European Surgical Research最新文献

{"title":"Front & Back Matter","authors":"","doi":"10.1159/000530321","DOIUrl":"https://doi.org/10.1159/000530321","url":null,"abstract":"","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48816000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Index Vol. 64, No. 1, 2023","authors":"","doi":"10.1159/000529174","DOIUrl":"https://doi.org/10.1159/000529174","url":null,"abstract":"","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47509534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Laboratory Parameters in Stroke Patients Based on Decompressive Craniectomy Timing","authors":"Ibrahim Acir, Haci Ali Erdogan, Mert Gobel, Vildan Yayla","doi":"10.33425/2689-1093.1051","DOIUrl":"https://doi.org/10.33425/2689-1093.1051","url":null,"abstract":"Background: Decompressive craniectomy reduces mortality and morbidity in ischemic stroke patients with malignant cerebral edema. Prognostic markers such as red cell distribution width, neutrophil lymphocyte ratio, and platelet count are needed to predict the timing of decompressive surgery in ischemic stroke patients. Sodium, a parameter that changes before and after decompression surgery, may also be a factor to consider when assessing the patient's prognosis and deciding whether to proceed with surgery. In this study, we aimed to examine the changes in laboratory parameters in stroke patients according to the time of decompression surgery. Material and Method: At our stroke center, 52 patients were diagnosed with stroke and underwent decompressive craniectomy. The patients were divided into four groups based on their decompression time (the first 24 hours, 24-48 hours, 48-72 hours, and after 72 hours). The width of the red cell distribution, platelet count, neutrophillymphocyte ratios, and sodium levels were calculated and compared between groups and National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores are all listed. Results: The patients had a mean age of 62 ± 11 years, with 31 males and 21 females. The patients' admission, 24th hour, and post-operative sodium levels were not significantly different. The patients' admission, 24th hour, and post-op RDW did not differ statistically significantly. The 24th hour NLR levels of the groups differed significantly (p=0.049). Conclusion: There is a need for laboratory measurements that can estimate the time required for decompression surgery. Nevertheless, no significant difference between groups was observed in our study, which investigated at RDW, NLR, platelet count, and sodium levels.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135827918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Nephrolithotomy: A Mini Invasive Approach for Renal and Pelvic Stones. Initial Experience from a Resource-Limited Setting in Douala Cameroon","authors":"Cyril Kamadjou, Divine Enoru Eyongeta, Annie Kameni, Jerry Kuitche, Lamine Niang, Khaled Atallah, Mohammed Lezrek, Herve Moby Mpah","doi":"10.33425/2689-1093.1049","DOIUrl":"https://doi.org/10.33425/2689-1093.1049","url":null,"abstract":"Background and Aim: We present in this paper the technique and results of percutaneous nephrolithotomy as a minimally invasive treatment for large renal and pyeloureteric junction stones at the Centre medico-chirugical d’urologie in Douala, Cameroon. Methods: This was a retrospective study carried out from January 2019 to July 2022. We included 25 patients with calculi in the renal pelvis and pyeloureteric junction treated through percutaneous nephrolithotomy. Results: We included a total of 25 patients (18 men and 7 women) with a median age of 44 [36-48] years. Of the 25 patients, 23(88%) had a single calculus and 3(22%) presented with a Staghorn calculus. The median size of the calculi was 23.5 [20.25–27.75] mm and in 60% of cases; the stone was on the right side of the body. In all cases, the definitive diagnosis was made using abdominal CT scans and in 20 (80%) patients, the diagnosis was made incidentally during a CT scan for other reasons. All patients were treated through percutaneous nephrolithotomy, performed in the prone position in 21(84%) patients. Three patients who had a positive urine culture prior to the procedure benefited from a preoperative double J stent placement and all patients had post-surgery percutaneous drain placement which was left in place for 24 hours. The median surgery duration was 135 [120–165] minutes. Seventeen patients (68%) were stone free after the procedure. Conclusion: Percutaneous nephrolithotomy is an effective mini-invasive technique in the treatment of voluminous kidney and pyeloureteric junction stones. It is reliable, reproducible and has fewer complications and, therefore, proves to be an excellent choice in Sub-Saharan Africa.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135827917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma: Focus on Surgical Treatment Approach","authors":"Zarrin Hossein-zadeh, Katherine Rivero-Soto, Roberto Rivero-Soto","doi":"10.33425/2689-1093.1050","DOIUrl":"https://doi.org/10.33425/2689-1093.1050","url":null,"abstract":"Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma (IPT-like FDC sarcomas, also known as FDC/FRC sarcoma) is a subgroup of follicular dendritic cell sarcoma (FDC), a rare neoplasm that often occurs in the spleen [1]. FDC/FRC sarcomas can affect other organs including the liver, colon, and the peripancreatic region [2-4]. The tumor has a predilection for young to middle-aged adults and may present with subset of symptoms including fever, abdominal pain, sweats, fatigue, and commonly a splenic solitary mass formation [5]. FDC/FRC sarcoma comprises of neoplastic spindle cells, typically with a follicular dendritic cell differentiation and over 90% of the cases are associated with EBV infection [6]. Here we present the a case of a IPT-like FDC sarcoma in a 49- year old female treated with splenectomy and a review of the literature.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135827916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents Vol. 63, 2022","authors":"","doi":"10.1159/000528891","DOIUrl":"https://doi.org/10.1159/000528891","url":null,"abstract":"<br />Eur Surg Res 2022;63:I–VI","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138526355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dot-Probe Attention Bias Task as a Method to Assess Psychological Well-Being after Anesthesia: A Study with Adult Female Long-Tailed Macaques (Macaca fascicularis).","authors":"Lauren C Cassidy,&nbsp;Emily J Bethell,&nbsp;Ralf R Brockhausen,&nbsp;Susann Boretius,&nbsp;Stefan Treue,&nbsp;Dana Pfefferle","doi":"10.1159/000521440","DOIUrl":"https://doi.org/10.1159/000521440","url":null,"abstract":"<p><p>Understanding the impact routine research and laboratory procedures have on animals is crucial to improving their well-being and to the success and reproducibility of the research they are involved in. Cognitive measures of welfare offer insight into animals' internal psychological state, but require validation. Attention bias - the tendency to attend to one type of information over another - is a cognitive phenomenon documented in humans and animals that is known to be modulated by affective state (i.e., emotions). Hence, changes in attention bias may offer researchers a deeper perspective of their animals' psychological well-being. The dot-probe task is an established method for quantifying attention bias in humans (by measuring reaction time to a dot-probe replacing pairs of stimuli), but has yet to be validated in animals. We developed a dot-probe task for long-tailed macaques (Macaca fascicularis) to determine if the task can detect changes in attention bias following anesthesia, a context known to modulate attention and trigger physiological arousal in macaques. Our task included the following features: stimulus pairs of threatening and neutral facial expressions of conspecifics and their scrambled counterparts, two stimuli durations (100 and 1,000 ms), and counterbalancing of the dot-probe's position on the touchscreen (left and right) and location relative to the threatening stimulus. We tested 8 group-housed adult females on different days relative to being anesthetized (baseline and 1-, 3-, 7-, and 14-days after). At baseline, monkeys were vigilant to threatening content when stimulus pairs were presented for 100 ms, but not 1,000 ms. On the day immediately following anesthesia, we found evidence that attention bias changed to an avoidance of threatening content. Attention bias returned to threat vigilance by the third day postanesthesia and remained so up to the last day of testing (14-days after anesthesia). We also found that attention bias was independent of the type of stimuli pair (i.e., whole face vs. scrambled counterparts), suggesting that the scrambled stimuli retained aspects of the original stimuli. Nevertheless, whole faces were more salient to the monkeys as responses to these trials were generally slower than to scrambled stimulus pairs. Overall, our study suggests it is feasible to detect changes in attention bias following anesthesia using the dot-probe task in nonhuman primates. Our results also reveal important aspects of stimulus preparation and experimental design.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9226053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Sex Matter in Liver Surgery? Comparison of Severity Assessments between Female and Male Rats after Partial Hepatectomy: A Pilot Study.","authors":"Anna Maria Kümmecke,&nbsp;Leonie Zieglowski,&nbsp;Lisa Ernst,&nbsp;Rupert Palme,&nbsp;René H Tolba","doi":"10.1159/000527334","DOIUrl":"https://doi.org/10.1159/000527334","url":null,"abstract":"<p><strong>Introduction: </strong>Current animal-based biomedical research, including studies on liver function and disease, is conducted almost exclusively on male animals to mitigate confounding effects of the estrous cycle. However, liver diseases afflict both men and women, so translational research findings should also be applicable to female patients. This pilot study investigated sex differences in objective and subjective severity assessment parameters in rats following 50% partial hepatectomy.</p><p><strong>Materials and methods: </strong>This study was performed using Wistar Han rats, in which measurements of body weight, spontaneous motor activity in the open field (OF) (movement distance, movement velocity, rearing frequency), and fecal corticosterone metabolites were conducted at baseline and at multiple times after partial hepatectomy. Subjective postsurgical severity assessments were conducted using modified score sheets. Blood parameters such as leukocyte count and serum aspartate aminotransferase, as well as estrogens and testosterone were measured from samples obtained during partial hepatectomy and at sacrifice. In addition, the amount of resected liver tissue was measured at partial hepatectomy, and the proliferated liver was weighed at sacrifice.</p><p><strong>Results: </strong>Fecal corticosterone metabolite concentrations differed significantly between males and females at baseline and following hepatectomy. Also, leukocyte counts and estrogen concentrations were significantly different between sexes before partial hepatectomy. Alternatively, there were no sex differences in severity assessments, body weight changes, and behavior in the OF at any measurement time point. Liver weight was significantly different in males and females at the time point of partial hepatectomy and sacrifice.</p><p><strong>Conclusion: </strong>The results of this pilot study suggest that males and females respond similarly following partial hepatectomy. Examination of both sexes is very important for translation to humans, where both men and women suffer from liver disease. Furthermore, the use of both sexes in animal-based research would improve the utilization of the animal breeding in terms of the 3 Rs. However, due to some limitations, larger scale investigations including a broader spectrum of pathophysiolological, behavioral, and pharmacokinetic measures are planned.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9540551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapamycin Does Not Act as a Dietary Restriction Mimetic in the Protection against Ischemia Reperfusion Injury.","authors":"Eline van den Akker,&nbsp;Frank J M F Dor,&nbsp;Jan N M IJzermans,&nbsp;Ron W F de Bruin","doi":"10.1159/000530011","DOIUrl":"https://doi.org/10.1159/000530011","url":null,"abstract":"<p><strong>Introduction: </strong>Short-term fasting protects against renal ischemia reperfusion injury (IRI). mTOR signaling is downregulated and may be involved in its protective effect. Rapamycin is considered a possible mimetic as it inhibits the mTOR pathway. This study examines the effect of rapamycin on renal IRI.</p><p><strong>Material and methods: </strong>Mice were divided into four groups: ad libitum (AL), fasted (F), AL treated with rapamycin (AL+R), and F treated with rapamycin (F+R). Rapamycin was administered intraperitoneally 24 h before bilateral renal IRI was induced. Survival was monitored for 7 days. Renal cell death, regeneration, and mTOR activity were determined 48 h after reperfusion. Oxidative stress resistance of human renal proximal tubular and human primary tubular epithelial cells after rapamycin treatment was determined.</p><p><strong>Results: </strong>All F and F+R mice survived the experiment. Although rapamycin substantially downregulated mTOR activity, survival in the AL+R group was similar to AL (10%). Renal regeneration was significantly reduced in AL+R but not in F+R. After IRI (48 h), pS6K/S6K ratio was lower in F, F+R, and AL+R groups compared to AL fed animals (p = 0.02). In vitro, rapamycin also significantly downregulated mTOR activity (p &lt; 0.001) but did not protect against oxidative stress.</p><p><strong>Conclusion: </strong>Rapamycin pretreatment does not protect against renal IRI. Thus, protection against renal IRI by fasting is not exclusively mediated through inhibition of mTOR activity but may involve preservation of regenerative mechanisms despite mTOR downregulation. Therefore, rapamycin cannot be used as a dietary mimetic to protect against renal IRI.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9673377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Surgical Research Gave Birth to a New Clinical Surgical Field: A Viewpoint from the Dallas Uterus Transplant Study.","authors":"Liza Johannesson,&nbsp;Giuliano Testa,&nbsp;Briget da Graca,&nbsp;Anji Wall","doi":"10.1159/000528989","DOIUrl":"https://doi.org/10.1159/000528989","url":null,"abstract":"<p><strong>Background: </strong>Uterus transplantation (UTx) has come of age in the 21st century, building on the 20th century developments in vascular anastomosis and effective immunosuppressive protocols that have enabled solid organ transplantation to become the life-extending and life-improving treatment option we know today. However, UTx has the goal of enabling reproduction, meaning that research has focused on establishment of pregnancy and healthy live birth in addition to surgical technique and immunosuppression.</p><p><strong>Summary: </strong>The Dallas Uterus Transplant Study (DUETS), established at Baylor University Medical Center in 2015, is one of four UTx programs in the USA, and it holds the distinction of being home not only to the first US live birth but also the highest volume UTx program worldwide, with 23 uterus transplants performed to date, resulting in 15 live births. Innovations pioneered at our center span all aspects of the UTx process, all seeking to improve success for recipients in terms of achieving pregnancy and live birth, while also minimizing the burden on donors and recipients. They have included the following: (1) a deceased donor hysterectomy approach that allows the uterus to be procured prior to cross clamp; (2) proof of concept with use of only superior uterine veins after procuring both the superior and inferior uterine veins during the donor surgery, enabling the choice of the best option in terms of size and location for outflow, while also preserving ovary viability in living donors; (3) contribution to robot-assisted technique/minimally invasive technique with vaginal extraction of the uterus graft for living donor surgeries, shortening donor recovery times; (4) developing a robot-assisted technique for graft hysterectomies, improving recovery times for recipients at the end of their UTx journey; (5) refining immunosuppression protocols to enable embryo transfer as early as 3 months after induction therapy, increasing recipients' chances for achieving up to two live births during the 5 years posttransplant the UTx protocol specifies; and (6) building on our clinical trial experience to now offer UTx in the U.S. outside the setting of a clinical study.</p><p><strong>Key messages: </strong>Our center along with others throughout the world has demonstrated that UTx can be reproducible, result in live births from both living and deceased donors, and be safely introduced as a clinical option. Due to the complexity of UTx as well as the need for long-term multidisciplinary care, centers implementing UTx should have an established abdominal transplant program, a gynecologic surgery program, high-risk obstetric and neonatal care, and institutional support and oversight, and should partner with established UTx programs for protocol development and operative proctoring.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9685032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}