignancies. It infects more than half of the population worldwide. To reduce <i>H. pylori</i> production, pharmacological therapy of <i>H. pylori</i> diseases typically involves using threefold treatment methods. However, as a result of such therapy, antimicrobial resistance is commonly developed. Alternative therapeutics for <i>H. pylori</i> diseases are thus of particular interest.</p><p><strong>Methods: </strong>Thyme essential oils (EOs) obtained from <i>T. caramanicus</i> Jalas plants in Iran were tested for antibacterial activity against <i>H. pylori</i> obtained from 320 poultry specimens in this investigation. Antibacterial activity was measured using inhibition zones, minimum inhibitory concentrations (MICs), and minimum bactericidal concentrations (MBCs). The impact of <i>T. caramanicus</i> Jalas essential oils on <i>H. pylori</i> isolate <i>cagA</i>, <i>vacA</i>, and <i>babA2</i> gene expression was evaluated using a quantitative real-time PCR method (<i>p</i> < 0.05).</p><p><strong>Results: </strong>The chemical content of these EOs varied significantly according to chromatographic examination. Thymol, carvacrol, and terpinene-4-ol are the most abundant components in these EOs. <i>H. pylori</i> was recognized as a <i>Helicobacter</i> species with a 175-bp PCR product of 16S rRNA in 20/20 (100%). According to PCR results, all 20 (100%) isolates belonged to <i>H. pylori</i>. The EOs inhibited <i>H. pylori</i> in a dose-dependent manner, with <i>T. caramanicus</i> Jalas being the most effective, followed by pterygium EOs in decreasing order. At 8 mg/mL of <i>T. caramanicus</i> Jalas EOs, IZs against <i>H. pylori</i> were 27.4 ± 0.42 mm, and at 8 mg/mL of pterygium, IZs against <i>H. pylori</i> were 1 ± 0.02. <i>T. caramanicus</i> Jalas essential oils were used to treat all bacteria, and the findings showed that <i>T. caramanicus</i> Jalas had a substantial inhibitory impact on the expression of <i>cagA</i>, <i>vacA</i>, and <i>babA2</i> virulence-related genes (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>In a dose-dependent manner, the EOs of <i>T. caramanicus</i> Jalas EO demonstrated a high degree of antimicrobial property against <i>H. pylori</i> bacteria. The most efficient EOs were those from <i>T. caramanicus</i> Jalas with relative concentrations of thymol and carvacrol, followed by the coumarin-dominated pterygium EO with reduced antibacterial activity.</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2024 ","pages":"3627074"},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11182686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial and Antioxidant Compounds from the Root Extract of Aloe debrana. 芦荟根提取物中的抗菌和抗氧化化合物
4区 医学
Evidence-based Complementary and Alternative Medicine Pub Date : 2024-05-07 eCollection Date: 2024-01-01 DOI: 10.1155/2024/6651648
Tokuma Getahun, Joydeep Das, Parames C Sil, Neeraj Gupta
{"title":"Antibacterial and Antioxidant Compounds from the Root Extract of <i>Aloe debrana</i>.","authors":"Tokuma Getahun, Joydeep Das, Parames C Sil, Neeraj Gupta","doi":"10.1155/2024/6651648","DOIUrl":"10.1155/2024/6651648","url":null,"abstract":"<p><p>This study was conducted to isolate and identify the chemical compounds from the roots of <i>Aloe debrana</i> (L.) and evaluate their antioxidant and antibacterial activities. From the acetone (99.5%) extract of the roots of this plant, four anthraquinones, such as chrysophanol (<b>1</b>), asphodeline (<b>2</b>), aloesaponarin I (<b>5</b>), and laccaic acid D-methyl ester (<b>6</b>), and a new catechol derivative, 5-allyl-3-methoxybenzene-1,2-diol (<b>3</b>), were isolated and elucidated by different chromatographic and spectroscopic methods together with linoleic acid (<b>4</b>), respectively. Compounds <b>2</b>, <b>3,</b> and <b>4</b> were reported here for the first time from this plant and compound <b>3</b> from the genus <i>Aloe</i>. The compounds were evaluated for their antioxidant activity using H<sub>2</sub>O<sub>2</sub> and DPPH assays and bactericidal activity against <i>S. aureus</i> and <i>E. coli</i>. Compounds <b>3</b> and <b>6</b> showed highest antioxidant activities with IC<sub>50</sub> values of 19.38 ± 0.64 and 32.81 ± 0.78 <i>μ</i>g/mL in DPPH, and 28.52 ± 1.08 and 27.31 ± 1.46 <i>μ</i>g/mL in H<sub>2</sub>O<sub>2</sub>, respectively. The isolated compounds also demonstrated considerable activity towards <i>S. aureus</i>. Among these compounds, compound <b>3</b> exhibited the highest activity (91.20 ± 0.12% and 9.14 ± 0.93 mm at 1.0 mg/mL) against this bacterium. The overall results suggest that the isolated compounds may be considered as potential sources of the bioactive agents to be used in the pharmacological, food, and other industries. Moreover, their high sensitivity against <i>S. aureus</i> may also support the use of <i>A. debrana</i> plant in the traditional medicine to treat wounds. Therefore, the isolated compounds are responsible for medicinal properties of this plant.</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2024 ","pages":"6651648"},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of In Vitro Antimicrobial, Cytotoxic, Thrombolytic, and Antiarthritic Property of Different Parts of Bari Orchid 评估巴里兰不同部位的体外抗菌、细胞毒性、溶栓和抗关节炎特性
4区 医学
Evidence-based Complementary and Alternative Medicine Pub Date : 2024-04-30 DOI: 10.1155/2024/8148610
Md. Samsur Rahaman, Md. Saifur Rahaman, Shah Md. Marzuk Hasnine, Salma Sultana, Md. Abdul Quaiyum Bhuiyan, Mohammad Shahriar Kabir, Md. Abdul Bari, Jahid M. M. Islam, Md. Ismail Hossain, Mubarak A. Khan
{"title":"Evaluation of In Vitro Antimicrobial, Cytotoxic, Thrombolytic, and Antiarthritic Property of Different Parts of Bari Orchid","authors":"Md. Samsur Rahaman, Md. Saifur Rahaman, Shah Md. Marzuk Hasnine, Salma Sultana, Md. Abdul Quaiyum Bhuiyan, Mohammad Shahriar Kabir, Md. Abdul Bari, Jahid M. M. Islam, Md. Ismail Hossain, Mubarak A. Khan","doi":"10.1155/2024/8148610","DOIUrl":"https://doi.org/10.1155/2024/8148610","url":null,"abstract":"Many different herbal extracts have historically been utilized to treat microbe-induced infections, injuries, cancer, thrombosis, and arthritis. The purpose of this study was to determine the antibacterial, cytotoxic, in vitro thrombolytic, and in vitro antiarthritic properties of ethanolic extracts of stem and seed of Bari orchid 1 (BO) plant. This orchid plant was developed by the Bangladesh Agriculture Research Institute (BARI) in Gazipur. Fourteen microbes were employed in the antimicrobial investigation, and samples of orchids were compared to ciprofloxacin as a reference. The BO/seed extract was found to possess more antibacterial activity. The lethality test of brine shrimps was used to assess the LC<sub>50</sub> values. The BO/stem extract exhibited a higher cytotoxicity potential, in comparison to the BO/seed extract. Two concentrations (1000 and 100 ppm) and two incubation times (24 hours and 1.5 hours) were used to assess the thrombolytic activity of the extracts. Regarding the thrombolytic effect, the BO/stem extract has demonstrated greater promise. Furthermore, the herbal extract’s antiarthritic activity was investigated at four different concentrations, and the results were evaluated in comparison with those of diclofenac sodium. When comparing BO/stem extract to other extracts, the greatest values for protein denaturation were obtained.","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140837972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Homotherapy for Heteropathy: A Molecular Mechanism of Poria Sini Decoction for Treatment of Liver Cancer and Chronic Heart Failure 异病同治:西尼茯苓煎剂治疗肝癌和慢性心力衰竭的分子机制
4区 医学
Evidence-based Complementary and Alternative Medicine Pub Date : 2024-04-29 DOI: 10.1155/2024/9958258
Zhe Zhao, Huiying Yue, Xiaohua Cui
{"title":"Homotherapy for Heteropathy: A Molecular Mechanism of Poria Sini Decoction for Treatment of Liver Cancer and Chronic Heart Failure","authors":"Zhe Zhao, Huiying Yue, Xiaohua Cui","doi":"10.1155/2024/9958258","DOIUrl":"https://doi.org/10.1155/2024/9958258","url":null,"abstract":"Poria sini decoction (PSD), a significant traditional Chinese herbal formula, is effective in liver cancer (LC) and chronic heart failure (CHF); however, little is known about its concurrent targeting mechanism. <i>Methods</i>. This study analyzed the potential molecular mechanism of PSD against the two distinct diseases using network pharmacology approaches, including multidatabase search, pharmacokinetic screening, network construction analysis, Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and molecular docking to elaborate the active components, signaling pathways, and potential mechanisms of PSD in the treatment of both LC and CHF. <i>Results</i>. A total of 155 active components and 193 potential targets in PSD were identified. Bioinformatics analysis revealed that quercetin, isorhamnetin, and naringenin, etc. may be potential candidate agents. TNF, AKT1, and IL6, etc. could become potential therapeutic targets. TNF-<i>α</i>, NF-<i>κ</i>B, PI3K-AKT, and TRP signaling pathways might play an important role in PSD against LC and CHF. Molecular docking results showed that most screened active compounds could embed itself into target proteins with a high binding affinity, and the hydrogen bonds number ≥3 indicated a more stable conformation of the compounds and target proteins. Overall, quercetin and isorhamnetin were the main active components, and TNF and AKT1 were the primary targets for PSD treatment of LC and CHF. <i>Conclusions</i>. This study illustrated that quercetin contained in PSD played an important role in the treatment of LC and CHF by acting on the key gene of TP53 and downregulating the PI3K-AKT signaling pathway.","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140810683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential JAK2 Inhibitors from Selected Natural Compounds: A Promising Approach for Complementary Therapy in Cancer Patients 从精选天然化合物中提取的潜在 JAK2 抑制剂:癌症患者有望采用的辅助疗法
4区 医学
Evidence-based Complementary and Alternative Medicine Pub Date : 2024-04-26 DOI: 10.1155/2024/1114928
Samaneh Vaziri-Amjad, Reza Rahgosha, Amir Taherkhani
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