Expert Review of Neurotherapeutics最新文献_第2页

Diagnostic advances and challenges in meningioma. 脑膜瘤的诊断进展与挑战。

IF 3.4 2区医学

Expert Review of Neurotherapeutics Pub Date : 2025-10-01 Epub Date: 2025-08-18 DOI: 10.1080/14737175.2025.2548327

Stefanie Quach, Matthias Simon

{"title":"Diagnostic advances and challenges in meningioma.","authors":"Stefanie Quach, Matthias Simon","doi":"10.1080/14737175.2025.2548327","DOIUrl":"10.1080/14737175.2025.2548327","url":null,"abstract":"Introduction: The rising incidence of meningiomas, coupled with the aggressive behavior observed in a subset of these tumors, presents significant clinical challenges. Accurate diagnosis and risk stratification are essential for effective patient management.Areas covered: This review offers a comprehensive overview of the evolving diagnostic landscape for meningiomas. It examines the roles of MRI, CT, and PET imaging - particularly somatostatin receptor type 2 (SSTR2) PET - in tumor detection and differentiation. In addition, it discusses the integration of molecular markers into the 2021 WHO classification and highlights the potential of multiomics analyses to enhance tumor classification and prognostication. It also addresses challenges related to standardization, clinical implementation, and accessibility of these advanced diagnostic tools. A literature search was conducted using PubMed and clinicaltrials.gov to identify clinical trials exploring the use of SSTR2 PET and treatments informed by molecular diagnostic findings.Expert opinion: The integration of molecular data with advanced imaging techniques offers significant promise for the development of an integrated diagnostic framework for meningiomas. This approach has the potential to improve risk stratification and support the implementation of personalized treatment strategies. However, achieving this will require extensive correlative research and the establishment of large, high-quality datasets that combine imaging, molecular, and clinical information.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"1209-1221"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does robot-assisted gait training represent a true advancement in post-stroke walking rehabilitation? 机器人辅助步态训练是否代表了中风后步行康复的真正进步？

IF 3.4 2区医学

Expert Review of Neurotherapeutics Pub Date : 2025-09-23 DOI: 10.1080/14737175.2025.2564712

Prakash V, Shrushti Shah

{"title":"Does robot-assisted gait training represent a true advancement in post-stroke walking rehabilitation?","authors":"Prakash V, Shrushti Shah","doi":"10.1080/14737175.2025.2564712","DOIUrl":"10.1080/14737175.2025.2564712","url":null,"abstract":"Introduction: Robot-assisted gait training (RAGT) has gained prominence in stroke rehabilitation, promoted as a technologically advanced intervention to improve walking outcomes. However, evidence from clinical trials and systematic reviews paints a more equivocal picture. Despite its widespread adoption, questions persist regarding its true clinical utility and whether it offers meaningful benefits beyond conventional physiotherapy.Areas covered: This perspective evaluates the evidence base for RAGT by critically reviewing recent systematic reviews and randomized controlled trials, with particular attention to study designs, comparator interventions, and reported outcomes. It highlights the overreliance on surrogate outcomes and underlines the need to focus on meaningful functional endpoints like walking independence and community mobility. Studies that directly compare RAGT with task-specific overground gait training (TOGT) are emphasized, as these provide the most relevant insights into RAGT's additive value.Expert opinion: Without evidence of clear additive value, the continued emphasis on RAGT may reflect technological enthusiasm more than therapeutic necessity. The field must reconsider its priorities, redirecting research efforts toward optimizing scalable, high-intensity TOGT that aligns more closely with real-world functional recovery. Future research should prioritize direct comparisons between RAGT and optimized TOGT, with a stronger focus on outcomes that matter to patients.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"1-10"},"PeriodicalIF":3.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redefining insomnia: from neural dysregulation to personalized therapeutics. 重新定义失眠：从神经失调到个性化治疗。

IF 3.4 2区医学

Expert Review of Neurotherapeutics Pub Date : 2025-09-21 DOI: 10.1080/14737175.2025.2564709

Oscar Arias-Carrión

{"title":"Redefining insomnia: from neural dysregulation to personalized therapeutics.","authors":"Oscar Arias-Carrión","doi":"10.1080/14737175.2025.2564709","DOIUrl":"https://doi.org/10.1080/14737175.2025.2564709","url":null,"abstract":"Introduction: Insomnia disorder (ID) is a prevalent and disabling neurological condition, affecting about one in three individuals over the lifespan. It is linked to elevated risks of cognitive decline, psychiatric illness, cardiometabolic conditions, and neurodegenerative disease. Despite being recognized as a distinct clinical entity, ID remains underdiagnosed and undertreated. Traditional diagnostic tools lack sensitivity to the neurobiological complexity of this condition, and current preclinical and clinical models fail to capture its chronic, heterogeneous, and hyperarousal-driven nature adequately.Areas covered: This review integrates interdisciplinary evidence framing insomnia as a disorder of arousal regulation. Key features include persistent hyperactivity in salience and executive control networks, heightened cortical excitability and disrupted emotional processing. This article also presents an examination of how genetic predispositions - particularly polymorphisms in circadian and emotion-related genes such as MEIS1, CLOCK, and PER2-interact with environmental stressors like early-life adversity and prenatal stress. These interactions shape vulnerability through epigenetic modification of stress-regulatory systems. Current treatments, including CBT-I, pharmacotherapy, and emerging neuromodulatory and digital therapeutics, are evaluated with attention to their limitations and potential.Expert opinion: Future research should adopt a precision neuroscience approach, moving from symptom-based classifications to biologically informed models. Integrating neurocircuit dysfunction, stress responsivity, and genetic architecture - alongside advanced tools like EEG, neuroimaging, and machine learning - will enable personalized care and novel therapeutic targets.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How impactful is deep brain stimulation for depression? 深部脑刺激对抑郁症有多大影响？

IF 3.4 2区医学

Expert Review of Neurotherapeutics Pub Date : 2025-09-18 DOI: 10.1080/14737175.2025.2562119

Katherine Scangos, Casey Halpern

引用次数: 0

Epilepsy surgery for seizure control in individuals with Dravet syndrome: is it a safe and practical option? Dravet综合征患者癫痫手术控制癫痫发作：这是一种安全实用的选择吗？

IF 3.4 2区医学

Expert Review of Neurotherapeutics Pub Date : 2025-09-18 DOI: 10.1080/14737175.2025.2562118

Keith Starnes, Elaine Wirrell, M Scott Perry

{"title":"Epilepsy surgery for seizure control in individuals with Dravet syndrome: is it a safe and practical option?","authors":"Keith Starnes, Elaine Wirrell, M Scott Perry","doi":"10.1080/14737175.2025.2562118","DOIUrl":"https://doi.org/10.1080/14737175.2025.2562118","url":null,"abstract":"Introduction: Dravet syndrome is a severe developmental and epileptic encephalopathy presenting in childhood with drug resistant seizures and multiple comorbidities including developmental and cognitive delays. While medical therapy has continued to advance, leading to improved seizure control, outcomes such as seizure freedom remain elusive. As the underlying cause of Dravet syndrome is a genetic channelopathy, epilepsy surgery is rarely considered.Areas covered: The authors weigh up the potential benefits of surgical therapy when seizure reduction, but not seizure freedom, is expected, discussing the literature related to surgical therapy in patients with Dravet syndrome and other similar genetic conditions.Expert opinion: In general, people with Dravet syndrome are rarely favorable candidates for epilepsy surgery, yet surgery is not necessarily contraindicated. Meaningful seizure reduction can be achieved in highly selected cases with perhaps the most benefit arising from neuromodulation procedures such as vagus nerve stimulation. It remains uncertain whether seizure reduction following surgery contributes to any non-seizure benefits.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"1-6"},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute and prophylactic treatment of dialysis headache: a systematic review. 急性和预防性治疗透析头痛：系统回顾。

IF 3.4 2区医学

Expert Review of Neurotherapeutics Pub Date : 2025-09-18 DOI: 10.1080/14737175.2025.2562123

Jonata Ribeiro de Sousa, Maria Clara Arcoverde de Santana, Pedro Augusto Sampaio Rocha-Filho

{"title":"Acute and prophylactic treatment of dialysis headache: a systematic review.","authors":"Jonata Ribeiro de Sousa, Maria Clara Arcoverde de Santana, Pedro Augusto Sampaio Rocha-Filho","doi":"10.1080/14737175.2025.2562123","DOIUrl":"https://doi.org/10.1080/14737175.2025.2562123","url":null,"abstract":"Introduction: Dialysis headache (DH) has a prevalence ranging from 27% to 73% among patients undergoing hemodialysis. Research on its treatment remains limited.Methods: This systematic review explores the treatment of DH. It was conducted according to the PRISMA statement and registered in PROSPERO (CRD42023493031). The following databases were used: PubMed/Medline, LILACS/Scielo, Cochrane, Scopus, Web of Science, Embase and Google Scholar.Results: Eight trials were included. One controlled clinical trial showed that watching comedy films during hemodialysis was associated with less headache. Another showed no benefit from drinking coffee. Open-label trials compared different dialysis techniques. There was less headache in profiled hemodialysis (combining sodium and ultrafiltration) than in standard hemodialysis, in hemodialysis using an automatic adjustment in ultrafiltration rate and hemofiltration than in standard hemodialysis. There was no difference between the step and linear sodium profiling programs. An open clinical trial reported a reduction in the intensity and frequency of DH after the use of nortriptyline. A retrospective cohort study reported less DH in patients undergoing online hemodiafiltration (combining diffusion and convection mechanisms) compared to those receiving conventional hemodialysis.Conclusion: Environmental changes and changes in dialysis techniques may contribute to a lower incidence of DH. Nortriptyline possibly improves DH.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"1-9"},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of virtual reality rehabilitation with exergames on functional rehabilitation in Parkinson's disease: a systematic review of chronic randomized controlled trials. 结合exergames的虚拟现实康复对帕金森病功能康复的有效性：一项慢性随机对照试验的系统综述。

IF 3.4 2区医学

Expert Review of Neurotherapeutics Pub Date : 2025-09-17 DOI: 10.1080/14737175.2025.2559180

João Lucas Lima, Pedro Augusto Inacio, Alberto Sá Filho, Flávia Paes, Rafael Ferreira-Garcia, Lucio Lage, Vicente Aprigliano, Mauro Giovani Carta, Henning Budde, Antonio Egidio Nardi, Sergio Machado

{"title":"Effectiveness of virtual reality rehabilitation with exergames on functional rehabilitation in Parkinson's disease: a systematic review of chronic randomized controlled trials.","authors":"João Lucas Lima, Pedro Augusto Inacio, Alberto Sá Filho, Flávia Paes, Rafael Ferreira-Garcia, Lucio Lage, Vicente Aprigliano, Mauro Giovani Carta, Henning Budde, Antonio Egidio Nardi, Sergio Machado","doi":"10.1080/14737175.2025.2559180","DOIUrl":"https://doi.org/10.1080/14737175.2025.2559180","url":null,"abstract":"Introduction: Exergaming is increasingly used to target gait and balance impairments in Parkinson's disease (PD), but the durability of effects and comparative efficacy versus active controls remain uncertain. The aim of this work is to evaluate the effectiveness and clinical implications of exergame-based rehabilitation for individuals with PD in randomized controlled trials, including studies with and without follow-up assessments.Methods: The authors conducted a PRISMA-guided systematic review (PROSPERO CRD42025642840). Eligible studies were RCTs in people with PD comparing exergaming programs with non-exergaming interventions.Results: Eighteen RCTs (n = 699; 341 exergaming, 358 control) met inclusion criteria; Typical programs spanned 4-12 weeks with 15-60-min sessions, most commonly 6 weeks, delivered predominantly under supervision. The outcomes that improved most consistently were mobility/locomotion (TUG, 6MWT/10MWT, gait speed) and balance. When exergames were compared with active, non-exergaming therapy, effects were generally comparable. Adverse events were rare, and adherence was documented as high where reported; most trials were facility-based with professional supervision. Only three trials included follow-up (≈1-2 months), suggesting short-term retention (~30 days), whereas one 60-day assessment showed return to baseline.Conclusion: Exergame is a safe, feasible, and effective adjunct for short-term improvement of mobility and balance in PD. However, scarce follow-up limit inferences on long-term maintenance.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"1-14"},"PeriodicalIF":3.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichotillomania and its treatment: an updated review and recommendations. 拔毛癖及其治疗：最新综述和建议。

IF 3.4 2区医学

Expert Review of Neurotherapeutics Pub Date : 2025-09-17 DOI: 10.1080/14737175.2025.2557395

Megan C DuBois, Bridget M Feler, Christopher A Flessner, Martin E Franklin

{"title":"Trichotillomania and its treatment: an updated review and recommendations.","authors":"Megan C DuBois, Bridget M Feler, Christopher A Flessner, Martin E Franklin","doi":"10.1080/14737175.2025.2557395","DOIUrl":"10.1080/14737175.2025.2557395","url":null,"abstract":"Introduction: Trichotillomania is an impulse control disorder in which individuals fail to resist urges to pull out their own hair and is associated with significant psychiatric comorbidity and functional impairment in affected children, adolescents, and adults. Onset in childhood or adolescence is typical, yet the literature on phenomenology, psychopathology, and treatment outcome involving pediatric samples remains particularly sparse. Efficacious treatments have been developed and found efficacious, most notably cognitive-behavioral interventions known collectively as habit reversal training, although relapse in adults appears to be somewhat common.Areas covered: Herein, the authors give an overview of the latest developments in the treatment of trichotillomania and provide their own expert recommendations for the management of the condition. This article is based on searches using the PubMed and PsycINFO databases for peer-reviewed articles from 2011 through to April 2025.Expert opinion: Recent developments in pharmacotherapies, both alone and in combination with cognitive behavioral treatments, hold promise, although further efforts are needed to examine their efficacy, effectiveness, and durability. Dissemination of information about trichotillomania and its treatment remains a critical next step in the field, since many affected individuals and their families experience difficulties with finding local treatment providers with sufficient knowledge to deliver interventions known to reduce hair pulling behaviors and associated symptoms.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"1-11"},"PeriodicalIF":3.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The value of radiotherapy in patients with recurrent atypical meningioma: an update. 放疗在复发性非典型脑膜瘤患者中的价值：最新进展。

IF 3.4 2区医学

Expert Review of Neurotherapeutics Pub Date : 2025-09-12 DOI: 10.1080/14737175.2025.2559181

Chia Ching Lee, Caryn Wujanto, Pooja Handa, Balamurugan Vellayappan

{"title":"The value of radiotherapy in patients with recurrent atypical meningioma: an update.","authors":"Chia Ching Lee, Caryn Wujanto, Pooja Handa, Balamurugan Vellayappan","doi":"10.1080/14737175.2025.2559181","DOIUrl":"https://doi.org/10.1080/14737175.2025.2559181","url":null,"abstract":"Introduction: Atypical meningiomas (WHO Grade 2) comprise approximately 18% of all meningiomas and may recur, despite surgical resection. Current evidence, derived from prospective cohort studies and retrospective series, supports the use of radiotherapy in achieving local control in atypical meningiomas. Given the lack of level 1 data, the role of RT in the management of recurrent disease in radiotherapy-naïve or previously irradiated patients remains a subject of ongoing debate, and optimal strategies are yet to be established.Areas covered: This narrative review examines recent developments in radiotherapy techniques, including dose escalation and particle therapy, alongside advances in imaging and molecular profiling relevant to meningioma management. The authors summarize the existing evidence and provide an updated perspective on the evolving role and value of radiotherapy in treating recurrent atypical meningiomas. This article also proposes a new treatment algorithm. This review is based on a literature search using PubMed to identify relevant studies on recurrent atypical meningioma (WHO grade 2) up to August 2025. Key references from recent guidelines and high-impact studies were also included.Expert opinion: The authors believe that treatment plans for recurrent atypical meningioma should consider prior radiotherapy exposure. The integration of PET-guided radiotherapy planning and molecular-based risk stratification will allow for personalized treatment plans, setting a framework for its future clinical management.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"1-17"},"PeriodicalIF":3.4,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145052591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paroxysmal sympathetic hyperactivity (PSH) after traumatic brain injury: the pathophysiological role of glutamate and potential treatment with branched-chain amino acids. 创伤性脑损伤后阵发性交感神经亢进（PSH）：谷氨酸的病理生理作用和支链氨基酸的潜在治疗

IF 3.4 2区医学

Expert Review of Neurotherapeutics Pub Date : 2025-09-09 DOI: 10.1080/14737175.2025.2558195

Rob Dickerman, Matthew Bennett, Ezek Mathew, John East

引用次数: 0