Expert Review of Neurotherapeutics最新文献_第10页

An analysis of omega-3 clinical trials and a call for personalized supplementation for dementia prevention. 分析欧米茄-3 临床试验，呼吁为预防痴呆症提供个性化补充剂。

IF 4.3 2区医学

Expert Review of Neurotherapeutics Pub Date : 2024-03-01 Epub Date: 2024-02-20 DOI: 10.1080/14737175.2024.2313547

Nicolás Castellanos-Perilla, Miguel Germán Borda, Dag Aarsland, George E Barreto

{"title":"An analysis of omega-3 clinical trials and a call for personalized supplementation for dementia prevention.","authors":"Nicolás Castellanos-Perilla, Miguel Germán Borda, Dag Aarsland, George E Barreto","doi":"10.1080/14737175.2024.2313547","DOIUrl":"10.1080/14737175.2024.2313547","url":null,"abstract":"Introduction: Targeted interventions are needed to delay or prevent the onset of neurodegenerative diseases. Poor dietary habits are associated with cognitive decline, highlighting the benefits of a healthy diet with fish and polyunsaturated fatty acids (PUFAs). Intake of omega-3 PUFAs docosahexaenoic acid (DHA), α-linolenic acid (ALA) and eicosapentaenoic acid (EPA) is linked with healthy aging, cardiovascular benefits, and reduced risk of Alzheimer's disease. Although omega-3 has health benefits, its intake is often inadequate and insufficient in modern diets. Although fish oil supplements offer an alternative source, inconsistent results from clinical trials raise questions about the factors determining their success.Areas covered: In this this review, the authors discuss the aforementioned determining factors and highlight strategies that could enhance the effectiveness of omega-3 PUFAs interventions for dementia and cognitive decline. Moreover, the authors provide suggestions for potential future research.Expert opinion: Factors such as diet, lifestyle, and genetic predisposition can all influence the effectiveness of omega-3 supplementation. When implementing clinical trials, it is crucial to consider these factors and recognize their potential impact on the interpretation of results. It is important to study each variable independently and the interactions between them.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"313-324"},"PeriodicalIF":4.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omaveloxolone for the treatment of Friedreich ataxia: clinical trial results and practical considerations. 治疗弗里德里希共济失调的奥马韦洛酮：临床试验结果和实际考虑因素。

IF 4.3 2区医学

Expert Review of Neurotherapeutics Pub Date : 2024-03-01 Epub Date: 2024-01-30 DOI: 10.1080/14737175.2024.2310617

David R Lynch, Susan Perlman, Kim Schadt

引用次数: 0

Are pharmacotherapeutics effective for treating aphasia? 药物治疗对治疗失语症有效吗？

IF 4.3 2区医学

Expert Review of Neurotherapeutics Pub Date : 2024-03-01 Epub Date: 2024-02-07 DOI: 10.1080/14737175.2024.2313557

Guadalupe Dávila, Marcelo L Berthier

{"title":"Are pharmacotherapeutics effective for treating aphasia?","authors":"Guadalupe Dávila, Marcelo L Berthier","doi":"10.1080/14737175.2024.2313557","DOIUrl":"10.1080/14737175.2024.2313557","url":null,"abstract":"Introduction: Aphasia is a communication disorder resulting from stroke and/or neurodegenerative conditions which involve the left cerebral hemisphere. It is a debilitating disorder affecting a person's ability to speak, understand, read, and write. Its impact on daily life necessitates therapeutic strategies to aid patients with aphasia.Areas covered: In this special report, the authors speculate whether current pharmacotherapeutic strategies are effective in treating aphasia. The authors look at aphasia caused by different conditions and how this could impact therapy before providing the reader with their expert perspectives. The aim of this paper is for the reader to gain a clearer understanding of the efficacy of the current pharmacotherapeutic treatment paradigms as well as potential future developments.Expert opinion: The exploration of pharmacotherapy for aphasia in vascular brain disorders and neurodegenerative diseases has received much attention in recent years with various therapeutic strategies having been put forward. In terms of whether pharmacotherapy is effective for the treatment of aphasia, there is still no clear-cut answer. Further research is needed with more studies requiring a greater emphasis on language and communication deficits. Biomarkers may also help clinicians provide their patients with a more personalized treatment plan.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"267-271"},"PeriodicalIF":4.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The management of Neurofibromatosis type 1 (NF1) in children and adolescents 儿童和青少年神经纤维瘤病 1 型 (NF1) 的管理

IF 4.3 2区医学

Expert Review of Neurotherapeutics Pub Date : 2024-02-26 DOI: 10.1080/14737175.2024.2324117

Nino Kerashvili, David H. Gutmann

引用次数: 0

Careful considerations for the treatment of posttraumatic stress disorder during and following pregnancy. 妊娠期间和妊娠后治疗创伤后应激障碍的注意事项。

IF 4.3 2区医学

Expert Review of Neurotherapeutics Pub Date : 2024-02-01 Epub Date: 2024-02-06 DOI: 10.1080/14737175.2024.2303430

Casey Oliver, Erika Puiras, Verinder Sharma, Dwight Mazmanian

{"title":"Careful considerations for the treatment of posttraumatic stress disorder during and following pregnancy.","authors":"Casey Oliver, Erika Puiras, Verinder Sharma, Dwight Mazmanian","doi":"10.1080/14737175.2024.2303430","DOIUrl":"10.1080/14737175.2024.2303430","url":null,"abstract":"Introduction: The focus on perinatal mental health has expanded recently, though there is less research on post-traumatic stress disorder (PTSD). Therefore, a review of the literature was undertaken and coupled with expert clinical insights to discuss current clinical practice recommendations for PTSD in the perinatal period.Areas covered: This review covers considerations for the assessment, prevention, and treatment of PTSD during the perinatal period. Within these sections, evidence-based and promising practices are outlined. Extra attention is afforded to treatment, which includes considerations from both psychotherapeutic and psychopharmacological perspectives. This review closes with coverage of three important and related areas of consideration, including bereavement, intimate partner violence, and childhood sexual abuse.Expert opinion: Psychotherapeutic interventions for PTSD during pregnancy are limited, and no strong recommendations can be supported at this time while evidence points toward the effectiveness of cognitive behavioral therapies and eye movement desensitization therapy as first-line treatments postpartum though research evidence is also limited. Research on psychopharmacological interventions is similarly scarce, though selective serotonin reuptake inhibitors may be beneficial. Clinicians should also be mindful of additional considerations that may be needed for the treatment of PTSD in the context of bereavement, intimate partner violence, and history of sexual violence.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"159-170"},"PeriodicalIF":4.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative analgesic options after spine surgery: finding the optimal treatment strategies. 脊柱手术后的术后镇痛选择：寻找最佳治疗策略。

IF 4.3 2区医学

Expert Review of Neurotherapeutics Pub Date : 2024-02-01 Epub Date: 2024-02-06 DOI: 10.1080/14737175.2023.2298824

Alina Razak, Benjamin Corman, John Servider, Ana Mavarez-Martinez, Zhaosheng Jin, Harry Mushlin, Sergio D Bergese

{"title":"Postoperative analgesic options after spine surgery: finding the optimal treatment strategies.","authors":"Alina Razak, Benjamin Corman, John Servider, Ana Mavarez-Martinez, Zhaosheng Jin, Harry Mushlin, Sergio D Bergese","doi":"10.1080/14737175.2023.2298824","DOIUrl":"10.1080/14737175.2023.2298824","url":null,"abstract":"Introduction: Spine surgery is one of the most common types of surgeries performed in the United States; however, managing postoperative pain following spine surgery has proven to be challenging. Patients with spine pathologies have higher incidences of chronic pain and resultant opioid use and potential for tolerance. Implementing a multimodal plan for postoperative analgesia after spine surgery can lead to enhanced recovery and outcomes.Areas covered: This review presents several options for analgesia following spine surgery with an emphasis on multimodal techniques to best aid this specific patient population. In addition to traditional therapeutics, such as acetaminophen, non-steroidal anti-inflammatory medications, and opioids, we discuss intrathecal morphine administration and emerging regional anesthesia techniques.Expert opinion: Several adjuncts to improve analgesia following spine surgery are efficacious in the postoperative period. Intrathecal morphine provides sustained analgesia and can be instilled intraoperatively by the surgical team under direct visualization. Local anesthetics deposited under ultrasound guidance by an anesthesiologist trained in regional techniques also provide the opportunity for single injections or continuous analgesia via an indwelling catheter.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"191-200"},"PeriodicalIF":4.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The latest developments with internet-based psychological treatments for depression. 基于互联网的抑郁症心理治疗的最新进展。

IF 4.3 2区医学

Expert Review of Neurotherapeutics Pub Date : 2024-02-01 Epub Date: 2024-02-06 DOI: 10.1080/14737175.2024.2309237

Gerhard Andersson

{"title":"The latest developments with internet-based psychological treatments for depression.","authors":"Gerhard Andersson","doi":"10.1080/14737175.2024.2309237","DOIUrl":"10.1080/14737175.2024.2309237","url":null,"abstract":"Introduction: Internet-based psychological treatments for depression have been around for more than 20 years. There has been a continuous line of research with new research questions being asked and studies conducted.Areas covered: In this paper, the author reviews studies with a focus on papers published from 2020 and onwards based on a Medline and Scopus search. Internet-based cognitive behavior therapy (ICBT) programs have been developed and tested for adolescents, older adults, immigrant groups and to handle a societal crisis (e.g. COVID-19). ICBT works in regular clinical settings and long-term effects can be obtained. Studies on different treatment orientations and approaches such as acceptance commitment therapy, unified protocol, and tailored treatments have been conducted. Effects on quality-of-life measures, knowledge acquisition and ecological momentary assessment as a research tool have been reported. Factorial design trials and individual patient data meta-analysis are increasingly used in association with internet intervention research. Finally, prediction studies and recent advances in artificial intelligence are mentioned.Expert opinion: Internet-delivered treatments are effective, in particular if therapist guidance is provided. More target groups have been covered but there are many remaining challenges including how new tools like artificial intelligence will be used when treating depression.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"171-176"},"PeriodicalIF":4.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139566936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Family accommodation: a diagnostic feature of obsessive-compulsive disorder? 家庭迁就：强迫症的诊断特征？

IF 4.3 2区医学

Expert Review of Neurotherapeutics Pub Date : 2024-02-01 Epub Date: 2024-02-06 DOI: 10.1080/14737175.2024.2309239

Rebecca G Etkin, Michael H Bloch, Eli R Lebowitz

引用次数: 0

An update on the role of magnetic resonance imaging in predicting and monitoring multiple sclerosis progression. 磁共振成像在预测和监测多发性硬化症进展方面的最新作用。

IF 4.3 2区医学

Expert Review of Neurotherapeutics Pub Date : 2024-02-01 Epub Date: 2024-02-06 DOI: 10.1080/14737175.2024.2304116

Piriyankan Ananthavarathan, Nitin Sahi, Declan T Chard

{"title":"An update on the role of magnetic resonance imaging in predicting and monitoring multiple sclerosis progression.","authors":"Piriyankan Ananthavarathan, Nitin Sahi, Declan T Chard","doi":"10.1080/14737175.2024.2304116","DOIUrl":"10.1080/14737175.2024.2304116","url":null,"abstract":"Introduction: While magnetic resonance imaging (MRI) is established in diagnosing and monitoring disease activity in multiple sclerosis (MS), its utility in predicting and monitoring disease progression is less clear.Areas covered: The authors consider changing concepts in the phenotypic classification of MS, including progression independent of relapses; pathological processes underpinning progression; advances in MRI measures to assess them; how well MRI features explain and predict clinical outcomes, including models that assess disease effects on neural networks, and the potential role for machine learning.Expert opinion: Relapsing-remitting and progressive MS have evolved from being viewed as mutually exclusive to having considerable overlap. Progression is likely the consequence of several pathological elements, each important in building more holistic prognostic models beyond conventional phenotypes. MRI is well placed to assess pathogenic processes underpinning progression, but we need to bridge the gap between MRI measures and clinical outcomes. Mapping pathological effects on specific neural networks may help and machine learning methods may be able to optimize predictive markers while identifying new, or previously overlooked, clinically relevant features. The ever-increasing ability to measure features on MRI raises the dilemma of what to measure and when, and the challenge of translating research methods into clinically useable tools.","PeriodicalId":12190,"journal":{"name":"Expert Review of Neurotherapeutics","volume":" ","pages":"201-216"},"PeriodicalIF":4.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A proposal for a shared therapeutic algorithm in children with prolonged convulsive seizures and status epilepticus. 针对长期惊厥发作和癫痫状态儿童的共同治疗算法建议。

IF 4.3 2区医学

Expert Review of Neurotherapeutics Pub Date : 2024-02-01 Epub Date: 2024-02-06 DOI: 10.1080/14737175.2024.2305813

Roberta Roberti, Antonella Riva, Gianluca D'Onofrio, Emanuele Giacheri, Elisabetta Amadori, Maria Stella Vari, Angela La Neve, Federico Vigevano, Alberto Verrotti, Duccio Maria Cordelli, Antonino Romeo, Antonella Palmieri, Maria Margherita Mancardi, Sergio Caglieris, Antonio Varone, Carlo Minetti, Emilio Russo, Silvia Buratti, Pasquale Striano

引用次数: 0