Fetal Diagnosis and Therapy最新文献

{"title":"Discordance between Fetal Ultrasound and MRI to Predict Severity in Congenital Diaphragmatic Hernia.","authors":"Payton Moody, Blair W Weikel, Jason Gien, Henry L Galan, Lamia Al-Amri, Mariana L Meyers, Caitlin R Eason, S Christopher Derderian","doi":"10.1159/000548620","DOIUrl":"10.1159/000548620","url":null,"abstract":"<p><strong>Introduction: </strong>Prenatal ultrasound (US) and MRI guide the diagnosis and management of congenital diaphragmatic hernia (CDH). A challenge arises when one imaging modality suggests a moderate case and the other a severe case (\"discordant severe CDH\"). We aimed to analyze newborn outcomes for this group.</p><p><strong>Methods: </strong>We reviewed all left-sided CDH cases at our fetal care center from 2012 to 2023. Discordant severe was defined as severe by either US (trace observed-to-expected lung-to-head ratio ≤25%) or MRI (percent predicted lung volume ≤15%) and moderate by the other. Concordant severe and concordant moderate groups were defined as both US and MRI predicting the same severity. Primary outcomes were rate of extracorporeal membrane oxygenation (ECMO) cannulation and survival to discharge.</p><p><strong>Results: </strong>We identified 35 concordant moderate, 21 discordant severe, and 11 concordant severe CDH cases. Compared to the concordant moderate group, the discordant severe group had significantly higher ECMO cannulation rates and significantly lower survival to discharge. No significant differences were found between concordant severe and discordant severe groups.</p><p><strong>Conclusion: </strong>Outcomes for discordant severe CDH are similar to concordant severe, suggesting teams should rely on the imaging modality that predicts the more severe categorization in the setting of discordant severe CDH.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"211-221"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrauterine Treatment in Two Fetuses Affected by Cystic Fibrosis: To Whom and Since When? Report of Cases.","authors":"Nuria Martínez Sánchez, Beatriz Herrero, Elena Mansilla, Carmen Prior de Castro, María De la Calle, María Concepción Prados Sánchez, Marta Ruiz de Valvuena Maíz, José Luis Bartha, Eugenia Antolín","doi":"10.1159/000549043","DOIUrl":"10.1159/000549043","url":null,"abstract":"<p><strong>Introduction: </strong>Cystic fibrosis (CF) is an autosomal recessive disease associated to low survival disease into adulthood. The appearance of the cystic fibrosis transmembrane conductance regulator (CFTR) therapy has revolutionized the management and the prognosis of these patients with an improvement in the pancreatic and lung function with a much better quality of life. More women with CF are considering being mothers. Other clinical scenario is the prenatal diagnosis of fetus with CF. Three case reports have been published, suggesting that CFTR therapy during pregnancy in fetuses affected by CF might prevent prenatal meconium ileus (MI), which are the one who have a higher risk of gastrointestinal morbidity and long-term complications.</p><p><strong>Case presentation: </strong>We present 2 cases in which the diagnosis of CF occurred during intrauterine life and treatment with CFTR therapy was administered to healthy pregnant women in order to reduce the risk MI in their fetuses. In both cases, the diagnosis suspicion was by ultrasound findings with a genetic confirmed diagnosis by amniocentesis. In the first case, the mother received the CFTR therapy during 5 weeks and MI was not developed by the newborn. In the second one, the mother received the treatment only for a week and MI could not be avoided.</p><p><strong>Conclusion: </strong>This clinical situation has special ethical considerations, since a drug is being administered through compassionate use to a woman who does not need it. The fundamental reason is the lack of authorization for the use of these drugs in newborns but in adults. We hope that these 2 clinical cases, together with those already published, will increase the knowledge and experience of using this drug in this context helping with the management of pregnant women with fetuses affected by CF in order to reduce associated complications.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"404-412"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slice-to-Volume Registration of the Fetal Thorax to Assess Observed/Expected Total Fetal Lungs Volume in Fetuses with Congenital Diaphragmatic Hernia Who Underwent Fetoscopic Endoluminal Tracheal Occlusion.","authors":"Romain Corroenne, Pamela M Ketwaroo, Magdalena Sanz Cortes","doi":"10.1159/000550698","DOIUrl":"10.1159/000550698","url":null,"abstract":"<p><strong>Introduction: </strong>The objectives of this study were to evaluate the feasibility of slice-to-volume registration (SVR) of the fetal thorax in congenital diaphragmatic hernia (CDH) and to compare observed-to-expected total fetal lung volume (O/E TFLV) obtained from original and SVR MRI volumes for prediction of postnatal survival.</p><p><strong>Methods: </strong>We retrospectively analyzed 35 fetuses with CDH undergoing MRI before and after fetoscopic endoluminal tracheal occlusion (FETO). High-resolution, motion-corrected SVR volumes were reconstructed using an automated pipeline. O/E TFLV was measured on both original and SVR volumes, and results were compared between survivors and non-survivors at 6 months of age. Agreement, correlation, and predictive accuracy were assessed using Pearson correlation and ROC analysis.</p><p><strong>Results: </strong>Four (11.4%) cases were excluded due to uncorrectable artifacts or technical issues. SVR reconstruction required only three acquisitions versus a median of six for conventional imaging. Post-processing took a median of 14 min, and lung delineation was longer for SVR than for original volumes. O/E TFLV measurements showed good to very good agreement between original and SVR volumes (r = 0.75 before and r = 0.96 after FETO), with comparable predictive accuracy for survival (AUC original = 0.81-0.83 vs. AUCSVR = 0.83, p > 0.7).</p><p><strong>Conclusion: </strong>SVR of the fetal thorax is feasible in CDH and provides reliable O/E TFLV measurements with prognostic accuracy comparable to conventional MRI, while reducing the need for repeated acquisitions.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"430-434"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"sFlt-1/PlGF Ratio Predicts Serious Outcomes in Early-Onset Fetal Growth Restriction.","authors":"Satoshi Shinohara, Rei Sunami, Genki Yasuda, Mayuko Kasai","doi":"10.1159/000547695","DOIUrl":"10.1159/000547695","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to identify a cutoff value for the soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio to predict adverse outcomes in early-onset fetal growth restriction (FGR).</p><p><strong>Methods: </strong>In this single-center, non-blinded, retrospective cohort study, maternal serum sFlt-1/PlGF ratios were measured at the time of early-onset FGR diagnosis (<34 weeks) using Roche Elecsys® assays. The optimal cutoff for predicting severe adverse outcomes within 2 weeks was determined using receiver operating characteristic analysis. The Kaplan-Meier analysis assessed delivery probability, and Cox proportional hazards models evaluated factors associated with pregnancy continuation.</p><p><strong>Results: </strong>Among 332 patients, 61 (18.4%) delivered within 2 weeks due to worsening FGR. An sFlt-1/PlGF ratio ≥99.0 predicted adverse outcomes leading to an inability to continue the pregnancy, with 85.3% sensitivity and 91.5% specificity (area under the curve: 0.92). Women with ratios ≥99.0 had a significantly shorter time to delivery (p < 0.001). The ratio remained a significant predictor of adverse outcomes in both asymptomatic and preeclampsia-complicated FGR.</p><p><strong>Conclusion: </strong>The sFlt-1/PlGF ratio is a strong predictor of short-term adverse outcomes in early-onset FGR, aiding in risk stratification and clinical decision-making.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"32-42"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordance of MRI, CT, and Surgical Pathology in Prenatally Diagnosed Lung Lesions.","authors":"Amelia Gavulic, Philip Stanic, Monica Wagner, Laura Galganski, Katherine Nicole Epstein, Foong-Yen Lim, Beth Rymeski","doi":"10.1159/000548472","DOIUrl":"10.1159/000548472","url":null,"abstract":"<p><strong>Introduction: </strong>This study quantified the concordance of pre- and postnatal imaging and pathology diagnoses of fetal lung lesions.</p><p><strong>Methods: </strong>This is a retrospective review of patients seen at a single fetal center from 2014 to 2024.</p><p><strong>Results: </strong>A total of 138 patients with prenatally diagnosed lung lesions were identified. Patients with an associated congenital diaphragmatic hernia (n = 7) and patients with neither postnatal imaging nor surgical pathology (n = 11) were excluded. Overall, 86.7% had postnatal imaging; of these, 79.8% had postnatal CT findings consistent with prenatal imaging. Overall, 68.3% had surgical resection at our institution. The remaining patients had surgery elsewhere or did not pursue resection of the lesion. Of those 82 patients, 90.2% had a pathologic diagnosis concordant with their prenatal MRI and 97.1% had a pathologic diagnosis concordant with postnatal CT. The most common case of discordance between pre- and postnatal imaging was bronchial atresia (71.4%, 15/21), which was originally called a CPAM/BPS/hybrid lesion on prenatal imaging. The most striking case of discordance between imaging and pathology was a pleuropulmonary blastoma initially called a CPAM on prenatal MRI.</p><p><strong>Conclusion: </strong>Congenital lung lesions may evolve during pregnancy, highlighting the value of postnatal imaging to further characterize the lesions and assess the appropriateness of patients for surgical resection.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"96-102"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Perinatal Management of a Large Fetal Intrapericardial Teratoma by Serial Fetal Echocardiogram and ex utero Intrapartum Treatment.","authors":"Jaime Alkon, Eva Hoffmann, Sandeep Sainathan, Leonardo Mulinari, Rodrigo Ruano","doi":"10.1159/000547933","DOIUrl":"10.1159/000547933","url":null,"abstract":"<p><strong>Introduction: </strong>Pericardial teratomas are rare tumors located in the pericardial space compressing the heart from the outside and usually associated with pericardial effusions. When these tumors are diagnosed in utero, there are some management challenges, including the best approach of prenatal follow-up, the ideal timing of delivery, and the perinatal therapeutic strategies. The tumors, although benign, tend to grow considerably prenatally, imposing increased risk of worsening pericardial effusion, compression of the heart, and potentially compromising cardiac output, leading to intrauterine death.</p><p><strong>Case presentation: </strong>We are presenting an extremely large pericardial teratoma diagnosed at 20 weeks' gestation that was followed serially and closely by fetal echocardiogram and ultrasound throughout the gestation. The baby was successfully delivered by ex utero intrapartum treatment (EXIT)-to-resection procedure because of sudden progression to fetal hydrops associated with maternal mirror syndrome. On placental-fetal circulation, the pericardial teratoma was completely resected, allowing for successful maternal-fetal outcome.</p><p><strong>Conclusion: </strong>Serial fetal echocardiogram is a key prenatal tool to evaluate fetal cardiac function in intrapericardial teratomas. EXIT procedure with intrapartum resection of large pericardial teratoma is a safe perinatal strategic option to improve the outcomes of those babies.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"89-95"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Character and Frequency of Early Postnatal Resection in Prenatally Diagnosed Congenital Lung Malformations.","authors":"Philip Stanic, Amelia Gavulic, Marissa Ray, Todd M Jenkins, Katherine Nicole Epstein, Beth Rymeski, Foong-Yen Lim, Laura Galganski","doi":"10.1159/000549705","DOIUrl":"10.1159/000549705","url":null,"abstract":"<p><strong>Introduction: </strong>Currently, risk stratification criteria and indications for early postnatal resection of high-risk congenital lung malformations (CLM) are not universally accepted. In this study, we sought to characterize prenatal risk factors and outcomes associated with early postnatal resection in prenatally diagnosed CLMs.</p><p><strong>Methods: </strong>Retrospective cohort study of patients seen at the Fetal Care Center from January 2014 to December 2023. Categorical data were analyzed with chi-square calculations. Receiver operating characteristic curves were generated for optimal CPAM volume ratio (CVR) and imaging cutoff values associated with hydrops development and/or need for early resection.</p><p><strong>Results: </strong>Of the 204 patients analyzed, 10.2% (21/204) patients underwent early postnatal resection. Hydropic fetuses required early resection significantly more than non-hydropic fetuses (33.3% vs. 5.0%, p < 0.001). A greater number of early resection patients had macrocystic lesions compared to non-early resection patients (76.2% vs. 12.3% p < 0.001). A maximum CVR ≥1.66 was highly predictive of early postnatal resection (AUC = 0.90; 95% CI = 0.84-0.96). An initial CVR <0.88 indicated a low likelihood of developing hydrops (negative predictive value = 98.6%).</p><p><strong>Conclusion: </strong>Prenatally, hydrops, macrocysts, and a maximum recorded CVR ≥1.66 are associated with early postnatal resection. Hydrops development is unlikely with an initial CVR <0.88.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"157-168"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Hypospadias Identified on Fetal Ultrasound: Genetic Investigation Results at a Single Referral Center.","authors":"Qiu-Xia Yu, Xiang-Yi Jing, Zhi-Qing Xiao, Si-Yun Li, Li Zhen, Dong-Zhi Li","doi":"10.1159/000548821","DOIUrl":"10.1159/000548821","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to investigate genetic defects in fetuses diagnosed with isolated hypospadias.</p><p><strong>Methods: </strong>This retrospective study analyzed 61 cases of isolated fetal hypospadias identified through second-trimester or third-trimester ultrasound examinations. All participants underwent invasive prenatal diagnostic procedures for copy number variant (CNV) detection via chromosomal microarray analysis (CMA). For those with normal CNV results, trio whole-exome sequencing (WES) was offered as an alternative. Clinical and laboratory data were systematically collected and reviewed, encompassing maternal demographics, prenatal sonographic findings, molecular testing outcomes, and pregnancy results.</p><p><strong>Results: </strong>Three cases of sex chromosomal abnormalities were identified. In the remaining 58 cases, all had the male karyotype. CMA detected only one case of pathogenic CNVs (2q13 microdeletion). Among the cases with normal CMA, 35 underwent trio WES; two had disease-causing variants: one carried a de novo CREBBP variant, and one carried two SRD5A2 variants.</p><p><strong>Conclusions: </strong>From our perspective, CMA and WES are valuable tools in antenatal care for isolated cases of hypospadias detected via ultrasound; this information should be communicated to patients through prenatal counseling.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"222-227"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000552432","DOIUrl":"10.1159/000552432","url":null,"abstract":"<p><p>In the article \"North American Fetal Therapy Network: Maternal Outcomes in Fetal Aqueductal Stenosis\" [Fetal Diagn Ther. 2024;51(6):612-616; https://doi.org/10.1159/000540196] by Emery et al., the authors wish to correct the following error which occurred due to editorial and proofreading oversight.The first sentence of the Abstract incorrectly reads: \"Fetal aqueductal stenosis (AS) affects approximately 1:1,000 pregnancies.\" The sentence should read: \"Fetal aqueductal stenosis (AS) affects approximately 1:10,000 pregnancies.\"The original article has been updated to reflect this correction.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"419-420"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediastinal Shift Angle and Its Association with Neonatal Mortality in Fetuses with Isolated Left Congenital Diaphragmatic Hernia.","authors":"Donatella Gerulewicz-Vannini, Edgar Hernandez-Andrade, Dejian Lai, Ramesha Papanna, Jimmy Espinoza, Sami Backley, Felicia Venable Lemoine, Matthew T Harting, Ashley H Ebanks, Anthony Johnson","doi":"10.1159/000550641","DOIUrl":"10.1159/000550641","url":null,"abstract":"<p><strong>Introduction: </strong>The mediastinal shift angle (MSA) estimates the lateral displacement of the heart in the fetal thorax. This study aimed to evaluate the MSA's performance in predicting neonatal mortality in fetuses with left isolated congenital diaphragmatic hernia (CDH) as an isolated marker and in combination with other ultrasound and MRI predictors.</p><p><strong>Methods: </strong>MSA was obtained by ultrasound in a cross-sectional four-chamber view of the thorax in 96 fetuses with left isolated CDH. MSA was calculated by drawing two lines from a common point from the skin edge posterior to the spinous process of the thoracic vertebrae, the first line dividing the thorax into two halves, and the second line directed to the lateral border of the right atrium. Additionally, the observed/expected (O/E) lung-to-head ratio LHR, O/E total fetal lung volume (TFLV), and percentage of liver herniation (%LH) were obtained. ROC analysis, prediction, and associations with neonatal mortality were evaluated.</p><p><strong>Results: </strong>Neonatal mortality was 28.1% (27/96). The areas under (AU) the ROC curve for neonatal mortality for MSA and O/E LHR were 0.69 and 0.75, respectively. The best MSA cutoff value was 35°, with 85.2% sensitivity and 67.1% specificity, and aOR 11.75 (95% CI 3.63-37.97; p < 0.0001). Among fetuses with O/E LHR >25% (n = 75), mortality was 17.5% (13/74). In this subgroup, an MSA ≥35° showed an AU-ROC of 0.72 with 83.3% sensitivity and 71.4% specificity, and an aOR 12.5 (95% CI 2.49-62.76; p = 0.002). There was a significant correlation between MSA and O/E LHR (-0.48, p < 0.001), between MSA and O/E TFLV (-0.36, p = 0.005), and between MSA and %LH (0.43, p = 0.001). However, when MSA and O/E LHR were combined, the AU-ROC for neonatal mortality was 0.832, and when MSA, O/E LHR, and O/E TFLV were combined, the AU-ROC improved to 0.901.</p><p><strong>Conclusion: </strong>MSA is a good predictor of neonatal mortality in fetuses with left isolated CDH. The prediction improves when MSA, O/E LHR, and O/E TFLV are combined.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"444-453"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}